Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis

Pediatric Pulmonology

Volumn 24, Issue 3, 1997, Pages 173-177

  Grasemann, H ^a   Michler, E ^a   Wallot, M ^a   Ratjen, F ^a,b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Airway inflammation; Cystic fibrosis; Lung disease; Nitric oxide; Single breath measurements

Indexed keywords

CYTOKINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ADOLESCENT; ADULT; ARTICLE; BREATH ANALYSIS; CHEMOLUMINESCENCE; CHILD; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE MARKER; EXPIRED AIR; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG ALVEOLUS EPITHELIUM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SPIROMETRY;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; BREATH TESTS; CASE-CONTROL STUDIES; CHEMILUMINESCENT MEASUREMENTS; CHILD; CYSTIC FIBROSIS; FEMALE; HUMANS; LUNG DISEASES; MALE; NITRIC OXIDE;

EID: 0030961127     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-0496(199709)24:3<173::AID-PPUL2>3.0.CO;2-O     Document Type: Article

References (37)

1. Barnes PJ, Belvisi MG. Nitric oxide and lung disease. Thorax. 1993; 48:1034-1043.
2. Zoritch B. Nitric oxide and asthma. Arch Dis Child. 1995; 72: 259-262.
3. Kobzik L, Bredt DS, Lovenstein CJ, Drazen J, Gaston B. Sugarbaker D, Stamler JS. Nitric oxide synthase in human and rat lung. Immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol. 1993; 9:371-377.
4. Ward JK, Barnes PJ, Springdall DR, Abelli L, Tadjkarimi S, Yacoub MH, Polak JM, Belvisi MG. Distribution of human i-NANC bronchodilator and nitric oxide-immunoreactive nerves. Am J Respir Cell Mol Biol. 1995; 13:175-184.
5. Hamid Q, Springall DR, Riveros-Moreno V, Chanez P, Howarth P, Redington A, Bousquet J, Godard P, Holgate S, Polak JM. Induction of nitric oxide synthase in asthma. Lancet. 1993; 342: 1510-1513.
6. Asano K, Chee CBE, Gaston B, Lilly CM, Gerard C, Drazen JM, Stamler JS. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci USA. 1994; 91:10089-10093.
7. Tracey WR, Xue C, Klinghofer V, Barlow J, Pollock JS, Förstermann U, Johns RA. Immunochemical detection of inducible NO synthase in human lung. Am J Physiol. 1994; 266:L722-L727.
8. Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea-pigs and humans. Biochem Biophys Res Commun. 1991; 181:852-857.
9. Borland C, Cox Y, Higenbottam T. Measurement of exhaled nitric oxide in man. Thorax. 1993; 48:1160-1162.
10. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Respir J. 1995; 8:295-297.
11. Kharitonov SA, Wells AU, O'Connor BJ, Hansell DM, Cole PJ, Barnes PJ. Elevated levels of exhaled nitric oxide in bronchiectasis. Am J Respir Crit Care Med. 1995; 151:1889-1893.
12. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J. 1993; 6:1268-1270.
13. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994; 343:133-135.
14. Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med. 1995; 152:800-803.
15. Massaro AF, Mehta S, Lilly CM, Kobzik L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med. 1996; 153: 1510-1514.
16. Dean TP, Dai Y, Shute JK, Church MK, Warner JO. Interleukin-8 concentrations are elevated in bronchoalveolar lavage, sputum, and sera of children with cystic fibrosis. Pediatr Res. 1993; 34: 159-161.
17. Bonfield TL, Panuska JR, Konstan MW, Hilliard KA, Hilliard JB, Ghnaim H, Berger M. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med. 1995; 152:2111-2118.
18. Konstan MW, Hilliard KA, Norvell TM, Berger M, Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med. 1994; 150:448-154.
19. Belvisi M, Barnes PJ, Larkin S, Yacoub M, Tadjkarimi S, Williams TJ, Mitchell JA. Nitric oxide synthase activity is elevated in inflammatory lung disease in humans. Eur J Pharmacol. 1995; 283:255-258.
20. van der Hardt H, Nowak-Beneke R. Lung volumes in healthy boys and girls 6-15 years of age. Lung 1976; 154:51-63.
21. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Eur Respir J. 1993; 6(suppl 16):5-40.
22. Balfour-Lynn IM, Laverty A, Dinwiddie R. Reduced upper airway nitric oxide in cystic fibrosis. Arch Dis Child. 1996; 75:319-322.
23. Lundberg JON, Nordvall SL, Weitzberg E, Kollberg H, Alving K. Exhaled nitric oxide in paediatric asthma and cystic fibrosis. Arch Dis Child. 1996; 75:323-326.
24. Woods J, Hunt J, Sears S, Walton S, Ling CY, Strunc M, Gaston B. Nitric oxide (NO) production during tidal breathing: an effort independent assay for airway inflammation in cystic fibrosis (CF). Pediatr Pulmonol. 1995: Suppl 12:251.
25. Robbins RA, Barnes PJ, Sprigall DR, Warren JB, Kwon OJ, Buttery LDK, Geller DA, Polak JM. Expression of inducible nitric oxide in human lung epithelial cells. Biochem Biophys Res Commun. 1984; 203:209-218.
26. McCall TB, Palmer RMJ, Moncada S. Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils. Biochem Biophys Res Commun. 1992; 186:680-685.
27. Francoeur C, Denis M. Nitric oxide and interleukin-8 as inflammatory components of cystic fibrosis. Inflammation 1995; 19: 587-598.
28. Park E, Quinn MR, Schuller-Levis GB. Taurine chloramine inhibits nitric oxide production, induction of NOS and expression of iNOS mRNA in activated RAW 264.7 cells. J Leukocyte Biol 1994; Suppl:32.
29. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med. 1994; 149:538-551.
30. Grasemann H, Ioannidis I, Wallot M, de Groot H, Ratjen F. Airway nitric oxide (NO) in cystic fibrosis. Am J Respir Crit Care Med. 1996: 153:A70.
31. Nathan CP, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol. 1991; 3:65-70.
32. Liew FY, Cox FF. Nonspecific resistance mechanisms. The role of nitric oxide. Immunol Today. 1991; 12:A17-A21.
33. Jain B, Lubinstein I, Robbins RA, Leise KL, Sisson JH. Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biochem Biophys Res Commun. 1993; 191:83-88.
34. Kubes P, Suzuki M, Granger DN. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA. 1991; 88:4651-4655.
35. Belensky S, Robbins RA, Rennard SI, Gossman R, Nelson KJ, Rubinstein I. Inhibitors of nitric oxide synthase attenuate neutrophil chemotaxis in vitro. J Lab Clin Med. 1993; 122:388-394.
36. Babior BM. The respiratory burst of phagocytes. J Clin Invest. 1984; 73:599-601.
37. Malawista SE, Montgomery RR, van Blaricom G. Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. J Clin Invest. 1992; 90:631-636.