Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR)

Clinical and Experimental Immunology

Volumn 106, Issue 2, 1996, Pages 374-388

  Moss, R B ^a,d   Bocian, R C ^a   Hsu, Y P ^a   Dong, Y J ^a,b   Kemna, M ^a,c   Wei, T ^a   Gardner, P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Medical Center ^*  (Netherlands)

^d STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cystic fibrosis; cystic fibrosis transmembrane conductance; immunity; lymphocytes; regulator; T cells

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; PHORBOL ESTER; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CELL CLONE; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029849044     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-826.x     Document Type: Article

References (71)

1. Moss RB. Cystic fibrosis: pathogenesis, pulmonary inlection, and treatment. Clin Infect Dis 1995; 21:839-51.
2. Riordan JR. The cystic fibrosis transmembrane conductance regulator. Annu Rev Physiol 1993; 55:609-30.
3. Chen JH, Schulman H, Gardner P. A cAMP-regulated chloride channel in lymphocytes that is affected in cystic fibrosis. Science 1989; 243:657-60.
4. McDonald TV, Nghiem PT, Gardner P, Martens CL. Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current. J Biol Chem 1992; 267:3242-8.
5. Dong Y, Chao AC, Kouyama K, Hsu Y, Bocian RC, Moss RB, Gardner P. Activation of CFTR chloride current by nitric oxide in human T lymphocytes. EMBO J 1995; 4:2700-7.
6. Bremer S, Hoof T, Wilke M, Busche R, Scholle B, Riordan JR, Maass G, Tummler B, Quantitative expression patterns of multidrug-resistance P-glycoprotein (MDRI) and differentially spliced cystic fibrosis transmembrane-conductance regulator mRNA transcripts in human epithelia. Eur J Biochem 1992; 206:137-49.
7. Hanto DW, Frizzcra G, Gajl-Peczalska KJ, Simmons RL. Epstein-Barr virus, immuno-deficiency, and B-cell lymphoproliferation. Transplantation 1985; 39:461-72.
8. Wall J, Chehab FF. A 31-mutation assay for cystic fibrosis testing in the clinical molecular diagnosis laboratory. Human Mutation 1995; 5:333-8.
9. Diaz PS, Smith S, Hunter E, Arvin AM. T lymphocyte cytotoxicity with natural varicella-zoster virus infection and after immunization with live attenuated varicella vaccine. J Immunol 1989; 142:636-41.
10. Fathman CG, Fitch FW, eds. Isolation, characterization, and utilization of T lymphocyte clones. New York: Academic Press, 1982.
11. Kruisbeek A, Shevach E. In: Coligan J, ed. Current protocols in immunology. New York: Green Publishing and Wiley-Interscience, 1991:3.12.
12. Co MS, Avdalovic NM, Caron PC, Avdalovic MV, Scheinberg DA, Queen C. Chimeric and humanized antibodies with specificity for the CD33 antigen. J Immunol 1992; 148:1149-54.
13. Andrew S, Titus JA. In: Coligan J, ed. Current protocols in immunology. New York: Greene Publishing and Wiley-Interscience, 1991:2.8.5.
14. Holmes K, Fowlkes BJ. In: Coligan J, ed. Current protocols in immunology. New York: Greene Publishing and Wiley-Interscience, 1991:5.3.4.
15. Gregory RJ, Cheng SH, Rich DP et al. Expression and characterization of the cystic fibrosis transmembrane conductance regulator. Nature 1990; 347:382-6.
16. Pawley JB, ed. Handbook of biological confocal microscopy. New York: Plenum Press, 1995.
17. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FG. Improved patch clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391:85-100.
18. Wagner JA, Cozens AL, Schulman H, Gruenert DC, Stryer L, Gardner P. Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multi-functional calcium/calmodulin-dependent protein kinase. Nature 1991; 349:793-6.
19. Worrell R.T, Butt AG, Cliff WH, Frizzell RA. A volume-sensitive chloride conductance in human colonic cell line T84. Am J Physiol 1989; 256:C1111-9.
20. Abrams JS. Immunoenzymatic assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In: Coligan J, ed. Current protocols in immunology, Suppl. 13. New York: Greene Publishing and Wiley-Interscience. 1995:6.20.
21. Abrams JS. Immunoenzymatic assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In: Coligan J, ed. Current protocols in immunology. Suppl. 13. Cytokines and their cellular receptors. New York: John Wiley & Sons, Inc., 1995: 6.20.1-15
22. Frizzell RA, Schoumacher RA, Halm DR. Chloride channel regulation in cystic fibrosis epithelia. Prog Clin Biol Res 1987; 254:101-13.
23. Fuller CM, Benos DJ. CFTRI Am J Physiol 1992; 263:C267-86.
24. Anderson MP, Gregory RJ, Thompson S, Souza DW, Sucharita P, Mulligan RC, Smith AE, Welsh MJ. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 1991; 253:202-7.
25. Maldonado D, Schumann M, Nghiem P, Dong Y, Gardner P. Prostaglandin El activates a chloride current in Jurkat T lymphocytes via cAMP-dependent protein kinase. FASEB J 1991; 5:2965-70.
26. Wagner JA, McDonald TV, Nghiem PT, Lowe AW, Schulman H, Gruenert DC, Stryer L, Gardner P. Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents. Proc Natl Acad Sci USA 1992; 89:6785-9.
27. H responses: a key role for the 'natural' immune response? Immunol Today 1992; 13:379-81.
28. Chalkley G, Harris A. Lymphocyte mRNA as a resource for detection of mutations and polymorphisms in the CF gene. J Med Genet 1991; 28:777-80.
29. Fonknechten N, Chelly J, Lepercq J, Kahn A, Kaplan JC, Kitzis A, Chomel JC. CFTR illegitimate transcription in lymphoid cells: quantification and applications to the investigation of pathological transcripts. Hum Genet 1992; 88:508-12.
30. Krauss R, Berta G, Rado TA, Buhien JK. Antisensc oligonucleotides to CFTR confer a cystic fibrosis phenotype on B lymphocytes. Am J Physiol 1992; 263:C1147-51.
31. Ward C, Krouse ME, Gruenert DC, Kopito RR, Wine JJ. Cystic fibrosis gene expression is not correlated with rectifying C1 channels. Proc Natl Acad Sci USA 1991; 88:5277-81.
32. Harris A. Cystic fibrosis transmembrane conductance regulator (CFTR) gene transcripts. EMBO J 1992; 1:379-80.
33. Trapnell BC, Chu CS, Paakko PK, Banks TC, Yoshimura K, Ferrans VJ, Chernick MS, Crystal RG. Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc Natl Acad Sci USA 1991; 88:6565-9.
34. Rosenfeld MA, Rosenfeld SJ, Danel C, Banks TC, Crystal RG. Increasing expression of the normal human CFTR cDNA in cystic fibrosis epithelial cells results in a progressive increase in the level of CFTR protein expression, but a limit on the level of cAMP-stimulated chloride secretion. Hum Gene Ther 1994; 5:1121-9.
35. Yoshimura K, Nakamura H, Trapnell BC, Dalemans W, Pavirani A, Lecocq JP, Crystal RG. The cystic fibrosis gene has a 'house-keeping'-type promoter and is expressed at low levels in cells of epithelial origin. J Biol Chem 1991; 266:9140-4.
36. Barasch J, Kiss B, Prince A, Saiman L, Gruenerl D, al-Awqati Q. Defective acidification of intracellular organelles in cystic fibrosis. Nature 1991; 352:70-73.
37. Bradbury NA, Jilling T, Berta G, Sorscher EJ, Bridges RJ, Kirk KL. Regulation of plasma membrane recycling by CFTR. Science 1992; 256:530-2.
38. Jiang C, Finkbeiner WE, Widdicombe JH, McCray PB, Miller SS. Altered fluid transport across airway epithelium in cystic fibrosis. Science 1993; 262:424-7.
39. Dosanjh A, Lencer W, Brown D, Ausiello DA, Stow JL. Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates. Am J Physiol 1994; 266:C360-6.
40. Schwiebert EM, Egan ME, Hwang TH, Fulmer SB, Allen SS, Cutting GR, Guggino WB. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995; 30:1063-73.
41. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn JA, Rossier BC, Boucher RC. CFTR as a cAMP-dependent regulator of sodium channels. Science 1995; 269:847-50.
42. Knutsen AP, Slavin RG, Roodman ST, Mueller KR. Decreased T helper function in patients with cystic fibrosis. Intl Arch Allergy Appl Immunol 1988; 85:208-12.
43. Lahat N, Rivlin J, Iancu TC. Functional immunoregulatory T cell abnormalities in cystic fibrosis patients. J Clin Immunol 1989; 9:287-94.
44. Eichler I, Joris L, Hsu YP, Van Wye J, Bram R, Moss RB. Nonopsonic antibodies in cystic fibrosis. J Clin Invest 1989: 84:1794-804.
45. Moss RB. Inflammatory response in cystic fibrosis lung disease. New Insights into Cystic Fibrosis 1995; 3:1-6.
46. Cahalan MD, Lewis RS. Regulation of chloride channels in lymphocytes. Curr Topic Memb 1994; 42:103-29.
47. Gray LS, Russell JH. Cytolytic T lymphocyte effector function requires a plasma membrane chloride flux. J Immunol 1986; 136:3032-7.
48. Prochazka G, Landon C, Dennert G. Transmembrane chloride flux is required for target cell lysis but not for golgi reorientation in cloned cytolytic effector cells. J Immunol 1988; 141:1288-94.
49. Lee SC, Price M, Prystowsky MB, Deutsch C. Volume response of quiescent and interleukin 2-stimulated T lymphocytes to hypotonicity. Am J Physiol 1988; 254:C286-96.
50. 2+ influx in human T lymphocytes. J Biol Chem 1988; 263:19535-40.
51. Premack BA, Gardner P. Role of ion channels in lymphocytes. J Clin Immunol 1991; 11:225-38.
52. Mix E, Correale J, Olsson T, Solders G, Link H. Effect of stilbene-type anion channel blockers on the immune response during experimental allergic neuritis. Immunopharmacol Immunotoxicol 1992; 14:579-609.
53. + T cell clones and peripheral blood T cells. J Immunol 1992; 149:2378-84.
54. Baricordi OR, Ferrari D, Melchiorri L, Chiozzi P, Hanau S, Chiari E, Rubini M, Di Virgilio F. An ATP-activated channel is involved in mitogenic stimulation of human T lymphocytes. Blood 1996; 87:682-90.
55. Jovov B, Ismailov II, Berdicv BK, Fuller CM, Sorscher EJ, Dedman JR, Kaetzel MA, Benos DJ. Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectifying chloride channels. J Biol Chem 1995; 270:29194-200.
56. Reddy MM, Quinton PM, Haws C et al. Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP. Science 1996; 271:1876-9.
57. Imundo L, Barasch J, Prince A, al-Awqati Q. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proceed Natl Acad Sci USA 1995; 92:3019-23.
58. Khan TZ, Wagener JS, Bost T, Martinez J, Accurso FJ, Riches DW. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995; 151:1075-82.
59. Balough K, McCubbin M, Weinberger M, Smits W, Ahrens R, Fick R. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis. Pediatr Pulmonol 1995; 20:63-70.
60. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P. Mosmann TR. Interleukin 10. Ann Rev Immunol 1993; 11:165-90.
61. Cassatella MA, Meda L, Bonora S, Ceska M, Constantin G. Interleukin 10 inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. J Exp Med 1993; 178:2207-11.
62. Kasama T, Stricter RM, Luckacs NW, Burdick MD, Kunkel SL. Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol 1994; 152:3559-66.
63. Dean TP, Dai Y, Shute JK, Church MK, Warner JO. Interleukin-8 concentrations are elevated in bronchoalveolar lavage, sputum, and sera of children with cystic fibrosis. Pediatr Res 1993; 34: 159-61.
64. Richman-Eisenstat JB, Jorens PG, Hebert CA, Ueki I, Nadel JA. Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol 1993; 264:L413-8.
65. Nakamura H, Yoshimura K, McElvaney NG, Crystal RG. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest 1992; 89:1478-84.
66. DiMango E, Zar HJ, Bryan R, Prince A. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 1995; 96:2204-10.
67. Bonfield TL, Konstan MW, Burfeind P, Panuska JR, Hilliard JB, Berger M. Normal bronchial epithelial cells produce the anti-inflammatory cytokine interleukin-10, which is down-regulated in cystic fibrosis. Am J Respir Cell Mol Biol 1995; 13:257-61.
68. Bonfield TL, Panuska JR, Konstan MW, Hilliard KA, Hilliard JB, Ghnaim H, Berger M. Inflammatory cytokines in cystic fibrosis lungs. Am J Respir Crit Care Med 1995; 152:2111-8.
69. Cozens AL, Yezzi MJ, Kunzelmann K et al. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 1994; 10:38-47.
70. Denning GM, Ostedgaard LS, Welsh MJ. Abnormal localization of cystic fibrosis transmembrance conductance regulator in primary cultures of cystic fibrosis airway epithelia. J Cell Biol 1992; 118:551-9.
71. Zeitlin PL, Crawford I, Lu L et al. CFTR protein expression in primary and cultured epithelia. Proc Natl Acad Sci USA 1992; 89:344-7.