Airway remodelling and its relationship to inflammation in cystic fibrosis

Thorax

Volumn 66, Issue 7, 2011, Pages 624-629

  Regamey, Nicolas ^a,b,c   Jeffery, Peter K ^b   Alton, Eric W F W ^b   Bush, Andrew ^a   Davies, Jane C ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE; MUCIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AIRWAY REMODELING; BASEMENT MEMBRANE; BIOPSY TECHNIQUE; BREATHING MUSCLE; BRONCHITIS; BRONCHUS MUCOSA; CYSTIC FIBROSIS; ENDOBRONCHIAL BIOPSY; EXTRACELLULAR MATRIX; GOBLET CELL; HISTOPATHOLOGY; HUMAN; INFLAMMATION; LUNG FUNCTION; LUNG INFECTION; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT BIOPSY; RETICULAR BASEMENT MEMBRANE; REVIEW; TRACHEA; TRACHEAL SUBMUCOSAL GLAND; WHEEZING;

EID: 79959287741     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thx.2009.134106     Document Type: Review

References (57)

1. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001;164:S28-38.
2. Bedrossian CW, Greenberg SD, Singer DB, et al. The lung in cystic fibrosis. A quantitative study including prevalence of pathologic findings among different age groups. Hum Pathol 1976;7:195-204.
3. Sobonya RE, Taussig LM. Quantitative aspects of lung pathology in cystic fibrosis. Am Rev Respir Dis 1986;134:290-5. (Pubitemid 16046912)
4. Hamutcu R, Rowland JM, Horn MV, et al. Clinical findings and lung pathology in children with cystic fibrosis. Am J Respir Crit Care Med 2002;165:1172-5. (Pubitemid 34415829)
5. Scholte BJ, Davidson DJ, Wilke M, et al. Animal models of cystic fibrosis. J Cyst Fibros 2004;3(Suppl 2):183-90. (Pubitemid 40045596)
6. Guilbault C, Saeed Z, Downey GP, et al. Cystic fibrosis mouse models. Am J Respir Cell Mol Biol 2007;36:1-7. (Pubitemid 46067701)
7. O'Sullivan BP, Freedman SD. Cystic fibrosis. Lancet 2009;373:1891-904.
8. Sly PD, Brennan S, Gangell C, et al. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med 2009;180:146-52.
9. Long FR, Williams RS, Castile RG. Structural airway abnormalities in infants and young children with cystic fibrosis. J Pediatr 2004;144:154-61. (Pubitemid 38869388)
10. Martinez TM, Llapur CJ, Williams TH, et al. High-resolution computed tomography imaging of airway disease in infants with cystic fibrosis. Am J Respir Crit Care Med 2005;172:1133-8. (Pubitemid 43066649)
11. Stick SM, Brennan S, Murray C, et al. Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening. J Pediatr 2009;155:623-8 e621.
12. Ranganathan SC, Stocks J, Dezateux C, et al. The evolution of airway function in early childhood following clinical diagnosis of cystic fibrosis. Am J Respir Crit Care Med 2004;169:928-33. (Pubitemid 38457319)
13. Linnane BM, Hall GL, Nolan G, et al. Lung function in infants with cystic fibrosis diagnosed by newborn screening. Am J Respir Crit Care Med 2008;178:1238-44.
14. Payne DN, Rogers AV, Adelroth E, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med 2003;167:78-82. (Pubitemid 36015921)
15. Saglani S, Malmstrom K, Pelkonen AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 2005;171:722-7. (Pubitemid 40471142)
16. Saglani S, Payne DN, Zhu J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 2007;176:858-64. (Pubitemid 350097074)
17. Saglani S, Mathie SA, Gregory LG, et al. Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice. Am J Respir Cell Mol Biol 2009;41:281-9.
18. Gilljam H, Motakefi AM, Robertson B, et al. Ultrastructure of the bronchial epithelium in adult patients with cystic fibrosis. Eur J Respir Dis 1987;71:187-94. (Pubitemid 17155856)
19. Durieu I, Peyrol S, Gindre D, et al. Subepithelial fibrosis and degradation of the bronchial extracellular matrix in cystic fibrosis. Am J Respir Crit Care Med 1998;158:580-8. (Pubitemid 28378190)
20. Wojnarowski C, Frischer T, Hofbauer E, et al. Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation. Eur Respir J 1999;14:1136-44.
21. Hauber HP, Tsicopoulos A, Wallaert B, et al. Expression of hclca1 in cystic fibrosis lungs is associated with mucus overproduction. Eur Respir J 2004;23:846-50. (Pubitemid 38807357)
22. Hays SR, Ferrando RE, Carter R, et al. Structural changes to airway smooth muscle in cystic fibrosis. Thorax 2005;60:226-8. (Pubitemid 40380282)
23. Hays SR, Fahy JV. Characterizing mucous cell remodeling in cystic fibrosis: relationship to neutrophils. Am J Respir Crit Care Med 2006;174:1018-24. (Pubitemid 44684451)
24. Hilliard TN, Regamey N, Shute JK, et al. Airway remodelling in children with cystic fibrosis. Thorax 2007;62:1074-80. (Pubitemid 350206200)
25. Regamey N, Ochs M, Hilliard TN, et al. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med 2008;177:837-43. (Pubitemid 351600661)
26. Molina-Teran A, Hilliard TN, Saglani S, et al. Safety of endobronchial biopsy in children with cystic fibrosis. Pediatr Pulmonol 2006;41:1021-4. (Pubitemid 44744088)
27. Regamey N, Balfour-Lynn I, Rosenthal M, et al. Time required to obtain endobronchial biopsies in children during fiberoptic bronchoscopy. Pediatr Pulmonol 2009;44:76-9.
28. Regamey N, Hilliard TN, Saglani S, et al. Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis. Chest 2007;131:1710-17. (Pubitemid 46981624)
29. Aurora P, Bush A, Gustafsson P, et al. Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis. Am J Respir Crit Care Med 2005;171:249-56.
30. Jeffery P, Holgate S, Wenzel S. Methods for the assessment of endobronchial biopsies in clinical research: application to studies of pathogenesis and the effects of treatment. Am J Respir Crit Care Med 2003;168:S1-17.
31. Regamey N, Hilliard TN, Saglani S, et al. Endobronchial biopsy in childhood. Chest 2008;133:312; author reply 313.
32. Oppenheimer EH. Similarity of the tracheobronchial mucous glands and epithelium in infants with and without cystic fibrosis. Hum Pathol 1981;12:36-48. (Pubitemid 12239393)
33. Gosden CM, Gosden JR. Fetal abnormalities in cystic fibrosis suggest a deficiency in proteolysis of cholecystokinin. Lancet 1984;2:541-6. (Pubitemid 14072057)
34. Ornoy A, Arnon J, Katznelson D, et al. Pathological confirmation of cystic fibrosis in the fetus following prenatal diagnosis. Am J Med Genet 1987;28:935-47. (Pubitemid 17163765)
35. Verhaeghe C, Delbecque K, de Leval L, et al. Early inflammation in the airways of a cystic fibrosis foetus. J Cyst Fibros 2007;6:304-8. (Pubitemid 46971896)
36. Kozlowska WJ, Bush A, Wade A, et al. Lung function from infancy to the preschool years after clinical diagnosis of cystic fibrosis. Am J Respir Crit Care Med 2008;178:42-9. (Pubitemid 351919192)
37. Nielsen KG, Pressler T, Klug B, et al. Serial lung function and responsiveness in cystic fibrosis during early childhood. Am J Respir Crit Care Med 2004;169:1209-16. (Pubitemid 38680398)
38. Regamey N, Tsartsali L, Hilliard TN, et al. Airway mucosa inflammation in children with cystic fibrosis. Pediatr Pulmonol 2007;(Suppl 30):A175.
39. Hubeau C, Lorenzato M, Couetil JP, et al. Quantitative analysis of inflammatory cells infiltrating the cystic fibrosis airway mucosa. Clin Exp Immunol 2001;124:69-76. (Pubitemid 32476936)
40. Tiddens HA, Koopman LP, Lambert RK, et al. Cartilaginous airway wall dimensions and airway resistance in cystic fibrosis lungs. Eur Respir J 2000;15:735-42. (Pubitemid 30196303)
41. Godfrey RW, Severs NJ, Jeffery PK. Structural alterations of airway epithelial tight junctions in cystic fibrosis: comparison of transplant and postmortem tissue. Am J Respir Cell Mol Biol 1993;9:148-56.
42. Hajj R, Lesimple P, Nawrocki-Raby B, et al. Human airway surface epithelial regeneration is delayed and abnormal in cystic fibrosis. J Pathol 2007;211:340-50. (Pubitemid 46172710)
43. Hilliard TN, Zhu J, Farley R, et al. Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation. Am J Respir Cell Mol Biol 2008;39:19-25. (Pubitemid 351883954)
44. Bruce MC, Poncz L, Klinger JD, et al. Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis. Am Rev Respir Dis 1985;132:529-35. (Pubitemid 15247968)
45. Laguna TA, Wagner BD, Luckey HK, et al. Sputum desmosine during hospital admission for pulmonary exacerbation in cystic fibrosis. Chest 2009;136:1561-8.
46. Shute J, Marshall L, Bodey K, et al. Growth factors in cystic fibrosisdwhen more is not enough. Paediatr Respir Rev 2003;4:120-7. (Pubitemid 36665480)
47. Burgel PR, Montani D, Danel C, et al. A morphometric study of mucins and small airway plugging in cystic fibrosis. Thorax 2007;62:153-61.
48. Henke MO, Renner A, Huber RM, et al. Muc5ac and muc5b mucins are decreased in cystic fibrosis airway secretions. Am J Respir Cell Mol Biol 2004;31:86-91. (Pubitemid 38888043)
49. James A, Carroll N. Airway smooth muscle in health and disease: methods of measurement and relation to function. Eur Respir J 2000;15:782-9. (Pubitemid 30196310)
50. Ogrinc G, Kampalath B, Tomashefski JF Jr. Destruction and loss of bronchial cartilage in cystic fibrosis. Hum Pathol 1998;29:65-73. (Pubitemid 28049548)
51. McDermott S, Barry SC, Judge EE, et al. Tracheomalacia in adults with cystic fibrosis: determination of prevalence and severity with dynamic cine CT. Radiology 2009;252:577-86.
52. Henno P, Maurey C, Danel C, et al. Pulmonary vascular dysfunction in end-stage cystic fibrosis: role of NF-kB and endothelin-1. Eur Respir J 2009;34:1329-37.
53. Hartl D, Latzin P, Hordijk P, et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med 2007;13:1423-30. (Pubitemid 350224252)
54. Tan HL, Regamey N, Hilliard T, et al. Exploring the phenotype of the lymphocytic infiltrate in the CF airway: do IL-17+ cells play a role in disease pathogenesis? Pediatr Pulmonol 2009;44:A126.
55. Milanese M, Crimi E, Scordamaglia A, et al. On the functional consequences of bronchial basement membrane thickening. J Appl Physiol 2001;91:1035-40. (Pubitemid 32803893)
56. Sont JK, Willems LN, Bel EH, et al. Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The Ampul Study Group. Am J Respir Crit Care Med 1999;159:1043-51. (Pubitemid 29202534)
57. Chetta A, Zanini A, Foresi A, et al. Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am J Respir Crit Care Med 2003;167:751-7. (Pubitemid 36801754)