Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses

American Journal of Respiratory Cell and Molecular Biology

Volumn 44, Issue 6, 2011, Pages 922-929

  Mueller, Christian ^a   Braag, Sofia A ^a   Keeler, Allison ^a   Hodges, Craig ^b   Drumm, Mitchell ^b   Flotte, Terence R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Allergy; Cystic fibrosis transmembrane conductance regulator; Intracellular calcium; Lymphocytes; Nuclear factor of activated T cell

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 14; NUCLEAR FACTOR; TRANSCRIPTION FACTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS FUMIGATUS; CALCIUM SIGNALING; CD3+ T LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; CYTOKINE RELEASE; IMMUNE RESPONSE; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN POLYMORPHISM; SPLEEN CELL;

ANIMALS; ANTIGENS, CD3; ASPERGILLUS; CALCIUM; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINES; HYPERSENSITIVITY; IMMUNE SYSTEM; IMMUNOGLOBULIN E; LYMPHOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NFATC TRANSCRIPTION FACTORS; SPLEEN;

ASPERGILLUS FUMIGATUS; MUS;

EID: 80051554943     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0224OC     Document Type: Article

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