Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 2, 2013, Pages 170-179

  Le Gars, Mathieu ^a,b,c   Descamps, Delphyne ^a,b   Roussel, Delphine ^c   Saussereau, Emilie ^c   Guillot, Loïc ^c,d   Ruffin, Manon ^c,d   Tabary, Olivier ^c,d   Hong, Saw See ^e   Boulanger, Pierre ^e   Paulais, Marc ^d   Malleret, Laurette ^f   Belaaouaj, Azzaq ^f   Edelman, Aleksander ^c   Huerre, Michel ^a   Chignard, Michel ^a,b   Sallenave, Jean Michel ^a,b,c  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e UNIVERSITÉ LYON 1   (France)

^f REIMS UNIVERSITY HOSPITAL   (France)

Author keywords

Cystic fibrosis transmembrane conductance regulator; Inflammation; Neutrophil; Protease; Pseudomonas aeruginosa

Indexed keywords

CALPAIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; LEUKOCYTE ELASTASE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; LUNG INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION;

ANIMALS; CALPAIN; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIUM; HUMANS; LEUKOCYTE ELASTASE; LUNG; MALE; MICE; MICE, INBRED C57BL; PATCH-CLAMP TECHNIQUES; PNEUMONIA, BACTERIAL; PSEUDOMONAS INFECTIONS;

EID: 84872502797     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201205-0875OC     Document Type: Article

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