Role of IL-10 deficiency in excessive nuclear factor-κB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice

Journal of Allergy and Clinical Immunology

Volumn 115, Issue 2, 2005, Pages 405-411

  Saadane, Aicha ^a   Soltys, Jindrich ^a   Berger, Melvin ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Chemokines; Cystic fibrosis; Cytokines; I B; IL 10; Neutrophils; NF B

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; CELL INTERACTION; CONTROLLED STUDY; CYSTIC FIBROSIS; EPITHELIUM CELL; KNOCKOUT MOUSE; LUNG LAVAGE; MALE; MEMBRANE CONDUCTANCE; MOUSE; MOUSE STRAIN; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; WILD TYPE;

EID: 13444312010     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.10.044     Document Type: Article

References (31)

1. T.L. Bonfield, J.R. Panuska, M.W. Konstan, K.A. Hilliard, J.B. Hilliard, and H. Ghnaim Inflammatory cytokines in cystic fibrosis lungs Am J Respir Crit Care Med 152 1995 2111 2118
2. T.L. Bonfield, M.W. Konstan, J.B. Hilliard, K.A. Hilliard, and M. Berger Altered respiratory epithelial cell cytokine production in cystic fibrosis J Allergy Clin Immunol 104 1999 72 78
3. M. Muhlebach, and T.L. Noah Endotoxin activity and inflammatory markers in the airways of young patients with cystic fibrosis Am J Respir Crit Care Med 165 2002 911 915
4. M.S. Muhlebach, P.W. Stewart, M.W. Leigh, and T.L. Noah Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients Am J Respir Crit Care Med 160 1999 186 191
5. T.L. Bonfield, M.W. Konstan, P. Burfeind, J.R. Panuska, J.B. Hilliard, and H. Ghnaim Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis Am J Respir Cell Mol Biol 13 1995 257 261
6. J. Soltys, T. Bonfield, J. Chmiel, and M. Berger Functional IL-10 deficiency in the lung of cystic fibrosis (cystic fibrosis transmembrane conductance regulator -/-) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophages J Immunol 168 2002 1903 1910
7. J.F. Chmiel, M.W. Konstan, A. Saadane, J.E. Krenicky, H.L. Kirchner, and M. Berger Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice Am J Respir Crit Care Med 165 2002 1176 1181
8. A.M. Van Heeckeren, J. Tccheikuna, R.W. Wallenga, M.W. Konstan, P.B. Davis, and B. Erokwu Effects of pseudomonas infection on weight loss, lung mechanics, and cytokines in mice Am J Respir Crit Care Med 161 2000 271 279
9. E. Osika, J.M. Cavaillon, K. Chadelat, M. Boule, C. Fitting, and G. Tournier Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease Eur Respir J 14 1999 339 346
10. K.M. Balough, M. McCubbin, W. Weinberger, R.A. Smits, and R. Fick The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis Pediatr Pulmonol 20 1995 63 70
11. J. Christian, and S. Balfour The IκB/NF-κB system: a key determinant of mucosal inflammation and protection Am J Physiol Cell Physiol 278 2000 C451 C462
12. K. Brown, S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation Science 267 1995 1485 1488
13. J.S. Snouwaert, K.K. Bringman, A.M. Latour, N.N. Malouf, R.C. Boucher, and O. Smithies An animal model for cystic fibrosis made by gene targeting Science 257 1992 1083 1088
14. E. Eckman, C. Cotton, D. Kube, and P.B. Davis Dietary changes improve survival of CFTR S489X homozygous mutant mouse Am J Physiol 269 1995 L625
15. A.B. Lentsch, T.P. Shanley, V. Sarma, and P. Ward In vivo suppression of NF-κB and preservation of Iκbα by interleukin-10 and interleukin-13 J Clin Invest 100 1997 2443 2448
16. F. Deryckere, and F. Gannon A one-hr minipreparation technique for extraction of DNA-binding proteins from animal tissues Biotechniques 16 1994 405
17. H.L. Pahl, M. Sester, H.G. Burgert, and P.A. Bauerle Activation of transcription factor NF-KB by the adenovirus E3/19K protein requires its ER retention J Cell Biol 132 1996 511 522
18. B. Ruth, D. Kube, A. Perez, P. Davis, and A. Prince Overproduction of the CFTR R domain leads to increased levels of asialoGM1 and increased Pseudomonas aeruginosa binding by epithelial cells Am J Respir Cell Mol Biol 19 1998 269 277
19. M. Berger, and M.W. Konstan J.R. Yankaskas M.R. Knowles Immunopathogenesis of cystic fibrosis lung disease 1999 Lippincott-Raven Philadelphia
20. S. Fernandez, P. Jose, M.G. Avdiushko, A.M. Kaplan, and D.A. Cohen Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists J Immunol 172 2004 2613 2620
21. H. Yu, M. Hanes, C.E. Chrisp, J.C. Boucher, and V. Deretic Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge Infect Immun 66 1998 280 288
22. S.D. Freedman, D. Weinstein, P.G. Blanco, P. Martinez-Clark, S. Urman, and M. Zaman Characterization of LPS-induced lung inflammation in CF-KO mice and the effect of docosahexaenoic acid J Appl Physiol 92 2002 2169 2176
23. G.R. Thomas, E.A. Costelloe, D.P. Lunn, K.J. Stacey, S.J. Delaney, and R. Passey G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages J Immunol 164 2000 3870 3877
24. D.F. Fiorentino, A. Zlotnik, T.R. Mosmann, M. Howard, and A. O'Garra IL-10 inhibits cytokine production by activated macrophages J Immunol 147 1991 3815 3822
25. A.J.G. Schottelius, M.W. Mayo, R.B. Sartor, and A.S. Baldwin Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding J Biol Chem 274 1999 31868 31874
26. M.E. Poynter, C.G. Irvin, and Y.M.W. Janssen-Heininger A prominent role for airway epithelial NF-κB activation in lipopolysaccharide-induced airway inflammation J Immunol 170 2003 6257 6265
27. S.J. Skerrett, H.D. Liggitt, A.M. Hajjar, R.K. Ernst, S.I. Miller, and C.B. Wilson Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxin Am J Physiol Lung Cell Mol Physiol 2004 (PMID: 15047567)
28. E. DiMango, A.J. Ratner, R. Bryan, S. Tabibi, and A. Prince Activation of NF-κB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells J Clin Invest 101 1998 2598 2605
29. A. Venkatakrishnan, A.A. Stecenko, G. King, T.R. Blackwell, K.L. Brigham, and J.W. Christman Exaggerated activation of nuclear factor-κB and altered IκB-β processing in cystic fibrosis bronchial epithelial cells Am J Respir Cell Mol Biol 23 2000 396 403
30. C.G. Lee, R.J. Homer, R. Cohn, H. Link, S. Jung, and J.E. Craft Transgenic overexpression of Interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways J Biol Chem 2002 35466 35474
31. O. Tabary, C. Muselet, S. Escotte, F. Antonicelli, D. Hubert, and D. Dusser Interleukin-10 inhibits elevated chemokine interleukin-8 and regulated on activation normal T cell expressed and secreted production in cystic fibrosis bronchial epithelial cells by targeting the IκB kinase α/β complex Am J Pathol 162 2003 293 302