Functional IL-10 deficiency in the lung of cystic fibrosis (cftr-/-) and IL-10 knockout mice causes increased expression and function of b7 costimulatory molecules on alveolar macrophages

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1903-1910

  Soltys, Jindrich ^a   Bonfield, Tracey ^a   Chmiel, James ^a   Berger, Melvin ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD3 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 10; MITOGENIC AGENT; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYSTIC FIBROSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; KNOCKOUT MOUSE; LUNG ALVEOLUS MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SPLEEN CELL; T LYMPHOCYTE;

EID: 0037083448     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1903     Document Type: Article

References (45)

1. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis
2. Altered respiratory epithelial cell cytokine production in cystic fibrosis
3. The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10
4. Inflammatory cytokines in cystic fibrosis lungs
5. TNF-α, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients
6. Selective up-regulation of chemokine IL-8 expression in cystic fibrosis bronchial gland cells in vivo and in vitro
7. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation
8. Early pulmonary inflammation in infants with cystic fibrosis
9. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients
10. Immunopathogenesis of cystic fibrosis lung disease
11. Distinct sputum profiles in cystic fibrosis and other chronic inflammatory airway diseases
12. Interleukin-10
13. IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice
14. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules
15. Interlieukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
16. IL-10 inhibits macrophage costimulating activity by selectively inhibiting the upregulation of B7 expression
17. Interleukin-10-deficient mice develop chronic enterocolitis
18. An animal model for cystic fibrosis made by gene targeting
19. Dietary changes improve survival of CFTR S489X homozygous mutant mouse
20. Antioxidant imbalance in the lungs of cystic fibrosis transmembrane regulator protein mutant mice
21. Estimation of volume of epithelial lining fluid recovered by lavage using urea as a marker of dilution
22. Related isolation procedures and functional assays
23. Isolation of dendritic cells
24. Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7
25. CTLA4 mediates antigen-specific apoptosis of human T cells
26. Human alveolar macrophages induce functional inactivation in antigen-specific CD4 T cells
27. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
28. G551D cystic fibrosis mice exhibit abnormal regulation of inflammation in lungs and macrophages
29. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa
30. IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia
31. Microbial pathogenesis in cystic fibrosis: Pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge
32. Accessory function of alveolar macrophages from patients with sarcoidosis and other granulomatous and nongranulomatous lung diseases
33. Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis
34. Regulation of alveolar macrophage-T cell interactions during Th1-type sarcoid inflammatory process
35. + T cells exhibiting an unbalanced Th1-type T cell cytokine pattern: Reversal with IL-10
36. Inteleukin-10 modulates the severity of hypersensitivity pneumonitis in mice
37. Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm
38. Selective inhibition of T cell proliferation but not expression of effector function by human alveolar macrophages
39. Cystic fibrosis
40. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung
41. CD28/B7 system of T cell costimulation
42. T-cell stimulation: An abundance of B7
43. + T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR)
44. Cytokine dysregulation in activated cystic fibrosis (CF) peripheral lymphocytes
45. Interleukin-10 and the interleukin-10 receptor