Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 287, Issue 5 31-5, 2004, Pages

  Van Heeckeren, Anna M ^a   Schluchter, Mark D ^a   Drumm, Mitchell L ^a   Davis, Pamela B ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Agarose beads; Cystic fibrosis transmembrane conductance regulator gene; Inflammation; Mutation

Indexed keywords

AGAROSE; CHEMOATTRACTANT; CYTOKINE; ICOSANOID; INTERLEUKIN 1BETA; INTERLEUKIN 6; ION CHANNEL; LEUKOTRIENE B4; MACROPHAGE INFLAMMATORY PROTEIN 2; PROSTAGLANDIN E2; TRANSMEMBRANE CONDUCTANCE REGULATOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BODY WEIGHT; CELL COUNT; CELL SURFACE; CFTR GENE; CONTROLLED STUDY; GENE MUTATION; GENOTYPE; GLYCOSYLATION; GRAM NEGATIVE INFECTION; INFLAMMATION; LUNG INFECTION; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REGULATOR GENE;

ANIMALS; CHEMOKINES; CHEMOKINES, CXC; CHRONIC DISEASE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINES; DINOPROSTONE; FEMALE; GENOTYPE; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTE COUNT; LEUKOTRIENE B4; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, INBRED CFTR; NEUTROPHILS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT LOSS;

EID: 6344291262     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00387.2003     Document Type: Article

References (31)

1. Boucher RC. An overview of the pathogenesis of cystic fibrosis lung disease. Adv Drug Delivery Res 54: 1359-1371, 2002.
2. Boucher RC. Regulation of airway surface liquid volume by human airway epithelia. Pflügers Arch 445: 495-498, 2003.
3. Brady KG, Kelley TJ, and Drumm ML. Examining basal chloride transport using the nasal potential difference response in a murine model. Am J Physiol Lung Cell Mol Physiol 281: L1173-L1179, 2001.
4. Chroneos ZC, Wert SE, Livingston JL, Hassett DJ, and Whitsett JA. Role of cystic fibrosis transmembrane conductance regulator in pulmonary clearance of Pseudomonas aeruginosa in vivo. J Immunol 165: 3941-3950, 2000.
5. Clarke LL, Grubb BR, Gabriel SE, Smithies O, Koller BH, and Boucher RC. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science 257: 1125-1128, 1992.
6. DiMango E, Ratner AJ, Bryan R, Tabibi S, and Prince A. Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells. J Clin Invest 101: 2598-2605, 1998.
7. DiMango E, Zar HJ, Bryan R, and Prince A. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 96: 2204-2210, 1995.
8. Estell K, Braunstein G, Tucker T, Varga K, Collawn JF, and Schwiebert LM. Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif. Mol Cell Biol 23: 594-606, 2003.
9. Gosselin D, Stevenson MM, Cowley EA, Griesenbach U, Eidelman DH, Boule M, Tam MF, Kent G, Skamene E, Tsui LC, and Radzioch D. Impaired ability of Cftr knockout mice to control lung infection with Pseudomonas aeruginosa. Am J Respir Crit Care Med 157: 1253-3262, 1998.
10. Heeckeren A, Walenga R, Konstan MW, Bonfield T, Davis PB, and Ferkol T. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa. J Clin Invest 100: 2810-2815, 1997.
11. Johnston JA, Ward CL, and Kopito RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143: 1883-1898, 1998.
12. Kelley TJ, Thomas K, Milgram LJ, and Drumm ML. In vivo activation of the cystic fibrosis transmembrane conductance regulator mutant deltaF508 in murine nasal epithelium. Proc Natl Acad Sci USA 94: 2604-2608, 1997.
13. Konstan MW and Berger M. Infection and inflammation of the lung in cystic fibrosis. In: Cystic Fibrosis, edited by Davis PB. New York: Dekker, 1993, p. 219-276.
14. Konstan MW, Walenga RW, Hilliard KA, and Hilliard JB. Leukotriene B4 markedly elevated in the epithelial lining fluid of patients with cystic fibrosis. Am Rev Respir Dis 148: 896-901, 1993.
15. Kopito RR and Ron D. Conformational disease. Nat Cell Biol 2: E207-E209, 2000.
16. Lehman EL. Nonparametrics-Statistical Methods Based on Ranks. San Francisco: Holden-Day, 1975.
17. McMorran BJ, Palmer JS, Lunn DP, Oceandy D, Costelloe EO, Thomas GR, Hume DA, and Wainwright BJ. G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease. Am J Physiol Lung Cell Mol Physiol 281: L740-L747, 2001.
18. Milewski MI, Mickle JE, Forrest JK, Stanton BA, and Cutting GR. Aggregation of misfolded proteins can be a selective process dependent upon peptide composition. J Biol Chem 277: 34462-34470, 2002.
19. Muhlebach MS, Stewart PW, Leigh MW, and Noah TL. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Am J Respir Crit Care Med 160: 186-191, 1999.
20. Oceandy D, McMorran BJ, Smith SN, Schreiber R, Kunzelmann K, Alton EW, Hume DA, and Wainwright BJ. Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities. Hum Mol Genet 11: 1059-1067, 2002.
21. Rennard SI, Basset G, Lecossier D, O'Donnell KM, Pinkston P, Martin PG, and Crystal RG. Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol 60: 532-538, 1986.
22. Schroeder TH, Reiniger N, Meluleni G, Grout M, Coleman FT, and Pier GB. Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J Immunol 166: 7410-7418, 2001.
23. Schwiebert LM, Estell K, and Propst SM. Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression. Am J Physiol Cell Physiol 276: C700-C710, 1999.
24. Smith JJ, Travis SM, Greenberg EP, and Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85: 229-236, 1996.
25. Thomas PJ, Qu BH, and Pedersen PL. Defective protein folding as a basis of human disease. Trends Blochem Sci 20: 456-459, 1995.
26. Van Heeckeren A, Ferkol T, and Tosi M. Effects of bronchopulmonary inflammation induced by pseudomonas aeruginosa on adenovirus-mediated gene transfer to airway epithelial cells in mice. Gene Ther 5: 345-351, 1998.
27. Van Heeckeren AM, Scaria A, Schluchter MD, Ferkol TW, Wadsworth S, and Davis PB. Delivery of CFTR by adenoviral vector to cystic fibrosis mouse lung in a model of chronic Pseudomonas aeruginosa lung infection. Am J Physiol Lung Cell Mol Physiol 286: L717-L726, 2004.
28. Van Heeckeren AM, Schluchter M, Xue L, Alvarez J, Freedman S, St. George J, and Davis PB. Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice. Infect Immun 72: 1479-1486, 2004.
29. Van Heeckeren AM and Schluchter MD. Murine models of chronic Pseudomonas aeruginosa lung infection. Lab Anim 36: 291-312, 2002.
30. - channel function. Am J Physiol Lung Cell Mol Physiol 281: L71-L78, 2001.
31. Zeiher BG, Eichwald E, Zabner J, Smith JJ, Puga AP, McCray PB Jr, Capecchi MR, Welsh MJ, and Thomas KR. A mouse model for the delta F508 allele of cystic fibrosis. J Clin Invest 96: 2051-2064, 1995.