Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18421-18428

  Chandler, Joshua D ^a,b   Nichols, David P ^b   Nick, Jerry A ^b   Hondal, Robert J ^c   Day, Brian J ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT DEFENSE; INNATE IMMUNITY; MAMMALIAN CELLS; THIOREDOXIN REDUCTASE;

IMMUNE SYSTEM;

MAMMALS;

AURANOFIN; BACTERIUM LYSATE; GLUTATHIONE REDUCTASE; HYPOCHLOROUS ACID; HYPOTHIOCYANOUS ACID; OXIDIZING AGENT; THIOL; THIOREDOXIN REDUCTASE; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING AFFINITY; CELL LYSATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; EPITHELIUM CELL; ESCHERICHIA COLI; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

CYSTIC FIBROSIS; HYPOTHIOCYANITE; INFECTIOUS DISEASES; INFLAMMATION; INNATE IMMUNITY; THIOCYANATE; THIOREDOXIN REDUCTASE;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIOXIDANTS; AURANOFIN; BACTERIAL PROTEINS; BRONCHIOLES; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE; EPITHELIAL CELLS; HUMANS; HYPOCHLOROUS ACID; IMMUNITY, INNATE; KINETICS; LUNG; MICE; MICROBIAL VIABILITY; RATS; SELENOCYSTEINE; SUBSTRATE SPECIFICITY; THIOCYANATES; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 84880052989     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.468090     Document Type: Article

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