Extracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria

Brain Research

Volumn 1620, Issue , 2015, Pages 17-28

  Zhu, Zhihui ^a,b   Li, Rongyu ^a   Stricker, Rolf ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Astrocytes; Neuroprotection; Reactive oxygen species; Small heat shock proteins HSPB4 and HSPB5; Crystallin

Indexed keywords

ALPHA B CRYSTALLIN; ALPHA CRYSTALLIN; CASPASE 3; CERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN HSPB4; PROTEIN HSPB5; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL HEAT SHOCK PROTEIN; STAUROSPORINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTIMYCIN A1; MTOR PROTEIN, RAT; N-ACETYLSPHINGOSINE; SPHINGOSINE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SERUM; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; ESCHERICHIA COLI; EXTRACELLULAR SPACE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

ALPHA-CRYSTALLINS; ANIMALS; ANTIMYCIN A; ASTROCYTES; BRAIN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; ESCHERICHIA COLI; EXTRACELLULAR SPACE; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SPHINGOSINE; STAUROSPORINE; TOR SERINE-THREONINE KINASES;

EID: 84940898158     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.05.011     Document Type: Article

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