Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protects against ceramide-induced cellular toxicity in rat brain astrocytes and neurons by activation of ceramide kinase

Molecular and Cellular Neuroscience

Volumn 59, Issue , 2014, Pages 127-134

  Aleshin, Stepan ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Neurodegeneration; Neuroprotection; Peroxisome proliferator activated receptors; Transcription factor

Indexed keywords

4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; CERAMIDE; CERAMIDE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; SMALL INTERFERING RNA; 4-(3-(2-PROPYL-3-HYDROXY-4-ACETYL)PHENOXY)PROPYLOXYPHENOXY ACETIC ACID; NEUROPROTECTIVE AGENT; PHENOXYACETIC ACID DERIVATIVE; PHOSPHOTRANSFERASE;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL CULTURE; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GENE SILENCING; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; BRAIN; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; TOXICITY; WISTAR RAT;

ANIMALS; ASTROCYTES; BRAIN; CELLS, CULTURED; CERAMIDES; NEURONS; NEUROPROTECTIVE AGENTS; PHENOXYACETATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PPAR DELTA; PPAR-BETA; RATS; RATS, WISTAR;

EID: 84897459180     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2014.01.008     Document Type: Article

References (29)

1. Adibhatla R.M., Hatcher J.F. Altered lipid metabolism in brain injury and disorders. Subcell. Biochem. 2008, 49:241-268.
2. Aleshin S., Grabeklis S., Hanck T., Sergeeva M., Reiser G. Peroxisome proliferator-activated receptor (PPAR)-γ positively controls and PPARα negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARβ/δ via mutual control of PPAR expression levels. Mol. Pharmacol. 2009, 76:414-424.
3. Bornancin F. Ceramide kinase: the first decade. Cell. Signal. 2011, 23:999-1008.
4. Cresser J., Bonen A., Chabowski A., Stefanyk L.E., Gulli R., Ritchie I., Dyck D.J. Oral administration of a PPAR-δ agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers. Am. J. Physiol. 2010, 299:R470-R479.
5. Gangoiti P., Arana L., Ouro A., Granado M.H., Trueba M., Gomez-Munoz A. Activation of mTOR and RhoA is a major mechanism by which ceramide 1-phosphate stimulates macrophage proliferation. Cell. Signal. 2011, 23:27-34.
6. Gorbacheva L., Davidova O., Sokolova E., Ishiwata S., Pinelis V., Strukova S., Reiser G. Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity. J. Neurochem. 2009, 111:967-975.
7. Graf C., Klumpp M., Habig M., Rovina P., Billich A., Baumruker T., Oberhauser B., Bornancin F. Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol. Pharmacol. 2008, 74:925-932.
8. Granado M.H., Gangoiti P., Ouro A., Arana L., Gomez-Munoz A. Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages. Biochim. Biophys. Acta 2009, 1791:263-272.
9. Grimaldi P.A. Fatty acid regulation of gene expression. Curr. Opin. Clin. Nutr. Metab. Care 2001, 4:433-437.
10. Gusain A., Hatcher J.F., Adibhatla R.M., Wesley U.V., Dempsey R.J. Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition. Mol. Neurobiol. 2012, 45:455-464.
11. Hannun Y.A., Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000, 10:73-80.
12. Hannun Y.A., Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 2002, 277:25847-25850.
13. Haughey N.J. Sphingolipids in neurodegeneration. Neuromolecular Med. 2010, 12:301-305.
14. Jiang Y.J., Uchida Y., Lu B., Kim P., Mao C., Akiyama M., Elias P.M., Holleran W.M., Grunfeld C., Feingold K.R. Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor δ in human keratinocytes. J. Biol. Chem. 2009, 284:18942-18952.
15. Li R., Reiser G. Phosphorylation of Ser45 and Ser59 of αB-crystallin and p38/extracellular regulated kinase activity determine αB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death. J. Neurochem. 2011, 118:354-364.
16. Li R., Zhu Z., Reiser G. Specific phosphorylation of αA-crystallin is required for the αA-crystallin-induced protection of astrocytes against staurosporine and C2-ceramide toxicity. Neurochem. Int. 2012, 60:652-658.
17. Liu L., Martin R., Chan C. Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases. Neurobiol. Aging 2013, 34:540-550.
18. Mencarelli C., Martinez-Martinez P. Ceramide function in the brain: when a slight tilt is enough. Cell. Mol. Life Sci. 2013, 70:181-203.
19. Mencarelli C., Bode G.H., Losen M., Kulharia M., Molenaar P.C., Veerhuis R., Steinbusch H.W., De Baets M.H., Nicolaes G.A., Martinez-Martinez P. Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques. J. Biol. Chem. 2012, 287:14897-14911.
20. Morales A., Lee H., Goni F.M., Kolesnick R., Fernandez-Checa J.C. Sphingolipids and cell death. Apoptosis 2007, 12:923-939.
21. 2 and n-3 polyunsaturated fatty acid docosahexaenoic acid in prostanoid production in brain: perspectives for protection in neuroinflammation. Int. J. Dev. Neurosci. 2004, 22:551-557.
22. Tan N.S., Michalik L., Noy N., Yasmin R., Pacot C., Heim M., Fluhmann B., Desvergne B., Wahli W. Critical roles of PPAR β/δ in keratinocyte response to inflammation. Genes Dev. 2001, 15:3263-3277.
23. Tsuji K., Mitsutake S., Yokose U., Sugiura M., Kohama T., Igarashi Y. Role of ceramide kinase in peroxisome proliferator-activated receptor β-induced cell survival of mouse keratinocytes. FEBS J. 2008, 275:3815-3826.
24. Tsuji K., Satoh S., Mitsutake S., Murakami I., Park J.J., Li Q., Chang Y.T., Chung S.K., Igarashi Y. Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors. Bioorg. Med. Chem. Lett. 2009, 19:1643-1646.
25. Van Overloop H., Gijsbers S., Van Veldhoven P.P. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. J. Lipid Res. 2006, 47:268-283.
26. Van Veldhoven P.P., Mannaerts G.P., Declercq P., Baes M. Do sphingoid bases interact with the peroxisome proliferator activated receptor α (PPAR-α)?. Cell. Signal. 2000, 12:475-479.
27. Wang J., Lv X., Shi J., Hu X. Ceramide induces apoptosis via a peroxisome proliferator-activated receptor γ-dependent pathway. Apoptosis 2006, 11:2043-2052.
28. Wang Y., Luo W., Reiser G. Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain. Biochem. J. 2007, 401:65-78.
29. Zündorf G., Reiser G. The phosphorylation status of extracellular-regulated kinase 1/2 in astrocytes and neurons from rat hippocampus determines the thrombin-induced calcium release and ROS generation. J. Neurochem. 2011, 119:1194-1204.