Phosphorylation of Ser45 and Ser59 of αb-crystallin and p38/extracellular regulated kinase activity determine αb-crystallin- mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death

Journal of Neurochemistry

Volumn 118, Issue 3, 2011, Pages 354-364

  Li, Rongyu ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

B crystallin; astrocytes; neuroprotection; phosphorylation; protease activated receptor 2; small heat shock protein

Indexed keywords

ALPHA CRYSTALLIN; ALPHAB CRYSTALLIN; CERAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE ACTIVATED RECEPTOR; SERINE; SMALL INTERFERING RNA; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; MOLECULAR MECHANICS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION;

ALPHA-CRYSTALLIN B CHAIN; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPROTECTIVE AGENTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RECEPTOR, PAR-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; SPHINGOSINE; STAUROSPORINE;

RATTUS;

EID: 79960287784     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07317.x     Document Type: Article

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