PAR-1 activation rescues astrocytes through the PI3K/Akt signaling pathway from chemically induced apoptosis that is exacerbated by gene silencing of β-arrestin 1

Neurochemistry International

Volumn 67, Issue 1, 2014, Pages 46-56

  Zhu, Zhihui ^a   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Astrocytes; Cell death; Neuroprotection; PAR 1; PI3K Akt pathway; Thrombin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA ARRESTIN 1; BETA ARRESTIN 2; CASPASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; PROTEINASE ACTIVATED RECEPTOR 1; STAUROSPORINE; THROMBIN; BETA ARRESTIN; RETINA S ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL DEATH; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; GENE SILENCING; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANIMAL; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION;

ANIMALS; APOPTOSIS; ARRESTINS; CASPASE 3; CELLS, CULTURED; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN;

EID: 84896108307     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.12.007     Document Type: Article

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