Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells

Stem Cell Reports

Volumn 3, Issue 1, 2014, Pages 44-59

  Rimmelé, Pauline ^a   Bigarella, Carolina L ^a   Liang, Raymond ^a   Izac, Brigitte ^a   Dieguez Gonzalez, Rebeca ^a   Barbet, Gaetan ^a   Donovan, Michael ^a   Brugnara, Carlo ^b   Blander, Julie M ^a   Sinclair, David A ^c   Ghaffari, Saghi ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; SIRTUIN 1; TRANSCRIPTION FACTOR FKHRL1; SIRTINOL; TAMOXIFEN; SIRT1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL AGING; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CONTROLLED STUDY; DNA DAMAGE; EXTRAMEDULLARY HEMATOPOIESIS; GENE DELETION; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; LONGEVITY; LYMPHOID CELL; MOLECULE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL; ANEMIA; APOPTOSIS; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; CELL COUNT; CELL VIABILITY; COLONY FORMING CELL; COLONY FORMING UNIT S; DEACETYLATION; DIFFERENTIATION; EOSINOPHIL; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; LYMPHOCYTE; MONOCYTE; NEUTROPHIL; PROTEIN DEPLETION; STEADY STATE; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL AGING; CELL DIFFERENTIATION; CELL LINEAGE; HEMATOPOIETIC STEM CELLS; MICE; SIRTUIN 1; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84904206273     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2014.04.015     Document Type: Article

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