Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 506-516

  Vangavaragu, Jhansi Rani ^a   Valasani, Koteswara Rao ^a   Gan, Xueqi ^a   Yan, Shirley Shidu ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Alzheimer's disease; Amyloid beta; Benzimidazole derivatives; Enzyme activators; hPreP

Indexed keywords

1 (4 FLUOROBENZYL) 2 (4 FLUOROPHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE; 1,3 BIS(4 FLUOROBENZYL) 2 (4 FLUOROPHENYL) 5 NITRO 2,3 DIHYDRO 1H BENZO[D]IMIDAZOLE; 2,2' [(2 (5 BROMO 2 HYDROXYPHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE 1,3(2H) DIYL)BIS(METHYLENE)]BIS(4 BROMOPHENOL); 4 (1 (4 HYDROXYBENZYL) 5 NITRO 1H BENZO[D]IMIDAZOL 2 YL)PHENOL; 4 BROMO 2 (1 (5 BROMO 2 HYDROXYBENZYL) 5 NITRO 1H BENZO[D]IMIDAZOL 2 YL)PHENOL; 4,4' [(2 (4 HYDROXYPHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE 1,3(2H) DIYL)BIS(METHYLENE)] DIPHENOL; AMYLOID BETA PROTEIN; BENZIMIDAZOLE DERIVATIVE; DIMETHYL 5,5' [(2 (4 HYDROXY 3 (METHOXYCARBONYL)PHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE 1,3(2H) DIYL)BIS(METHYLENE)]BIS(2 HYDROXYBENZOATE); ENZYME ACTIVATOR; HUMAN PRESEQUENCE PROTEASE AGONIST; METHYL 2 HYDROXY 5 (1 (4 HYDROXY 3 (METHOXYCARBONYL)BENZYL) 5 NITRO 1H BENZO[D]IMIDAZOL 2 YL)BENZOATE; PROTEIN PRECURSOR; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; PEPTIDE HYDROLASE;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DEGRADATION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; IMMUNOBLOTTING; MASS SPECTROMETRY; MITOCHONDRIAL TOXICITY; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR WEIGHT; PHARMACOPHORE; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RELAXATION TIME; SEQUENCE HOMOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; DRUG DESIGN; ENZYME ACTIVATORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NEUROPROTECTIVE AGENTS; PEPTIDE HYDROLASES; PROTEOLYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84895825128     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.046     Document Type: Article

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