Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition

Free Radical Biology and Medicine

Volumn 45, Issue 3, 2008, Pages 284-294

  Hansson, Magnus J ^a   Månsson, Roland ^a,b   Morota, Saori ^a,c,d   Uchino, Hiroyuki ^c   Kallur, Thérese ^e   Sumi, Tetsuo ^c   Ishii, Nagao ^c   Shimazu, Motohide ^c   Keep, Marcus F ^f   Jegorov, Alexandr ^g   Elmér, Eskil ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c TOKYO MEDICAL UNIVERSITY HACHIOJI MEDICAL CENTER   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^e Stem Cell Institute   (Sweden)

^f SWEDISH MEDICAL CENTER   (United States)

^g TEVA PHARMACEUTICALS   (Israel)

Author keywords

Brain; Calcium; Cyclophilin; Delayed calcium deregulation; Excitotoxicity; GSH; Human; Mitochondria; Neurodegeneration; Permeability transition; Reactive oxygen species; Respirometry

Indexed keywords

ACETYLCYCLOSPORIN A; ALAMETHICIN; ANTIMYCIN A1; ASCORBIC ACID; CALCIUM; CYCLOSPORIN 3 OXO D; CYCLOSPORIN A; CYCLOSPORIN A 3 OXO; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; CYCLOSPORIN A DERIVATIVE; CYCLOSPORIN A SULPHATE; CYCLOSPORIN B; CYCLOSPORIN C; CYCLOSPORIN D; CYCLOSPORIN E; CYCLOSPORIN F; CYCLOSPORIN G; CYCLOSPORIN H; CYCLOSPORIN U; DIHYDRO CYCLOSPORIN A; EGTAZIC ACID; HYDROGEN PEROXIDE; ISO CYCLOSPORIN A; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRIFLUOROACETYLCYCLOSPORIN A; UNIL 025;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; BRAIN MITOCHONDRION; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; EXCITOTOXICITY; HUMAN; HUMAN TISSUE; ISOLATION PROCEDURE; LIVER MITOCHONDRION; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; CALCIUM; HUMANS; MALE; MITOCHONDRIA; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL SWELLING; NADP; PERMEABILITY; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

RODENTIA;

EID: 46449116985     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.04.021     Document Type: Article

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