TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production

BMC Developmental Biology

Volumn 14, Issue 1, 2014, Pages

  Wu, Junfang ^a   Niu, Jie ^a   Li, Xiaopeng ^a   Wang, Xianwei ^a   Guo, Zhikun ^a   Zhang, Fenxi ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow mesenchymal stem cells; Cell senescence; Mitochondrial reactive oxygen species; Senescence associated galactosidase activity; Transforming growth factor beta 1

Indexed keywords

4 HYDROXYNONENAL; 4-HYDROXY-2-NONENAL; ACETYLCARNITINE; ALDEHYDE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GALACTOSIDASE; IDB1 PROTEIN, MOUSE; INHIBITOR OF DIFFERENTIATION 1; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN B COMPLEX;

ADIPOGENESIS; ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; C57BL MOUSE; CELL AGING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; MESENCHYMAL STROMA CELL; METABOLISM; MITOCHONDRION; MOUSE; WESTERN BLOTTING;

ACETYLCARNITINE; ADIPOGENESIS; ALDEHYDES; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOSE-RESPONSE RELATIONSHIP, DRUG; GALACTOSIDASES; INHIBITOR OF DIFFERENTIATION PROTEIN 1; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; OSTEOGENESIS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN B COMPLEX;

EID: 84901484906     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-14-21     Document Type: Article

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