The cyclooxygenase-2-prostaglandin e2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts

American Journal of Respiratory and Critical Care Medicine

Volumn 187, Issue 7, 2013, Pages 703-714

  Dagouassat, Maylis ^a,b   Gagliolo, Jean Marie ^a,b   Chrusciel, Sandra ^a,b   Bourin, Marie Claude ^a,b   Duprez, Corinne ^c   Caramelle, Philippe ^a,b   Boyer, Laurent ^a,b   Hue, Sophie ^a,b,c   Stern, Jean Baptiste ^d   Validire, Pierre ^e   Longrois, Dan ^f,g   Norel, Xavier ^f   Dubois Randé, Jean Luc ^a,h   Le Gouvello, Sabine ^a,b,c   Adnot, Serge ^a,b,i   Boczkowski, Jorge ^a,b,i,j  

^a FACULTÉ DE MÉDECINE   (France)

^b INSERM U955   (France)

^c Service d'Immunologie Clinique   (France)

^d Nstitut Montsouris   (France)

^e INSTITUT MUTUALISTE MONTSOURIS   (France)

^f INSERM   (France)

^g BICHAT HOSPITAL   (France)

^h Service de Cardiologie 1   (France)

ⁱ HENRI MONDOR HOSPITAL   (France)

^j CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

more..

Author keywords

COPD; Fibroblasts; Lung; Prostaglandins; Senescence

Indexed keywords

BETA GALACTOSIDASE; CELL MARKER; CHEMOKINE; CYCLOOXYGENASE 2; FRACTALKINE; GELATINASE A; GROWTH REGULATED ONCOGENE; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROTEIN P16; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CELL AGING; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG FIBROBLAST; MALE; MEDIATOR; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SMOKING; WILD TYPE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; AUTOCRINE COMMUNICATION; CASE-CONTROL STUDIES; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; FIBROBLASTS; GENES, P53; HUMANS; LUNG; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; PARACRINE COMMUNICATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; STATISTICS, NONPARAMETRIC;

EID: 84875849501     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201208-1361OC     Document Type: Article

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