Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 10, 2013, Pages

  Hara, Hiromichi ^a   Araya, Jun ^a   Ito, Saburo ^a   Kobayashi, Kenji ^a   Takasaka, Naoki ^a   Yoshii, Yutaka ^a   Wakui, Hiroshi ^a   Kojima, Jun ^a   Shimizu, Kenichiro ^a   Numata, Takanori ^a   Kawaishi, Makoto ^a   Kamiya, Noriki ^a   Odaka, Makoto ^a   Morikawa, Toshiaki ^a   Kaneko, Yumi ^a   Nakayama, Katsutoshi ^a   Kuwano, Kazuyoshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic obstructive pulmonary disease; Mitochondria dynamics

Indexed keywords

BETA GALACTOSIDASE; CIGARETTE SMOKE; MITOCHONDRIAL PROTEIN; MITOFUSIN 1; MITOFUSIN 2; PROTEIN P21; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SUPEROXIDE;

ARTICLE; BRONCHIAL EPITHELIAL CELL; BRONCHUS MUCOSA; CELL AGING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DNA FRAGMENTATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG PARENCHYMA; MITOCHONDRIA FRAGMENTATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL VOLUME; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

CHRONIC OBSTRUCTIVE PULMONARY DISEASE; MITOCHONDRIA DYNAMICS;

BLOTTING, WESTERN; BRONCHI; CELL AGING; CELLS, CULTURED; EPITHELIAL CELLS; GTP PHOSPHOHYDROLASES; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TOBACCO;

EID: 84887581901     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00146.2013     Document Type: Article

References (55)

1. Aoshiba K, Nagai A. Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease. Proc Am Thorac Soc 6: 596-601, 2009.
2. Aoshiba K, Zhou F, Tsuji T, Nagai A. DNA damage as a molecular link in the pathogenesis of COPD in smokers. Eur Respir J 39: 1368-1376, 2012.
3. Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 33: 1165-1185, 2009.
4. Campello S, Scorrano L. Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep 11: 678-684, 2010.
5. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120: 513-522, 2005.
6. Cerveny KL, Tamura Y, Zhang Z, Jensen RE, Sesaki H. Regulation of mitochondrial fusion and division. Trends Cell Biol 17: 563-569, 2007.
7. Cha SI, Groshong SD, Frankel SK, Edelman BL, Cosgrove GP, Terry-Powers JL, Remigio LK, Curran-Everett D, Brown KK, Cool CD, Riches DW. Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 42: 140-148, 2010.
8. Chapman KR, Mannino DM, Soriano JB, Vermeire PA, Buist AS, Thun MJ, Connell C, Jemal A, Lee TA, Miravitlles M, Aldington S, Beasley R. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J 27: 188-207, 2006.
9. Chen H, Chomyn A, Chan DC. Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280: 26185-26192, 2005.
10. Chen L, Knowlton AA. Mitochondrial dynamics in heart failure. Congest Heart Fail 17: 257-261, 2005.
11. Dekhuijzen PN, Aben KK, Dekker I, Aarts LP, Wielders PL, van Herwaarden CL, Bast A. Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 154: 813-816, 1996.
12. Eisner MD, Anthonisen N, Coultas D, Kuenzli N, Perez-Padilla R, Postma D, Romieu I, Silverman EK, Balmes JR. An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 182: 693-718, 2010.
13. Fan X, Hussien R, Brooks GA. H2O2-induced mitochondrial fragmentation in C2C12 myocytes. Free Radic Biol Med 49: 1646-1654, 2010.
14. Frank M, Duvezin-Caubet S, Koob S, Occhipinti A, Jagasia R, Petcherski A, Ruonala MO, Priault M, Salin B, Reichert AS. Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochim Biophys Acta 1823: 2297-2310, 2012.
15. Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K. Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. Oncoimmunology 1: 630-641, 2012.
16. Gosker HR, Hesselink MK, Duimel H, Ward KA, Schols AM. Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD. Eur Respir J 30: 73-79, 2007.
17. Hackett TL, Scarci M, Zheng L, Tan W, Treasure T, Warner JA. Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease (Abstract). Respir Res 11: 180, 2010.
18. Hara H, Aizaki H, Matsuda M, Shinkai-Ouchi F, Inoue Y, Murakami K, Shoji I, Kawakami H, Matsuura Y, Lai MM, Miyamura T, Wakita T, Suzuki T. Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein. J Virol 83: 5137-5147, 2009.
19. Hara H, Araya J, Takasaka N, Fujii S, Kojima J, Yumino Y, Shimizu K, Ishikawa T, Numata T, Kawaishi M, Saito K, Hirano J, Odaka M, Morikawa T, Hano H, Nakayama K, Kuwano K. Involvement of creatine kinase B in cigarette smoke-induced bronchial epithelial cell senescence. Am J Respir Cell Mol Biol 46: 306-312, 2012.
20. Harman D. Free radical theory of aging: an update: increasing the functional life span. Ann NY Acad Sci 1067: 10-21, 2006.
21. Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest 135: 173-180, 2009.
22. Ito K, Colley T, Mercado N. Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. Int J Chron Obstruct Pulmon Dis 7: 641-652, 2012.
23. Jacob KD, Noren Hooten N, Trzeciak AR, Evans MK. Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev 134: 139-157, 2013.
24. Kolosova NG, Stefanova NA, Muraleva NA, Skulachev VP. The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats. Aging 4: 686-694, 2012.
25. Kowald A, Kirkwood TB. The evolution and role of mitochondrial fusion and fission in aging and disease. Commun Integr Biol 4: 627-629, 2011.
26. Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, Youle RJ, Cho H. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 282: 22977-22983, 2007.
27. Lemasters JJ, Theruvath TP, Zhong Z, Nieminen AL. Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta 1787: 1395-1401, 2009.
28. Lenaz G. The mitochondrial production of reactive oxygen species: mechanisms and implications in human pathology. IUBMB Life 52: 159-164, 2001.
29. Liesa M, Palacin M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev 89: 799-845, 2009.
30. Marin-Garcia J, Akhmedov AT, Moe GW. Mitochondria in heart failure: the emerging role of mitochondrial dynamics. Heart Fail Rev 18: 439-456, 2013.
31. Miro O, Casademont J, Casals E, Perea M, Urbano-Marquez A, Rustin P, Cardellach F. Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. Cardiovasc Res 47: 624-631, 2000.
32. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 349: 1498-1504, 1997.
33. Okamoto K, Kondo-Okamoto N. Mitochondria and autophagy: critical interplay between the two homeostats. Biochim Biophys Acta 1820: 595-600, 2011.
34. Otera H, Mihara K. Molecular mechanisms and physiologic functions of mitochondrial dynamics. J Biochem 149: 241-251, 2011.
35. Passos JF, Zglinicki T. Mitochondrial dysfunction and cell senescence-skin deep into mammalian aging. Aging 4: 74-75, 2012.
36. Petropoulos I, Friguet B. Maintenance of proteins and aging: the role of oxidized protein repair. Free Radic Res 40: 1269-1276, 2006.
37. Picard M, Godin R, Sinnreich M, Baril J, Bourbeau J, Perrault H, Taivassalo T, Burelle Y. The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction? Am J Respir Crit Care Med 178: 1040-1047, 2008.
38. Pletjushkina OY, Lyamzaev KG, Popova EN, Nepryakhina OK, Ivanova OY, Domnina LV, Chernyak BV, Skulachev VP. Effect of oxidative stress on dynamics of mitochondrial reticulum. Biochim Biophys Acta 1757: 518-524, 2006.
39. Puente-Maestu L, Perez-Parra J, Godoy R, Moreno N, Tejedor A, Gonzalez-Aragoneses F, Bravo JL, Alvarez FV, Camano S, Agusti A. Abnormal mitochondrial function in locomotor and respiratory muscles of COPD patients. Eur Respir J 33: 1045-1052, 2009.
40. Rahman I, van Schadewijk AA, Crowther AJ, Hiemstra PS, Stolk J, MacNee W, De Boer WI. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 166: 490-495, 2002.
41. Santos D, Cardoso SM. Mitochondrial dynamics and neuronal fate in Parkinson's disease. Mitochondrion 12: 428-437, 2012.
42. Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci 123: 2533-2542, 2010.
43. Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 124: 444-453, 2011.
44. Skulachev VP, Anisimov VN, Antonenko YN, Bakeeva LE, Chernyak BV, Erichev VP, Filenko OF, Kalinina NI, Kapelko VI, Kolosova NG, Kopnin BP, Korshunova GA, Lichinitser MR, Obukhova LA, Pasyukova EG, Pisarenko OI, Roginsky VA, Ruuge EK, Senin II, Severina II, Skulachev MV, Spivak IM, Tashlitsky VN, Tkachuk VA, Vyssokikh MY, Yaguzhinsky LS, Zorov DB. An attempt to prevent senescence: a mitochondrial approach. Biochim Biophys Acta 1787: 437-461, 2009.
45. Solesio ME, Prime TA, Logan A, Murphy MP, Del Mar Arroyo-Jimenez, Jordan J, and Galindo MF. The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease. Biochim Biophys Acta 1832: 174-182, 2012.
46. Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, Youle R, Langer T, Martinou JC. SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J 28: 1589-1600, 2009.
47. Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med 174: 886-893, 2006.
48. Tsuji T, Aoshiba K, Nagai A. Cigarette smoke induces senescence in alveolar epithelial cells. Am J Respir Cell Mol Biol 31: 643-649, 2004.
49. Valavanidis A, Vlachogianni T, Fiotakis K. Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles. Int J Environ Res Public Health 6: 445-462, 2009.
50. van der Toorn M, Rezayat D, Kauffman HF, Bakker SJ, Gans RO, Koeter GH, Choi AM, van Oosterhout AJ, Slebos DJ. Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 297: L109-L114, 2009.
51. van der Toorn M, Slebos DJ, de Bruin HG, Leuvenink HG, Bakker SJ, Gans RO, Koeter GH, van Oosterhout AJ, Kauffman HF. Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis. Am J Physiol Lung Cell Mol Physiol 292: L1211-L1218, 2007.
52. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging 4: 3-12, 2012.
53. Westermann B. Bioenergetic role of mitochondrial fusion and fission. Biochim Biophys Acta 1817: 1833-1838, 2012.
54. Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 11: 872-884, 2010.
55. Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, stress. Science 337: 1062-1065, 2012.