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Volumn 6, Issue 5, 2015, Pages 334-350

The physiological role of drug transporters

Author keywords

physiological role; therapeutic implication; transporter

Indexed keywords

CARRIER PROTEIN;

EID: 84939948900     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-015-0148-2     Document Type: Review
Times cited : (84)

References (88)
  • 1
    • 84875206850 scopus 로고    scopus 로고
    • The SLC26 gene family of anion transporters and channels
    • COI: 1:CAS:528:DC%2BC3sXksVyrsL0%3
    • Alper SL, Sharma AK (2013) The SLC26 gene family of anion transporters and channels. Mol Asp Med 34:494–515
    • (2013) Mol Asp Med , vol.34 , pp. 494-515
    • Alper, S.L.1    Sharma, A.K.2
  • 2
    • 15744392298 scopus 로고    scopus 로고
    • Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel
    • COI: 1:CAS:528:DC%2BD2MXitVCisLg%3D, PID: 1561346
    • Bancila V, Cens T, Monnier D, Chanson F, Faure C, Dunant Y, Bloc A (2005) Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel. J Biol Chem 280:8793–8799
    • (2005) J Biol Chem , vol.280 , pp. 8793-8799
    • Bancila, V.1    Cens, T.2    Monnier, D.3    Chanson, F.4    Faure, C.5    Dunant, Y.6    Bloc, A.7
  • 4
    • 84901051205 scopus 로고    scopus 로고
    • Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake
    • PID: 2468807
    • Boxberger KH, Hagenbuch B, Lampe JN (2014) Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Drug Metab Dispos 42:990–995
    • (2014) Drug Metab Dispos , vol.42 , pp. 990-995
    • Boxberger, K.H.1    Hagenbuch, B.2    Lampe, J.N.3
  • 5
    • 77954485702 scopus 로고    scopus 로고
    • Xenopus laevis Oocytes
    • PID: 2041944
    • Bröer S (2010) Xenopus laevis Oocytes. Methods Mol Biol 637:295–310
    • (2010) Methods Mol Biol , vol.637 , pp. 295-310
    • Bröer, S.1
  • 6
    • 84903977464 scopus 로고    scopus 로고
    • OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
    • COI: 1:CAS:528:DC%2BC2cXhtVamu7nI, PID: 2496137
    • Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ et al (2014) OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci USA 111:9983–9988
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 9983-9988
    • Chen, L.1    Shu, Y.2    Liang, X.3    Chen, E.C.4    Yee, S.W.5    Zur, A.A.6    Li, S.7    Xu, L.8    Keshari, K.R.9    Lin, M.J.10
  • 8
    • 84455171488 scopus 로고    scopus 로고
    • In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans
    • COI: 1:CAS:528:DC%2BC38Xjs1ajtbk%3D, PID: 2196562
    • Dawson S, Stahl S, Paul N, Barber J, Kenna JG (2012) In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug Metab Dispos 40:130–138
    • (2012) Drug Metab Dispos , vol.40 , pp. 130-138
    • Dawson, S.1    Stahl, S.2    Paul, N.3    Barber, J.4    Kenna, J.G.5
  • 9
    • 79959593077 scopus 로고    scopus 로고
    • Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes
    • PID: 2160566
    • De Bruyn T, Ye ZW, Peeters A, Sahi J, Baes M, Augustijns PF, Annaert PP (2011) Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes. Eur J Pharm Sci 43:297–307
    • (2011) Eur J Pharm Sci , vol.43 , pp. 297-307
    • De Bruyn, T.1    Ye, Z.W.2    Peeters, A.3    Sahi, J.4    Baes, M.5    Augustijns, P.F.6    Annaert, P.P.7
  • 10
    • 84902002905 scopus 로고    scopus 로고
    • Crystal structure of the human glucose transporter GLUT1
    • COI: 1:CAS:528:DC%2BC2MXitFGitL8%3D, PID: 2484788
    • Deng D, Xu C, Sun P, Wu J, Yan C, Hu M, Yan N (2014) Crystal structure of the human glucose transporter GLUT1. Nature 510:121–125
    • (2014) Nature , vol.510 , pp. 121-125
    • Deng, D.1    Xu, C.2    Sun, P.3    Wu, J.4    Yan, C.5    Hu, M.6    Yan, N.7
  • 12
    • 0033059196 scopus 로고    scopus 로고
    • Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome
    • COI: 1:CAS:528:DyaK1MXkt1eqtro%3D, PID: 1039122
    • Diaz GA, Banikazemi M, Oishi K, Desnick RJ, Gelb BD (1999) Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome. Nat Genet 22:309–312
    • (1999) Nat Genet , vol.22 , pp. 309-312
    • Diaz, G.A.1    Banikazemi, M.2    Oishi, K.3    Desnick, R.J.4    Gelb, B.D.5
  • 15
    • 66249128300 scopus 로고    scopus 로고
    • Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
    • PID: 1947907
    • Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK, Cohen DM (2009) Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One 4:e5679
    • (2009) PLoS One , vol.4 , pp. 5679
    • Fu, Y.1    Tian, W.2    Pratt, E.B.3    Dirling, L.B.4    Shyng, S.L.5    Meshul, C.K.6    Cohen, D.M.7
  • 17
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
    • COI: 1:CAS:528:DC%2BC3sXnsVyiu7c%3D, PID: 2366477
    • Gaj T, Gersbach CA, Barbas CF 3rd (2013) ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 31:397–405
    • (2013) Trends Biotechnol , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 18
    • 67649200539 scopus 로고    scopus 로고
    • Structure and mechanism of an amino acid antiporter
    • COI: 1:CAS:528:DC%2BD1MXnsFOrs7o%3D, PID: 1947813
    • Gao X, Lu F, Zhou L, Dang S, Sun L, Li X, Wang J, Shi Y (2009) Structure and mechanism of an amino acid antiporter. Science 324:1565–1568
    • (2009) Science , vol.324 , pp. 1565-1568
    • Gao, X.1    Lu, F.2    Zhou, L.3    Dang, S.4    Sun, L.5    Li, X.6    Wang, J.7    Shi, Y.8
  • 20
    • 34548083160 scopus 로고    scopus 로고
    • ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions
    • COI: 1:CAS:528:DC%2BD2sXpslKqsro%3D, PID: 1753787
    • Glavinas H, Kis E, Pal A, Kovacs R, Jani M, Vagi E, Molnar E, Bansaghi S, Kele Z, Janaky T et al (2007) ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions. Drug Metab Dispos 35:1533–1542
    • (2007) Drug Metab Dispos , vol.35 , pp. 1533-1542
    • Glavinas, H.1    Kis, E.2    Pal, A.3    Kovacs, R.4    Jani, M.5    Vagi, E.6    Molnar, E.7    Bansaghi, S.8    Kele, Z.9    Janaky, T.10
  • 21
    • 0035682189 scopus 로고    scopus 로고
    • Overview: ABC transporters and human disease
    • COI: 1:CAS:528:DC%2BD38XlsVymuw%3D%3D, PID: 1180418
    • Gottesman MM, Ambudkar SV (2001) Overview: ABC transporters and human disease. J Bioenerg Biomembr 33:453–458
    • (2001) J Bioenerg Biomembr , vol.33 , pp. 453-458
    • Gottesman, M.M.1    Ambudkar, S.V.2
  • 25
    • 84875163715 scopus 로고    scopus 로고
    • The SLCO (former SLC21) superfamily of transporters
    • COI: 1:CAS:528:DC%2BC3sXksV2js74%3
    • Hagenbuch B, Stieger B (2013) The SLCO (former SLC21) superfamily of transporters. Mol Asp Med 34:396–412
    • (2013) Mol Asp Med , vol.34 , pp. 396-412
    • Hagenbuch, B.1    Stieger, B.2
  • 26
    • 84973274740 scopus 로고    scopus 로고
    • Concepts and treatment approaches in nonalcoholic fatty liver disease. Adv Hepatol
    • Halegoua-De Marzio DL, Fenkel JM (2014) Concepts and treatment approaches in nonalcoholic fatty liver disease. Adv Hepatol, Article ID 357965
    • (2014) Article ID
    • Halegoua-De Marzio, D.L.1    Fenkel, J.M.2
  • 27
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • COI: 1:STN:280:DyaL1M7itFeqsg%3D%3D, PID: 291463
    • Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736–749
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 29
    • 57049182408 scopus 로고    scopus 로고
    • Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2
    • COI: 1:CAS:528:DC%2BD1cXhsVOis7zF, PID: 1903825
    • Ito K, Hoekstra D, van Ijzendoorn SC (2008) Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2. FEBS Lett 582:4153–4157
    • (2008) FEBS Lett , vol.582 , pp. 4153-4157
    • Ito, K.1    Hoekstra, D.2    van Ijzendoorn, S.C.3
  • 31
    • 84891624684 scopus 로고    scopus 로고
    • Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins
    • COI: 1:CAS:528:DC%2BC3sXht1ShtL3O, PID: 2390753
    • Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H et al (2014) Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins. Pharm Res 31:136–147
    • (2014) Pharm Res , vol.31 , pp. 136-147
    • Kato, K.1    Mori, H.2    Kito, T.3    Yokochi, M.4    Ito, S.5    Inoue, K.6    Yonezawa, A.7    Katsura, T.8    Kumagai, Y.9    Yuasa, H.10
  • 32
    • 82955184472 scopus 로고    scopus 로고
    • Cholestasis and the role of basolateral efflux pumps
    • COI: 1:CAS:528:DC%2BC38XjsFemtrc%3D, PID: 2213988
    • Keppler D (2011) Cholestasis and the role of basolateral efflux pumps. Z Gastroenterol 49:1553–1557
    • (2011) Z Gastroenterol , vol.49 , pp. 1553-1557
    • Keppler, D.1
  • 34
    • 70349153908 scopus 로고    scopus 로고
    • Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors
    • COI: 1:CAS:528:DC%2BD1MXhtVOrsrbN, PID: 1952077
    • Kis E, Ioja E, Nagy T, Szente L, Heredi-Szabo K, Krajcsi P (2009) Effect of membrane cholesterol on BSEP/Bsep activity: species specificity studies for substrates and inhibitors. Drug Metab Dispos 37:1878–1886
    • (2009) Drug Metab Dispos , vol.37 , pp. 1878-1886
    • Kis, E.1    Ioja, E.2    Nagy, T.3    Szente, L.4    Heredi-Szabo, K.5    Krajcsi, P.6
  • 35
    • 82455203879 scopus 로고    scopus 로고
    • BSEP inhibition: in vitro screens to assess cholestatic potential of drugs
    • COI: 1:CAS:528:DC%2BC38Xhs1Kls77I, PID: 2212013
    • Kis E, Ioja E, Rajnai Z, Jani M, Mehn D, Heredi-Szabo K, Krajcsi P (2012) BSEP inhibition: in vitro screens to assess cholestatic potential of drugs. Toxicol In Vitro 26:1294–1299
    • (2012) Toxicol In Vitro , vol.26 , pp. 1294-1299
    • Kis, E.1    Ioja, E.2    Rajnai, Z.3    Jani, M.4    Mehn, D.5    Heredi-Szabo, K.6    Krajcsi, P.7
  • 36
    • 84887978608 scopus 로고    scopus 로고
    • Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4
    • PID: 2415460
    • Köck K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, Brouwer KL (2014) Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos 42:665–674
    • (2014) Drug Metab Dispos , vol.42 , pp. 665-674
    • Köck, K.1    Ferslew, B.C.2    Netterberg, I.3    Yang, K.4    Urban, T.J.5    Swaan, P.W.6    Stewart, P.W.7    Brouwer, K.L.8
  • 37
    • 84875181483 scopus 로고    scopus 로고
    • The SLC22 family with transporters of organic cations, anions and zwitterions
    • COI: 1:CAS:528:DC%2BC3sXksVyksr8%3
    • Koepsell H (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Asp Med 34:413–435
    • (2013) Mol Asp Med , vol.34 , pp. 413-435
    • Koepsell, H.1
  • 38
    • 79251527930 scopus 로고    scopus 로고
    • The use of Xenopus oocytes in drug screening
    • COI: 1:CAS:528:DC%2BC3MXhtVSls7Y%3D, PID: 2264713
    • Kvist T, Hansen KB, Bräuner-Osborne H (2011) The use of Xenopus oocytes in drug screening. Expert Opin Drug Discov 6:141–153
    • (2011) Expert Opin Drug Discov , vol.6 , pp. 141-153
    • Kvist, T.1    Hansen, K.B.2    Bräuner-Osborne, H.3
  • 39
    • 0032990411 scopus 로고    scopus 로고
    • Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness
    • COI: 1:CAS:528:DyaK1MXkt1eqtrw%3D, PID: 1039122
    • Labay V, Raz T, Baron D, Mandel H, Williams H, Barrett T, Szargel R, McDonald L, Shalata A, Nosaka K et al (1999) Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Nat Genet 22:300–304
    • (1999) Nat Genet , vol.22 , pp. 300-304
    • Labay, V.1    Raz, T.2    Baron, D.3    Mandel, H.4    Williams, H.5    Barrett, T.6    Szargel, R.7    McDonald, L.8    Shalata, A.9    Nosaka, K.10
  • 41
    • 79952485264 scopus 로고    scopus 로고
    • Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice
    • COI: 1:CAS:528:DC%2BC3cXhsVGru77F, PID: 2110430
    • Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM (2011) Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharm Res 28:610–625
    • (2011) Pharm Res , vol.28 , pp. 610-625
    • Li, S.1    Chen, Y.2    Zhang, S.3    More, S.S.4    Huang, X.5    Giacomini, K.M.6
  • 46
    • 84869884515 scopus 로고    scopus 로고
    • Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter
    • COI: 1:CAS:528:DC%2BC38XhsFCgtbvK, PID: 2308614
    • Mancusso R, Gregorio GG, Liu Q, Wang DN (2012) Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter. Nature 491:622–626
    • (2012) Nature , vol.491 , pp. 622-626
    • Mancusso, R.1    Gregorio, G.G.2    Liu, Q.3    Wang, D.N.4
  • 47
    • 0042468096 scopus 로고    scopus 로고
    • Impact of drug transporter studies on drug discovery and development
    • COI: 1:CAS:528:DC%2BD3sXnsVynuro%3D, PID: 1286965
    • Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (2003) Impact of drug transporter studies on drug discovery and development. Pharmacol Rev 55:425–461
    • (2003) Pharmacol Rev , vol.55 , pp. 425-461
    • Mizuno, N.1    Niwa, T.2    Yotsumoto, Y.3    Sugiyama, Y.4
  • 48
    • 52949091163 scopus 로고    scopus 로고
    • Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtFOltrjJ, PID: 1877433
    • Mocchegiani E, Giacconi R, Malavolta M (2008) Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes. Trends Mol Med 14:419–428
    • (2008) Trends Mol Med , vol.14 , pp. 419-428
    • Mocchegiani, E.1    Giacconi, R.2    Malavolta, M.3
  • 49
    • 84901772228 scopus 로고    scopus 로고
    • Functional characterization of a Na+-dependent dicarboxylate transporter from Vibrio cholerae
    • COI: 1:CAS:528:DC%2BC2cXhtFKks77I, PID: 2482196
    • Mulligan C, Fitzgerald GA, Wang DN, Mindell JA (2014) Functional characterization of a Na+-dependent dicarboxylate transporter from Vibrio cholerae. J Gen Physiol 143:745–759
    • (2014) J Gen Physiol , vol.143 , pp. 745-759
    • Mulligan, C.1    Fitzgerald, G.A.2    Wang, D.N.3    Mindell, J.A.4
  • 50
    • 34547138910 scopus 로고    scopus 로고
    • Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter
    • COI: 1:CAS:528:DC%2BD2sXoslSjt7o%3D, PID: 1747590
    • Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H (2007) Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. J Pharmacol Exp Ther 322:469–476
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 469-476
    • Nakai, Y.1    Inoue, K.2    Abe, N.3    Hatakeyama, M.4    Ohta, K.Y.5    Otagiri, M.6    Hayashi, Y.7    Yuasa, H.8
  • 53
    • 34248530310 scopus 로고    scopus 로고
    • Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2
    • COI: 1:CAS:528:DC%2BD2sXmsFeqs7g%3D, PID: 1734732
    • Pal A, Mehn D, Molnar E, Gedey S, Meszaros P, Nagy T, Glavinas H, Janaky T, von Richter O, Bathori G et al (2007) Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2. J Pharmacol Exp Ther 321:1085–1094
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1085-1094
    • Pal, A.1    Mehn, D.2    Molnar, E.3    Gedey, S.4    Meszaros, P.5    Nagy, T.6    Glavinas, H.7    Janaky, T.8    von Richter, O.9    Bathori, G.10
  • 55
    • 84897395077 scopus 로고    scopus 로고
    • Zinc transport and diabetes risk
    • COI: 1:CAS:528:DC%2BC2cXkvF2ltLY%3D, PID: 2467552
    • Pearson E (2014) Zinc transport and diabetes risk. Nat Genet 46:323–324
    • (2014) Nat Genet , vol.46 , pp. 323-324
    • Pearson, E.1
  • 56
    • 34247623972 scopus 로고    scopus 로고
    • Regulation of drug transporters during infection and inflammation
    • COI: 1:CAS:528:DC%2BD2sXlvFCmur4%3D, PID: 1746839
    • Petrovic V, Teng S, Piquette-Miller M (2007) Regulation of drug transporters during infection and inflammation. Mol Interv 7:99–111
    • (2007) Mol Interv , vol.7 , pp. 99-111
    • Petrovic, V.1    Teng, S.2    Piquette-Miller, M.3
  • 57
    • 77952486005 scopus 로고    scopus 로고
    • Zinc in cancer prevention
    • COI: 1:CAS:528:DC%2BC3cXjsVOntg%3D%3D, PID: 2015563
    • Prasad AS, Beck FW, Snell DC, Kucuk O (2009) Zinc in cancer prevention. Nutr Cancer 61:879–887
    • (2009) Nutr Cancer , vol.61 , pp. 879-887
    • Prasad, A.S.1    Beck, F.W.2    Snell, D.C.3    Kucuk, O.4
  • 58
    • 4544331383 scopus 로고    scopus 로고
    • Zinc is both an intracellular and extracellular regulator of KATP channel function
    • Prost AL, Bloc A, Hussy N, Derand R, Vivaudou M (2004) Zinc is both an intracellular and extracellular regulator of KATP channel function. J Physiol 15:157–167
    • (2004) J Physiol , vol.15 , pp. 157-167
    • Prost, A.L.1    Bloc, A.2    Hussy, N.3    Derand, R.4    Vivaudou, M.5
  • 59
    • 0035969512 scopus 로고    scopus 로고
    • SLC19A3 encodes a second thiamine transporter ThTr2
    • COI: 1:CAS:528:DC%2BD3MXos1Cnsbk%3D, PID: 1173122
    • Rajgopal A, Edmondnson A, Goldman ID, Zhao R (2001) SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta 1537:175–178
    • (2001) Biochim Biophys Acta , vol.1537 , pp. 175-178
    • Rajgopal, A.1    Edmondnson, A.2    Goldman, I.D.3    Zhao, R.4
  • 60
    • 0027405191 scopus 로고
    • Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization
    • COI: 1:CAS:528:DyaK3sXkvV2gsrs%3D, PID: 768160
    • Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD (1993) Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90:2542–2546
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2542-2546
    • Ramamoorthy, S.1    Bauman, A.L.2    Moore, K.R.3    Han, H.4    Yang-Feng, T.5    Chang, A.S.6    Ganapathy, V.7    Blakely, R.D.8
  • 63
    • 0034671596 scopus 로고    scopus 로고
    • Extended life-span conferred by cotransporter gene mutations in Drosophila
    • COI: 1:CAS:528:DC%2BD3cXptVyisLg%3D, PID: 1111814
    • Rogina B, Reenan RA, Nilsen SP, Helfand SL (2000) Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290:2137–2140
    • (2000) Science , vol.290 , pp. 2137-2140
    • Rogina, B.1    Reenan, R.A.2    Nilsen, S.P.3    Helfand, S.L.4
  • 64
    • 67649851008 scopus 로고    scopus 로고
    • Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
    • COI: 1:CAS:528:DC%2BD1MXnvVOnsbY%3D, PID: 1941997
    • Sanna S, Busonero F, Maschio A, McArdle PF, Usala G, Dei M, Lai S, Mulas A, Piras MG, Perseu L et al (2009) Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet 18:2711–2718
    • (2009) Hum Mol Genet , vol.18 , pp. 2711-2718
    • Sanna, S.1    Busonero, F.2    Maschio, A.3    McArdle, P.F.4    Usala, G.5    Dei, M.6    Lai, S.7    Mulas, A.8    Piras, M.G.9    Perseu, L.10
  • 65
    • 80053167954 scopus 로고    scopus 로고
    • Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET
    • COI: 1:CAS:528:DC%2BC3MXht1emtr3O, PID: 2188573
    • Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A (2011) Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc Natl Acad Sci USA 108:15810–15815
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 15810-15815
    • Schlessinger, A.1    Geier, E.2    Fan, H.3    Irwin, J.J.4    Shoichet, B.K.5    Giacomini, K.M.6    Sali, A.7
  • 66
    • 84868313349 scopus 로고    scopus 로고
    • High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach
    • COI: 1:CAS:528:DC%2BC38Xhs1WjtLjI, PID: 2293290
    • Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A (2012) High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. J Biol Chem 287:37745–37756
    • (2012) J Biol Chem , vol.287 , pp. 37745-37756
    • Schlessinger, A.1    Wittwer, M.B.2    Dahlin, A.3    Khuri, N.4    Bonomi, M.5    Fan, H.6    Giacomini, K.M.7    Sali, A.8
  • 68
    • 69249116947 scopus 로고    scopus 로고
    • Structure and mechanism of a na+-independent amino acid transporter
    • COI: 1:CAS:528:DC%2BD1MXhtValsrrP, PID: 1960885
    • Shaffer PL, Goehring A, Shankaranarayanan A, Gouaux E (2009) Structure and mechanism of a na+-independent amino acid transporter. Science 325:1010–1014
    • (2009) Science , vol.325 , pp. 1010-1014
    • Shaffer, P.L.1    Goehring, A.2    Shankaranarayanan, A.3    Gouaux, E.4
  • 71
    • 2942750350 scopus 로고    scopus 로고
    • ATP-binding cassette (ABC) transporters in human metabolism and diseases
    • PID: 1520953
    • Stefková J, Poledne R, Hubacek JA (2004) ATP-binding cassette (ABC) transporters in human metabolism and diseases. Physiol Res 53:235–243
    • (2004) Physiol Res , vol.53 , pp. 235-243
    • Stefková, J.1    Poledne, R.2    Hubacek, J.A.3
  • 73
    • 77954273723 scopus 로고    scopus 로고
    • Mitochondrial and plasma membrane citrate transporters: discovery of selective inhibitors and application to structure/function analysis
    • COI: 1:CAS:528:DC%2BC3cXovFGlur4%3D, PID: 2068667
    • Sun J, Aluvila S, Kotaria R, Mayor JA, Walters DE, Kaplan RS (2010) Mitochondrial and plasma membrane citrate transporters: discovery of selective inhibitors and application to structure/function analysis. Mol Cell Pharmacol 2:101–110
    • (2010) Mol Cell Pharmacol , vol.2 , pp. 101-110
    • Sun, J.1    Aluvila, S.2    Kotaria, R.3    Mayor, J.A.4    Walters, D.E.5    Kaplan, R.S.6
  • 75
    • 73349098768 scopus 로고    scopus 로고
    • Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
    • PID: 1990111
    • Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH et al (2009) Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol 27:5972–5978
    • (2009) J Clin Oncol , vol.27 , pp. 5972-5978
    • Treviño, L.R.1    Shimasaki, N.2    Yang, W.3    Panetta, J.C.4    Cheng, C.5    Pei, D.6    Chan, D.7    Sparreboom, A.8    Giacomini, K.M.9    Pui, C.H.10
  • 76
    • 84879417173 scopus 로고    scopus 로고
    • Transporter studies in drug development: experience to date and follow-up on decision trees from the international transporter consortium
    • COI: 1:STN:280:DC%2BC3srltl2ruw%3D%3D, PID: 2358831
    • Tweedie D, Polli JW, Berglund EG, Huang SM, Zhang L, Poirier A, Chu X, Feng B, International Transporter, C (2013) Transporter studies in drug development: experience to date and follow-up on decision trees from the international transporter consortium. Clin Pharmacol Ther 94:113–125
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 113-125
    • Tweedie, D.1    Polli, J.W.2    Berglund, E.G.3    Huang, S.M.4    Zhang, L.5    Poirier, A.6    Chu, X.7    Feng, B.8
  • 77
    • 0036070666 scopus 로고    scopus 로고
    • Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
    • COI: 1:CAS:528:DC%2BD38Xls1Ogsbg%3D, PID: 1213070
    • Wang DS, Jonker JW, Kato Y, Kusuhara H, Schinkel AH, Sugiyama Y (2002) Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin. J Pharmacol Exp Ther 302:510–515
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 510-515
    • Wang, D.S.1    Jonker, J.W.2    Kato, Y.3    Kusuhara, H.4    Schinkel, A.H.5    Sugiyama, Y.6
  • 80
    • 70350331456 scopus 로고    scopus 로고
    • Zinc, a regulator of islet function and glucose homeostasis
    • COI: 1:CAS:528:DC%2BD1MXhsVOlsb3E, PID: 1981780
    • Wijesekara N, Chimienti F, Wheeler MB (2009) Zinc, a regulator of islet function and glucose homeostasis. Diabetes Obes Metab 11(Suppl 4):202–214
    • (2009) Diabetes Obes Metab , vol.11 , pp. 202-214
    • Wijesekara, N.1    Chimienti, F.2    Wheeler, M.B.3
  • 82
    • 84873928187 scopus 로고    scopus 로고
    • Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling
    • COI: 1:CAS:528:DC%2BC38XhvVCjurjE, PID: 2324102
    • Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM (2013) Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 56:781–795
    • (2013) J Med Chem , vol.56 , pp. 781-795
    • Wittwer, M.B.1    Zur, A.A.2    Khuri, N.3    Kido, Y.4    Kosaka, A.5    Zhang, X.6    Morrissey, K.M.7    Sali, A.8    Huang, Y.9    Giacomini, K.M.10
  • 83
    • 67649886415 scopus 로고    scopus 로고
    • Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    • COI: 1:CAS:528:DC%2BD1MXot1Gitbk%3D, PID: 1950625
    • Woodward OM, Kottgen A, Coresh J, Boerwinkle E, Guggino WB, Kottgen M (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci USA 106:10338–10342
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10338-10342
    • Woodward, O.M.1    Kottgen, A.2    Coresh, J.3    Boerwinkle, E.4    Guggino, W.B.5    Kottgen, M.6
  • 84
    • 0032484146 scopus 로고    scopus 로고
    • Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain
    • COI: 1:CAS:528:DyaK1cXnvFOnurg%3D, PID: 983002
    • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V (1998) Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem 273:32776–32786
    • (1998) J Biol Chem , vol.273 , pp. 32776-32786
    • Wu, X.1    Kekuda, R.2    Huang, W.3    Fei, Y.J.4    Leibach, F.H.5    Chen, J.6    Conway, S.J.7    Ganapathy, V.8
  • 85
    • 84930473646 scopus 로고    scopus 로고
    • SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population
    • COI: 1:CAS:528:DC%2BC38Xot1Kqsrw%3D, PID: 2265363
    • Xu J, Wang J, Chen B (2012a) SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population. Genet Mol Res 11:1592–1598
    • (2012) Genet Mol Res , vol.11 , pp. 1592-1598
    • Xu, J.1    Wang, J.2    Chen, B.3
  • 86
    • 84862908149 scopus 로고    scopus 로고
    • Multimerization and aggregation of native-state insulin: effect of zinc
    • COI: 1:CAS:528:DC%2BC3MXhsVarsrjN, PID: 2205943
    • Xu Y, Yan Y, Seeman D, Sun L, Dubin PL (2012b) Multimerization and aggregation of native-state insulin: effect of zinc. Langmuir 28:579–586
    • (2012) Langmuir , vol.28 , pp. 579-586
    • Xu, Y.1    Yan, Y.2    Seeman, D.3    Sun, L.4    Dubin, P.L.5
  • 87
    • 33644692006 scopus 로고    scopus 로고
    • Scientific perspectives on drug transporters and their role in drug interactions
    • COI: 1:CAS:528:DC%2BD28XlvFSj, PID: 1668637
    • Zhang L, Strong JM, Qiu W, Lesko LJ, Huang SM (2006) Scientific perspectives on drug transporters and their role in drug interactions. Mol Pharm 3:62–69
    • (2006) Mol Pharm , vol.3 , pp. 62-69
    • Zhang, L.1    Strong, J.M.2    Qiu, W.3    Lesko, L.J.4    Huang, S.M.5
  • 88
    • 33845209862 scopus 로고    scopus 로고
    • Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain
    • Zhou M, Engel K, Wang J (2007) Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain. Biochem Pharmacol 1:147–154
    • (2007) Biochem Pharmacol , vol.1 , pp. 147-154
    • Zhou, M.1    Engel, K.2    Wang, J.3


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