Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain

Biochemical Pharmacology

Volumn 73, Issue 1, 2007, Pages 147-154

  Zhou, Mingyan ^a   Engel, Karen ^a   Wang, Joanne ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

hENT4; Human brain; Hybrid depletion; PMAT; Serotonin; SSRIs

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CITALOPRAM; FLUOXETINE; FLUVOXAMINE; MESSENGER RNA; PAROXETINE; POLYADENYLIC ACID; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN METABOLISM; CONTROLLED STUDY; DOG; DRUG MECHANISM; DRUG PROTEIN BINDING; FEMALE; HYBRIDIZATION; IC 50; KIDNEY CELL; MICROINJECTION; NEUROCHEMISTRY; NEUROPHARMACOLOGY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTONIN RELEASE; SEROTONIN UPTAKE; STATISTICAL SIGNIFICANCE; TRANSPORT KINETICS; XENOPUS LAEVIS;

ANIMALS; BRAIN; CELL LINE; DNA PRIMERS; DOGS; HUMANS; SEROTONIN; VESICULAR MONOAMINE TRANSPORT PROTEINS; XENOPUS LAEVIS;

EID: 33845209862     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.09.008     Document Type: Article

References (33)

1. Carlsson A. Perspectives on the discovery of central monoaminergic neurotransmission. Annu Rev Neurosci 10 (1987) 19-40
2. Greengard P. The neurobiology of slow synaptic transmission. Science 294 (2001) 1024-1030
3. Gainetdinov R.R., and Caron M.G. Monoamine transporters: from genes to behavior. Annu Rev Pharmacol Toxicol 43 (2003) 261-284
4. Torres G.E., Gainetdinov R.R., and Caron M.G. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 4 (2003) 13-25
5. White K.J., Walline C.C., and Barker E.L. Serotonin transporters: implications for antidepressant drug development. AAPS J 7 (2005) E421-E433
6. Youdim M.B., Edmondson D., and Tipton K.F. The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci 7 (2006) 295-309
7. Blakely R.D., De Felice L.J., and Hartzell H.C. Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196 (1994) 263-281
8. Iversen L. Neuronal uptake process for amines and amino in acids (1970), Raven Press, New York
9. Shaskan E.G., and Snyder S.H. Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake. J Pharmacol Exp Ther 175 (1970) 404-418
10. Schomig E., Russ H., Staudt K., Martel F., Gliese M., and Grundemann D. The extraneuronal monoamine transporter exists in human central nervous system glia. Adv Pharmacol 42 (1998) 356-359
11. Eisenhofer G. The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol Ther 91 (2001) 35-62
12. Engel K., Zhou M., and Wang J. Identification and characterization of a novel monoamine transporter in the human brain. J Biol Chem 279 (2004) 50042-50049
13. 2) and evidence for the expression of the transporter in the brain. J Biol Chem 273 (1998) 32776-32786
14. 2) hypothesis. Am J Psychiatry 161 (2004) 909-911
15. Ramamoorthy S., Bauman A.L., Moore K.R., Han H., Yang-Feng T., Chang A.S., et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90 (1993) 2542-2546
16. Hagenbuch B., Scharschmidt B.F., and Meier P.J. Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes. Biochem J 316 Part 3 (1996) 901-904
17. +-dependent phosphate co-transporters to phosphate transport in mouse kidney: RNase H-mediated hybrid depletion analysis. Biochem J 327 Part 3 (1997) 735-739
18. You G., Lee W.S., Barros E.J., Kanai Y., Huo T.L., Khawaja S., et al. Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney. J Biol Chem 270 (1995) 29365-29371
19. Nakai D., Nakagomi R., Furuta Y., Tokui T., Abe T., Ikeda T., et al. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 297 (2001) 861-867
20. + RNA from rabbit intestinal mucosa induces b0,+ and y+ amino acid transport activities in Xenopus laevis oocytes. J Biol Chem 267 (1992) 15384-15390
21. Rosenthal S.J., Tomlinson I., Adkins E.M., Schroeter S., Adams S., Swafford L., et al. Targeting cell surface receptors with ligand-conjugated nanocrystals. J Am Chem Soc 124 (2002) 4586-4594
22. Thakker D.R., Natt F., Husken D., van der Putten H., Maier R., Hoyer D., et al. siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain. Mol Psychiatry 10 (2005) p. 782-9, 14
23. DeVane C.L. Metabolism and pharmacokinetics of selective serotonin reuptake inhibitors. Cell Mol Neurobiol 19 (1999) 443-466
24. Baumann P. Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet 31 (1996) 444-469
25. Feng N., Mo B., Johnson P.L., Orchinik M., Lowry C.A., and Renner K.J. Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus. Brain Res 1063 (2005) 69-76
26. Pan Y., Gembom E., Peng W., Lesch K.P., Mossner R., and Simantov R. Plasticity in serotonin uptake in primary neuronal cultures of serotonin transporter knockout mice. Brain Res Dev Brain Res 126 (2001) 125-129
27. Ravary A., Muzerelle A., Darmon M., Murphy D.L., Moessner R., Lesch K.P., et al. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. Eur J Neurosci 13 (2001) 1349-1362
28. Reyes-Haro D., Garcia-Alcocer G., Miledi R., and Garcia-Colunga J. Uptake of serotonin by adult rat corpus callosum is partially reduced by common antidepressants. J Neurosci Res 74 (2003) 97-102
29. Engel K., and Wang J. Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol 68 (2005) 1397-1407
30. Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., et al. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (Ecstasy) in serotonin transporter-deficient mice. Mol Pharmacol 53 (1998) 649-655
31. Austin M.C., Bradley C.C., Mann J.J., and Blakely R.D. Expression of serotonin transporter messenger RNA in the human brain. J Neurochem 62 (1994) 2362-2367
32. Barker E.L., Perlman M.A., Adkins E.M., Houlihan W.J., Pristupa Z.B., Niznik H.B., et al. High affinity recognition of serotonin transporter antagonists defined by species-scanning mutagenesis. An aromatic residue in transmembrane domain I dictates species-selective recognition of citalopram and mazindol. J Biol Chem 273 (1998) 19459-19468
33. Liu X., Smith B.J., Chen C., Callegari E., Becker S.L., Chen X., et al. Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration. Drug Metab Dispos 34 (2006) 1443-1447