In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans

Drug Metabolism and Disposition

Volumn 40, Issue 1, 2012, Pages 130-138

  Dawson, Sarah ^a   Stahl, Simone ^a   Paul, Nikki ^a   Barber, Jane ^a   Kenna, J Gerald ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPIDEM; AZATHIOPRINE; BENOXAPROFEN; BILE SALT EXPORT PUMP; BOSENTAN; CARBAMAZEPINE; CARRIER PROTEIN; CHLORPROMAZINE; CHLORPROPAMIDE; CIPROFIBRATE; CLAVULANIC ACID; CLOZAPINE; CYCLOSPORIN; DAPSONE; DICLOXACILLIN; ETRETIN; FAMOTIDINE; FELBAMATE; FUROSEMIDE; GLAFENINE; IBUPROFEN; NIFEDIPINE; PIOGLITAZONE; RANITIDINE; RIFAMPICIN; TACRINE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAUSAL ATTRIBUTION; CHOLESTASIS; CONTROLLED STUDY; IC 50; INCIDENCE; MAXIMUM PLASMA CONCENTRATION; MEMBRANE VESICLE; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RISK FACTOR; TOXIC HEPATITIS; TOXICITY TESTING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; CELL LINE; CHOLESTASIS; DRUG-INDUCED LIVER INJURY; HUMANS; INSECTS; PHARMACEUTICAL PREPARATIONS; RATS; RISK FACTORS;

EID: 84455171488     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.040758     Document Type: Article

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