메뉴 건너뛰기




Volumn 6, Issue 2, 2011, Pages 141-153

The use of Xenopus oocytes in drug screening

Author keywords

drug discovery; drug screening; electrophysiology; GPCR; ligand gated ion channel; transporter; two electrode voltage clamp; voltage gated ion channel; Xenopus oocytes

Indexed keywords

G PROTEIN COUPLED RECEPTOR; ION CHANNEL;

EID: 79251527930     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.2011.546396     Document Type: Review
Times cited : (24)

References (79)
  • 1
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science 2001;291:1304-51
    • (2001) Science , vol.291 , pp. 1304-51
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 2
    • 33645300737 scopus 로고    scopus 로고
    • From molecule to malady
    • Ashcroft FM. From molecule to malady. Nature 2006;440:440-7
    • (2006) Nature , vol.440 , pp. 440-7
    • Ashcroft, F.M.1
  • 3
    • 77949953074 scopus 로고    scopus 로고
    • Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice
    • Farkas AS, Nattel S. Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice. Drugs 2010;70:573-603
    • Drugs , vol.2010 , Issue.70 , pp. 573-603
    • Farkas, A.S.1    Nattel, S.2
  • 4
    • 0032321374 scopus 로고    scopus 로고
    • Electrophysiologic recordings from Xenopus oocytes
    • Stuhmer W. Electrophysiologic recordings from Xenopus oocytes. Methods Enzymol 1998;293:280-300
    • (1998) Methods Enzymol , vol.293 , pp. 280-300
    • Stuhmer, W.1
  • 5
    • 44249093505 scopus 로고    scopus 로고
    • Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements
    • Hansen KB, Brauner-Osborne H, Egebjerg J. Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. Comb Chem High Throughput Screen 2008;11:304-15
    • (2008) Comb Chem High Throughput Screen , vol.11 , pp. 304-15
    • Hansen, K.B.1    Brauner-Osborne, H.2    Egebjerg, J.3
  • 6
    • 67650370117 scopus 로고    scopus 로고
    • FLIPR assays of intracellular calcium in GPCR drug discovery
    • Hansen KB, Brauner-Osborne H. FLIPR assays of intracellular calcium in GPCR drug discovery. Methods Mol Biol 2009;552:269-78
    • (2009) Methods Mol Biol , vol.552 , pp. 269-78
    • Hansen, K.B.1    Brauner-Osborne, H.2
  • 8
    • 12244299864 scopus 로고    scopus 로고
    • Upscaling and automation of electrophysiology: Toward high throughput screening in ion channel drug discovery
    • Asmild M, Oswald N, Krzywkowski KM, et al. Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery. Receptors Channels 2003;9:49-58
    • (2003) Receptors Channels , vol.9 , pp. 49-58
    • Asmild, M.1    Oswald, N.2    Krzywkowski, K.M.3
  • 10
    • 42149193214 scopus 로고    scopus 로고
    • High-throughput electrophysiology: An emerging paradigm for ion-channel screening and physiology
    • Dunlop J, Bowlby M, Peri R, et al. High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov 2008;7:358-68
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 358-68
    • Dunlop, J.1    Bowlby, M.2    Peri, R.3
  • 12
    • 0002919262 scopus 로고    scopus 로고
    • Electrophysiological recordings from Xenopus oocytes
    • Sakmann B, Neher E, editors Springer, New York
    • Stuhmer W, Parekh AB. Electrophysiological recordings from Xenopus oocytes. In: Sakmann B, Neher E, editors, Single-channel recording. 2nd edition. Springer, New York; 2009
    • (2009) Single-channel Recording. 2nd Edition.
    • Stuhmer, W.1    Parekh, A.B.2
  • 13
    • 67650410456 scopus 로고    scopus 로고
    • Xenopus oocyte electrophysiology in GPCR drug discovery
    • Hansen KB, Brauner-Osborne H. Xenopus oocyte electrophysiology in GPCR drug discovery. Methods Mol Biol 2009;552:343-57
    • (2009) Methods Mol Biol , vol.552 , pp. 343-57
    • Hansen, K.B.1    Brauner-Osborne, H.2
  • 14
    • 0026655809 scopus 로고
    • Maintenance of Xenopus laevis and oocyte injection
    • Goldin AL. Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol 1992;207:266-79
    • (1992) Methods Enzymol , vol.207 , pp. 266-79
    • Goldin, A.L.1
  • 15
    • 34547658012 scopus 로고    scopus 로고
    • Exogenous protein expression in Xenopus oocytes: Basic procedures
    • Bossi E, Fabbrini MS, Ceriotti A. Exogenous protein expression in Xenopus oocytes: basic procedures. Methods Mol Biol 2007;375:107-31
    • (2007) Methods Mol Biol , vol.375 , pp. 107-31
    • Bossi, E.1    Fabbrini, M.S.2    Ceriotti, A.3
  • 16
    • 0026732898 scopus 로고
    • Preparation of RNA for injection into Xenopus oocytes
    • Goldin AL, Sumikawa K. Preparation of RNA for injection into Xenopus oocytes. Methods Enzymol 1992;207:279-97
    • (1992) Methods Enzymol , vol.207 , pp. 279-97
    • Goldin, A.L.1    Sumikawa, K.2
  • 18
    • 0026661874 scopus 로고
    • In vitro synthesis of RNA for expression of ion channels in Xenopus oocytes
    • Swanson R, Folander K. In vitro synthesis of RNA for expression of ion channels in Xenopus oocytes. Methods Enzymol 1992;207:310-19
    • (1992) Methods Enzymol , vol.207 , pp. 310-19
    • Swanson, R.1    Folander, K.2
  • 19
    • 0015230553 scopus 로고
    • Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells
    • Gurdon JB, Lane CD, Woodland HR, Marbaix G. Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells. Nature 1971;233:177-82
    • (1971) Nature , vol.233 , pp. 177-82
    • Gurdon, J.B.1    Lane, C.D.2    Woodland, H.R.3    Marbaix, G.4
  • 20
    • 0020645064 scopus 로고
    • The use of Xenopus oocytes for the expression of cloned genes
    • Gurdon JB, Wickens MP. The use of Xenopus oocytes for the expression of cloned genes. Methods Enzymol 1983;101:370-86
    • (1983) Methods Enzymol , vol.101 , pp. 370-86
    • Gurdon, J.B.1    Wickens, M.P.2
  • 21
    • 0021777414 scopus 로고
    • The biosynthesis of biologically active proteins in mRNA-microinjected Xenopus oocytes
    • Soreq H. The biosynthesis of biologically active proteins in mRNA-microinjected Xenopus oocytes. CRC Crit Rev Biochem 1985;18:199-238
    • (1985) CRC Crit Rev Biochem , vol.18 , pp. 199-238
    • Soreq, H.1
  • 22
    • 0025236914 scopus 로고
    • Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes
    • Bertrand D, Ballivet M, Rungger D. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes. Proc Natl Acad Sci USA 1990;87:1993-7
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1993-7
    • Bertrand, D.1    Ballivet, M.2    Rungger, D.3
  • 23
    • 0020964899 scopus 로고
    • Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes
    • Gundersen CB, Miledi R, Parker I. Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes. Proc R Soc Lond B Biol Sci 1983;219:103-9
    • (1983) Proc R Soc Lond B Biol Sci , vol.219 , pp. 103-9
    • Gundersen, C.B.1    Miledi, R.2    Parker, I.3
  • 24
    • 0021110035 scopus 로고
    • Recording of single gamma-aminobutyrate-and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes
    • Miledi R, Parker I, Sumikawa K. Recording of single gamma-aminobutyrate- and acetylcholine-activated receptor channels translated by exogenous mRNA in Xenopus oocytes. Proc R Soc Lond B Biol Sci 1983;218:481-4
    • (1983) Proc R Soc Lond B Biol Sci , vol.218 , pp. 481-4
    • Miledi, R.1    Parker, I.2    Sumikawa, K.3
  • 25
    • 0027765508 scopus 로고
    • Cloning and characterization of an extracellular Ca2(+)-sensing receptor from bovine parathyroid
    • Brown EM, Gamba G, Riccardi D, et al. Cloning and characterization of an extracellular Ca2(+)-sensing receptor from bovine parathyroid. Nature 1993;366:575-80
    • (1993) Nature , vol.366 , pp. 575-80
    • Brown, E.M.1    Gamba, G.2    Riccardi, D.3
  • 26
    • 0021268167 scopus 로고
    • Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes
    • Gundersen CB, Miledi R, Parker I. Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes. Proc R Soc Lond B Biol Sci 1984;221:127-43
    • (1984) Proc R Soc Lond B Biol Sci , vol.221 , pp. 127-43
    • Gundersen, C.B.1    Miledi, R.2    Parker, I.3
  • 27
    • 0024367836 scopus 로고
    • Cloning by functional expression of a member of the glutamate receptor family
    • Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S. Cloning by functional expression of a member of the glutamate receptor family. Nature 1989;342:643-8
    • (1989) Nature , vol.342 , pp. 643-8
    • Hollmann, M.1    O'Shea-Greenfield, A.2    Rogers, S.W.3    Heinemann, S.4
  • 28
    • 0026093312 scopus 로고
    • Sequence and expression of a metabotropic glutamate receptor
    • Masu M, Tanabe Y, Tsuchida K, et al. Sequence and expression of a metabotropic glutamate receptor. Nature 1991;349:760-5
    • (1991) Nature , vol.349 , pp. 760-5
    • Masu, M.1    Tanabe, Y.2    Tsuchida, K.3
  • 29
    • 0020340076 scopus 로고
    • Properties of acetylcholine receptors translated by cat muscle mRNA in Xenopus oocytes
    • Miledi R, Parker I, Sumikawa K. Properties of acetylcholine receptors translated by cat muscle mRNA in Xenopus oocytes. EMBO J 1982;1:1307-12
    • (1982) EMBO J , vol.1 , pp. 1307-12
    • Miledi, R.1    Parker, I.2    Sumikawa, K.3
  • 30
    • 0026419327 scopus 로고
    • Molecular cloning and characterization of the rat NMDA receptor
    • Moriyoshi K, Masu M, Ishii T, et al. Molecular cloning and characterization of the rat NMDA receptor. Nature 1991;354:31-7
    • (1991) Nature , vol.354 , pp. 31-7
    • Moriyoshi, K.1    Masu, M.2    Ishii, T.3
  • 31
    • 0027243541 scopus 로고
    • Interplay between expressed non-NMDA receptors and endogenous calcium-activated chloride currents in Xenopus laevis oocytes
    • Bowie D, Smart TG. Interplay between expressed non-NMDA receptors and endogenous calcium-activated chloride currents in Xenopus laevis oocytes. Neurosci Lett 1993;151:4-8
    • (1993) Neurosci Lett , vol.151 , pp. 4-8
    • Bowie, D.1    Smart, T.G.2
  • 32
    • 0023505641 scopus 로고
    • The use of Xenopus oocytes for the study of ion channels
    • Dascal N. The use of Xenopus oocytes for the study of ion channels. CRC Crit Rev Biochem 1987;22:317-87
    • (1987) CRC Crit Rev Biochem , vol.22 , pp. 317-87
    • Dascal, N.1
  • 33
    • 0034607753 scopus 로고    scopus 로고
    • N-Methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: Characterization using fluorescent measures of cell viability and reactive oxygen species production
    • Anegawa NJ, Guttmann RP, Grant ER, et al. N-Methyl-D-aspartate receptor mediated toxicity in nonneuronal cell lines: characterization using fluorescent measures of cell viability and reactive oxygen species production. Brain Res Mol Brain Res 2000;77:163-75
    • (2000) Brain Res Mol Brain Res , vol.77 , pp. 163-75
    • Anegawa, N.J.1    Guttmann, R.P.2    Grant, E.R.3
  • 34
    • 0030434063 scopus 로고    scopus 로고
    • Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits
    • Boeckman FA, Aizenman E. Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits. J Pharmacol Exp Ther 1996;279:515-23
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 515-23
    • Boeckman, F.A.1    Aizenman, E.2
  • 35
    • 33947311829 scopus 로고    scopus 로고
    • Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations
    • Christiansen B, Hansen KB, Wellendorph P, Brauner-Osborne H. Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations. Br J Pharmacol 2007;150:798-807
    • (2007) Br J Pharmacol , vol.150 , pp. 798-807
    • Christiansen, B.1    Hansen, K.B.2    Wellendorph, P.3    Brauner-Osborne, H.4
  • 36
    • 33645809317 scopus 로고    scopus 로고
    • Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24
    • Christiansen B, Wellendorph P, Brauner-Osborne H. Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. Eur J Pharmacol 2006;536:98-101
    • (2006) Eur J Pharmacol , vol.536 , pp. 98-101
    • Christiansen, B.1    Wellendorph, P.2    Brauner-Osborne, H.3
  • 37
    • 0028157126 scopus 로고
    • Expression of NMDAR1-1a (N598Q)/NMDAR2A receptors results in decreased cell mortality
    • Cik M, Chazot PL, Stephenson FA. Expression of NMDAR1-1a (N598Q)/NMDAR2A receptors results in decreased cell mortality. Eur J Pharmacol 1994;266:R1-3
    • (1994) Eur J Pharmacol , vol.266
    • Cik, M.1    Chazot, P.L.2    Stephenson, F.A.3
  • 38
    • 17444394482 scopus 로고    scopus 로고
    • Cloning and characterization of a family C orphan G-protein coupled receptor
    • Kuang D, Yao Y, Lam J, et al. Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem 2005;93:383-91
    • (2005) J Neurochem , vol.93 , pp. 383-91
    • Kuang, D.1    Yao, Y.2    Lam, J.3
  • 39
    • 0028076043 scopus 로고
    • L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a
    • Thomsen C, Hansen L, Suzdak PD. L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a. J Neurochem 1994;63:2038-47
    • (1994) J Neurochem , vol.63 , pp. 2038-47
    • Thomsen, C.1    Hansen, L.2    Suzdak, P.D.3
  • 40
    • 14944341203 scopus 로고    scopus 로고
    • Deorphanization of GPRC6A: A promiscuous L-alpha-amino acid receptor with preference for basic amino acids
    • Wellendorph P, Hansen KB, Balsgaard A, et al. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol 2005;67:589-97
    • (2005) Mol Pharmacol , vol.67 , pp. 589-97
    • Wellendorph, P.1    Hansen, K.B.2    Balsgaard, A.3
  • 41
    • 22844450313 scopus 로고    scopus 로고
    • Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors
    • Castillo M, Mulet J, Gutierrez LM, et al. Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. J Biol Chem 2005;280:27062-8
    • (2005) J Biol Chem , vol.280 , pp. 27062-8
    • Castillo, M.1    Mulet, J.2    Gutierrez, L.M.3
  • 42
    • 14944366485 scopus 로고    scopus 로고
    • Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors
    • Priel A, Kolleker A, Ayalon G, et al. Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J Neurosci 2005;25:2682-6
    • (2005) J Neurosci , vol.25 , pp. 2682-6
    • Priel, A.1    Kolleker, A.2    Ayalon, G.3
  • 43
    • 38649114374 scopus 로고    scopus 로고
    • Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit
    • Schmidt C, Hollmann M. Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit. J Mol Biol 2008;376:658-70
    • (2008) J Mol Biol , vol.376 , pp. 658-70
    • Schmidt, C.1    Hollmann, M.2
  • 44
    • 67349222916 scopus 로고    scopus 로고
    • Xenopus laevis oocytes endogenously express all subunits of the ionotropic glutamate receptor family
    • Schmidt C, Klein C, Hollmann M. Xenopus laevis oocytes endogenously express all subunits of the ionotropic glutamate receptor family. J Mol Biol 2009;390:182-95
    • (2009) J Mol Biol , vol.390 , pp. 182-95
    • Schmidt, C.1    Klein, C.2    Hollmann, M.3
  • 45
    • 12544250630 scopus 로고    scopus 로고
    • Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells
    • Williams ME, Burton B, Urrutia A, et al. Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells. J Biol Chem 2005;280:1257-63
    • (2005) J Biol Chem , vol.280 , pp. 1257-63
    • Williams, M.E.1    Burton, B.2    Urrutia, A.3
  • 47
    • 77951879079 scopus 로고    scopus 로고
    • Working with OpusXpress: Methods for high volume oocyte experiments
    • Papke RL, Stokes C. Working with OpusXpress: methods for high volume oocyte experiments. Methods 2010;51:121-33
    • (2010) Methods , vol.51 , pp. 121-33
    • Papke, R.L.1    Stokes, C.2
  • 48
    • 58149231544 scopus 로고    scopus 로고
    • The roboocyte: Automated electrophysiology based on Xenopus oocytes
    • Leisgen C, Kuester M, Methfessel C. The roboocyte: automated electrophysiology based on Xenopus oocytes. Methods Mol Biol 2007;403:87-109
    • (2007) Methods Mol Biol , vol.403 , pp. 87-109
    • Leisgen, C.1    Kuester, M.2    Methfessel, C.3
  • 49
    • 0037232056 scopus 로고    scopus 로고
    • The roboocyte: Automated cDNA/mRNA injection and subsequent TEVC recording on Xenopus oocytes in 96-well microtiter plates
    • Schnizler K, Kuster M, Methfessel C, Fejtl M. The roboocyte: automated cDNA/mRNA injection and subsequent TEVC recording on Xenopus oocytes in 96-well microtiter plates. Receptors Channels 2003;9:41-8
    • (2003) Receptors Channels , vol.9 , pp. 41-8
    • Schnizler, K.1    Kuster, M.2    Methfessel, C.3    Fejtl, M.4
  • 50
    • 10244256419 scopus 로고    scopus 로고
    • Automated higher-throughput compound screening on ion channel targets based on the Xenopus laevis oocyte expression system
    • Pehl U, Leisgen C, Gampe K, Guenther E. Automated higher-throughput compound screening on ion channel targets based on the Xenopus laevis oocyte expression system. Assay Drug Dev Technol 2004;2:515-24
    • (2004) Assay Drug Dev Technol , vol.2 , pp. 515-24
    • Pehl, U.1    Leisgen, C.2    Gampe, K.3    Guenther, E.4
  • 51
    • 1942465539 scopus 로고    scopus 로고
    • Automated Parallel Oocyte Electrophysiology Test station (POETs): A screening platform for identification of ligand-gated ion channel modulators
    • Shieh CC, Trumbull JD, Sarthy JF, et al. Automated Parallel Oocyte Electrophysiology Test station (POETs): a screening platform for identification of ligand-gated ion channel modulators. Assay Drug Dev Technol 2003;1:655-63
    • (2003) Assay Drug Dev Technol , vol.1 , pp. 655-63
    • Shieh, C.C.1    Trumbull, J.D.2    Sarthy, J.F.3
  • 52
    • 12244269066 scopus 로고    scopus 로고
    • High throughput electrophysiology using a fully automated, multiplexed recording system
    • Trumbull JD, Maslana ES, McKenna DG, et al. High throughput electrophysiology using a fully automated, multiplexed recording system. Receptors Channels 2003;9:19-28
    • (2003) Receptors Channels , vol.9 , pp. 19-28
    • Trumbull, J.D.1    Maslana, E.S.2    McKenna, D.G.3
  • 53
    • 0142107369 scopus 로고    scopus 로고
    • Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes
    • Witchel HJ, Milnes JT, Mitcheson JS, Hancox JC Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. J Pharmacol Toxicol Methods 2002;48:65-80
    • (2002) J Pharmacol Toxicol Methods , vol.48 , pp. 65-80
    • Witchel, H.J.1    Milnes, J.T.2    Mitcheson, J.S.3    Hancox, J.C.4
  • 55
    • 3242793327 scopus 로고    scopus 로고
    • Historical review: A brief history and personal retrospective of seven-transmembrane receptors
    • Lefkowitz RJ. Historical review: a brief history and personal retrospective of seven-transmembrane receptors. Trends Pharmacol Sci 2004;25:413-22
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 413-22
    • Lefkowitz, R.J.1
  • 56
    • 0035283073 scopus 로고    scopus 로고
    • Orphan G-protein-coupled receptors and natural ligand discovery
    • Howard AD, McAllister G, Feighner SD, et al. Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol Sci 2001;22:132-40
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 132-40
    • Howard, A.D.1    McAllister, G.2    Feighner, S.D.3
  • 57
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • Lagerstrom MC, Schioth HB. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 2008;7:339-57
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 339-57
    • Lagerstrom, M.C.1    Schioth, H.B.2
  • 58
    • 0344604512 scopus 로고    scopus 로고
    • Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1)
    • Bachner D, Kreienkamp H, Weise C, et al. Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1). FEBS Lett 1999;457:522-4
    • (1999) FEBS Lett , vol.457 , pp. 522-4
    • Bachner, D.1    Kreienkamp, H.2    Weise, C.3
  • 59
    • 0033229899 scopus 로고    scopus 로고
    • Reverse physiology in drosophila: Identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family
    • Birgul N, Weise C, Kreienkamp HJ, Richter D. Reverse physiology in drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/ opioid receptor family. EMBO J 1999;18:5892-900
    • (1999) EMBO J , vol.18 , pp. 5892-900
    • Birgul, N.1    Weise, C.2    Kreienkamp, H.J.3    Richter, D.4
  • 60
    • 0033600291 scopus 로고    scopus 로고
    • Characterization of the human cysteinyl leukotriene CysLT1 receptor
    • Lynch KR, O'Neill GP, Liu Q, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999;399:789-93
    • (1999) Nature , vol.399 , pp. 789-93
    • Lynch, K.R.1    O'Neill, G.P.2    Liu, Q.3
  • 61
    • 0033166071 scopus 로고    scopus 로고
    • Functional identification of a goldfish odorant receptor
    • Speca DJ, Lin DM, Sorensen PW, et al. Functional identification of a goldfish odorant receptor. Neuron 1999;23:487-98
    • (1999) Neuron , vol.23 , pp. 487-98
    • Speca, D.J.1    Lin, D.M.2    Sorensen, P.W.3
  • 63
    • 0031984517 scopus 로고    scopus 로고
    • The many faces of G protein signaling
    • Hamm HE. The many faces of G protein signaling. J Biol Chem 1998;273:669-72
    • (1998) J Biol Chem , vol.273 , pp. 669-72
    • Hamm, H.E.1
  • 64
    • 3042798261 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: Molecular modeling and mutagenesis approaches to receptor structure and function
    • Kristiansen K. Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function. Pharmacol Ther 2004;103:21-80
    • (2004) Pharmacol Ther , vol.103 , pp. 21-80
    • Kristiansen, K.1
  • 66
    • 5644227379 scopus 로고    scopus 로고
    • Analysis of the effects of halothane on Gi-coupled muscarinic M2 receptor signaling in Xenopus oocytes using a chimeric G alpha protein
    • Minami K, Uezono Y, Shiraishi M, et al. Analysis of the effects of halothane on Gi-coupled muscarinic M2 receptor signaling in Xenopus oocytes using a chimeric G alpha protein. Pharmacology 2004;72:205-12
    • (2004) Pharmacology , vol.72 , pp. 205-12
    • Minami, K.1    Uezono, Y.2    Shiraishi, M.3
  • 67
    • 33747682900 scopus 로고    scopus 로고
    • The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage-sensitive
    • Ohana L, Barchad O, Parnas I, Parnas H. The metabotropic glutamate G-protein-coupled receptors mGluR3 and mGluR1a are voltage-sensitive. J Biol Chem 2006;281:24204-15
    • (2006) J Biol Chem , vol.281 , pp. 24204-15
    • Ohana, L.1    Barchad, O.2    Parnas, I.3    Parnas, H.4
  • 68
    • 0030925182 scopus 로고    scopus 로고
    • The G alpha protein GL2 alpha improves the ability to detect the subthreshold expressions of receptors linked to phospholipase C in Xenopus oocytes
    • Yamashita S, Minakami R, Sugiyama H. The G alpha protein GL2 alpha improves the ability to detect the subthreshold expressions of receptors linked to phospholipase C in Xenopus oocytes. Jpn J Physiol 1997;47:67-72
    • (1997) Jpn J Physiol , vol.47 , pp. 67-72
    • Yamashita, S.1    Minakami, R.2    Sugiyama, H.3
  • 69
    • 0026434559 scopus 로고
    • Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain
    • Houamed KM, Kuijper JL, Gilbert TL, et al. Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. Science 1991;252:1318-21
    • (1991) Science , vol.252 , pp. 1318-21
    • Houamed, K.M.1    Kuijper, J.L.2    Gilbert, T.L.3
  • 70
    • 0028348035 scopus 로고
    • Direct G protein activation of ion channels?
    • Clapham DE. Direct G protein activation of ion channels? Annu Rev Neurosci 1994;17:441-64
    • (1994) Annu Rev Neurosci , vol.17 , pp. 441-64
    • Clapham, D.E.1
  • 71
    • 0032820954 scopus 로고    scopus 로고
    • Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors
    • Lingenhoehl K, Brom R, Heid J, et al. Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors. Neuropharmacology 1999;38:1667-73
    • (1999) Neuropharmacology , vol.38 , pp. 1667-73
    • Lingenhoehl, K.1    Brom, R.2    Heid, J.3
  • 73
    • 67650264127 scopus 로고    scopus 로고
    • Elucidating conformational changes in the gamma-aminobutyric acid transporter-1
    • Meinild AK, Loo DD, Skovstrup S, et al. Elucidating conformational changes in the gamma-aminobutyric acid transporter-1. J Biol Chem 2009;284:16226-35
    • (2009) J Biol Chem , vol.284 , pp. 16226-35
    • Meinild, A.K.1    Loo, D.D.2    Skovstrup, S.3
  • 74
    • 77951230460 scopus 로고    scopus 로고
    • The N terminus of monoamine transporters is a lever required for the action of amphetamines
    • Sucic S, Dallinger S, Zdrazil B, et al. The N terminus of monoamine transporters is a lever required for the action of amphetamines. J Biol Chem 2010;285:10924-38
    • J Biol Chem , vol.2010 , Issue.285 , pp. 10924-38
    • Sucic, S.1    Dallinger, S.2    Zdrazil, B.3
  • 75
    • 9644295740 scopus 로고    scopus 로고
    • Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter
    • Meinild AK, Sitte HH, Gether U. Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. J Biol Chem 2004;279:49671-9
    • (2004) J Biol Chem , vol.279 , pp. 49671-9
    • Meinild, A.K.1    Sitte, H.H.2    Gether, U.3
  • 76
    • 77956362466 scopus 로고    scopus 로고
    • Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model
    • Larsson HP, Wang X, Lev B, et al. Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model. Proc Natl Acad Sci USA 2010;107:13912-17
    • Proc Natl Acad Sci USA , vol.2010 , Issue.107 , pp. 13912-17
    • Larsson, H.P.1    Wang, X.2    Lev, B.3
  • 77
    • 77956312761 scopus 로고    scopus 로고
    • Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase
    • Poulsen H, Khandelia H, Morth JP, et al. Neurological disease mutations compromise a C-terminal ion pathway in the Na(+)/K(+)-ATPase. Nature 2010;467:99-102
    • Nature , vol.2010 , Issue.467 , pp. 99-102
    • Poulsen, H.1    Khandelia, H.2    Morth, J.P.3
  • 78
    • 2342467905 scopus 로고    scopus 로고
    • Pharmacological characterization of human excitatory amino acid transporters EAAT1 EAAT2 and EAAT3 in a fluorescence-based membrane potential assay
    • Jensen AA, Brauner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol 2004;67:2115-27
    • (2004) Biochem Pharmacol , vol.67 , pp. 2115-27
    • Jensen, A.A.1    Brauner-Osborne, H.2
  • 79
    • 65549106893 scopus 로고    scopus 로고
    • The four human gamma-aminobutyric acid (GABA) transporters: Pharmacological characterization and validation of a highly efficient screening assay
    • Kvist T, Christiansen B, Jensen AA, Brauner-Osborne H. The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay. Comb Chem High Throughput Screen 2009;12:241-9
    • (2009) Comb Chem High Throughput Screen , vol.12 , pp. 241-9
    • Kvist, T.1    Christiansen, B.2    Jensen, A.A.3    Brauner-Osborne, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.