Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes

European Journal of Pharmaceutical Sciences

Volumn 43, Issue 4, 2011, Pages 297-307

  De Bruyn, Tom ^a   Ye, Zhi Wei ^a,c   Peeters, Annelies ^a   Sahi, Jasminder ^b   Baes, Myriam ^a   Augustijns, Patrick F ^a   Annaert, Pieter P ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b Life Technologies ADME/Tox Division   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cryopreserved human hepatocytes; Drug interaction; Drug transport; Hepatic drug uptake; NTCP; OATP

Indexed keywords

CHOLINE; CORTICOSTERONE; DIGOXIN; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; MESSENGER RNA; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1B3; ORGANIC CATION TRANSPORTER; POLYPEPTIDE; PRAZOSIN; RIFAMPICIN; SODIUM; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CELL SUSPENSION; CONTROLLED STUDY; CRYOPRESERVATION; DRUG CLEARANCE; FEMALE; HUMAN; HUMAN CELL; LIVER CELL; MALE; PRIORITY JOURNAL;

1-METHYL-4-PHENYLPYRIDINIUM; ADOLESCENT; ADULT; BIOLOGICAL TRANSPORT; CORTICOSTERONE; CRYOPRESERVATION; DIGOXIN; ESTRADIOL; ESTRONE; HEPATOCYTES; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; PRAZOSIN; RIFAMPIN; RNA, MESSENGER; SYMPORTERS; TAUROCHOLIC ACID;

EID: 79959593077     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.05.002     Document Type: Article

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