메뉴 건너뛰기




Volumn 59, Issue 4, 2015, Pages 603-614

The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; ATRIP PROTEIN; DOUBLE STRANDED DNA; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MUTS; PROTEIN MUTS BETA; REGULATOR PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; ATM PROTEIN; ATR PROTEIN, HUMAN; DNA BINDING PROTEIN; G-T MISMATCH-BINDING PROTEIN; MSH2 PROTEIN, HUMAN; MSH3 PROTEIN, HUMAN; PROTEIN BINDING;

EID: 84939564392     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.06.026     Document Type: Article
Times cited : (27)

References (51)
  • 1
    • 37249080597 scopus 로고    scopus 로고
    • Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair
    • Anantha R.W., Vassin V.M., Borowiec J.A. Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J. Biol. Chem. 2007, 282:35910-35923.
    • (2007) J. Biol. Chem. , vol.282 , pp. 35910-35923
    • Anantha, R.W.1    Vassin, V.M.2    Borowiec, J.A.3
  • 2
    • 0023807621 scopus 로고
    • Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks
    • Avemann K., Knippers R., Koller T., Sogo J.M. Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. Mol. Cell. Biol. 1988, 8:3026-3034.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 3026-3034
    • Avemann, K.1    Knippers, R.2    Koller, T.3    Sogo, J.M.4
  • 3
    • 18244385718 scopus 로고    scopus 로고
    • ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation
    • Ball H.L., Myers J.S., Cortez D. ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol. Biol. Cell 2005, 16:2372-2381.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2372-2381
    • Ball, H.L.1    Myers, J.S.2    Cortez, D.3
  • 4
    • 84880952894 scopus 로고    scopus 로고
    • DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast
    • Balogun F.O., Truman A.W., Kron S.J. DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast. DNA Repair (Amst.) 2013, 12:751-760.
    • (2013) DNA Repair (Amst.) , vol.12 , pp. 751-760
    • Balogun, F.O.1    Truman, A.W.2    Kron, S.J.3
  • 5
    • 39549114009 scopus 로고    scopus 로고
    • Differential regulation of the cellular response to DNA double-strand breaks in G1
    • Barlow J.H., Lisby M., Rothstein R. Differential regulation of the cellular response to DNA double-strand breaks in G1. Mol. Cell 2008, 30:73-85.
    • (2008) Mol. Cell , vol.30 , pp. 73-85
    • Barlow, J.H.1    Lisby, M.2    Rothstein, R.3
  • 6
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J., Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003, 3:421-429.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 7
    • 73349098442 scopus 로고    scopus 로고
    • Limiting the persistence of a chromosome break diminishes its mutagenic potential
    • Bennardo N., Gunn A., Cheng A., Hasty P., Stark J.M. Limiting the persistence of a chromosome break diminishes its mutagenic potential. PLoS Genet. 2009, 5:e1000683.
    • (2009) PLoS Genet. , vol.5
    • Bennardo, N.1    Gunn, A.2    Cheng, A.3    Hasty, P.4    Stark, J.M.5
  • 8
    • 84884254858 scopus 로고    scopus 로고
    • A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
    • Britton S., Coates J., Jackson S.P. A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair. J. Cell Biol. 2013, 202:579-595.
    • (2013) J. Cell Biol. , vol.202 , pp. 579-595
    • Britton, S.1    Coates, J.2    Jackson, S.P.3
  • 10
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: making it safe to play with knives
    • Ciccia A., Elledge S.J. The DNA damage response: making it safe to play with knives. Mol. Cell 2010, 40:179-204.
    • (2010) Mol. Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 11
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 12
    • 34250705797 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
    • Delacroix S., Wagner J.M., Kobayashi M., Yamamoto K., Karnitz L.M. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 2007, 21:1472-1477.
    • (2007) Genes Dev. , vol.21 , pp. 1472-1477
    • Delacroix, S.1    Wagner, J.M.2    Kobayashi, M.3    Yamamoto, K.4    Karnitz, L.M.5
  • 13
    • 77953441990 scopus 로고    scopus 로고
    • Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation
    • Dowen J.M., Putnam C.D., Kolodner R.D. Functional studies and homology modeling of Msh2-Msh3 predict that mispair recognition involves DNA bending and strand separation. Mol. Cell. Biol. 2010, 30:3321-3328.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3321-3328
    • Dowen, J.M.1    Putnam, C.D.2    Kolodner, R.D.3
  • 14
    • 84867693856 scopus 로고    scopus 로고
    • Structure and conformational change of a replication protein A heterotrimer bound to ssDNA
    • Fan J., Pavletich N.P. Structure and conformational change of a replication protein A heterotrimer bound to ssDNA. Genes Dev. 2012, 26:2337-2347.
    • (2012) Genes Dev. , vol.26 , pp. 2337-2347
    • Fan, J.1    Pavletich, N.P.2
  • 15
    • 0038297562 scopus 로고    scopus 로고
    • The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase
    • Franchitto A., Pichierri P., Piergentili R., Crescenzi M., Bignami M., Palitti F. The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 2003, 22:2110-2120.
    • (2003) Oncogene , vol.22 , pp. 2110-2120
    • Franchitto, A.1    Pichierri, P.2    Piergentili, R.3    Crescenzi, M.4    Bignami, M.5    Palitti, F.6
  • 18
    • 84868592402 scopus 로고    scopus 로고
    • I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks
    • Gunn A., Stark J.M. I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks. Methods Mol. Biol. 2012, 920:379-391.
    • (2012) Methods Mol. Biol. , vol.920 , pp. 379-391
    • Gunn, A.1    Stark, J.M.2
  • 19
    • 84855463183 scopus 로고    scopus 로고
    • Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops
    • Gupta S., Gellert M., Yang W. Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops. Nat. Struct. Mol. Biol. 2012, 19:72-78.
    • (2012) Nat. Struct. Mol. Biol. , vol.19 , pp. 72-78
    • Gupta, S.1    Gellert, M.2    Yang, W.3
  • 20
    • 0030250603 scopus 로고    scopus 로고
    • Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3
    • Habraken Y., Sung P., Prakash L., Prakash S. Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3. Curr. Biol. 1996, 6:1185-1187.
    • (1996) Curr. Biol. , vol.6 , pp. 1185-1187
    • Habraken, Y.1    Sung, P.2    Prakash, L.3    Prakash, S.4
  • 21
    • 55449088400 scopus 로고    scopus 로고
    • Recruitment of mismatch repair proteins to the site of DNA damage in human cells
    • Hong Z., Jiang J., Hashiguchi K., Hoshi M., Lan L., Yasui A. Recruitment of mismatch repair proteins to the site of DNA damage in human cells. J. Cell Sci. 2008, 121:3146-3154.
    • (2008) J. Cell Sci. , vol.121 , pp. 3146-3154
    • Hong, Z.1    Jiang, J.2    Hashiguchi, K.3    Hoshi, M.4    Lan, L.5    Yasui, A.6
  • 22
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson S.P., Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 23
    • 33646187811 scopus 로고    scopus 로고
    • The multifaceted mismatch-repair system
    • Jiricny J. The multifaceted mismatch-repair system. Nat. Rev. Mol. Cell Biol. 2006, 7:335-346.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 335-346
    • Jiricny, J.1
  • 24
    • 33644757806 scopus 로고    scopus 로고
    • TopBP1 activates the ATR-ATRIP complex
    • Kumagai A., Lee J., Yoo H.Y., Dunphy W.G. TopBP1 activates the ATR-ATRIP complex. Cell 2006, 124:943-955.
    • (2006) Cell , vol.124 , pp. 943-955
    • Kumagai, A.1    Lee, J.2    Yoo, H.Y.3    Dunphy, W.G.4
  • 26
    • 39549102855 scopus 로고    scopus 로고
    • Rad52 promotes postinvasion steps of meiotic double-strand-break repair
    • Lao J.P., Oh S.D., Shinohara M., Shinohara A., Hunter N. Rad52 promotes postinvasion steps of meiotic double-strand-break repair. Mol. Cell 2008, 29:517-524.
    • (2008) Mol. Cell , vol.29 , pp. 517-524
    • Lao, J.P.1    Oh, S.D.2    Shinohara, M.3    Shinohara, A.4    Hunter, N.5
  • 27
    • 34948889415 scopus 로고    scopus 로고
    • The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR
    • Lee J., Kumagai A., Dunphy W.G. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 2007, 282:28036-28044.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28036-28044
    • Lee, J.1    Kumagai, A.2    Dunphy, W.G.3
  • 28
    • 77949329988 scopus 로고    scopus 로고
    • Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway
    • Liu Y., Fang Y., Shao H., Lindsey-Boltz L., Sancar A., Modrich P. Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway. J. Biol. Chem. 2010, 285:5974-5982.
    • (2010) J. Biol. Chem. , vol.285 , pp. 5974-5982
    • Liu, Y.1    Fang, Y.2    Shao, H.3    Lindsey-Boltz, L.4    Sancar, A.5    Modrich, P.6
  • 29
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes D.A., Glick G.G., Zhao R., Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008, 22:1478-1489.
    • (2008) Genes Dev. , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 30
    • 84876333995 scopus 로고    scopus 로고
    • Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates
    • Neelsen K.J., Zanini I.M., Herrador R., Lopes M. Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J. Cell Biol. 2013, 200:699-708.
    • (2013) J. Cell Biol. , vol.200 , pp. 699-708
    • Neelsen, K.J.1    Zanini, I.M.2    Herrador, R.3    Lopes, M.4
  • 31
    • 79953186673 scopus 로고    scopus 로고
    • HMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis
    • Pabla N., Ma Z., McIlhatton M.A., Fishel R., Dong Z. hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J. Biol. Chem. 2011, 286:10411-10418.
    • (2011) J. Biol. Chem. , vol.286 , pp. 10411-10418
    • Pabla, N.1    Ma, Z.2    McIlhatton, M.A.3    Fishel, R.4    Dong, Z.5
  • 32
    • 0029659046 scopus 로고    scopus 로고
    • HMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
    • Palombo F., Iaccarino I., Nakajima E., Ikejima M., Shimada T., Jiricny J. hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr. Biol. 1996, 6:1181-1184.
    • (1996) Curr. Biol. , vol.6 , pp. 1181-1184
    • Palombo, F.1    Iaccarino, I.2    Nakajima, E.3    Ikejima, M.4    Shimada, T.5    Jiricny, J.6
  • 33
    • 0035101436 scopus 로고    scopus 로고
    • DNA mismatch repair and cancer
    • Peltomäki P. DNA mismatch repair and cancer. Mutat. Res. 2001, 488:77-85.
    • (2001) Mutat. Res. , vol.488 , pp. 77-85
    • Peltomäki, P.1
  • 34
    • 0035166517 scopus 로고    scopus 로고
    • Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair
    • Pichierri P., Franchitto A., Piergentili R., Colussi C., Palitti F. Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair. Carcinogenesis 2001, 22:1781-1787.
    • (2001) Carcinogenesis , vol.22 , pp. 1781-1787
    • Pichierri, P.1    Franchitto, A.2    Piergentili, R.3    Colussi, C.4    Palitti, F.5
  • 37
    • 50649100744 scopus 로고    scopus 로고
    • Mechanism of eukaryotic homologous recombination
    • San Filippo J., Sung P., Klein H. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 2008, 77:229-257.
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 229-257
    • San Filippo, J.1    Sung, P.2    Klein, H.3
  • 40
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington L.S., Gautier J. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 2011, 45:247-271.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 44
    • 36949012967 scopus 로고    scopus 로고
    • Non-homologous end-joining, a sticky affair
    • van Gent D.C., van der Burg M. Non-homologous end-joining, a sticky affair. Oncogene 2007, 26:7731-7740.
    • (2007) Oncogene , vol.26 , pp. 7731-7740
    • van Gent, D.C.1    van der Burg, M.2
  • 45
    • 84905050986 scopus 로고    scopus 로고
    • The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair
    • van Oers J.M., Edwards Y., Chahwan R., Zhang W., Smith C., Pechuan X., Schaetzlein S., Jin B., Wang Y., Bergman A., et al. The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. Oncogene 2014, 33:3939-3946.
    • (2014) Oncogene , vol.33 , pp. 3939-3946
    • van Oers, J.M.1    Edwards, Y.2    Chahwan, R.3    Zhang, W.4    Smith, C.5    Pechuan, X.6    Schaetzlein, S.7    Jin, B.8    Wang, Y.9    Bergman, A.10
  • 46
    • 0347364654 scopus 로고    scopus 로고
    • MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation
    • Wang Y., Qin J. MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc. Natl. Acad. Sci. USA 2003, 100:15387-15392.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15387-15392
    • Wang, Y.1    Qin, J.2
  • 47
    • 4944257913 scopus 로고    scopus 로고
    • ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining
    • Wang H., Wang H., Powell S.N., Iliakis G., Wang Y. ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining. Cancer Res. 2004, 64:7139-7143.
    • (2004) Cancer Res. , vol.64 , pp. 7139-7143
    • Wang, H.1    Wang, H.2    Powell, S.N.3    Iliakis, G.4    Wang, Y.5
  • 48
    • 0033618407 scopus 로고    scopus 로고
    • Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3
    • Wilson T., Guerrette S., Fishel R. Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3. J. Biol. Chem. 1999, 274:21659-21664.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21659-21664
    • Wilson, T.1    Guerrette, S.2    Fishel, R.3
  • 49
    • 33646503204 scopus 로고    scopus 로고
    • ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts
    • Yoshioka K., Yoshioka Y., Hsieh P. ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 2006, 22:501-510.
    • (2006) Mol. Cell , vol.22 , pp. 501-510
    • Yoshioka, K.1    Yoshioka, Y.2    Hsieh, P.3
  • 50
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2
  • 51
    • 0037080675 scopus 로고    scopus 로고
    • Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
    • Zou L., Cortez D., Elledge S.J. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 2002, 16:198-208.
    • (2002) Genes Dev. , vol.16 , pp. 198-208
    • Zou, L.1    Cortez, D.2    Elledge, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.