Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair

Carcinogenesis

Volumn 22, Issue 11, 2001, Pages 1781-1787

  Pichierri, Pietro ^a,c   Franchitto, Annapaola ^a,c   Piergentili, Rita ^a   Colussi, Claudia ^b   Palitti, Fabrizio ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c INSTITUT ANDRÉ LWOFF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA POLYMERASE; INTERMEDIN; RAD51 PROTEIN;

ANIMAL CELL; ARTICLE; BASE MISPAIRING; CHROMOSOME DAMAGE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG HYPERSENSITIVITY; GENE INSERTION; GENETIC RECOMBINATION; HORMONE DEFICIENCY; KNOCKOUT MOUSE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SISTER CHROMATID EXCHANGE; SURVIVAL RATE;

EID: 0035166517     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.11.1781     Document Type: Article

References (52)

1. Mismatch repair defects in cancer
2. DNA damage tolerance, mismatch repair and genome instability
3. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
4. 6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells
5. Correction of hypermutability, N-methyl-N′-nitro-N-nitrosoguanidine resistance and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6
6. The role of DNA mismatch repair in platinum drug resistance
7. Sensitivity to DNA cross-linking chemotherapeutic agents in mismatch repair-defective cells in vitro and in xenografts
8. Cisdichlorodiammineplatinum [II]: Inhibition of nucleic acid synthesis in lymphocytes stimulated with phytohemagglutinin
9. 2 arrest and DNA double-strand breaks
10. Mutagenic damage to mammalian cells by therapeutic alkylating agents
11. Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors
12. Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
13. Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
14. DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells
15. Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of the cell cycle
16. Induction of chromosomal aberrations and SCE by camptothecin, an inhibitor of mammalian topoisomerase I
17. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells
18. Defining the roles of nucleotide excision repair of DNA interstrand cross-links in mammalian cells
19. The role of homologous recombination processes in repair of severe forms of DNA damage in mammalian cells
20. Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae
21. Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA
22. Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
23. Mismatch repair proteins regulate heteroduplex formation during mitotic recombination in yeast
24. The Saccharomyces cerevisiae Msh2 mismatch repair protein localizes to recombination intermediates in vivo
25. Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination and predisposition to cancer
26. The role of the mismatch repair machinery in regulating mitotic and meiotic recombination between diverged sequences in yeast
27. Repair of double-strand breaks by homologous recombination in mismatch repair-defective mammalian cells
28. Mismatch repair and differential sensitivity of mouse and human cells to methylating agents
29. 2 lymphocytes and cell-cycle progression
30. New Giemsa method for the differential staining of sister chromatids
31. Classification and relationships of induced chromosomal structural changes
32. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
33. Mechanism of induction of chromosomal aberrations by inhibitors of DNA topoisomerases
34. 2 phases of the cell cycle
35. The CHO XRCC1 mutants, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication
36. 2 phase of cell cycle of chinese hamster ovary (CHO) cell lines is associated with transcription
37. Topoisomerase-I inhibitor SN-38 can induce DNA damage and chromosomal aberrations independent from DNA synthesis
38. Targeting double-strand breaks to replicating DNA identifies a subpathway of DSB repair that is defective in ataxia-telangiectasia cells
39. Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks
40. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
41. DNA double strand break repair in mammalian cells
42. Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins
43. Mismatch repair and the fidelity of genetic recombination
44. Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae
45. The mismatch repair system reduces meiotic homologous recombination and stimulates recombination-dependent chromosome loss
46. 2 sensitivity to the induction of chromosomal damage in the CHO mutant EM9 than in its parental line AA8 by camptothecin, an inhibitor of DNA topoisomerase I
47. Cytogenetic effects of inhibition of topoisomerase I or II activities in the CHO mutant EM9 and its parental line AA8
48. Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
49. 2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells
50. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function
51. Links between replication, recombination and genome instability in eukaryotes
52. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases