The modeling of ethanol production by Kluyveromyces marxianus using whey as substrate in continuous A-Stat bioreactors

Journal of Industrial Microbiology and Biotechnology

Volumn 42, Issue 9, 2015, Pages 1243-1253

  Gabardo, Sabrina ^a   Pereira, Gabriela Feix ^a   Rech, Rosane ^a   Ayub, Marco Antônio Záchia ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

A stat control; Bioprocess modeling; Continuous fermentation; Ethanol; Kluyveromyces marxianus; Whey

Indexed keywords

ALCOHOL; CALCIUM ALGINATE; CULTURE MEDIUM; LACTOSE;

ACCELERATION; ALCOHOL PRODUCTION; ARTICLE; BIOTECHNOLOGICAL PRODUCTION; BIOTRANSFORMATION; CELL FUNCTION; CELL METABOLISM; CONTINUOUS CULTURE; CONTINUOUS FLOW REACTOR; CONTROLLED STUDY; DILUTION; FUNGAL CELL; FUNGAL METABOLISM; FUNGUS CULTURE; FUNGUS GROWTH; GROWTH RATE; IMMOBILIZED CELL; KINETICS; KLUYVEROMYCES MARXIANUS; MATHEMATICAL MODEL; MOLECULAR MODEL; NEGATIVE FEEDBACK; NONHUMAN; SCALE UP; SUBSTRATE CONCENTRATION; WHEY; BIOREACTOR; BIOSYNTHESIS; CULTURE MEDIUM; CYTOLOGY; KLUYVEROMYCES; METABOLISM;

KLUYVEROMYCES MARXIANUS;

BIOREACTORS; CELLS, IMMOBILIZED; CULTURE MEDIA; ETHANOL; KINETICS; KLUYVEROMYCES; LACTOSE; WHEY;

EID: 84939257952     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-015-1661-2     Document Type: Article

References (55)

1. Adamberg K, Lahtvee P-J, Valgepea K, Abner K, Vilu R (2009) Quasi steady state growth of Lactococcus lactis in glucose-limited acceleration stat (A-stat) cultures. Antonie Van Leeuwenhoek International J Gen Mol Microbiol 95:219–226. doi:10.1007/s10482-009-9305-z
2. Albergaria H, Duarte LC, Amaral-Collaco MT, Girio FM (2000) Study of Saccharomyces uvarum CCMI 885 physiology under fed-batch, chemostat and accelerostat cultivation techniques. Food Technol Biotechnol 38:33–38
3. Barbosa MJ, Hoogakker J, Wijffels RH (2003) Optimisation of cultivation parameters in photobiore actors for microalgae cultivation using the A-stat technique. Biomol Eng 20:115–123. doi:10.1061/s1389-0344(03)00033-9
4. Birol G, Doruker P, Kirdar B, Onsan ZI, Ulgen K (1998) Mathematical description of ethanol fermentation by immobilised Saccharomyces cerevisiae. Process Biochem 33:763–771. doi:10.1016/s0032-9592(98)00047-8
5. Cheng JJ, Timilsina GR (2011) Status and barriers of advanced biofuel technologies: a review. Renew Energy 36:3541–3549. doi:10.1016/j.renene.2011.04.031
6. Christensen AD, Kadar Z, Oleskowicz-Popiel P, Thomsen MH (2011) Production of bioethanol from organic whey using Kluyveromyces marxianus. J Ind Microbiol Biotechnol 38:283–289. doi:10.1007/s10295-010-0771-0
7. da Cunha-Pereira F, Hickert LR, Sehnem NT, de Souza-Cruz PB, Rosa CA, Ayub MAZ (2011) Conversion of sugars present in rice hull hydrolysates into ethanol by Spathaspora arborariae, Saccharomyces cerevisiae, and their co-fermentations. Bioresour Technol 102:4218–4225. doi:10.1016/j.biortech.2010.12.060
8. de Andrade RR, Maugeri Filho F, Maciel Filho R, da Costa AC (2013) Kinetics of ethanol production from sugarcane bagasse enzymatic hydrolysate concentrated with molasses under cell recycle. Bioresour Technol 130:351–359. doi:10.1016/j.biortech.2012.12.045
9. Dodic JM, Vucurovic DG, Dodic SN, Grahovac JA, Popov SD, Nedeljkovic NM (2012) Kinetic modelling of batch ethanol production from sugar beet raw juice. Appl Energy 99:192–197. doi:10.1016/j.apenergy.2012.05.016
10. Fonseca GG, Heinzle E, Wittmann C, Gombert AK (2008) The yeast Kluyveromyces marxianus and its biotechnological potential. Appl Microbiol Biotechnol 79:339–354. doi:10.1007/s00253-008-1458-6
11. Furlan SA, Carvalho-Jonas MF, Merkle R, Bértoli GB, Jonas R (1995) Aplicação do sistema Microtiter Reader na seleção de microrganismos produtores de ß galactosidase. Braz Arch Biol Technol 38:1261–1268
12. Gabardo S, Rech R, Ayub MAnZc (2011) Determination of lactose and ethanol diffusion coefficients in calcium alginate gel spheres: predicting values to be used in immobilized bioreactors. J Chem Eng Data 56:2305–2309. doi:10.1021/je101288g
13. Gabardo S, Rech R, Ayub MAZ (2012) Performance of different immobilized-cell systems to efficiently produce ethanol from whey: fluidized batch, packed-bed and fluidized continuous bioreactors. J Chem Technol Biotechnol 87:1194–1201. doi:10.1002/jctb.3749
14. Gabardo S, Rech R, Rosa CA, Ayub MAZ (2014) Dynamics of ethanol production from whey and whey permeate by immobilized strains of Kluyveromyces marxianus in batch and continuous bioreactors. Renew Energy 69:89–96. doi:10.1016/j.renene.2014.03.023
15. Ghaly AE, ElTaweel AA (1997) Kinetic modelling of continuous production of ethanol from cheese whey. Biomass Bioenergy 12:461–472. doi:10.1016/s0961-9534(97)00012-3
16. Ghose TK, Tyagi RD (1979) Rapid ethanol fermentation of cellulose hydrolysate. II. Product and substrate inhibition and optimization of fermentor design. Biotechnol Bioeng 21:1401–1420
17. Guimaraes P, Teixeira J, Domingues L (2010) Fermentation of lactose to bio-ethanol by yeasts as part of integrated solutions for the valorisation of cheese whey. Biotechnol Adv 28:375–384. doi:10.1016/j.biotechadv.2010.02.002
18. Hill GA, Robinson CW (1988) Morphological behavior of saccharomyces-cerevisiae during continuous fermentation. Biotechnol Lett 10:815–820. doi:10.1007/bf01027579
19. Hinshelwood CN (1946) Kinetics of bacterial cell. Oxford University Press, Oxford
20. Jamai L, Sendide K, Ettayebi K, Errachidi F, Hamdouni-Alami O, Tahri-Jouti MA, McDermott T, Ettayebi M (2001) Physiological difference during ethanol fermentation between calcium alginate-immobilized Candida tropicalis and Saccharomyces cerevisiae. FEMS Microbiol Lett 204:375–379. doi:10.1111/j.1574-6968.2001.tb10913.x
21. Kargi F, Ozmihci S (2006) Utilization of cheese whey powder (CWP) for ethanol fermentations: effects of operating parameters. Enz Microb Technol 38:711–718. doi:10.1016/j.enzmictec.2005.11.006
22. Kasemets K, Drews M, Nisamedtinov I, Adamberg K, Paalme T (2003) Modification of A-stat for the characterization of microorganisms. J Microb Method 55:187–200. doi:10.1016/s0167-7012(03)00143-x
23. Kosseva M, Panesar P, Kaur G, Kennedy J (2009) Use of immobilised biocatalysts in the processing of cheese whey. Int J Biol Macromols 45:437–447. doi:10.1016/j.ijbiomac.2009.09.005
24. Kourkoutas Y, Bekatorou A, Banat I, Marchant R, Koutinas A (2004) Immobilization technologies and support materials suitable in alcohol beverages production: a review. Food Microbiol 21:377–397. doi:10.1016/j.fm.2003.10.005
25. Kumar S, Singh SP, Mishra IM, Adhikari DK (2011) Continuous ethanol production by Kluyveromyces sp. IIPE453 immobilized on bagasse chips in packed bed reactor. J Pet Technol Altern Fuels 2:1–6
26. Lane MM, Burke N, Karreman R, Wolfe KH, O’Byrne CP, Morrissey JP (2011) Physiological and metabolic diversity in the yeast Kluyveromyces marxianus. Antonie Van Leeuwenhoek Inte J Gen Mol Microbiol 100:507–519. doi:10.1007/s10482-011-9606-x
27. Lewandowska M, Kujawski W (2007) Ethanol production from lactose in a fermentation/pervaporation system. J Food Eng 79:430–437. doi:10.1016/j.jfoodeng.2006.01.071
28. LsGS Longhi, DbJ Luvizetto, Ferreira LS, Rech R, Ayub MAZ, Secchi AR (2004) A growth kinetic model of Kluyveromyces marxianus cultures on cheese whey as substrate. J Ind Microbiol Biotechnol 31:35–40. doi:10.1007/s10295-004-0110-4
29. Luedeking R, Piret EL (2000) A kinetic study of the lactic acid fermentation. Batch process at controlled pH (Reprinted from Journal of Biochemical and Microbiological Technology and Engineering, vol 1, pg 393, 1959). Biotechnol Bioeng 67:636–644. doi:10.1002/(sici)1097-0290(20000320)67:6<636:aid-bit3>3.0.co;2-u
30. Monod J (1950) The growth of bacterial culture. Ann Review Microbiol 3:371–394
31. Moser A (1985) Kinetics of batch fermentations. In: HJ Rehm, Reed G Biotechnology (ed), 243–283
32. Mussatto SI, Dragone G, Guimaraes PMR, Silva JPA, Carneiro LM, Roberto IC, Vicente A, Domingues L, Teixeira JA (2010) Technological trends, global market, and challenges of bio-ethanol production. Biotechnol Adv 28:817–830. doi:10.1016/j.biotechadv.2010.07.001
33. Najafpour G, Younesi H, Ismail K (2004) Ethanol fermentation in an immobilized cell reactor using Saccharomyces cerevisiae. Bioresour Technol 92:251–260. doi:10.1016/j.biortech.2003.09.009
34. Nelder JA, Mead R (1965) Comput. A simplex-method for function minimization 7:308–313
35. Nigam JN (2000) Continuous ethanol production from pineapple cannery waste using immobilized yeast cells. J Biotechnol 80:189–193. doi:10.1016/s0168-1656(00)00246-7
36. O’Shea DG, Walsh PK (2000) The effect of culture conditions on the morphology of the dimorphic yeast Kluyveromyces marxianus var. marxianus NRRLy2415: a study incorporating image analysis. Appl Microbiol Biotechnol 53:316–322
37. Ozmihci S, Kargi F (2007) Continuous ethanol fermentation of cheese whey powder solution: effects of hydraulic residence time. Bioprocess Biosyst Eng 30:79–86. doi:10.1007/s00449-006-0101-0
38. Ozmihci S, Kargi F (2009) Fermentation of cheese whey powder solution to ethanol in a packed-column bioreactor: effects of feed sugar concentration. J Chem Technol Biotechnol 84:106–111. doi:10.1002/jctb.2013
39. Paalme T, Elken R, Vilu R, Korhola M (1997) Growth efficiency of Saccharomyces cerevisiae on glucose/ethanol media with a smooth change in the dilution rate (A-stat). Enz Microb Technol 20:174–181. doi:10.1016/s0141-0229(96)00114-7
40. Paalme T, Kahru A, Elken R, Vanatalu K, Tiisma K, Vilu R (1995) The computer-controlled continuous culture of Escherichia coli with smooth change of dilution rate (A-stat). J Microbiol Method 24:145–153. doi:10.1016/0167-7012(95)00064-x
41. Paalme T, Vilu R (1992) A new method of continuous cultivation with computer-controlled change of dilution rate. In: Karim MN, Stephanopoulos G (eds) Modeling and control of biotechnical processes, Ifac Symposia Series, vol 10, pp 299–301
42. Parrondo J, Garcia LA, Diaz M (2000) Production of an alcoholic beverage by fermentation of whey permeate with Kluyveromyces fragilis I: primary metabolism. J Instit Brewing 106:367–375
43. Sansonetti S, Hobley TJ, Calabro V, Villadsen J, Sin G (2011) A biochemically structured model for ethanol fermentation by Kluyveromyces marxianus: a batch fermentation and kinetic study. Bioresour Technol 102:7513–7520. doi:10.1016/j.biortech.2011.05.014
44. Sansonetti S, Hobley TJ, Curcio S, Villadsen J, Sin G (2013) Use of continuous lactose fermentation for ethanol production by Kluveromyces marxianus for verification and extension of a biochemically structured model. Bioresour Technol 130:703–709. doi:10.1016/j.biortech.2012.12.080
45. Silveira WB, Passos F, Mantovani HC, Passos FML (2005) Ethanol production from cheese whey permeate by Kluyveromyces marxianus UFV-3: a flux analysis of oxido-reductive metabolism as a function of lactose concentration and oxygen levels. Enz Microb Technol 36:930–936. doi:10.1016/j.enzmictec.2005.01.018
46. Siso MIG (1996) The biotechnological utilization of cheese whey: a review. Bioresour Technol 57:1–11. doi:10.1016/0960-8524(96)00036-3
47. Soares RDP, Secchi AR (2003) EMSO: a new environment for modelling, simulation and optimisation. Comput Aided Chem Eng. 14:947–952
48. Staniszewski M, Kujawski W, Lewandowska M (2009) Semi-continuous ethanol production in bioreactor from whey with co-immobilized enzyme and yeast cells followed by pervaporative recovery of product—Kinetic model predictions considering glucose repression. J Food Eng 91:240–249. doi:10.1016/j.jfoodeng.2008.08.026
49. Szajani B, Buzas Z, Dallmann K, Gimesi I, Krisch J, Toth M (1996) Continuous production of ethanol using yeast cells immobilized in preformed cellulose beads. Appl Microbiol Biotechnol 46:122–125
50. van der Sluis C, Westerink BH, Dijkstal MM, Castelein SJ, van Boxtel AJB, Giuseppin MLF, Tramper J, Wijffels RH (2001) Estimation of steady-state culture characteristics during acceleration-stats with yeasts. Biotechnol Bioeng 75:267–275. doi:10.1002/bit.1181
51. Verbelen P, De Schutter D, Delvaux F, Verstrepen K, Delvaux F (2006) Immobilized yeast cell systems for continuous fermentation applications. Biotechnol Lett 28:1515–1525. doi:10.1007/s10529-006-9132-5
52. Yang K-M, Lee N-R, Woo J-M, Choi W, Zimmermann M, Blank LM, Park J-B (2012) Ethanol reduces mitochondrial membrane integrity and thereby impacts carbon metabolism of Saccharomyces cerevisiae. FEMS Yeast Res 12:675–684. doi:10.1111/j.1567-1364.2012.00818.x
53. Yu JL, Yue GJ, Zhong J, Zhang X, Tan TW (2010) Immobilization of Saccharomyces cerevisiae to modified bagasse for ethanol production. Renew Energy 35:1130–1134. doi:10.1016/j.renene.2009.11.045
54. Yu JL, Zhang X, Tan TW (2007) An novel immobilization method of Saccharomyces cerevisiae to sorghum bagasse for ethanol production. J Biotechnol 129:415–420. doi:10.1016/j.jbiotec.2007.01.039
55. Zafar S, Owais M, Salleemuddin M, Husain S (2005) Batch kinetics and modelling of ethanolic fermentation of whey. Int J Food Sci Technol 40:597–604. doi:10.1111/j.1365-2621.2005.00957.x