Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 31, 2015, Pages E4236-E4245

  Kang, Jinsuk ^a   Lienhard, Matthias ^a,b   Pastor, William A ^a,j   Chawla, Ashu ^a   Novotny, Mark ^c   Tsagaratou, Ageliki ^a   Lasken, Roger S ^c   Thompson, Elizabeth C ^a,k   Azim Surani, M ^d   Koralov, Sergei B ^e   Kalantry, Sundeep ^f   Chavez, Lukas ^a,l   Rao, Anjana ^a,g,h,i  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^c J CRAIG VENTER INSTITUTE   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

ⁱ SANFORD CONSORTIUM FOR REGENERATIVE MEDICINE   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k Cell Press   (United States)

^l GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

more..

Author keywords

5 hydroxymethylcytosine; 5hmC; Cholesterol biosynthesis; Dna methylation; Tet methylcytosine oxidases

Indexed keywords

5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; DNA; OXIDOREDUCTASE; PROTEIN TET1; PROTEIN TET3; SONIC HEDGEHOG PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CHOLESTEROL; DNA BINDING PROTEIN; ONCOPROTEIN; SHH PROTEIN, MOUSE; TET1 PROTEIN, MOUSE; TET3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; BLASTOMA; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DNA METHYLATION; DNA MODIFICATION; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; ENZYME REGULATION; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HOLOPROSENCEPHALY; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; ANIMAL; ANIMAL EMBRYO; BIOSYNTHESIS; C57BL MOUSE; CELL LINEAGE; DEFICIENCY; EMBRYO DEATH; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; GENOME IMPRINTING; KNOCKOUT MOUSE; METABOLISM; NUCLEOTIDE REPEAT; PATHOLOGY; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

5-METHYLCYTOSINE; ANIMALS; BIOMARKERS; BLASTOCYST; BLASTOMERES; CELL LINEAGE; CHOLESTEROL; DNA; DNA-BINDING PROTEINS; DOWN-REGULATION; EMBRYO LOSS; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOMIC IMPRINTING; HEDGEHOG PROTEINS; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84938719137     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1510510112     Document Type: Article

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