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Volumn 12, Issue 2, 2000, Pages 193-203

Cholesterol in signal transduction

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN; CHOLESTEROL; MEMBRANE LIPID; RECEPTOR; SONIC HEDGEHOG PROTEIN;

EID: 0034092240     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(99)00076-9     Document Type: Review
Times cited : (197)

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    • Burke R., Nellen D., Bellotto M., Hafen E., Senti K.A., Dickson B.J., Basler K. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell. 99:1999;803-815. Recent data suggest that even the release of Hh may be regulated by cholesterol. A gene called dispatched was identified in a screen for mutations with a Hedgehog-like phenotype. Like patched, it has sterol-sensing domain but seems to be required for the release of Hh from the cells that synthesize it. Intriguingly, dispatched does not facilitate the release of GPI-anchored Hh, suggesting that the release of normal cholesterol-modified Hh is not simply related to raft association.
    • (1999) Cell , vol.99 , pp. 803-815
    • Burke, R.1    Nellen, D.2    Bellotto, M.3    Hafen, E.4    Senti, K.A.5    Dickson, B.J.6    Basler, K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.