Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan

Veterinary Parasitology

Volumn 212, Issue 1-2, 2015, Pages 35-46

  Lanusse, Carlos ^a   Lifschitz, Adrian ^a   Alvarez, Luis ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Anthelmintic pharmacology; Derquantel and monepantel; Drug combinations; Drug resistance; Novel anthelmintics

Indexed keywords

ABAMECTIN; ALBENDAZOLE; ALBENDAZOLE SULFOXIDE; ANTHELMINTIC AGENT; CLOSANTEL; DERQUANTEL; FENBENDAZOLE; IVERMECTIN; LEVAMISOLE; MEBENDAZOLE; MONEPANTEL; MOXIDECTIN; NETOBIMIN; OXFENDAZOLE; PIPERONYL BUTOXIDE; PYRANTEL EMBONATE; THIAMAZOLE; TRICLABENDAZOLE; AMINOACETONITRILE; INDOLE DERIVATIVE; OXEPINE DERIVATIVE;

ARTICLE; DRUG ABSORPTION; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RESISTANCE; DRUG RESPONSE; GOAT DISEASE; HELMINTHIASIS; HUMAN; NONHUMAN; PARASITE CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SHEEP DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; CLINICAL PHARMACOLOGY; DRUG COMBINATION; DRUG EFFECTS; DRUG INTERACTION; HELMINTH; METABOLISM; PARASITOLOGY; RUMINANT; TIME;

ANIMALIA; VERMES;

AMINOACETONITRILE; ANIMALS; ANTHELMINTICS; DRUG INTERACTIONS; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; HELMINTHS; INDOLES; OXEPINS; PHARMACOLOGY, CLINICAL; RUMINANTS; TIME;

EID: 84938556504     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2015.07.015     Document Type: Article

References (98)

1. Aloysius H.A., Silva Elipe M.V., Arison B.H., Faidley T.D., Blizzard T.A., Michael B.F., Thompson D.R., Shoop W.L., Tschirret-Guth R.A. Comparative disposition and metabolism of paraherquamide in sheep, gerbils and dogs. Drug Metab. Dispos. 2008, 36:1659-1669.
2. Alvarez L., Solana H., Mottier L., Virkel G., Fairweather I., Lanusse C. Altered drug influx/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes. Parasitology 2005, 131:501-510.
3. Alvarez L., Lifschitz A., Entrocasso C., Manazza J., Mottier L., Borda B., Virkel G., Lanusse C. Evaluation of the interaction between ivermectin and albendazole following their combined use in lambs. J. Vet. Pharmacol. Ther. 2008, 31:230-239.
4. Alvarez L., Suarez G., Ceballos L., Moreno L., Canton C., Lifschitz A., Ballent M., Mate L., Virkel G., Lanusse C. Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels. Vet. Parasitol. 2015, 210:53-63. 10.1016/j.vetpar.2015.03.001.
5. Alvinerie M., Dupuy J., Kiki-Mvouaka S., Sutra J., Lespine A. Ketoconazole increases the plasma levels of ivermectin in sheep. Vet. Parasitol. 2008, 157:117-122.
6. Anderson N., Martin P.J., Jarrett R.G. Mixtures of anthelmintics: a strategy against resistance. Aust. Vet. J. 1988, 65:62-64.
7. Anderson N., Martin P.J., Jarret R.G. Field evaluation of a mixture of albendazole sulphoxide and levamisole against Ostertagia and Trichostrongylus spp. in sheep. Aust. Vet. J. 1991, 68:133-136.
8. Baker K.E., George S.D., Stein P.A., Seewald W., Rolfe P.F., Hosking B.C. Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate. Vet. Parasitol. 2012, 186:513-517.
9. Ballent M., Lifschitz A., Virkel G., Sallovitz J., Lanusse C. Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments. Drug Metab. Dispos. 2006, 34:457-463.
10. Ballent M., Lifschitz A., Virkel G., Sallovitz J., Lanusse C. Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition. J. Vet. Pharmacol. Ther. 2007, 30:242-248.
11. Barnes E.H., Dobson R.J., Barger I.A. Worm control and anthelmintic resistance: adventures with a model. Parasitol. Today 1995, 11:56-63.
12. Barrère V., Alvarez L., Suarez G., Ceballos L., Moreno L., Lanusse C., Prichard R. Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the beta-tubulin isotype 1 encoding gene in Haemonchus contortus. Vet. Parasitol. 2012, 186:344-349.
13. Bartley D.J., McAllister H., Bartley Y., Dupuy J., Ménez C., Alvinerie M., Jackson F., Lespine A. P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus. Parasitology 2009, 136:1081-1088.
14. Bartley D.J., Morrison A.A., Dupuy J., Bartley Y., Sutra J.F., Menez C., Alvinerie M., Jackson F., Devin L., Lespine A. Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate. Vet. Parasitol. 2012, 187:464-472.
15. Belizario V.Y., Amarillo M.E., de Leon W.U., de los Reyes A.E., Bugayong M.G., Macatangay B.J. A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp. Bull. World Health Organ. 2003, 81:35-42.
16. Benchaoui H.A., McKellar Q.A. Interaction between fenbendazole and piperonyl butoxide: pharmacokinetic and pharmacodynamic implications. J. Pharm. Pharmacol. 1996, 48:753-759.
17. Canton C., Ceballos L., Moreno L., Fiel C., Yaguez P., Lanusse C., Alvarez L. Evaluation of the combined use of ivermectin and ricobendazole in cattle: pharmacokinetic and/or pharmacodynamic interactions. Proceedings of the XVIII Congresso Brasileiro de Parasitologia Veterinária 2014.
18. Canton C., Ceballos L., Moreno L., Fiel C., Domínguez P., Bernat G., Lanusse C., Alvarez L. Assessment of the ricobendazole plus levamisole nematodicidal combination in cattle. Proceedings of the 25th International Conference of the World Association for the Advancement of Veterinary Parasitology 2015.
19. Ceballos L., Moreno L., Alvarez L., Shaw L., Fairweather I., Lanusse C. Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes. BMC Vet. Res. 2010, 6(1):8.
20. Cromie L., Ferry M., Couper A., Fields C., Taylor S.M. Pharmacokinetics of a novel closantel/ivermectin injection in cattle. J. Vet. Pharmacol. Ther. 2006, 29:205-211.
21. Chou T.C., Talalay P. Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol. Sci. 1983, 4:450-454.
22. Chou T.C. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010, 70:440-446.
23. Demeler J., Krücken J., Algusbi S., Ramünke S., De Graef J., Kerboeuf D., Geldhof P., Pomroy W.E., von Samson-Himmelstjerna G. Potential contribution of P-glycoproteins to macrocyclic lactone resistance in the cattle parasitic nematode Cooperia oncophora. Mol. Biochem. Parasitol. 2013, 188:10-19.
24. Devine C., Brennan G.P., Lanusse C.E., Alvarez L.I., Trudgett A., Hoey E., Fairweather I. Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica. Parasitology 2009, 136:183-192.
25. Devine C., Brennan G.P., Lanusse C.E., Alvarez L.I., Trudgett A., Hoey E., Fairweather I. Piperonyl butoxide enhance triclabendazole action against triclabendazole-resistant Fasciola hepatica. Parasitology 2011, 138:224-236.
26. Devine C., Brennan G.P., Lanusse C.E., Alvarez L.I., Trudgett A., Hoey E., Fairweather I. Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole. Vet. Parasitol. 2012, 84:37-47.
27. Dobson R.J., Besier R.B., Barnes E.H., Love S.C.J., Vizard A., Bell K., Le Jambre L.F. Principles of use of macrocyclic lactones to minimise selection for resistance. Aust. Vet. J. 2001, 79:756-761.
28. Dupuy J., Larrieu G., Sutra J.F., Lespine A., Alvinerie M. Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin. Vet. Parasitol. 2003, 112:337-347.
29. Entrocasso C., Alvarez L., Manazza J., Lifschitz A., Borda B., Virkel G., Mottier L., Lanusse C. Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes. Vet. Parasitol. 2008, 155:249-256.
30. Epe C., Kaminsky R. New advancement in anthelmintic drugs in veterinary medicine. Trends Parasitol. 2013, 29:129-134.
31. EMEA (European Medicines Agency) Committee for Medicinal Products for Veterinary use (CVMP), Guideline on Pharmaceutical Fixed Combination Products, EMEA/CVMP/83804/2005 2006.
32. EMEA (European Medicines Agency) European Public MRL Assessment Report, Committee for Medicinal Products for Veterinary Use, EMEA/CVMP/529651/2009 2010.
33. Friedlander L., Le Bizec B., Swan G. Derquantel. Evaluations of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) 2012, 1-28.
34. Geary T.G., Hosking B.C., Skuce P.J., von Samson-Himmelstjerna G., Maeder S., Holdsworth P., Pomroy W., Vercruysse J. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: anthelmintic combination products targeting nematode infections of ruminants and horses. Vet. Parasitol. 2012, 190:306-316.
35. George S.D., George A.J., Stein P.A., Rolfe P.F., Hosking B.C., Seewald W. The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep. Vet. Parasitol. 2012, 188:190-193.
36. Goldin A., Mantel N. The employment of combinations of drugs in the chemotherapy of neoplasia: a review. Cancer Res. 1957, 17:635-654.
37. Halwachs S., Wassermann L., Honscha W. A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. Toxicol. In Vitro 2014, 28:432-441.
38. Hennessy D.R. Pharmacokinetic disposition of benzimidazole drugs in the ruminant gastrointestinal tract. Parasitol. Today 1993, 9:329-333.
39. Hosking B.C., Dobson D.P., Stein P.A., Kaminsky R., Bapst B., Mosimann D., Mason P.C., Seewald W., Strehlau G., Sager H. Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Vet. Parasitol. 2009, 160:251-257.
40. Hosking B. The Control of Gastro-Intestinal Nematodes in Sheep With the Amino-Acetonitrile Derivative, Monepantel With a Particular Focus on Australia and New Zealand 2010, 115. (Ph.D. thesis), University of Ghent, (Chapter 3).
41. Hosking B.C., Stein P.A., Karadzovska D., House J.K., Seewald W., Giraudel J.M. Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep. Vet. Rec. 2010, 166:490-494.
42. Kaminsky R., Ducray P., Jung M., Clover R., Rufener L., Bouvier J., Schorderet Weber S., Wenger A., Wieland-Berghausen S., Goebel T., Gauvry N., Pautrat F., Skripsky T., Froelich O., Komoin-Oka C., Westlund B., Sluder A., Maser P. A new class of anthelmintics effective against drug-resistant nematodes. Nature 2008, 452:176-180.
43. Kaminsky R., Mosimann D., Sager H., Stein P., Hosking B. Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. Int. J. Parasitol. 2009, 39:443-446.
44. Kaminsky R., Bapst B., Stein P., Strehlau G., Allan B., Hosking B., Rolfe P., Sager H. Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep. Parasitol. Res. 2011, 109:19-23.
45. Kaminsky R., Rufener L., Bouvier J., Lizundia R., Schorderet Weber S., Sager H. Worms-a "license to kill". Vet. Parasitol. 2013, 195:286-291.
46. Karadzovska D., Seewald W., Browning A., Smal M., Bouvier J., Giraudel J.M. Pharmacokinetics of monepantel and its suphone metabolite, monepantel suphone, after intravenous and oral administrations in sheep. J. Vet. Pharmacol. Ther. 2009, 32:359-367.
47. Keiser J., Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 2008, 299:1937-1948.
48. Keiser J., Utzinger J. The drugs we have and the drugs we need against major helminth infections. Adv. Parasitol. 2010, 73:197-230.
49. Keiser J., Tritten L., Adelfio R., Vargas M. Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo. Parasit. Vectors 2012, 5:292.
50. Keiser J., Tritten L., Silbereisen A., Speich B., Adelfio R., Vargas M. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl. Trop. Dis. 2013, 7:e2119.
51. Kerboeuf D., Guegnard F., Le Vern Y. Analysis and partial reversal of multidrug resistance to anthelmintics due to P-glycoprotein in Haemonchus contortus eggs using Lens culinaris lectin. Parasitol. Res. 2002, 88:816-821.
52. Knopp S., Mohammed K.A., Speich B., Hattendorf J., Khamis I.S., Khamis A.N., Stothard J.R., Rollinson D., Marti H., Utzinger J. Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial. Clin. Infect. Dis. 2011, 51:1420-1428.
53. Laffont C.M., Toutain P.L., Alvinerie M., Bousquet-Melou A. Intestinal secretion is a major route for parent ivermectin elimination in the rat. Drug Metab. Dispos. 2002, 30:626-630.
54. Lanusse C., Prichard R. Effects of methimazole on the kinetics of netobimin metabolites in cattle. Xenobiotica 1992, 22:115-123.
55. Lanusse C., Alvarez L., Lifschitz A. Pharmacological knowledge and sustainable anthelmintic therapy in ruminants. Vet. Parasitol. 2014, 204:18-33.
56. Learmount J., Taylor M.A., Bartram D.J. A computer simulation study to evaluate resistance development with a derquantel-abamectin combination on UK sheep farms. Vet. Parasitol. 2012, 187:244-253.
57. Leathwick D.M., Hosking B.C., Bisset S.A., McKay C.H. Managing anthelmintic resistance: is it feasible in New Zealand to delay the emergence of resistance to a new anthelmintic class?. N. Z. Vet. J. 2009, 57:181-192.
58. Lee B.H., Clothier M.F., Dutton F.E., Nelson S.J., Johnson S.S., Thompson D.P., Geary T.G., Whaley H.D., Haber C.L., Marshall V.P. Marcfortine and paraherquamide class of anthelmintics: discovery of PNU-141962. Curr. Top. Med. Chem. 2002, 2:779-793.
59. Lespine A., Ménez C., Bourguinat C., Prichard R. P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: prospects for reversing transport-dependent anthelmintic resistance. Int. J. Parasitol. Drugs Drug Resist. 2012, 2:58-75.
60. Lifschitz A., Virkel G., Sallovitz J., Imperiale F., Pis A., Lanusse C. Loperamide-induced enhancement of moxidectin availability in cattle. J. Vet. Pharmacol. Ther. 2002, 25:111-120.
61. Lifschitz A., Suarez V.H., Sallovitz J., Cristel S.L., Imperiale F., Ahoussou S., Schiavi C., Lanusse C. Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin. Exp. Parasitol. 2010, 125:172-178.
62. Lifschitz A., Entrocasso C., Alvarez L., Lloberas M., Ballent M., Manazza G., Virkel G., Borda B., Lanusse C. Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep. Vet. Parasitol. 2010, 172:291-298.
63. Lifschitz A., Ballent M., Lanusse C. Macrocyclic lactones and cellular transport-related drug interactions. A perspective from in vitro assays to nematode control in the field. Curr. Pharmacol. Biotech. 2012, 13:912-923.
64. Lifschitz A., Ballent M., Virkel G., Sallovitz J., Viviani P., Mate L., Lanusse C. Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep-pharmacokinetic support to its excellent nematodicidal activity. Vet. Parasitol. 2014, 203:120-126.
65. Lin J.H. Drug-drug interaction mediated by inhibition and induction of P-glycoprotein. Adv. Drug Deliv. Rev. 2003, 55:53-81.
66. Little P., Hodge A., Maeder S., Wirtherle N., Nicholas D., Cox G., Conder G. Efficacy of a combined oral formulation of derquantel-abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains. Vet. Parasitol. 2011, 181:180-193.
67. Lloberas M., Alvarez L., Entrocasso C., Ballent M., Virkel G., Luque S., Lanusse C., Lifschitz A. Comparative pharmacokinetic and efficacy assessments of single and double ivermectin and moxidectin doses in nematode-infected lambs. N. Z. Vet. 2015, 17:1-21.
68. Luque S., Lloberas M., Entrocasso C., Lanusse C., Virkel G., Alvarez L., Lifschitz A. Pharmacological evaluation of a 5-fold incremented dosage of the ivermectin+fenbendazole combination against highly resistant Haemonchus contortus in lambs. Proceedings of the 25th International Conference of the World Association for the Advancement of Veterinary Parasitology 2015.
69. Mederos A.E., Banchero G.E., Ramos Z. First report of monepantel Haemonchus contortus resistance on sheep farms in Uruguay. Parasit. Vectors 2014, 7:598.
70. Mehlhorn H., Hanser E., Harder A., Hansen O., Mencke N., Schaper R. A light and electron microscopic study on the synergistic effect of pyrantel and the febantel metabolite febendazole on adult Toxocara canis in vitro. Parasitol. Res. 2003, 90:305-313.
71. Merino G., Jonker J.W., Wagenaar E., Pulido M.M., Molina A.J., Alvarez A.I., Schinkel A.H. Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2). Drug Metab. Dispos. 2005, 33:614-618.
72. Miller D.K., Craig T.M. Use of anthelmintic combinations against multiple resistant Haemonchus contortus in Angora goats. Small Rumin. Res. 1996, 19:281-283.
73. Molento M., Lifschitz A., Sallovitz J., Lanusse C., Prichard R.K. Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep. Parasitol. Res. 2004, 92:121-127.
74. Moreno L., Echevarria F., Muñoz F., Alvarez L.I., Sánchez S., Lanusse C. Dose-dependent activity of albendazole against benzimidazole-resistant nematodes in sheep: relationship between pharmacokinetics and efficacy. Exp. Parasitol. 2004, 106:150-157.
75. Mottier L., Alvarez L., Fairweather I., Lanusse C. Resistance induced changes on triclabendazole transport in Fasciola hepatica: ivermectin reversal effect. J. Parasitol. 2006, 92:1355-1360.
76. Namwanje H., Kabatereine N.B., Olsen A. Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. Trans. R. Soc. Trop. Med. Hyg. 2011, 105:586-590.
77. Ndyomugyenyi R., Kabatereine N., Olsen A., Magnussen P. Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda. Am. J. Trop. Med. Hyg. 2008, 79:856-863.
78. Nies A., Spielberg S. Principles of therapeutics. The Pharmacological Basis of Therapeutics 1996, 43-61. McGraw-Hill, New York. J. Hardman, L. Limbird, P. Molinoff, R. Ruddon, A. Goodman Gilman (Eds.).
79. Prescott J.F. Antimicrobial drug action and interaction: an introduction. Antimicrobial Therapy in Veterinary Medicine 2000, 3-11. Iowa State Press, Iowa. J.F. Prescott, J.D. Baggot, R.D. Walker (Eds.).
80. Prichard R.K., Roulet A. ABC transporters and β-tubulin in macrocyclic lactones resistance: prospects for marker development. Parasitology 2007, 134:1123-1132.
81. Puttachary S., Trailovic S.M., Robertson A.P., Thompson D.P., Woods D.J., Martin R.J. Derquantel and abamectin: effects and interactions on isolated tissues of Ascaris suum. Mol. Biochem. Parasitol. 2013, 188:79-86.
82. Robinson M.W., Lawson J., Trudgett A., Hoey L., Fairweather I. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol. Res. 2004, 92:205-210.
83. Rufener L., Mäser P., Roditi I., Kaminsky R. Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS Pathog. 2009, 5:e1000380.
84. Rufener L., Baur R., Kaminsky R., Mäser P., Sigel E. Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus. Mol. Pharmacol. 2010, 78:895-902.
85. Ruiz-Lancheros E., Viau C., Walter T.N., Francis A., Geary T.G. Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans. Int. J. Parasitol. 2011, 41:455-461.
86. Sager H., Rolfe P., Strehlau G., Allan B., Kaminsky R., Hosking B. Quarantine treatment of sheep with monepantel-rapidity of fecal egg count reduction. Vet. Parasitol. 2010, 170:336-339.
87. Sanchez Bruni S., Fuse L., Moreno L., Saumell C., Alvarez L., Fiel C., McKellar Q., Lanusse C. Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses. Equine Vet. J. 2005, 37:257-262.
88. Scott I., Pomroy W.E., Kenyon P.R., Smith G., Adlington B., Moss A. Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis. Vet. Parasitol. 2013, 198:166-171.
89. Smith L.L. Combination anthelmintics effectively control ML-resistantparasites: a real-world case history. Vet. Parasitol. 2014, 204:12-17.
90. Stuchlíková L., Jirásko R., Vokřál I., Lamka J., Spulák M., Holčapek M., Szotáková B., Bártíková H., Pour M., Skálová L. Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS. Anal. Bioanal. Chem. 2013, 405:1705-1712.
91. Stuchlíková L., Jirásko R., Vokřál I., Valát M., Lamka J., Szotáková B., Holčapek M., Skálová L. Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus). Drug Test Anal. 2014, 6:1055-1062.
92. Stuchlíková L., Matoušková P., Bártíková H., Vokřál I., Lamka J., Štolcová T., Pětníková H., Szotáková B., Kubíček V., Skálová L. Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo. Chem. Biol. Interact. 2015, 227:63-68.
93. Suarez G., Alvarez L., Castells D., Berretta C., Bentancor S., Fagiolino P., Lanusse C. Pharmaco-therapeutic evaluation of the closantel-moxidectin combination in lambs. Proceedings of the 24th International Conference of the World Association for the Advancement of Veterinary Parasitology 2013.
94. Suarez G., Alvarez L., Castells D., Moreno L., Fagiolino P., Lanusse C. Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs. Vet. Parasitol. 2014, 201:110-119.
95. Sutherland I.A., Leathwick D.M. Anthelmintic resistance in nematode parasites of cattle: a global issue?. Trends Parasitol. 2011, 27:176-181.
96. Van den Brom R., Moll L., Kappert C., Vellema P. Haemonchus contortus resistance to monepantel in sheep. Vet. Parasitol. 2015, 209:278-280.
97. Várady M., Petersen M.B., Bjørn H., Nansen P. The efficacy of ivermectin against nodular worms of pigs: the response to treatment using three different dose levels against Oesophagostomum dentatum and Oesophagostomum quadrispinulatum. Int. J. Parasitol. 1996, 26:369-374.
98. Xu M., Molento M., Blackhall W., Ribeiro P., Beech R., Prichard R.K. Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog. Mol. Biochem. Parasitol. 1998, 91:327-335.