Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate

Veterinary Parasitology

Volumn 186, Issue 3-4, 2012, Pages 513-517

  Baker, K E ^a   George, S D ^a   Stein, P A ^a   Seewald, W ^b   Rolfe, P F ^a   Hosking, B C ^a  

^a Novartis Animal Health Australasia Pty Limited   (Australia)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Anthelmintic; Combination; Efficacy; Haemonchus contortus; Monepantel; Resistance; Sheep

Indexed keywords

ABAMECTIN; ALBENDAZOLE; ANTHELMINTIC AGENT; BENZIMIDAZOLE; CLOSANTEL; CLOSICARE; COPPERS; HAT TRICK; IVERMECTIN; LEVAMISOLE; MACROLIDE; MONEPANTEL; MOXIDECTIN; NAFTALOFOS; OXFENDAZOLE; Q DRENCH; SALICYLANILIDE DERIVATIVE; SCANDA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTHELMINTIC ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FECES ANALYSIS; FEMALE; HAEMONCHOSIS; HAEMONCHUS CONTORTUS; MALE; NONHUMAN; PARASITE IDENTIFICATION; PARASITE ISOLATION; PARASITE LOAD; SHEEP;

AMINOACETONITRILE; ANIMALS; ANTHELMINTICS; DRUG THERAPY, COMBINATION; FEMALE; HAEMONCHIASIS; HAEMONCHUS; MALE; SHEEP; SHEEP DISEASES;

HAEMONCHUS; HAEMONCHUS CONTORTUS; OVIS ARIES;

EID: 84860235570     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2011.11.060     Document Type: Article

References (25)

1. Abbott W.S. A method for computing the effectiveness of an insecticide. J. Econ. Entomol. 1925, 18:265-267.
2. Anon., 1999. Efficacy of Anthelmintics: Specific Recommendations for Ovines. VICH Guideline 13. (accessed 11 May 2011). http://www.vichsec.org/pdf/2000/GL13_ST7.pdf.
3. Anon., 2000a. Good Clinical Practice. VICH Guideline 9. (accessed 11 May 2011). http://www.vichsec.org/pdf/2000/Gl09_st7.pdf.
4. Anon., 2000b. Efficacy of Anthelmintics: General Requirements. VICH Guideline 7. (accessed 11 May 2011). http://www.vichsec.org/pdf/Gl07_st7final+corr.pdf.
5. Cezar A.S., Toscan G., Camillo G., Sangioni L.A., Ribas H.O., Vogel F.S.F. Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil. Vet. Parasitol. 2010, 173:157-160.
6. Dobson R.J., Hosking B.C., Besier R.B., Love S., Larsen J.W.A., Rolfe P.F., Bailey J.N. Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems. Aust. Vet. J. 2011, 89:160-166.
7. Dobson R.J., Barnes E.H., Tyrrell K.L., Hosking B.C., Larsen J.W.A., Besier R.B., Love S., Rolfe P.F., Bailey J.N. A multi-species model to assess the impact of refugia on worm control and anthelmintic resistance in sheep grazing systems. Aust. Vet. J. 2011, 89:200-208.
8. Echevarria F.A.M., Armour J., Duncan J.L. Efficacy of some anthelmintics on an ivermectin-resistant strain of Haemonchus contortus in sheep. Vet. Parasitol. 1991, 39:279-284.
9. Echevarria F., Borba M.F.S., Pinheiro A.C., Waller P.J., Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Brazil. Vet. Parasitol. 1996, 62:199-206.
10. Eddi C., Caracostantogolo J., Peña M., Schapiro J., Marangunich L., Waller P.J., Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Argentina. Vet. Parasitol. 1996, 62:189-197.
11. Hosking B.C., Dobson D.P., Stein P.A., Kaminsky R., Bapst B., Mosimann D., Mason P.C., Seewald W., Strehlau G., Sager H. Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Vet. Parasitol. 2009, 160:251-257.
12. Hosking B.C., Griffiths T.M., Woodgate R.G., Besier R.B., Le Feuvre A.S., Nilon P., Trengove C., Vanhoff K.J., Kaye-Smith B.G., Seewald W. Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia. Aust. Vet. J. 2009, 87:455-462.
13. Kaminsky R., Gauvry N., Schorderet Weber S., Skripsky T., Bouvier J., Wenger A., Schroeder F., Desaules Y., Hotz R., Goebel T., Hosking B.C., Pautrat F., Wieland-Berghausen S., Ducray P. Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. Parasitol. Res. 2008, 103:931-939.
14. Parasitic Infections of Domestic Animals: A Diagnostic Manual 1996, Birkhauser, Berlin. J. Kaufmann (Ed.).
15. Love S.C.J., Neilson F.J.A., Biddle A.J., McKinnon R. Moxidectin-resistant Haemonchus contortus in sheep in northern New South Wales. Aust. Vet. J. 2003, 81:359-360.
16. Maciel S., Giménez A.M., Gaona C., Waller P.J., Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Paraguay. Vet. Parasitol. 1996, 62:207-212.
17. Nari A., Salles J., Gil A., Waller P.J., Hansen J.W. The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Uruguay. Vet. Parasitol. 1996, 62:213-222.
18. SAS SAS 9.1 Documentation 2004, SAS Institute Inc., Cary, NC.
19. SAS SAS 9.2 Documentation 2008, SAS Institute Inc., Cary, NC.
20. van Wyk J.A., Malan F.S. Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa. Vet. Rec. 1988, 123:226-228.
21. van Wyk J.A., Malan F.S., Gerber H.M., Alves R.M.R. The problem of escalating resistance of Haemonchus contortus to the modern anthelmintics in South Africa. Onderstepoort J. Vet. Res. 1989, 56:41-49.
22. van Wyk J.A., Malan F.S., Randles J.L. How long before resistance makes it impossible to control some field strains of Haemonchus contortus in South Africa with any of the modern anthelmintics?. Vet. Parasitol. 1997, 70:111-122.
23. van Wyk J.A., Stenson M.O., Van der Merwe J.S., Vorster R.J., Viljoen P.G. Anthelmintic resistance in South Africa: surveys indicate an extremely serious situation in sheep and goat farming. Onderstepoort J. Vet. Res. 1999, 66:273-284.
24. Vercruysse J., Holdsworth P., Letonja T., Barth D., Conder G., Hamamoto K., Okano K. International harmonisation of anthelmintic efficacy guidelines. Vet. Parasitol. 2001, 96:171-193.
25. Wood I.B., Amaral N.K., Bairden K., Duncan J.L., Kassai T., Malone J.B., Pankavich J.A., Reinecke R.K., Slocombe O., Taylor S.M., Vercruysse J. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Vet. Parasitol. 1995, 58:181-213.