Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 5, 2013, Pages 1705-1712

  Stuchlíková, Lucie ^a   Jirásko, Robert ^b   Vokřál, Ivan ^a   Lamka, Jiří ^a   Špulák, Marcel ^a   Holčapek, Michal ^b   Szotáková, Barbora ^a   Bártíková, Hana ^a   Pour, Milan ^a   Skálová, Lenka ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF PARDUBICE   (Czech Republic)

Author keywords

Aminoacetonitrile derivatives; Biotransformation; Drug metabolism; Monepantel; Ultrahigh performance liquid chromatography mass spectrometry

Indexed keywords

ACETONITRILE; AMINES; DRUG INTERACTIONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHASE SEPARATION; SULFUR COMPOUNDS; VETERINARY MEDICINE;

BIOTRANSFORMATION; DRUG METABOLISMS; DRUG-DRUG INTERACTIONS; ELEMENTAL COMPOSITIONS; MONEPANTEL; QUADRUPOLE-TIME OF FLIGHTS; SOLID-PHASE EXTRACTION; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

METABOLISM;

ANIMALIA; OVIS; OVIS ARIES;

EID: 84873729287     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6584-4     Document Type: Article

References (23)

1. Leathwick DM (2012) Modelling the benefits a new class of anthelmintic in combination. Vet Parasitol 186:93-100
2. Papadopoulos E (2008) Anthelmintic resistance in sheep nematodes. Small Rumin Res 76:99-103
3. Gobert NG, Jones MK (2008) Discovering new schistosome drug targets: the role of transcriptomics. Curr Drug Targets 9:922-930
4. Kaplan RM (2004) Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol 20:477-481
5. Kaminsky R, Ducray P, Jung M, Clover R, Rufener L, Bouvier J, Weber SS, Wenger A, Wieland-Berghausen S, Goebel T, Gauvry N, Pautrat F, Skripsky T, Froelich O, Komoin-Oka C, Westlund B, Sluder A, Mäser P (2008) A new class of anthelmintics effective against drug-resistant nematodes. Nature 452:176-180
6. Ducray P, Gauvry N, Pautrat F, Goebel T, Fruechtel J, Desaules Y, Weber SS, Bouvier J, Wagner T, Froelich O, Kaminsky R (2008) Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bioorg Med Chem Lett 18:2935-2938
7. Kinsella B, Byrne P, Cantwell H, McCormack M, Furey A, Danaher M (2011) Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method. J Chromatogr B 879:3707-3713
8. Karadzovska D, Seewald W, Browning A, Smal M, Bouvier J, Giraudel JM (2008) Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep. J Vet Pharmacol Ther 32:359-367
9. Holčapek M, Kolářová L, Nobilis M (2008) High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites. Anal Bioanal Chem 391:59-78
10. Vokřál I, Jedličková V, Jirásko R, Stuchlíková L, Bártíková H, Skálová L, Lamka J, Holčapek M, Szotáková B (2011) Metabolic fate of ivermectin in host (Ovis aries) and parasite (Haemonchus contortus). Vet Parasitol 185:168-174
11. Vokřál I, Jirásko R, Jedličková V, Bártíková H, Skálová L, Lamka J, Holčapek M, Szotáková B (2012) The inability of tapeworm Hymenolepis diminuta and fluke Dicrocoelium dendriticum to metabolize praziquantel. Vet Parasitol 185:168-174
12. Holčapek M, Jirásko R, Lísa M (2012) Recent developments in liquid chromatography-mass spectrometry and related techniques. J Chromatogr A 1259:3-15
13. Liu DQ, Hop CE (2005) Strategies for characterization of drug metabolites using liquid chromatography-tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches. J Pharm Biomed Anal 37:1-18
14. Liu X, Jia L (2007) The conduct of drug metabolism studies considered good practice (I): analytical systems and in vivo studies. Curr Drug Metab 8:815-821
15. Jirásko R, Holčapek M, Nobilis M (2011) Identification of phase I and phase II metabolites of benfluron and dimefluron in rat urine using high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Sp 25:2153-2162
16. Staack RF, Hopfgartner G (2007) New analytical strategies in studying drug metabolism. Anal Bioanal Chem 388:1365-1380
17. Berry MN, Edwards AM, Barritt GJ (1991) Laboratory techniques in biochemistry and molecular biology. In: Burdow RH, van Knippenberg PH (eds) Isolated hepatocytes preparation, properties and applications. Elsevier Science, Amsterdam, pp 15-35
18. Baliharová V, Velík J, Savlík M, Szotáková B, Lamka J, Tahotná L, Skálová L (2004) The effects of fenbendazole, flubendazole and mebendazole on activities of hepatic cytochromes P450 in pig. J Vet Pharmacol Ther 27:85-90
19. Velík J, Baliharová V, Skálová L, Szotáková B, Wsól V, Lamka J (2003) Stereospecific biotransformation of albendazole in muflon and rat-isolated hepatocytes. J Vet Pharmacol Ther 26:297-302
20. Montesissa C, Anfossi P, Van't Klooster G, Mengelers M (1996) The use of cultured hepatocytes from goats and cattle to investigate xenobiotic oxidative metabolism. Vet Res Commun 20:449-460
21. Parkinson A (2001) In: Klaassen CD (ed) Casarett & Doull's toxicology - the basic science of poisons. New York, McGraw-Hill
22. Nobilis M, Anzenbacher P, Pastera J, Svoboda Z, Hrubý K, Květina J, Ubik K, Trejtnar F (1996) Study of the biotransformation of a potential benzocfluorene antineoplastic using high-performance liquid chromatography with high-speed-scanning ultraviolet detection. J Chromatogr B 681:143-151
23. Holčapek M, Jirásko R, Lísa M (2010) Basic rules for the interpretation of atmospheric pressure ionization mass spectra of small molecules. J Chromatogr A 25:3908-3921