Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: A randomized controlled trial

Clinical Infectious Diseases

Volumn 51, Issue 12, 2010, Pages 1420-1428

  Knopp, Stefanie ^a,b   Mohammed, Khalfan A ^c   Speich, Benjamin ^a,b   Hattendorf, Jan ^a,b   Khamis, I Simba ^c   Khamis, Alipo N ^c   Stothard, J Russell ^d   Rollinson, David ^d   Marti, Hanspeter ^a,b   Utzinger, Jürg ^a,b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c Ministry of Health Zanzibar   (Tanzania)

^d DEPARTMENT OF LIFE SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; IVERMECTIN; MEBENDAZOLE; PLACEBO;

ABDOMINAL CRAMP; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG MONITORING; DRUG SAFETY; EGG PARASITOID; FATIGUE; FEMALE; FEVER; HEADACHE; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; NAUSEA; PARASITE TRANSMISSION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SHIVERING; TANZANIA; TREATMENT DURATION; TREATMENT OUTCOME; TRICHURIASIS; TRICHURIS; VERTIGO; VOMITING;

ADOLESCENT; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; CHILD; DRUG THERAPY, COMBINATION; FECES; FEMALE; HUMANS; IVERMECTIN; MALE; MEBENDAZOLE; PARASITE EGG COUNT; PLACEBOS; TANZANIA; TREATMENT OUTCOME; TRICHURIASIS; TRICHURIS;

EID: 78649850260     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/657310     Document Type: Article

References (28)

1. Chan MS. The global burden of intestinal nematode infections - fifty years on. Parasitol Today 1997; 13:438-443.
2. Bethony J, Brooker S, Albonico M, et al. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 2006; 367:1521-1532.
3. Hotez PJ, Kamath A. Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis 2009; 3:e412.
4. World Health Organization. Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. Geneva: World Health Organization, 2006.
5. Smits HL. Prospects for the control of neglected tropical diseases by mass drug administration. Expert Rev Anti Infect Ther 2009; 7:37-56.
6. Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 2008; 299:1937-1948.
7. Keiser J, Utzinger J. The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 2010; 73:197-230.
8. Belizario VY, Amarillo ME, de Leon WU, de los Reyes AE, Bugayong MG, Macatangay BJ. A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp. Bull World Health Organ 2003; 81:35-42.
9. Beach MJ, Streit TG, Addiss DG, Prospere R, Roberts JM, Lammie PJ. Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. Am J Trop Med Hyg 1999; 60:479-486.
10. Ndyomugyenyi R, Kabatereine N, Olsen A, Magnussen P. Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda. Am J Trop Med Hyg 2008; 79:856-863.
11. Olsen A. Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis. Trans R Soc Trop Med Hyg 2007; 101:747-758. (Pubitemid 46930627)
12. Knopp S, Mohammed KA, Rollinson D, et al. Changing patterns of soil-transmitted helminth infections in Zanzibar in the context of national control programs. Am J Trop Med Hyg 2009; 81:1071-1078.
13. Knopp S, Mohammed KA, Khamis IS, et al. Spatial distribution of soil-transmitted helminths, including Strongyloides stercoralis, among children in Zanzibar. Geospat Health 2008; 3:47-56.
14. Fleiss JL. The measurement of interrater agreement: statistical methods for rates and proportions. 2nd ed. New York: Wiley, 1981:212-236.
15. Knopp S, Mohammed KA, Stothard JR, et al. Patterns and risk factors of helminthiasis and anemia in a rural and a periurban community in Zanzibar, in the context of helminth control programs. PLoS Negl Trop Dis 2010; 4:e681.
16. Katz N, Chaves A, Pellegrino J. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop São Paulo 1972; 14:397-400.
17. Montresor A, Crompton DWT, Hall A, Bundy DAP, Savioli L. Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level. Geneva: World Health Organization, 1998.
18. Stothard JR, Rollinson D, Imison E, Khamis IS. A spot-check of the efficacies of albendazole or levamisole, against soil-transmitted helminthiases in young Ungujan children, reveals low frequencies of cure. Ann Trop Med Parasitol 2009; 103:357-360.
19. Albonico M, Bickle Q, Ramsan M, Montresor A, Savioli L, Taylor M. Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bull World Health Organ 2003; 81:343-352.
20. Albonico M, Smith PG, Hall A, Chwaya HM, Alawi KS, Savioli L. A randomized controlled trial comparing mebendazole and albendazole against Ascaris, Trichuris and hookworm infections. Trans R Soc Trop Med Hyg 1994; 88:585-589.
21. World Health Organization. The World Health Report 1999: making a difference. Geneva: World Health Organization, 1999.
22. Albonico M. Methods to sustain drug efficacy in helminth control programmes. Acta Trop 2003; 86:233-242.
23. Albonico M, Wright V, Ramsan M, et al. Development of the egg hatch assay for detection of anthelminthic resistance in human hookworms. Int J Parasitol 2005; 35:803-811. (Pubitemid 40733619)
24. Albonico M, Bickle Q, Haji HJ, et al. Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections. Trans R Soc Trop Med Hyg 2002; 96:685-690. (Pubitemid 36231498)
25. Steinmann P, Zhou XN, Du ZW, et al. Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial. PLoS Negl Trop Dis 2008; 2:e322.
26. Marti HP, Haji HJ, Savioli L, et al. A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children. Am J Trop Med Hyg 1996; 55:477-481.
27. Scherrer AU, Sjöberg MK, Allangba A, et al. Sequential analysis of helminth egg output in human stool samples following albendazole and praziquantel administration. Acta Trop 2009; 109:226-231.
28. Horton J. Albendazole: a review of anthelmintic efficacy and safety in humans. Parasitology 2000; 121(suppl):S113-132.