Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses

Equine Veterinary Journal

Volumn 37, Issue 3, 2005, Pages 257-262

  Sanchez Bruni S F ^a,b,c   Fuse L A ^a   Moreno, L ^a,b   Saumell, C A ^a   Alvarez L I ^a,b   Fiel, C ^a   McKellar, Q A ^c   Lanusse, C E ^a,b  

^a UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c MOREDUN RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Benzimidazoles; Chirality; Efficacy; Horse; Pharmacokinetics; Piperonyl butoxide

Indexed keywords

FENBENDAZOLE; OXFENDAZOLE; PIPERONYL BUTOXIDE;

ANIMAL EXPERIMENT; ANTHELMINTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; ENANTIOMER; EUTHANASIA; LARVA; MALE; NEMATODE; NONHUMAN; PARASITOSIS;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; FORMICIDAE;

EID: 18544379427     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/0425164054530669     Document Type: Article

References (26)

1. Ali, D. and Hennessy, D. (1995) The effect of feed intake on the rate of flow digesta and the disposition and activity of oxfendazole in sheep. Int. J. Parasitol. 23, 477-484.
2. Alvarez, L.I., Imperiale, F.A., Sánchez, S.F. and Lanusse, C.E. (2000) In vivo and ex vivo uptake of albendazole and albendazole sulphoxide by Haemonchus contenus and Fasciola hepatica in sheep. Vet. Parasitol. 94, 75-89.
3. Anon (1984) Técnicas de Necropsias y Laboratorio Aplicadas en el Centro de Investigaciones en Ciencias Veterinarias, Laboratorio del Departamento de Patología Animal, INTA, Castelar, Argentina.
4. Benchaoui, H.A. and McKellar, Q.A. (1996) Interaction between fenbendazole and piperonyl butoxide: pharmacokinetic and pharmacodynamic implications. J. Pharm. Pharmacol. 48, 763-759.
5. Beretta, C., Fadini, L., Malvisi Stracciari, J. and Montesissa, C. (1987) In vitro febantel transformation by sheep and cattle ruminal fluids and metabolism by hepatic subcellular fractions from different animal species. Biochem. Pharmacol. 36, 3107-3114.
6. Braide, E.I. and Georgi, J.R. (1974) Number of external leaf crown elements of 18 species of equine cyathostomes. Cornell Vet. 64, 233-239.
7. Coles, G.C., Bauer, F.H.M., Borgsteede, S., Geerst, T.R., Klei, T.R., Taylor, M.A. and Waller, P.J. (1992) World Association for the Advancement of Veterinary Parasitology (WAAVP). Methods for detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 44, 35-44.
8. Delatour, P., Benoit, E., Garnier, F. and Besse, S. (1990) Chirality of the sulphoxide metabolites of fenbendazole and albendazole in sheep. J. vet. Pharmacol. Therap. 13, 361-366.
9. Gibaldi, M. and Perrier, D. (1982) Pharmacokinetics, 2nd edn., Marcel Dekker, New York. pp 145-198.
10. Herd, R. (1990) Equine parasite control-problem associate with intensive anthelmintic therapy. Equine vet. Educ. 2, 41-47.
11. Kaplan, R. (2002) Anthelmintic resistance in nematodes of horses. Vet. Res. 33, 491-507.
12. Lacey, E. (1988) The role of the cytoskeletal protein tubulin in the mode of action and mechanism of drug resistance to benzimidazole. Int. J. Parasitol. 18, 885-936.
13. Lanusse, C.E. and Prichard, R. (1992) Effects of methimazole on the kinetics of netobimin metabolites in cattle. Xenobiotica 22, 115-123.
14. Lanusse, C.E. and Prichard, R. (1993) Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants. Drug Metab. Rev. 25, 235-279.
15. Lichtenfels, J.R. (1975) Helminths of domestic equids. Proc. Helmint. Soc. Wash. 42, 1-92.
16. Love, S., Murphy, D. and Mellor, D. (1999) Pathogenicity of cyathostome infection. Vet. Parasitol. 85, 113-122.
17. McKellar, Q., Gokbulut, C., Muzandu, K. and Benchaoui, H. (2002) Fenbendazole pharmacokinetics, metabolism and potentiation in horses. Drug Metab. Dispos. 30, 1230-1239.
18. Moreno, L., Echevarria, P., Muñoz, F., Alvarez, L.I., Sánchez Bruni, S.F. and Lanusse, C.E. (2004) Dose-dependent activity of albendazole against benzimidazole-resistant nematodes in sheep: relationship between pharmacokinetics and efficacy. Expt. Parasitol. 106, 150-157.
19. Murray, M., Hudson, A.M. and Yassa, V. (1992) Hepatic microsomal metabolism of the anthelmintic benzimidazole fenbendazole: enhanced inhibition of cytochrome P450 reactions by oxidized metabolites of the drug. Chem. Res. Toxicol. 5, 60-66.
20. Notari, R.E. (1987) Pharmacokinetics. In: Biopharmaceutics and Clinical Pharmacokinetics, 4th edn., Marcel Dekker, New York. pp 45-129.
21. Prichard, R., Hennessy, D., Steel, J. and Lacey, E. (1985) Metabolite concentrations in plasma following treatment of cattle with five anthelmintics. Res. vet. Sci. 39, 113-178.
22. Reinemeyer, C.R. and Herd, R.P. (1986) Comparison of two techniques for quantitation of encysted cyathostome larvae in the horse. Am. J. vet. Res. 47, 507-509.
23. Roberts, F. and O'Sullivan, P. (1950) Methods for egg counts and larval culture for strongyles infesting gastrointestinal tract of cattle. Aust. J. Agric. Res. 1, 99-102.
24. Sánchez, S.F., Small, J., Jones, D. and McKellar, Q.A. (2002) Plasma achiral and chiral pharmacokinetic behaviour of intravenous oxfendazole co-administered with piperonyl butoxide in sheep. J. vet. Pharmacol. Therap. 25, 7-13.
25. Sangster, N. (2003) A practical approach to anthelmintic resistance. Equine vet. J. 35, 218-219.
26. Virkel, G.L., Lifschitz, A.L., Pis, A. and Lanusse, C.E. (2002) In vitro ruminal biotransformation of benzimidazole sulphoxide anthelmintics: enantioselective sulphoreduction in sheep and cattle. J. vet. Pharmacol. Ther. 25, 15-23.