Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep

Veterinary Record

Volumn 166, Issue 16, 2010, Pages 490-494

  Hosking, B C ^a   Stein, P A ^a   Karadzovska, D ^a   House, J K ^b   Seewald, W ^c   Giraudel, J M ^d  

^a Yarrandoo Rand Centre   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NOVARTIS PHARMA AG   (Switzerland)

^d Novartis Centre de Recherche Santé Animale   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COOPERIA CURTICEI; HAEMONCHUS CONTORTUS; NEMATODA; OVIS ARIES; TELADORSAGIA CIRCUMCINCTA; TRICHOSTRONGYLUS COLUBRIFORMIS;

EID: 77952065387     PISSN: 00424900     EISSN: None     Source Type: Journal    
DOI: 10.1136/vr.b4830     Document Type: Article

References (24)

1. ABBOTT, W. S. (1925) A method of computing the effectiveness of an insecticide. Journal of Economic Entomology 18, 265-267
2. DUCRAY, P., GAUVRY, N., PAUTRAT, F., GOEBEL, T., FRUECHTEL, J., DESAULES, Y., WEBER, S. S., BOUVIER, J., WAGNER, T., FROELICH, O. & KAMINSKY, R. (2008) Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. Bioorganic and Medicinal Chemistry Letters 18, 2935-2938 (Pubitemid 351622043)
3. GORDON, H. (1962) Recent advances In anthelmintics for use in sheep. Opening of Discussion. Australian Veterinary Journal 38, 170-176
4. HENNESSY, D. R., MARTIN, P. J. & MURRAY, S. (1997) Influence of drench volume on the disposition of oxfendazole in sheep. Veterinary Record 140, 429-430 (Pubitemid 27174183)
5. HENNESSY, D. R. & PRICHARD, R. K. (1979) Deaths in cattle after administration of large doses of thiabendazole. Australian Veterinary Journal 55, 298
6. HOSKING, B. C., STEIN, P. A., MOSIMANN, D., SEEWALD, W., STREHLAU, G. & KAMINSKY, R. (2008) Dose determination studies for monepantel, an aminoacetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Veterinary Parasitology 157, 72-80
7. HOSKING, B. C., DOBSON, D. P., STEIN, P. A., KAMINSKY, R., BAPST, B., MOSIMANN, D., MASON, P. C., SEEWALD, W., STREHLAU, G. & SAGER, H. (2009a) Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Veterinary Parasitology 160, 251-257
8. HOSKING, B. C., GRIFFITHS, T. M., WOODGATE, R. G., BESIER, R. B., LE FEUVRE, A. S., NILON, P., TRENGOVE, C., VANHOFF, K. J., KAYE-SMITH, B. G. & SEEWALD, W. (2009b) Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia. Australian Veterinary Journal 87, 455-462
9. HOSKING, B. C. & STEIN, P. A. (2009) Effect of fasting sheep for a short period on the efficacy and safety of monepantel. Veterinary Record 165, 50-52
10. KAMINSKY, R., DUCRAY, P., JUNG, M., CLOVER, R., RUFENER, L., BOUVIER, J. & OTHERS (2008a) A new class of anthelmintics effective against drug-resistant nematodes. Nature 452, 176-180
11. KAMINSKY, R., GAUVRY, N., SCHORDERET WEBER, S., SKRIPSKY, T., BOUVIER, J., WENGER, A. & OTHERS (2008b) Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. Parasitology Research 103, 931-939
12. KAMINSKY, R., MOSIMANN, D., SAGER, H., STEIN, P. & HOSKING, B. (2009) Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. International Journal for Parasitology 39, 443446
13. KARADZOVSKA, D., SEEWALD, W., BROWNING, A., SMAL, M., BOUVIER, J. & GIRAUDEL, J. M. (2009) Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep. Journal of Veterinary Pharmacology and Therapeutics 32, 359-367
14. KELLY, J. D., HALL, C. A., WHITLOCK, H. V., THOMPSON, H. G., CAMPBELL, N. J. & MARTIN, I. C. (1977) The effect of route of administration on the anthelmintic efficacy of benzimidazole anthelmintics in sheep infected with strains of Haemonchus contortus and Trichostrongylus colubrifomis resistant or susceptible to thiabendazole. Research in Veterinary Science 22, 161-168
15. MALIKIDES, N., HELBIG, R., MAHONEY, R., GEORGE, B., BAKER, K., VANHOFF, K., SPENCER, K., HALL, C., DEBENEDETTI, R. & STREHLAU, G. A. (2009a) Reproductive safety of an amino-acetonitrile derivative (AAD), monepantel, in rams following repeated oral administration. New Zealand Veterinary Journal 57, 16-21
16. MALIKIDES, N., HELBIG, R., ROTH, D. R., ALEXANDER, A., HOSKING, B. C. & STREHLAU, G. A. (2009b) Safety of an amino-acetonitrile derivative (AAD), monepantel, In weaned lambs following repeated oral administration. New Zealand Veterinary Journal 57, 10-15
17. MALIKIDES, N., SPENCER, K., MAHONEY, R., BAKER, K., VANHOFF, K., HALL, C., DEBENEDETTI, R. & STREHLAU, G. A. (2009c) Safety of an aminoacetonitrile derivative (AAD), monepantel, in ewes and their offspring following repeated oral administration. New Zealand Veterinary Journal 57, 193-202
18. MASON, P. C., HOSKING, B. C., NOTTINGHAM, R. M., COLE, D. J., SEEWALD, W., MCKAY, C. H., GRIFFITHS, T. M., KAYE-SMITH, B. G. & CHAMBERLAIN, B. (2009) A large-scale clinical field study to evaluate the efficacy and safety of an oral formulation of the amino-acetonitrile derivative (AAD), monepantel, in sheep in New Zealand. New Zealand Veterinary Journal 57, 3-9
19. SAGER, H., HOSKING, B., BAPST, B., STEIN, P., VANHOFF, K & KAMINSKY, R. (2009) Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep. Veterinary Parasitology 159, 49-54
20. SARGISON, N. D., STAFFORD, K. J. & WEST, D. M. (1998) The effects of age, weaning, drench volume and yarding on ruminoreticulum bypass in sheep, with reference to the anthelmintic efficacy of benzimidazole drenches. New Zealand Veterinary Journal 46, 20, 23-20, 27
21. VERCRUYSSE, J., HOLDSWORTH, P., LETONA, T., BARTH, D. CONDER, G., HAMAMOTO, K., OKANO, K. & WORLD ORGANISATION FOR ANIMAL HEALTH (2001) International harmonisation of anthelmintic efficacy guidelines. Veterinary Parasitology 96, 171-193
22. WILLIAMS, J. C., KNOX, J. W., SHEEHAN, D. S. & FUSELIER, R. H. (1979) Activity of fenbendazole against inhibited early fourth-stage larvae of Ostertagia ostertagi. American Journal of Veterinary Research 40, 1087-1090
23. WILLIAMS, J. C., KNOX, J. W., BAUMANN, B. A., SNIDER, T. G. & HOERNER, T. J. (1981) Anthelmintic efficacy of albendazole against inhibited larvae of Ostertagia ostertagi. American Journal of Veterinary Research 42, 318-321
24. WOOD, I. B., AMARAL, N. K., BAIRDEN, K., DUNCAN, J. L., KASSAI, T., MALONE, J. B., Jr, PANKAVICH, J. A., REINECKE, R. K., SLOCOMBE, O. & TAYLOR, S. M. (1995) World Association for the Advancement of Veterinary Parasitology (WAAVP) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine). Veterinary Parasitology 58, 181-213