-
1
-
-
21344470873
-
Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells
-
Stettner MR, Wang W, Nabors LB, Bharara S, Flynn DC, Grammer JR et al. Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells. Cancer Res 2005; 65: 5535-5543.
-
(2005)
Cancer Res
, vol.65
, pp. 5535-5543
-
-
Stettner, M.R.1
Wang, W.2
Nabors, L.B.3
Bharara, S.4
Flynn, D.C.5
Grammer, J.R.6
-
2
-
-
60149089005
-
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
-
Du J, Bernasconi P, Clauser KR, Mani DR, Finn SP, Beroukhim R et al. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nat Biotechnol 2009; 27: 77-83.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 77-83
-
-
Du, J.1
Bernasconi, P.2
Clauser, K.R.3
Mani, D.R.4
Finn, S.P.5
Beroukhim, R.6
-
3
-
-
70149112112
-
Fyn and src are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients
-
Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D et al. Fyn and Src are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer Res 2009; 69: 6889-6898.
-
(2009)
Cancer Res
, vol.69
, pp. 6889-6898
-
-
Lu, K.V.1
Zhu, S.2
Cvrljevic, A.3
Huang, T.T.4
Sarkaria, S.5
Ahkavan, D.6
-
4
-
-
77957937844
-
Targeting src in glioblastoma tumors and brain metastases: Rationale and preclinical studies
-
Ahluwalia MS, de Groot J, Liu WM, Gladson CL. Targeting Src in glioblastoma tumors and brain metastases: rationale and preclinical studies. Cancer Lett 2010; 298: 139-149.
-
(2010)
Cancer Lett
, vol.298
, pp. 139-149
-
-
Ahluwalia, M.S.1
De Groot, J.2
Liu, W.M.3
Gladson, C.L.4
-
5
-
-
2942618768
-
A renaissance for SRC
-
Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004; 4: 470-480.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 470-480
-
-
Yeatman, T.J.1
-
6
-
-
15544389207
-
Novel insights into c-src
-
Alper O, Bowden ET. Novel insights into c-Src. Curr Pharm Des 2005; 11: 1119-1130.
-
(2005)
Curr Pharm des
, vol.11
, pp. 1119-1130
-
-
Alper, O.1
Bowden, E.T.2
-
7
-
-
0033522510
-
Src family kinases are required for integrin but not PDGFR signal transduction
-
Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 1999; 18: 2459-2471.
-
(1999)
EMBO J
, vol.18
, pp. 2459-2471
-
-
Klinghoffer, R.A.1
Sachsenmaier, C.2
Cooper, J.A.3
Soriano, P.4
-
8
-
-
0033175564
-
Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase src
-
Felsenfeld DP, Schwartzberg PL, Venegas A, Tse R, Sheetz MP. Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol 1999; 1: 200-206.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 200-206
-
-
Felsenfeld, D.P.1
Schwartzberg, P.L.2
Venegas, A.3
Tse, R.4
Sheetz, M.P.5
-
9
-
-
0034268796
-
Src tyrosine kinase is a novel directeffector of G proteins
-
Ma YC, Huang J, Ali S, Lowry W, Huang XY. Src tyrosine kinase is a novel directeffector of G proteins. Cell 2000; 102: 635-646.
-
(2000)
Cell
, vol.102
, pp. 635-646
-
-
Ma, Y.C.1
Huang, J.2
Ali, S.3
Lowry, W.4
Huang, X.Y.5
-
10
-
-
0035887309
-
Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase
-
Kubota Y, Tanaka T, Kitanaka A, Ohnishi H, Okutani Y, Waki M et al. Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase. EMBO J 2001; 20: 5666-5677.
-
(2001)
EMBO J
, vol.20
, pp. 5666-5677
-
-
Kubota, Y.1
Tanaka, T.2
Kitanaka, A.3
Ohnishi, H.4
Okutani, Y.5
Waki, M.6
-
11
-
-
0141668894
-
Rac1 function is required for src-induced transformation. Evidence of a role for tiam1 and vav2 in rac activation by src
-
Servitja JM, Marinissen MJ, Sodhi A, Bustelo XR, Gutkind JS. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem 2003; 278: 34339-34346.
-
(2003)
J Biol Chem
, vol.278
, pp. 34339-34346
-
-
Servitja, J.M.1
Marinissen, M.J.2
Sodhi, A.3
Bustelo, X.R.4
Gutkind, J.S.5
-
12
-
-
0033573921
-
Mechanism of biological synergy between cellular src and epidermal growth factor receptor
-
Tice DA, Biscardi JS, Nickles AL, Parsons SJ. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci USA 1999; 96: 1415-1420.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1415-1420
-
-
Tice, D.A.1
Biscardi, J.S.2
Nickles, A.L.3
Parsons, S.J.4
-
13
-
-
0037449766
-
STAT5b, a mediator of synergism between c-src and the epidermal growth factor receptor
-
Kloth MT, Laughlin KK, Biscardi JS, Boerner JL, Parsons SJ, Silva CM. STAT5b, a mediator of synergism between c-Src and the epidermal growth factor receptor. J Biol Chem 2003; 278: 1671-1679.
-
(2003)
J Biol Chem
, vol.278
, pp. 1671-1679
-
-
Kloth, M.T.1
Laughlin, K.K.2
Biscardi, J.S.3
Boerner, J.L.4
Parsons, S.J.5
Silva, C.M.6
-
14
-
-
34247340196
-
Urokinase receptor primes cells to proliferate in response to epidermal growth factor
-
Jo M, Thomas K, Takimoto S, Gaultier A, Hsieh E, Lester R et al. Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene 2007; 26: 2585-2594.
-
(2007)
Oncogene
, vol.26
, pp. 2585-2594
-
-
Jo, M.1
Thomas, K.2
Takimoto, S.3
Gaultier, A.4
Hsieh, E.5
Lester, R.6
-
15
-
-
80053135166
-
Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells
-
Hu J, Jo M, Cavenee WK, Furnari F, Vanden Berg SR, Gonias SL. Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci USA 2011; 108: 15984-15989.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 15984-15989
-
-
Hu, J.1
Jo, M.2
Cavenee, W.K.3
Furnari, F.4
Vanden Berg, S.R.5
Gonias, S.L.6
-
16
-
-
79952386422
-
Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of delta EGFR
-
Chumbalkar V, Latha K, Hwang Y, Maywald R, Hawley L, Sawaya R et al. Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of Delta EGFR. J Proteome Res 2011; 10: 1343-1352.
-
(2011)
J Proteome Res
, vol.10
, pp. 1343-1352
-
-
Chumbalkar, V.1
Latha, K.2
Hwang, Y.3
Maywald, R.4
Hawley, L.5
Sawaya, R.6
-
17
-
-
3543025709
-
Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II
-
Boerner JL, Demory ML, Silva C, Parsons SJ. Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II. Mol Cell Biol 2004; 24: 7059-7071.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7059-7071
-
-
Boerner, J.L.1
Demory, M.L.2
Silva, C.3
Parsons, S.J.4
-
18
-
-
0021932240
-
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
-
Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985; 313: 144-147.
-
(1985)
Nature
, vol.313
, pp. 144-147
-
-
Libermann, T.A.1
Nusbaum, H.R.2
Razon, N.3
Kris, R.4
Lax, I.5
Soreq, H.6
-
19
-
-
0028641258
-
Amplification and differential expression of members of the erbB-gene family in human glioblastoma
-
Schlegel J, Stumm G, Brandle K, Merdes A, Mechtersheimer G, Hynes NE et al. Amplification and differential expression of members of the erbB-gene family in human glioblastoma. J Neurooncol 1994; 22: 201-207.
-
(1994)
J Neurooncol
, vol.22
, pp. 201-207
-
-
Schlegel, J.1
Stumm, G.2
Brandle, K.3
Merdes, A.4
Mechtersheimer, G.5
Hynes, N.E.6
-
20
-
-
0028097815
-
Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma
-
Schlegel J, Merdes A, Stumm G, Albert FK, Forsting M, Hynes N et al. Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma. Int J Cancer 1994; 56: 72-77.
-
(1994)
Int J Cancer
, vol.56
, pp. 72-77
-
-
Schlegel, J.1
Merdes, A.2
Stumm, G.3
Albert, F.K.4
Forsting, M.5
Hynes, N.6
-
21
-
-
0025114687
-
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas
-
Sugawa N, Ekstrand AJ, James CD, Collins VP. Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 1990; 87: 8602-8606.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 8602-8606
-
-
Sugawa, N.1
Ekstrand, A.J.2
James, C.D.3
Collins, V.P.4
-
22
-
-
14444288522
-
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
-
Huang HS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 1997; 272: 2927-2935.
-
(1997)
J Biol Chem
, vol.272
, pp. 2927-2935
-
-
Huang, H.S.1
Nagane, M.2
Klingbeil, C.K.3
Lin, H.4
Nishikawa, R.5
Ji, X.D.6
-
23
-
-
0036906177
-
UPAR: A versatile signalling orchestrator
-
Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002; 3: 932-943.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 932-943
-
-
Blasi, F.1
Carmeliet, P.2
-
24
-
-
0036596352
-
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
-
Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 2002; 1: 445-457.
-
(2002)
Cancer Cell
, vol.1
, pp. 445-457
-
-
Liu, D.1
Aguirre Ghiso, J.2
Estrada, Y.3
Ossowski, L.4
-
25
-
-
0028925552
-
Urokinase plasminogen activator receptor, beta 2-integrins, and src-kinases within a single receptor complex of human monocytes
-
Bohuslav J, Horejsi V, Hansmann C, Stockl J, Weidle UH, Majdic O et al. Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes. J Exp Med 1995; 181: 1381-1390.
-
(1995)
J Exp Med
, vol.181
, pp. 1381-1390
-
-
Bohuslav, J.1
Horejsi, V.2
Hansmann, C.3
Stockl, J.4
Weidle, U.H.5
Majdic, O.6
-
26
-
-
0033566354
-
Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells
-
Degryse B, Resnati M, Rabbani SA, Villa A, Fazioli F, Blasi F. Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. Blood 1999; 94: 649-662.
-
(1999)
Blood
, vol.94
, pp. 649-662
-
-
Degryse, B.1
Resnati, M.2
Rabbani, S.A.3
Villa, A.4
Fazioli, F.5
Blasi, F.6
-
27
-
-
0034705424
-
Urokinase-type plasminogen activator stimulates the ras/Extracellular signalregulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, src, and shc. Rapid dissociation of GRB2/Sos-shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells
-
Nguyen DH, Webb DJ, Catling AD, Song Q, Dhakephalkar A, Weber MJ et al. Urokinase-type plasminogen activator stimulates the Ras/Extracellular signalregulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sos-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells. J Biol Chem 2000; 275: 19382-19388.
-
(2000)
J Biol Chem
, vol.275
, pp. 19382-19388
-
-
Nguyen, D.H.1
Webb, D.J.2
Catling, A.D.3
Song, Q.4
Dhakephalkar, A.5
Weber, M.J.6
-
28
-
-
50249145697
-
UPAR promotes formation of the p130Cas-crk complex to activate rac through DOCK180
-
Smith HW, Marra P, Marshall CJ. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol 2008; 182: 777-790.
-
(2008)
J Cell Biol
, vol.182
, pp. 777-790
-
-
Smith, H.W.1
Marra, P.2
Marshall, C.J.3
-
29
-
-
84870449601
-
Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas
-
Shi Z, Liu Y, Johnson JJ, Stack MS. Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas. Mol Cel Biochem 2011; 357: 151-161.
-
(2011)
Mol Cel Biochem
, vol.357
, pp. 151-161
-
-
Shi, Z.1
Liu, Y.2
Johnson, J.J.3
Stack, M.S.4
-
30
-
-
0028171075
-
Epidermal-growth-factor-dependent activation of the srcfamily kinases
-
Osherov N, Levitzki A. Epidermal-growth-factor-dependent activation of the srcfamily kinases. European Journal of Biochemistry/FEBS 1994; 225: 1047-1053.
-
(1994)
European Journal of Biochemistry/FEBS
, vol.225
, pp. 1047-1053
-
-
Osherov, N.1
Levitzki, A.2
-
31
-
-
0033525759
-
EGF receptor signaling stimulates src kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
-
Wilde A, Beattie EC, Lem L, Riethof DA, Liu SH, Mobley WC et al. EGF receptor signaling stimulates Src kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 1999; 96: 677-687.
-
(1999)
Cell
, vol.96
, pp. 677-687
-
-
Wilde, A.1
Beattie, E.C.2
Lem, L.3
Riethof, D.A.4
Liu, S.H.5
Mobley, W.C.6
-
32
-
-
0141544141
-
Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation
-
Cooper JA, MacAuley A. Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation. Proc Natl Acad Sci USA 1988; 85: 4232-4236.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 4232-4236
-
-
Cooper, J.A.1
MacAuley, A.2
-
33
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich JN, Reardon DA, Peery T, Dowell JM, Quinn JA, Penne KL et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 2004; 22: 133-142.
-
(2004)
J Clin Oncol
, vol.22
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
Dowell, J.M.4
Quinn, J.A.5
Penne, K.L.6
-
34
-
-
34247218483
-
Gefitinib in patients with progressive high-grade gliomas: A multicentre phase II study by gruppo Italiano cooperativo di neuro-oncologia (GICNO)
-
Franceschi E, Cavallo G, Lonardi S, Magrini E, Tosoni A, Grosso D et al. Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Br J Cancer 2007; 96: 1047-1051.
-
(2007)
Br J Cancer
, vol.96
, pp. 1047-1051
-
-
Franceschi, E.1
Cavallo, G.2
Lonardi, S.3
Magrini, E.4
Tosoni, A.5
Grosso, D.6
-
35
-
-
80052749324
-
Retrospective study of dasatinib for recurrent glioblastoma after bevacizumab failure
-
Lu-Emerson C, Norden AD, Drappatz J, Quant EC, Beroukhim R, Ciampa AS et al. Retrospective study of dasatinib for recurrent glioblastoma after bevacizumab failure. J Neurooncol 2011; 104: 287-291.
-
(2011)
J Neurooncol
, vol.104
, pp. 287-291
-
-
Lu-Emerson, C.1
Norden, A.D.2
Drappatz, J.3
Quant, E.C.4
Beroukhim, R.5
Ciampa, A.S.6
-
36
-
-
84874005713
-
Targeting src family kinases inhibits bevacizumab-induced glioma cell invasion
-
Huveldt D, Lewis-Tuffin LJ, Carlson BL, Schroeder MA, Rodriguez F, Giannini C et al. Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. PLoS ONE 2013; 8: e56505.
-
(2013)
PLoS ONE
, vol.8
, pp. e56505
-
-
Huveldt, D.1
Lewis-Tuffin, L.J.2
Carlson, B.L.3
Schroeder, M.A.4
Rodriguez, F.5
Giannini, C.6
-
37
-
-
0028146767
-
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
-
Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 1994; 91: 7727-7731.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7727-7731
-
-
Nishikawa, R.1
Ji, X.D.2
Harmon, R.C.3
Lazar, C.S.4
Gill, G.N.5
Cavenee, W.K.6
-
38
-
-
84878172399
-
Cellular functions regulated by phosphorylation of EGFR on tyr845
-
Sato K. Cellular functions regulated by phosphorylation of EGFR on Tyr845. Int J Mol Sci 2013; 14: 10761-10790.
-
(2013)
Int J Mol Sci
, vol.14
, pp. 10761-10790
-
-
Sato, K.1
-
39
-
-
0023649622
-
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
-
Piwnica-Worms H, Saunders KB, Roberts TM, Smith AE, Cheng SH. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell 1987; 49: 75-82.
-
(1987)
Cell
, vol.49
, pp. 75-82
-
-
Piwnica-Worms, H.1
Saunders, K.B.2
Roberts, T.M.3
Smith, A.E.4
Cheng, S.H.5
-
40
-
-
34147184365
-
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel
-
Sarkaria JN, Yang L, Grogan PT, Kitange GJ, Carlson BL, Schroeder MA et al. Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Mol Cancer Ther 2007; 6: 1167-1174.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1167-1174
-
-
Sarkaria, J.N.1
Yang, L.2
Grogan, P.T.3
Kitange, G.J.4
Carlson, B.L.5
Schroeder, M.A.6
-
41
-
-
0032566763
-
Quantum dot bioconjugates for ultrasensitive nonisotopic detection
-
Chan WC, Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998; 281: 2016-2018.
-
(1998)
Science
, vol.281
, pp. 2016-2018
-
-
Chan, W.C.1
Nie, S.2
-
42
-
-
77249101567
-
Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence
-
Mukasa A, Wykosky J, Ligon KL, Chin L, Cavenee WK, Furnari F. Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence. Proc Natl Acad Sci USA 2010; 107: 2616-2621.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 2616-2621
-
-
Mukasa, A.1
Wykosky, J.2
Ligon, K.L.3
Chin, L.4
Cavenee, W.K.5
Furnari, F.6
-
43
-
-
0033549558
-
Myosin light chain kinase functions downstream of ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrinselective manner
-
Nguyen D, Catling A, Webb D, Sankovic M, Walker L, Somlyo A et al. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrinselective manner. J Cell Biol 1999; 146: 149-164.
-
(1999)
J Cell Biol
, vol.146
, pp. 149-164
-
-
Nguyen, D.1
Catling, A.2
Webb, D.3
Sankovic, M.4
Walker, L.5
Somlyo, A.6
-
44
-
-
0035911966
-
Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin
-
Kjoller L, Hall A. Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol 2001; 152: 1145-1157.
-
(2001)
J Cell Biol
, vol.152
, pp. 1145-1157
-
-
Kjoller, L.1
Hall, A.2
-
45
-
-
0037164811
-
Regulation of rac1 activation by the low density lipoprotein receptor-related protein
-
Ma Z, Thomas KS, Webb DJ, Moravec R, Salicioni AM, Mars WM et al. Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol 2002; 159: 1061-1070.
-
(2002)
J Cell Biol
, vol.159
, pp. 1061-1070
-
-
Ma, Z.1
Thomas, K.S.2
Webb, D.J.3
Moravec, R.4
Salicioni, A.M.5
Mars, W.M.6
-
46
-
-
67649910151
-
The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice
-
Jo M, Takimoto S, Montel V, Gonias S. The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Amer J Pathol 2009; 175: 190-200.
-
(2009)
Amer J Pathol
, vol.175
, pp. 190-200
-
-
Jo, M.1
Takimoto, S.2
Montel, V.3
Gonias, S.4
-
47
-
-
84862650960
-
A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen
-
Eastman BM, Jo M, Webb DL, Takimoto S, Gonias SL. A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen. Cell Signal 2012; 24: 1847-1855.
-
(2012)
Cell Signal
, vol.24
, pp. 1847-1855
-
-
Eastman, B.M.1
Jo, M.2
Webb, D.L.3
Takimoto, S.4
Gonias, S.L.5
-
48
-
-
35949002429
-
Malignant astrocytic glioma: Genetics, biology, and paths to treatment
-
Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007; 21: 2683-2710.
-
(2007)
Genes Dev
, vol.21
, pp. 2683-2710
-
-
Furnari, F.B.1
Fenton, T.2
Bachoo, R.M.3
Mukasa, A.4
Stommel, J.M.5
Stegh, A.6
-
49
-
-
0029961912
-
A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis
-
Nagane M, Coufal F, Lin H, Bogler O, Cavenee WK, Huang HJ. A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. Cancer Res 1996; 56: 5079-5086.
-
(1996)
Cancer Res
, vol.56
, pp. 5079-5086
-
-
Nagane, M.1
Coufal, F.2
Lin, H.3
Bogler, O.4
Cavenee, W.K.5
Huang, H.J.6
-
50
-
-
0030027206
-
A common region of loss of heterozygosity in wilms' tumor and embryonal rhabdomyosarcoma distal to the D11S988 locus on chromosome 11p15.5
-
Besnard-Guerin C, Newsham I, Winqvist R, Cavenee WK. A common region of loss of heterozygosity in Wilms' tumor and embryonal rhabdomyosarcoma distal to the D11S988 locus on chromosome 11p15.5. Hum Genet 1996; 97: 163-170.
-
(1996)
Hum Genet
, vol.97
, pp. 163-170
-
-
Besnard-Guerin, C.1
Newsham, I.2
Winqvist, R.3
Cavenee, W.K.4
-
51
-
-
77955911497
-
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
-
Inda M, Bonavia R, Mukasa A, Narita Y, Sah D, Vandenberg S et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 2010; 24: 1731-1745.
-
(2010)
Genes Dev
, vol.24
, pp. 1731-1745
-
-
Inda, M.1
Bonavia, R.2
Mukasa, A.3
Narita, Y.4
Sah, D.5
Vandenberg, S.6
-
52
-
-
77953573187
-
Escape from targeted inhibition: The dark side of kinase inhibitor therapy
-
Wykosky J, Mukasa A, Furnari F, Cavenee WK. Escape from targeted inhibition: the dark side of kinase inhibitor therapy. Cell Cycle 2010; 9: 1661-1662.
-
(2010)
Cell Cycle
, vol.9
, pp. 1661-1662
-
-
Wykosky, J.1
Mukasa, A.2
Furnari, F.3
Cavenee, W.K.4
-
53
-
-
20444478292
-
Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator
-
Jo M, Thomas K, Marozkina N, Amin T, Silva C, Parsons S et al. Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem 2005; 280: 17449-17457.
-
(2005)
J Biol Chem
, vol.280
, pp. 17449-17457
-
-
Jo, M.1
Thomas, K.2
Marozkina, N.3
Amin, T.4
Silva, C.5
Parsons, S.6
-
54
-
-
0037461901
-
Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells
-
Chandrasekar N, Mohanam S, Gujrati M, Olivero WC, Dinh DH, Rao JS. Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells. Oncogene 2003; 22: 392-400.
-
(2003)
Oncogene
, vol.22
, pp. 392-400
-
-
Chandrasekar, N.1
Mohanam, S.2
Gujrati, M.3
Olivero, W.C.4
Dinh, D.H.5
Rao, J.S.6
-
55
-
-
84857916018
-
Targeting src family kinases in anti-cancer therapies: Turning promise into triumph
-
Zhang S, Yu D. Targeting Src family kinases in anti-cancer therapies: turning promise into triumph. Trends Pharmacol Sci 2012; 33: 122-128.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 122-128
-
-
Zhang, S.1
Yu, D.2
-
56
-
-
0002460807
-
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
-
Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999; 147: 89-104.
-
(1999)
J Cell Biol
, vol.147
, pp. 89-104
-
-
Aguirre Ghiso, J.A.1
Kovalski, K.2
Ossowski, L.3
-
57
-
-
80051703869
-
Regulation of cell migration and invasion by specific modules of uPA: Mechanistic insights and specific inhibitors
-
Carriero MV, Franco P, Votta G, Longanesi-Cattani I, Vento MT, Masucci MT et al. Regulation of cell migration and invasion by specific modules of uPA: mechanistic insights and specific inhibitors. Curr Drug Targets 2011; 12: 1761-1771.
-
(2011)
Curr Drug Targets
, vol.12
, pp. 1761-1771
-
-
Carriero, M.V.1
Franco, P.2
Votta, G.3
Longanesi-Cattani, I.4
Vento, M.T.5
Masucci, M.T.6
-
58
-
-
84873278736
-
UPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLFreceptors
-
Montuori N, Cosimato V, Rinaldi L, Rea VE, Alfano D, Ragno P. uPAR regulates pericellular proteolysis through a mechanism involving integrins and fMLFreceptors. Thromb Haemost 2013; 109: 309-318.
-
(2013)
Thromb Haemost
, vol.109
, pp. 309-318
-
-
Montuori, N.1
Cosimato, V.2
Rinaldi, L.3
Rea, V.E.4
Alfano, D.5
Ragno, P.6
-
59
-
-
0032698213
-
Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer
-
Carriero MV, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A et al. Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Res 1999; 59: 5307-5314.
-
(1999)
Cancer Res
, vol.59
, pp. 5307-5314
-
-
Carriero, M.V.1
Del Vecchio, S.2
Capozzoli, M.3
Franco, P.4
Fontana, L.5
Zannetti, A.6
-
60
-
-
0030956119
-
Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy
-
Yu W, Kim J, Ossowski L. Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy. J Cell Biol 1997; 137: 767-777.
-
(1997)
J Cell Biol
, vol.137
, pp. 767-777
-
-
Yu, W.1
Kim, J.2
Ossowski, L.3
-
61
-
-
0034782160
-
Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells
-
Ma Z, Webb D, Jo M, Gonias S. Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells. J Cell Sci 2001; 114: 3387-3396.
-
(2001)
J Cell Sci
, vol.114
, pp. 3387-3396
-
-
Ma, Z.1
Webb, D.2
Jo, M.3
Gonias, S.4
-
62
-
-
13844256438
-
The urokinase plasminogen activator and its receptor: Role in cell growth and apoptosis
-
Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A et al. The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb Haemost 2005; 93: 205-211.
-
(2005)
Thromb Haemost
, vol.93
, pp. 205-211
-
-
Alfano, D.1
Franco, P.2
Vocca, I.3
Gambi, N.4
Pisa, V.5
Mancini, A.6
-
63
-
-
33745841867
-
Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels
-
Alfano D, Iaccarino I, Stoppelli M. Urokinase signaling through its receptor protects against anoikis by increasing BCL-xL expression levels. J Biol Chem 2006; 281: 17758-17767.
-
(2006)
J Biol Chem
, vol.281
, pp. 17758-17767
-
-
Alfano, D.1
Iaccarino, I.2
Stoppelli, M.3
-
64
-
-
0027426213
-
Cellular receptor for urokinase-type plasminogen activator: Function in cell-surface proteolysis
-
Ellis V, Behrendt N, Dano K. Cellular receptor for urokinase-type plasminogen activator: function in cell-surface proteolysis. Methods Enzymol 1993; 223: 223-233.
-
(1993)
Methods Enzymol
, vol.223
, pp. 223-233
-
-
Ellis, V.1
Behrendt, N.2
Dano, K.3
-
65
-
-
84880679702
-
Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma
-
Parker JJ, Dionne KR, Massarwa R, Klaassen M, Foreman NK, Niswander L et al. Gefitinib selectively inhibits tumor cell migration in EGFR-amplified human glioblastoma. Neuro Oncol 2013; 15: 1048-1057.
-
(2013)
Neuro Oncol
, vol.15
, pp. 1048-1057
-
-
Parker, J.J.1
Dionne, K.R.2
Massarwa, R.3
Klaassen, M.4
Foreman, N.K.5
Niswander, L.6
-
66
-
-
80051697374
-
Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic
-
Mazar AP, Ahn RW, O'Halloran TV. Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic. Curr Pharm Des 2011; 17: 1970-1978.
-
(2011)
Curr Pharm des
, vol.17
, pp. 1970-1978
-
-
Mazar, A.P.1
Ahn, R.W.2
O'Halloran, T.V.3
-
67
-
-
69249111313
-
Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling
-
Jo M, Lester R, Montel V, Eastman B, Takimoto S, Gonias S. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem 2009; 284: 22825-22833.
-
(2009)
J Biol Chem
, vol.284
, pp. 22825-22833
-
-
Jo, M.1
Lester, R.2
Montel, V.3
Eastman, B.4
Takimoto, S.5
Gonias, S.6
|