Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells

Journal of Cell Science

Volumn 114, Issue 18, 2001, Pages 3387-3396

  Ma, Z ^a   Webb, D J ^a   Jo, M ^a   Gonias, S L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Apoptosis; Breast cancer; MAP kinase extracellular signal regulated kinase; uPAR; Urokinase type plasminogen activator

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTIBODY; ANTISENSE OLIGODEOXYNUCLEOTIDE; CASPASE 3; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; UROKINASE; UROKINASE RECEPTOR;

ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOSOME; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; CULTURE MEDIA, CONDITIONED; DISEASE PROGRESSION; FEMALE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0034782160     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
2. The urokinase-type plasminogen activator system in cancer metastasis: A review
3. Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-uPAR-PAI-1 system
4. Cell survival promoted by the ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
5. Role of urokinase receptor and caveolin in regulation of integrin signaling
6. Extracellular signal-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix
7. IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells
8. Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin
9. Urokinase antisense oligodeoxynucleotides as a novel therapeutic agent for malignant glioma: In vitro and in vivo studies of uptake, effects, and toxicity
10. Endogenous FGF1-induced activation and synthesis of extracellular signal-regulated kinase II reduce cell apoptosis in retinal-pigmented epithelial cells
11. Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex
12. Defining apoptosis
13. Urokinase-type plasminogen activator in three human breast cancer cell lines correlates with their in vitro invasiveness
14. Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells
15. Induction of vascular SMC proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disorders
16. A novel role for the urokinase-type plasminogen activator receptor in apoptosis of malignant gliomas
17. Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction
18. 2-macroglobulin receptor mediates cellular uptake of pro-urokinase
19. Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade
20. Inhibition of urokinase synthesis and cell surface binding alters the motile behavior of embryonic endocardial-derived mesenchymal cells in vitro
21. Non-enzymatic interactions between proteinases and the cell surface: Novel roles in normal and malignant cell physiology
22. Differential expression and mutation of the ras family genes in human breast cancer
23. 1 cells down-regulated for protein kinase C
24. Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility
25. Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
26. Ras proteins: Recent advances and new functions
27. Mitogen-activated protein kinase regulates the expression of progelatinase B (MMP-9) in breast epithelial cells
28. Incidents of activating ras oncogene mutations associated with primary and metastatic human breast cancer
29. ERK signaling in metastatic human MDA-MB-231 breast carcinoma cells is adapted to obtain high urokinase expression and rapid cell proliferation
30. ras in human breast cancers: Evidence for the existence of distinctive patterns of genetic evolution that are common to patients
31. Effect of PD098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion
32. Hyperexpression of mitogen-activated protein kinase in human breast cancer
33. Correlations among p53, her-2/neu and ras overexpression and aneuploidy by multiparameter flow cytometry in human breast cancer: Evidence for a common phenotypic evolutionary pattern in infiltrating ductal carcinomas
34. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
35. Analysis of ras-dependent signals that prevent caspase-3 activation in apoptosis induced by cytokine deprivation in hematopoietic cells
36. The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro
37. Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and Matrigel invasion
38. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
39. Reduction in surface urokinase receptor forces malignant cells into a protracted state of dormancy