Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase

EMBO Journal

Volumn 20, Issue 20, 2001, Pages 5666-5677

  Kubota, Yoshitsugu ^a   Tanaka, Terukazu ^a   Kitanaka, Akira ^a   Ohnishi, Hiroaki ^a   Okutani, Yuichi ^a   Waki, Masato ^a   Ishida, Toshihiko ^a   Kamano, Hiroshi ^b  

^a KAGAWA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Erythroid differentiation; Erythropoietin; Phosphatidylinositol 3 kinase; Signal transduction; Src

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ERYTHROPOIETIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CERCOPITHECUS AETHIOPS; CHROMONES; COLONY-FORMING UNITS ASSAY; COS CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; ERYTHROID PROGENITOR CELLS; ERYTHROPOIETIN; ERYTHROPOIETIN, RECOMBINANT; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, SRC; HUMANS; K562 CELLS; MACROMOLECULAR SUBSTANCES; MORPHOLINES; NEOPLASM PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RECEPTORS, ERYTHROPOIETIN; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; TRANSFECTION;

EID: 0035887309     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.20.5666     Document Type: Article

References (39)

1. Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
2. Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: A parental line requiring granulocyte-macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin
3. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the stat5 pathway
4. The when and how of Src regulation
5. Phosphatidylinositol 3-kinase associates, via its src homology 2 domains, with the activated erythropoietin receptor
6. Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the p85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI3-kinase activity
7. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation
8. Physical and functional interaction between p72(syk) and erythropoietin receptor
9. PDGFα- and β-receptors activate unique and common signal transduction pathways
10. Phosphoinositide kinases
11. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
12. Erythropoietin induces tyrosine phosphorylation and kinase activity of the c-fps/fes proto-oncogene product in human erythropoietin-responsive cells
13. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
14. Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain
15. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
16. The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line
17. Antisense src expression inhibits proliferation and erythropoietin-induced erythroid differentiation of K562 human leukemia cells
18. Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells
19. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
20. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
21. Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells
22. Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
23. v-Src SH3 domain binds phosphatidylinositol 3-kinase
24. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain
25. Erythropoietin-dependent association of phosphatidylinositol 3-kinase with tyrosine-phosphorylated erythropoietin receptor
26. Erythropoietin induces association of the Jak2 protein tyrosine kinase with the erythropoietin receptor in vivo
27. Src directly tyrosine phosphorylates STAT5 on its activation site and is involved in erythropoietin-induced signaling pathway
28. src
29. Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
30. SH2 domains recognize specific phosphopeptide sequences
31. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
32. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
33. Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol 3-kinase in interleukin-2-dependent T-cells
34. Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells
35. Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn
36. Cancer genes and hematopoiesis
37. Jak2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
38. src substrate
39. Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: Identification of potential binding sites