Urokinase-type plasminogen activator stimulates the ras/extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of Grb2/Sos-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells

Journal of Biological Chemistry

Volumn 275, Issue 25, 2000, Pages 19382-19388

  Nguyen, Diem H D ^a   Webb, Donna J ^a   Catling, Andrew D ^a   Song, Qian ^a   Dhakephalkar, Anita ^a   Weber, Michael J ^a   Ravichandran, Kodimangalam S ^a   Gonias, Steven L ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; UROKINASE;

ARTICLE; CELL MIGRATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; CELL MOVEMENT; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GRB2 ADAPTOR PROTEIN; HUMANS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS PP60(C-SRC); TUMOR CELLS, CULTURED; URINARY PLASMINOGEN ACTIVATOR;

EID: 0034705424     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M909575199     Document Type: Article

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