Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas

Molecular and Cellular Biochemistry

Volumn 357, Issue 1-2, 2011, Pages 151-161

  Shi, Zonggao ^a   Liu, Yueying ^a   Johnson, Jeffrey J ^a   Stack, M Sharon ^a  

^a University of Missouri   (United States)

Author keywords

Carcinoma of oral cavity; Metastasis; P130cas; Paxillin; UPAR; Urinary type plasminogen activator receptor

Indexed keywords

CRK ASSOCIATED SUBSTRATE PROTEIN; KALININ; PAXILLIN; PROTEIN CDC42; PROTEIN KINASE P60; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; URINARY TYPE UROKINASE RECEPTOR; UROKINASE RECEPTOR; BCAR1 PROTEIN, HUMAN; INTEGRIN;

ARTICLE; CANCER CELL; CANCER INVASION; CARCINOGENICITY; CELL ADHESION; CELL MOTILITY; FOCAL ADHESION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR MECHANICS; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; TISSUE MICROARRAY; VECTOR CONTROL; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; LYMPH NODE; METABOLISM; METASTASIS; MOUTH TUMOR; PATHOLOGY; PROTEIN MICROARRAY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CRK-ASSOCIATED SUBSTRATE PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRINS; LYMPH NODES; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROTEIN ARRAY ANALYSIS; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; SIGNAL TRANSDUCTION;

EID: 84870449601     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0885-3     Document Type: Article

References (43)

1. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74-108 (Pubitemid 40372904)
2. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60(5):277-300
3. Gorsky M, Epstein JB, Oakley C, Le ND, Hay J, StevensonMoore P (2004) Carcinoma of the tongue: a case series analysis of clinical presentation, risk factors, staging, and outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98(5):546-552 (Pubitemid 39505024)
4. Shiboski CH, Schmidt BL, Jordan RC (2005) Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years. Cancer 103(9):1843-1849 (Pubitemid 40563256)
5. Zhen W, Karnell LH, Hoffman HT, Funk GF, Buatti JM, Menck HR (2004) The National Cancer Data Base report on squamous cell carcinoma of the base of tongue. Head Neck 26(8):660-674 (Pubitemid 39014630)
6. Sano D, Myers JN (2007) Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev 26(3-4):645-662 (Pubitemid 350115112)
7. Macfarlane GJ, Boyle P, Evstifeeva TV, Robertson C, Scully C (1994) Rising trends of oral cancer mortality among males worldwide: the return of an old public health problem. Cancer Causes Control 5(3):259-265 (Pubitemid 24186016)
8. Blasi F, Carmeliet P (2002) uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 3(12):932-943 (Pubitemid 35477371)
9. Shi Z, Stack MS (2007) Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity. Biochem J 407(2):153-159 (Pubitemid 47556980)
10. Lindberg P, Larsson A, Nielsen BS (2006) Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma. Int J Cancer 118(12):2948-2956
11. Nozaki S, Endo Y, Kawashiri S, Nakagawa K, Yamamoto E, Yonemura Y, Sasaki T (1998) Immunohistochemical localization of a urokinase-type plasminogen activator system in squamous cell carcinoma of the oral cavity: association with mode of invasion and lymph node metastasis. Oral Oncol 34(1):58-62 (Pubitemid 28210532)
12. Yasuda T, Sakata Y, Kitamura K, Morita M, Ishida T (1997) Localization of plasminogen activators and their inhibitor in squamous cell carcinomas of the head and neck. Head Neck 19(7):611-616 (Pubitemid 27407316)
13. Hundsdorfer B, Zeilhofer HF, Bock KP, Dettmar P, Schmitt M, Kolk A, Pautke C, Horch HH (2005) Tumour-associated urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in normal and neoplastic tissues of patients with squamous cell cancer of the oral cavity - clinical relevance and prognostic value. J Craniomaxillofac Surg 33(3):191-196 (Pubitemid 40614180)
14. Hillig T, Engelholm LH, Ingvarsen S, Madsen DH, Gardsvoll H, Larsen JK, Ploug M, Dano K, Kjoller L, Behrendt N (2008) A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor. J Biol Chem 283(22):15217-15223
15. Tang CH, Wei Y (2008) The urokinase receptor and integrins in cancer progression. Cell Mol Life Sci 65(12):1916-1932
16. Ghosh S, Brown R, Jones JC, Ellerbroek SM, Stack MS (2000) Urinary-type plasminogen activator (uPA) expression and uPA receptor localization are regulated by alpha 3beta 1 integrin in oral keratinocytes. J Biol Chem 275(31):23869-23876 (Pubitemid 30624674)
17. Ghosh S, Johnson JJ, Sen R, Mukhopadhyay S, Liu Y, Zhang F, Wei Y, Chapman HA, Stack MS (2006) Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem 281(19):13021-13029 (Pubitemid 43855211)
18. Ghosh S, Munshi HG, Sen R, Linz-McGillem LA, Goldman RD, Lorch J, Green KJ, Jones JC, Stack MS (2002) Loss of adhesion-regulated proteinase production is correlated with invasive activity in oral squamous cell carcinoma. Cancer 95(12): 2524-2533 (Pubitemid 35424038)
19. Ghosh S, Koblinski J, Johnson J, Liu Y, Ericsson A, Davis JW, Shi Z, Ravosa MJ, Crawford S, Frazier S, Stack MS (2010) Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression. Mol Cancer Res 8(2):145-158
20. Lyons AJ, Jones J (2007) Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma. Int J Oral Maxillofac Surg 36(8):671-679 (Pubitemid 47091508)
21. Baker SE, Hopkinson SB, Fitchmun M, Andreason GL, Frasier F, Plopper G, Quaranta V, Jones JC (1996) Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. J Cell Sci 109(Pt 10):2509-2520 (Pubitemid 26377526)
22. Wei Y, Eble JA, Wang Z, Kreidberg JA, Chapman HA (2001) Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Mol Biol Cell 12(10): 2975-2986 (Pubitemid 33062955)
23. Chen CS, Alonso JL, Ostuni E, Whitesides GM, Ingber DE (2003) Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun 307(2):355-361 (Pubitemid 36818878)
24. DeMali KA, Wennerberg K, Burridge K (2003) Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol 15(5):572-582 (Pubitemid 37176966)
25. Wozniak MA, Modzelewska K, Kwong L, Keely PJ (2004) Focal adhesion regulation of cell behavior. Biochim Biophys Acta 1692(2-3):103-119 (Pubitemid 38891769)
26. Zamir E, Geiger B (2001) Molecular complexity and dynamics of cell-matrix adhesions. J Cell Sci 114(Pt 20):3583-3590 (Pubitemid 33041040)
27. Petit V, Boyer B, Lentz D, Turner CE, Thiery JP, Valles AM (2000) Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol 148(5):957-970
28. Brown MC, Turner CE (2004) Paxillin: adapting to change. Physiol Rev 84(4):1315-1339 (Pubitemid 39287952)
29. Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF (2004) FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 6(2):154-161 (Pubitemid 38425715)
30. Zhao J, Guan JL (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28(1-2):35-49
31. Heasman SJ, Ridley AJ (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9(9):690-701
32. D'Alessio S, Blasi F (2009) The urokinase receptor as an entertainer of signal transduction. Front Biosci 14:4575-4587
33. Madsen CD, Ferraris GM, Andolfo A, Cunningham O, Sidenius N (2007) uPAR-induced cell adhesion and migration: vitronectin provides the key. J Cell Biol 177(5):927-939 (Pubitemid 46873097)
34. Ossowski L, Aguirre-Ghiso JA (2000) Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol 12(5):613-620
35. Liang X, Yang X, Tang Y, Zhou H, Liu X, Xiao L, Gao J, Mao Z (2008) RNAi-mediated downregulation of urokinase plasminogen activator receptor inhibits proliferation, adhesion, migration and invasion in oral cancer cells. Oral Oncol 44(12):1172-1180
36. Yano H, Uchida H, Iwasaki T, Mukai M, Akedo H, Nakamura K, Hashimoto S, Sabe H (2000) Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation. Proc Natl Acad Sci USA 97(16):9076-9081 (Pubitemid 30626676)
37. Nakamura K, Yano H, Uchida H, Hashimoto S, Schaefer E, Sabe H (2000) Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells. J Biol Chem 275(35):27155-27164
38. Deakin NO, Turner CE (2008) Paxillin comes of age. J Cell Sci 121(Pt 15):2435-2444
39. Panetti TS (2002) Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Front Biosci 7:d143-d150
40. Kjoller L, Hall A (2001) Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol 152(6):1145-1157 (Pubitemid 34280173)
41. Choma DP, Milano V, Pumiglia KM, DiPersio CM (2007) Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5. J Invest Dermatol 127(1):31-40 (Pubitemid 46005658)
42. Smith HW, Marra P, Marshall CJ (2008) uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol 182(4):777-790
43. Jo M, Takimoto S, Montel V, Gonias SL (2009) The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol 175(1):190-200