메뉴 건너뛰기




Volumn 34, Issue 28, 2015, Pages 3617-3626

Mechanism-based cancer therapy: Resistance to therapy, therapy for resistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BAFETINIB; BOSUTINIB; CD135 ANTIGEN; CETUXIMAB; CRIZOTINIB; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; EVEROLIMUS; FIBROBLAST GROWTH FACTOR RECEPTOR; IMATINIB; INTERLEUKIN 6 ANTIBODY; JANUS KINASE; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; NILOTINIB; PANITUMUMAB; PF 0029980; PHOSPHATIDYLINOSITOL 3 KINASE; PONATINIB; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; TAMOXIFEN; TRASTUZUMAB; TUMOR MARKER; UNCLASSIFIED DRUG; VEMURAFENIB;

EID: 84938367162     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.314     Document Type: Article
Times cited : (204)

References (129)
  • 1
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 2
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
    • Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 2012; 486: 346-352.
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1    Shah, S.P.2    Chin, S.F.3    Turashvili, G.4    Rueda, O.M.5    Dunning, M.J.6
  • 4
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012; 486: 395-399.
    • (2012) Nature , vol.486 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3    Oloumi, A.4    Ha, G.5    Zhao, Y.6
  • 7
    • 79953271634 scopus 로고    scopus 로고
    • The evolving war on cancer
    • Haber DA, Gray NS, Baselga J. The evolving war on cancer. Cell 2011; 145: 19-24.
    • (2011) Cell , vol.145 , pp. 19-24
    • Haber, D.A.1    Gray, N.S.2    Baselga, J.3
  • 8
    • 80053508297 scopus 로고    scopus 로고
    • A blueprint for advancing genetics-based cancer therapy
    • Sellers WR. A blueprint for advancing genetics-based cancer therapy. Cell 2011; 147: 26-31.
    • (2011) Cell , vol.147 , pp. 26-31
    • Sellers, W.R.1
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 37149028451 scopus 로고    scopus 로고
    • Tamoxifen: Catalyst for the change to targeted therapy
    • Jordan VC. Tamoxifen: Catalyst for the change to targeted therapy. Eur J Cancer 2008; 44: 30-38.
    • (2008) Eur J Cancer , vol.44 , pp. 30-38
    • Jordan, V.C.1
  • 13
    • 0017046748 scopus 로고
    • Antiestrogenic and antitumor properties of tamoxifen in laboratory animals
    • Jordan VC. Antiestrogenic and antitumor properties of tamoxifen in laboratory animals. Cancer Treat Rep 1976; 60: 1409-1419.
    • (1976) Cancer Treat Rep , vol.60 , pp. 1409-1419
    • Jordan, V.C.1
  • 14
    • 0016736721 scopus 로고
    • The effect of synthetic anti-oestrogens on the growth and biochemistry of rat mammary tumours
    • Nicholson RI, Golder MP. The effect of synthetic anti-oestrogens on the growth and biochemistry of rat mammary tumours. Eur J Cancer 1975; 11: 571-579.
    • (1975) Eur J Cancer , vol.11 , pp. 571-579
    • Nicholson, R.I.1    Golder, M.P.2
  • 15
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative G. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005; 365: 1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 17
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, Druker BJ, Branford S, Foroni L et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23: 1054-1061.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3    Druker, B.J.4    Branford, S.5    Foroni, L.6
  • 18
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3    Gathmann, I.4    Baccarani, M.5    Cervantes, F.6
  • 23
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-792.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3    Fuchs, H.4    Paton, V.5    Bajamonde, A.6
  • 24
    • 34249723218 scopus 로고    scopus 로고
    • Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer
    • Galizia G, Lieto E, De Vita F, Orditura M, Castellano P, Troiani T et al. Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer. Oncogene 2007; 26: 3654-3660.
    • (2007) Oncogene , vol.26 , pp. 3654-3660
    • Galizia, G.1    Lieto, E.2    De Vita, F.3    Orditura, M.4    Castellano, P.5    Troiani, T.6
  • 26
    • 0037561111 scopus 로고    scopus 로고
    • Inhibitors of epidermal-growth-factor receptors: A review of clinical research with a focus on non-small-cell lung cancer
    • Sridhar SS, Seymour L, Shepherd FA. Inhibitors of epidermal-growth-factor receptors: A review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol 2003; 4: 397-406.
    • (2003) Lancet Oncol , vol.4 , pp. 397-406
    • Sridhar, S.S.1    Seymour, L.2    Shepherd, F.A.3
  • 29
    • 84858439267 scopus 로고    scopus 로고
    • Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis
    • Yauch RL, Settleman J. Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis. Curr Opin Genet Dev 2012; 22: 45-49.
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 45-49
    • Yauch, R.L.1    Settleman, J.2
  • 32
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer 2009; 9: 550-562.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 33
    • 80755127903 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol 3-kinase pathway: Role in tumor progression and therapeutic implications in breast cancer
    • Miller TW, Rexer BN, Garrett JT, Arteaga CL. Mutations in the phosphatidylinositol 3-kinase pathway: Role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res 2011; 13: 224.
    • (2011) Breast Cancer Res , vol.13 , pp. 224
    • Miller, T.W.1    Rexer, B.N.2    Garrett, J.T.3    Arteaga, C.L.4
  • 34
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: Lessons learned from early clinical trials
    • Rodon J, Dienstmann R, Serra V, Tabernero J. Development of PI3K inhibitors: Lessons learned from early clinical trials. Nat Rev Clin Oncol 2013; 10: 143-153.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3    Tabernero, J.4
  • 35
    • 84863697538 scopus 로고    scopus 로고
    • The BOLERO-2 trial: The addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer
    • Beaver JA, Park BH. The BOLERO-2 trial: The addition of everolimus to exemestane in the treatment of postmenopausal hormone receptor-positive advanced breast cancer. Future Oncol 2012; 8: 651-657.
    • (2012) Future Oncol , vol.8 , pp. 651-657
    • Beaver, J.A.1    Park, B.H.2
  • 36
    • 84879446651 scopus 로고    scopus 로고
    • Everolimus in combination with exemestane: A review of its use in the treatment of patients with postmenopausal hormone receptor-positive HER2-negative advanced breast cancer
    • Dhillon S. Everolimus in combination with exemestane: A review of its use in the treatment of patients with postmenopausal hormone receptor-positive, HER2-negative advanced breast cancer. Drugs 2013; 73: 475-485.
    • (2013) Drugs , vol.73 , pp. 475-485
    • Dhillon, S.1
  • 37
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, Burris HA III, Rugo HS, Sahmoud T et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366: 520-529.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3    Burris, H.A.4    Rugo, H.S.5    Sahmoud, T.6
  • 38
    • 84857823194 scopus 로고    scopus 로고
    • Mechanisms and novel approaches in overriding tyrosine kinase inhibitor resistance in chronic myeloid leukemia
    • Karvela M, Helgason GV, Holyoake TL. Mechanisms and novel approaches in overriding tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Expert Review Anticancer Ther 2012; 12: 381-392.
    • (2012) Expert Review Anticancer Ther , vol.12 , pp. 381-392
    • Karvela, M.1    Helgason, G.V.2    Holyoake, T.L.3
  • 39
    • 0348140591 scopus 로고    scopus 로고
    • Mechanisms and implications of imatinib resistance mutations in BCR-ABL
    • Nardi V, Azam M, Daley GQ. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol 2004; 11: 35-43.
    • (2004) Curr Opin Hematol , vol.11 , pp. 35-43
    • Nardi, V.1    Azam, M.2    Daley, G.Q.3
  • 40
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCRABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J et al. Multiple BCRABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2002; 2: 117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5    Kuriyan, J.6
  • 41
    • 84875880394 scopus 로고    scopus 로고
    • Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib
    • Quintas-Cardama A, Jabbour EJ. Considerations for early switch to nilotinib or dasatinib in patients with chronic myeloid leukemia with inadequate response to first-line imatinib. Leukemia Res 2013; 37: 487-495.
    • (2013) Leukemia Res , vol.37 , pp. 487-495
    • Quintas-Cardama, A.1    Jabbour, E.J.2
  • 42
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2: E73.
    • (2005) PLoS Med , vol.2 , pp. e73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 43
    • 4644240387 scopus 로고    scopus 로고
    • Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia
    • Cools J, Mentens N, Furet P, Fabbro D, Clark JJ, Griffin JD et al. Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia. Cancer Res 2004; 64: 6385-6389.
    • (2004) Cancer Res , vol.64 , pp. 6385-6389
    • Cools, J.1    Mentens, N.2    Furet, P.3    Fabbro, D.4    Clark, J.J.5    Griffin, J.D.6
  • 44
    • 2642558897 scopus 로고    scopus 로고
    • Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors
    • Blencke S, Zech B, Engkvist O, Greff Z, Orfi L, Horvath Z et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol 2004; 11: 691-701.
    • (2004) Chem Biol , vol.11 , pp. 691-701
    • Blencke, S.1    Zech, B.2    Engkvist, O.3    Greff, Z.4    Orfi, L.5    Horvath, Z.6
  • 45
    • 69949151386 scopus 로고    scopus 로고
    • Factors underlying sensitivity of cancers to smallmolecule kinase inhibitors
    • Janne PA, Gray N, Settleman J. Factors underlying sensitivity of cancers to smallmolecule kinase inhibitors. Nat Rev Drug Discov 2009; 8: 709-723.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 709-723
    • Janne, P.A.1    Gray, N.2    Settleman, J.3
  • 47
    • 77951643141 scopus 로고    scopus 로고
    • Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
    • Ercan D, Zejnullahu K, Yonesaka K, Xiao Y, Capelletti M, Rogers A et al. Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene 2010; 29: 2346-2356.
    • (2010) Oncogene , vol.29 , pp. 2346-2356
    • Ercan, D.1    Zejnullahu, K.2    Yonesaka, K.3    Xiao, Y.4    Capelletti, M.5    Rogers, A.6
  • 49
    • 78649436372 scopus 로고    scopus 로고
    • BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation
    • Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci Signal 2010; 3: Ra84.
    • (2010) Sci Signal , vol.3 , pp. 84
    • Corcoran, R.B.1    Dias-Santagata, D.2    Bergethon, K.3    Iafrate, A.J.4    Settleman, J.5    Engelman, J.A.6
  • 50
    • 84895788887 scopus 로고    scopus 로고
    • Trastuzumab or lapatinib with standard chemotherapy for HER2-positive breast cancer: Results from the GEICAM/2006-14 trial
    • Alba E, Albanell J, De La Haba J, Barnadas A, Calvo L, Sanchez-Rovira P et al. Trastuzumab or lapatinib with standard chemotherapy for HER2-positive breast cancer: Results from the GEICAM/2006-14 trial. Br J Cancer 2014; 110: 1139-1147.
    • (2014) Br J Cancer , vol.110 , pp. 1139-1147
    • Alba, E.1    Albanell, J.2    De La Haba, J.3    Barnadas, A.4    Calvo, L.5    Sanchez-Rovira, P.6
  • 51
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Practice Oncol 2006; 3: 269-280.
    • (2006) Nat Clin Practice Oncol , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 52
    • 84871713793 scopus 로고    scopus 로고
    • Efficacy of HER2-targeted therapy in metastatic breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors
    • Nielsen DL, Kumler I, Palshof JA, Andersson M. Efficacy of HER2-targeted therapy in metastatic breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors. Breast 2013; 22: 1-12.
    • (2013) Breast , vol.22 , pp. 1-12
    • Nielsen, D.L.1    Kumler, I.2    Palshof, J.A.3    Andersson, M.4
  • 53
    • 5144226211 scopus 로고    scopus 로고
    • PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
    • Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004; 6: 117-127.
    • (2004) Cancer Cell , vol.6 , pp. 117-127
    • Nagata, Y.1    Lan, K.H.2    Zhou, X.3    Tan, M.4    Esteva, F.J.5    Sahin, A.A.6
  • 54
    • 84871238855 scopus 로고    scopus 로고
    • Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer
    • Chandarlapaty S, Sakr RA, Giri D, Patil S, Heguy A, Morrow M et al. Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer. Clin Cancer Res 2012; 18: 6784-6791.
    • (2012) Clin Cancer Res , vol.18 , pp. 6784-6791
    • Chandarlapaty, S.1    Sakr, R.A.2    Giri, D.3    Patil, S.4    Heguy, A.5    Morrow, M.6
  • 55
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer
    • Esteva FJ, Guo H, Zhang S, Santa-Maria C, Stone S, Lanchbury JS et al. PTEN, PIK3CA, p-AKT, and p-p70S6K status: Association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol 2010; 177: 1647-1656.
    • (2010) Am J Pathol , vol.177 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3    Santa-Maria, C.4    Stone, S.5    Lanchbury, J.S.6
  • 56
    • 35148885729 scopus 로고    scopus 로고
    • A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
    • Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007; 12: 395-402.
    • (2007) Cancer Cell , vol.12 , pp. 395-402
    • Berns, K.1    Horlings, H.M.2    Hennessy, B.T.3    Madiredjo, M.4    Hijmans, E.M.5    Beelen, K.6
  • 57
    • 56449111358 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
    • Eichhorn PJ, Gili M, Scaltriti M, Serra V, Guzman M, Nijkamp W et al. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res 2008; 68: 9221-9230.
    • (2008) Cancer Res , vol.68 , pp. 9221-9230
    • Eichhorn, P.J.1    Gili, M.2    Scaltriti, M.3    Serra, V.4    Guzman, M.5    Nijkamp, W.6
  • 58
    • 84859627290 scopus 로고    scopus 로고
    • Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas
    • Gallardo A, Lerma E, Escuin D, Tibau A, Munoz J, Ojeda B et al. Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas. Br J Cancer 2012; 106: 1367-1373.
    • (2012) Br J Cancer , vol.106 , pp. 1367-1373
    • Gallardo, A.1    Lerma, E.2    Escuin, D.3    Tibau, A.4    Munoz, J.5    Ojeda, B.6
  • 59
    • 79958765919 scopus 로고    scopus 로고
    • PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
    • Wang L, Zhang Q, Zhang J, Sun S, Guo H, Jia Z et al. PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib. BMC Cancer 2011; 11: 248.
    • (2011) BMC Cancer , vol.11 , pp. 248
    • Wang, L.1    Zhang, Q.2    Zhang, J.3    Sun, S.4    Guo, H.5    Jia, Z.6
  • 60
    • 51849111524 scopus 로고    scopus 로고
    • NVPBEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
    • Serra V, Markman B, Scaltriti M, Eichhorn PJ, Valero V, Guzman M et al. NVPBEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 2008; 68: 8022-8030.
    • (2008) Cancer Res , vol.68 , pp. 8022-8030
    • Serra, V.1    Markman, B.2    Scaltriti, M.3    Eichhorn, P.J.4    Valero, V.5    Guzman, M.6
  • 61
    • 35348917266 scopus 로고    scopus 로고
    • Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency
    • Lu CH, Wyszomierski SL, Tseng LM, Sun MH, Lan KH, Neal CL et al. Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Clin Cancer Res 2007; 13: 5883-5888.
    • (2007) Clin Cancer Res , vol.13 , pp. 5883-5888
    • Lu, C.H.1    Wyszomierski, S.L.2    Tseng, L.M.3    Sun, M.H.4    Lan, K.H.5    Neal, C.L.6
  • 62
    • 78650984926 scopus 로고    scopus 로고
    • Phase i study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
    • Andre F, Campone M, O'Regan R, Manlius C, Massacesi C, Sahmoud T et al. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 2010; 28: 5110-5115.
    • (2010) J Clin Oncol , vol.28 , pp. 5110-5115
    • Andre, F.1    Campone, M.2    O'Regan, R.3    Manlius, C.4    Massacesi, C.5    Sahmoud, T.6
  • 63
    • 84860389569 scopus 로고    scopus 로고
    • Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo
    • Barok M, Tanner M, Koninki K, Isola J. Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo. Breast Cancer Res 2011; 13: R46.
    • (2011) Breast Cancer Res , vol.13 , pp. 46
    • Barok, M.1    Tanner, M.2    Koninki, K.3    Isola, J.4
  • 64
    • 79959700509 scopus 로고    scopus 로고
    • Trastuzumab-DM1 (TDM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
    • Junttila TT, Li G, Parsons K, Phillips GL, Sliwkowski MX. Trastuzumab-DM1 (TDM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer. Breast Cancer Res Treat 2011; 128: 347-356.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 347-356
    • Junttila, T.T.1    Li, G.2    Parsons, K.3    Phillips, G.L.4    Sliwkowski, M.X.5
  • 65
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA 3rd, Rugo HS, Vukelja SJ, Vogel CL, Borson RA, Limentani S et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 2011; 29: 398-405.
    • (2011) J Clin Oncol , vol.29 , pp. 398-405
    • Burris, H.A.1    Rugo, H.S.2    Vukelja, S.J.3    Vogel, C.L.4    Borson, R.A.5    Limentani, S.6
  • 66
    • 77954031486 scopus 로고    scopus 로고
    • Phase i study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
    • Krop IE, Beeram M, Modi S, Jones SF, Holden SN, Yu W et al. Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 2010; 28: 2698-2704.
    • (2010) J Clin Oncol , vol.28 , pp. 2698-2704
    • Krop, I.E.1    Beeram, M.2    Modi, S.3    Jones, S.F.4    Holden, S.N.5    Yu, W.6
  • 67
    • 84873728334 scopus 로고    scopus 로고
    • Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance
    • Das Thakur M, Salangsang F, Landman AS, Sellers WR, Pryer NK, Levesque MP et al. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature 2013; 494: 251-255.
    • (2013) Nature , vol.494 , pp. 251-255
    • Das Thakur, M.1    Salangsang, F.2    Landman, A.S.3    Sellers, W.R.4    Pryer, N.K.5    Levesque, M.P.6
  • 68
    • 79960237399 scopus 로고    scopus 로고
    • Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways
    • McCubrey JA, Steelman LS, Kempf CR, Chappell WH, Abrams SL, Stivala F et al. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. J Cell Physiol 2011; 226: 2762-2781.
    • (2011) J Cell Physiol , vol.226 , pp. 2762-2781
    • McCubrey, J.A.1    Steelman, L.S.2    Kempf, C.R.3    Chappell, W.H.4    Abrams, S.L.5    Stivala, F.6
  • 69
    • 84858984798 scopus 로고    scopus 로고
    • The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: Role in cancer pathogenesis and implications for therapeutic approaches
    • De Luca A, Maiello MR, D'Alessio A, Pergameno M, Normanno N. The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: Role in cancer pathogenesis and implications for therapeutic approaches. Expert Opin Ther Targets 2012; 16: S17-S27.
    • (2012) Expert Opin Ther Targets , vol.16 , pp. 17-27
    • De Luca, A.1    Maiello, M.R.2    D'Alessio, A.3    Pergameno, M.4    Normanno, N.5
  • 70
    • 84871491627 scopus 로고    scopus 로고
    • Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: How mutations can result in therapy resistance and how to overcome resistance
    • McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Franklin RA, Montalto G et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: How mutations can result in therapy resistance and how to overcome resistance. Oncotarget 2012; 3: 1068-1111.
    • (2012) Oncotarget , vol.3 , pp. 1068-1111
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3    Abrams, S.L.4    Franklin, R.A.5    Montalto, G.6
  • 71
    • 84878831559 scopus 로고    scopus 로고
    • Overcoming acquired resistance to anticancer therapy: Focus on the PI3K/AKT/mTOR pathway
    • Burris HA III. Overcoming acquired resistance to anticancer therapy: Focus on the PI3K/AKT/mTOR pathway. Cancer Chemother Pharmacol 2013; 71: 829-842.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 829-842
    • Burris, H.A.1
  • 72
    • 84857184141 scopus 로고    scopus 로고
    • Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review)
    • Hafsi S, Pezzino FM, Candido S, Ligresti G, Spandidos DA, Soua Z et al. Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review). Int J Oncol 2012; 40: 639-644.
    • (2012) Int J Oncol , vol.40 , pp. 639-644
    • Hafsi, S.1    Pezzino, F.M.2    Candido, S.3    Ligresti, G.4    Spandidos, D.A.5    Soua, Z.6
  • 74
    • 51349098887 scopus 로고    scopus 로고
    • Cotargeting survival signaling pathways in cancer
    • Grant S. Cotargeting survival signaling pathways in cancer. J Clin Invest 2008; 118: 3003-3006.
    • (2008) J Clin Invest , vol.118 , pp. 3003-3006
    • Grant, S.1
  • 75
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008; 118: 3065-3074.
    • (2008) J Clin Invest , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3    Rojo, F.4    Salmena, L.5    Alimonti, A.6
  • 76
    • 51349111250 scopus 로고    scopus 로고
    • Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
    • Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest 2008; 118: 3051-3064.
    • (2008) J Clin Invest , vol.118 , pp. 3051-3064
    • Kinkade, C.W.1    Castillo-Martin, M.2    Puzio-Kuter, A.3    Yan, J.4    Foster, T.H.5    Gao, H.6
  • 77
    • 79957917078 scopus 로고    scopus 로고
    • PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
    • Serra V, Scaltriti M, Prudkin L, Eichhorn PJ, Ibrahim YH, Chandarlapaty S et al. PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer. Oncogene 2011; 30: 2547-2557.
    • (2011) Oncogene , vol.30 , pp. 2547-2557
    • Serra, V.1    Scaltriti, M.2    Prudkin, L.3    Eichhorn, P.J.4    Ibrahim, Y.H.5    Chandarlapaty, S.6
  • 78
    • 50949104555 scopus 로고    scopus 로고
    • Response and determinants of cancer cell susceptibility to PI3K inhibitors: Combined targeting of PI3K and Mek1 as an effective anticancer strategy
    • Yu K, Toral-Barza L, Shi C, Zhang WG, Zask A. Response and determinants of cancer cell susceptibility to PI3K inhibitors: Combined targeting of PI3K and Mek1 as an effective anticancer strategy. Cancer Biol Ther 2008; 7: 307-315.
    • (2008) Cancer Biol Ther , vol.7 , pp. 307-315
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3    Zhang, W.G.4    Zask, A.5
  • 79
    • 84871968444 scopus 로고    scopus 로고
    • PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials
    • Janku F, Wheler JJ, Naing A, Falchook GS, Hong DS, Stepanek VM et al. PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials. Cancer Res 2013; 73: 276-284.
    • (2013) Cancer Res , vol.73 , pp. 276-284
    • Janku, F.1    Wheler, J.J.2    Naing, A.3    Falchook, G.S.4    Hong, D.S.5    Stepanek, V.M.6
  • 80
    • 84894557306 scopus 로고    scopus 로고
    • Rapid induction of apoptosis by pi3k inhibitors is dependent upon their transient inhibition of ras-erk signaling
    • Will M, Qin AC, Toy W, Yao Z, Rodrik-Outmezguine V, Schneider C et al. Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS-ERK Signaling. Cancer Discov 2014; 4: 334-347.
    • (2014) Cancer Discov , vol.4 , pp. 334-347
    • Will, M.1    Qin, A.C.2    Toy, W.3    Yao, Z.4    Rodrik-Outmezguine, V.5    Schneider, C.6
  • 81
    • 66249116702 scopus 로고    scopus 로고
    • PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers
    • Wee S, Jagani Z, Xiang KX, Loo A, Dorsch M, Yao YM et al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res 2009; 69: 4286-4293.
    • (2009) Cancer Res , vol.69 , pp. 4286-4293
    • Wee, S.1    Jagani, Z.2    Xiang, K.X.3    Loo, A.4    Dorsch, M.5    Yao, Y.M.6
  • 82
    • 68049085887 scopus 로고    scopus 로고
    • Vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
    • Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009; 15: 4649-4664.
    • (2009) Clin Cancer Res , vol.15 , pp. 4649-4664
    • Hoeflich, K.P.1    O'Brien, C.2    Boyd, Z.3    Cavet, G.4    Guerrero, S.5    Jung, K.6
  • 83
    • 84855415767 scopus 로고    scopus 로고
    • Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition
    • Hoeflich KP, Merchant M, Orr C, Chan J, Den Otter D, Berry L et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res 2012; 72: 210-219.
    • (2012) Cancer Res , vol.72 , pp. 210-219
    • Hoeflich, K.P.1    Merchant, M.2    Orr, C.3    Chan, J.4    Den Otter, D.5    Berry, L.6
  • 84
    • 37049010979 scopus 로고    scopus 로고
    • Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression
    • Legrier ME, Yang CP, Yan HG, Lopez-Barcons L, Keller SM, Perez-Soler R et al. Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression. Cancer Res 2007; 67: 11300-11308.
    • (2007) Cancer Res , vol.67 , pp. 11300-11308
    • Legrier, M.E.1    Yang, C.P.2    Yan, H.G.3    Lopez-Barcons, L.4    Keller, S.M.5    Perez-Soler, R.6
  • 85
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008; 14: 1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 87
    • 84870825008 scopus 로고    scopus 로고
    • JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: A rationale for cotargeting these pathways in metastatic breast cancer
    • Britschgi A, Andraos R, Brinkhaus H, Klebba I, Romanet V, Muller U et al. JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: A rationale for cotargeting these pathways in metastatic breast cancer. Cancer Cell 2012; 22: 796-811.
    • (2012) Cancer Cell , vol.22 , pp. 796-811
    • Britschgi, A.1    Andraos, R.2    Brinkhaus, H.3    Klebba, I.4    Romanet, V.5    Muller, U.6
  • 88
    • 84890115298 scopus 로고    scopus 로고
    • Targeting PI3K, HER2 and the IL-8/JAK2 axis in metastatic breast cancer: Which combination makes the whole greater than the sum of its parts?
    • Britschgi A, Radimerski T, Bentires-Alj M. Targeting PI3K, HER2 and the IL-8/JAK2 axis in metastatic breast cancer: Which combination makes the whole greater than the sum of its parts?. Drug Resist Updat 2013; 16: 68-72.
    • (2013) Drug Resist Updat , vol.16 , pp. 68-72
    • Britschgi, A.1    Radimerski, T.2    Bentires-Alj, M.3
  • 89
    • 80052490834 scopus 로고    scopus 로고
    • Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
    • Liu P, Cheng H, Santiago S, Raeder M, Zhang F, Isabella A et al. Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med 2011; 17: 1116-1120.
    • (2011) Nat Med , vol.17 , pp. 1116-1120
    • Liu, P.1    Cheng, H.2    Santiago, S.3    Raeder, M.4    Zhang, F.5    Isabella, A.6
  • 91
    • 84862013453 scopus 로고    scopus 로고
    • Betacatenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
    • Tenbaum SP, Ordonez-Moran P, Puig I, Chicote I, Arques O, Landolfi S et al. Betacatenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med 2012; 18: 892-901.
    • (2012) Nat Med , vol.18 , pp. 892-901
    • Tenbaum, S.P.1    Ordonez-Moran, P.2    Puig, I.3    Chicote, I.4    Arques, O.5    Landolfi, S.6
  • 92
    • 84882619034 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: From understanding pathways to effective clinical trials
    • Fang H, Declerck YA. Targeting the tumor microenvironment: From understanding pathways to effective clinical trials. Cancer Res 2013; 73: 4965-4977.
    • (2013) Cancer Res , vol.73 , pp. 4965-4977
    • Fang, H.1    Declerck, Y.A.2
  • 93
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • Junttila MR, De Sauvage FJ. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013; 501: 346-354.
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 94
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: A major contributor to minimal residual disease
    • Meads MB, Gatenby RA, Dalton WS. Environment-mediated drug resistance: A major contributor to minimal residual disease. Nat Rev Cancer. 2009; 9: 665-674.
    • (2009) Nat Rev Cancer. , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 95
    • 4644357296 scopus 로고    scopus 로고
    • Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
    • Mori Y, Shimizu N, Dallas M, Niewolna M, Story B, Williams PJ et al. Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis. Blood 2004; 104: 2149-2154.
    • (2004) Blood , vol.104 , pp. 2149-2154
    • Mori, Y.1    Shimizu, N.2    Dallas, M.3    Niewolna, M.4    Story, B.5    Williams, P.J.6
  • 96
    • 49249107671 scopus 로고    scopus 로고
    • Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts
    • Park CC, Zhang HJ, Yao ES, Park CJ, Bissell MJ. Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer research 2008; 68: 4398-4405.
    • (2008) Cancer Research , vol.68 , pp. 4398-4405
    • Park, C.C.1    Zhang, H.J.2    Yao, E.S.3    Park, C.J.4    Bissell, M.J.5
  • 97
    • 0034893416 scopus 로고    scopus 로고
    • Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation
    • Damiano JS, Hazlehurst LA, Dalton WS. Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation. Leukemia 2001; 15: 1232-1239.
    • (2001) Leukemia , vol.15 , pp. 1232-1239
    • Damiano, J.S.1    Hazlehurst, L.A.2    Dalton, W.S.3
  • 98
    • 80052181422 scopus 로고    scopus 로고
    • Beta1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib
    • Huang C, Park CC, Hilsenbeck SG, Ward R, Rimawi MF, Wang YC et al. Beta1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res 2011; 13: R84.
    • (2011) Breast Cancer Res , vol.13 , pp. 84
    • Huang, C.1    Park, C.C.2    Hilsenbeck, S.G.3    Ward, R.4    Rimawi, M.F.5    Wang, Y.C.6
  • 101
    • 84864286442 scopus 로고    scopus 로고
    • Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
    • Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012; 487: 505-509.
    • (2012) Nature , vol.487 , pp. 505-509
    • Wilson, T.R.1    Fridlyand, J.2    Yan, Y.3    Penuel, E.4    Burton, L.5    Chan, E.6
  • 102
    • 84868007134 scopus 로고    scopus 로고
    • Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth
    • Harbinski F, Craig VJ, Sanghavi S, Jeffery D, Liu L, Sheppard KA et al. Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth. Cancer Discov 2012; 2: 948-959.
    • (2012) Cancer Discov , vol.2 , pp. 948-959
    • Harbinski, F.1    Craig, V.J.2    Sanghavi, S.3    Jeffery, D.4    Liu, L.5    Sheppard, K.A.6
  • 103
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    • Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012; 487: 500-504.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3    Barzily-Rokni, M.4    Qian, Z.R.5    Du, J.6
  • 104
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • Anderson K, Lutz C, Van Delft FW, Bateman CM, Guo Y, Colman SM et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 2011; 469: 356-361.
    • (2011) Nature , vol.469 , pp. 356-361
    • Anderson, K.1    Lutz, C.2    Van Delft, F.W.3    Bateman, C.M.4    Guo, Y.5    Colman, S.M.6
  • 106
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467: 1114-1117.
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3    Antal, T.4    Leary, R.5    Fu, B.6
  • 107
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton C. Intratumor heterogeneity: Evolution through space and time. Cancer Res 2012; 72: 4875-4882.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 108
    • 84884369881 scopus 로고    scopus 로고
    • Selection and adaptation during metastatic cancer progression
    • Klein CA. Selection and adaptation during metastatic cancer progression. Nature 2013; 501: 365-372.
    • (2013) Nature , vol.501 , pp. 365-372
    • Klein, C.A.1
  • 109
    • 84870383180 scopus 로고    scopus 로고
    • Discrepancies between primary tumor and metastasis: A literature review on clinically established biomarkers
    • Vignot S, Besse B, Andre F, Spano JP, Soria JC. Discrepancies between primary tumor and metastasis: A literature review on clinically established biomarkers. Crit Rev Oncol Hematol 2012; 84: 301-313.
    • (2012) Crit Rev Oncol Hematol , vol.84 , pp. 301-313
    • Vignot, S.1    Besse, B.2    Andre, F.3    Spano, J.P.4    Soria, J.C.5
  • 110
    • 84880240161 scopus 로고    scopus 로고
    • Nextgeneration sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer
    • Vignot S, Frampton GM, Soria JC, Yelensky R, Commo F, Brambilla C et al. Nextgeneration sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer. J Clin Oncol 2013; 31: 2167-2172.
    • (2013) J Clin Oncol , vol.31 , pp. 2167-2172
    • Vignot, S.1    Frampton, G.M.2    Soria, J.C.3    Yelensky, R.4    Commo, F.5    Brambilla, C.6
  • 112
    • 84863561243 scopus 로고    scopus 로고
    • Differential response to EGFR-and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases
    • Jin K, Lan H, Cao F, Han N, Xu Z, Li G et al. Differential response to EGFR-and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases. Int J Oncol 2012; 41: 583-588.
    • (2012) Int J Oncol , vol.41 , pp. 583-588
    • Jin, K.1    Lan, H.2    Cao, F.3    Han, N.4    Xu, Z.5    Li, G.6
  • 114
    • 84899129255 scopus 로고    scopus 로고
    • Tumor heterogeneity in the clinic: Is it a real problem?
    • Janku F. Tumor heterogeneity in the clinic: Is it a real problem? Ther Adv Med Oncol 2014; 6: 43-51.
    • (2014) Ther Adv Med Oncol , vol.6 , pp. 43-51
    • Janku, F.1
  • 115
    • 84893792203 scopus 로고    scopus 로고
    • Individual xenograft as a personalized therapeutic resort for women with metastatic triple-negative breast carcinoma
    • Bousquet G, Feugeas JP, Ferreira I, Vercellino L, Jourdan N, Bertheau P et al. Individual xenograft as a personalized therapeutic resort for women with metastatic triple-negative breast carcinoma. Breast Cancer Res 2014; 16: 401.
    • (2014) Breast Cancer Res , vol.16 , pp. 401
    • Bousquet, G.1    Feugeas, J.P.2    Ferreira, I.3    Vercellino, L.4    Jourdan, N.5    Bertheau, P.6
  • 117
    • 84877579861 scopus 로고    scopus 로고
    • Noninvasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • Murtaza M, Dawson SJ, Tsui DW, Gale D, Forshew T, Piskorz AM et al. Noninvasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013; 497: 108-112.
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3    Gale, D.4    Forshew, T.5    Piskorz, A.M.6
  • 118
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 2005; 436: 272-276.
    • (2005) Nature , vol.436 , pp. 272-276
    • Collier, L.S.1    Carlson, C.M.2    Ravimohan, S.3    Dupuy, A.J.4    Largaespada, D.A.5
  • 119
    • 78449294626 scopus 로고    scopus 로고
    • PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice
    • Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S et al. PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice. Science 2010; 330: 1104-1107.
    • (2010) Science , vol.330 , pp. 1104-1107
    • Rad, R.1    Rad, L.2    Wang, W.3    Cadinanos, J.4    Vassiliou, G.5    Rice, S.6
  • 120
    • 84874245525 scopus 로고    scopus 로고
    • Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics
    • Chen L, Stuart L, Ohsumi TK, Burgess S, Varshney GK, Dastur A et al. Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics. BMC Cancer 2013; 13: 93.
    • (2013) BMC Cancer , vol.13 , pp. 93
    • Chen, L.1    Stuart, L.2    Ohsumi, T.K.3    Burgess, S.4    Varshney, G.K.5    Dastur, A.6
  • 121
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 2005; 436: 221-226.
    • (2005) Nature , vol.436 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 123
    • 84894275509 scopus 로고    scopus 로고
    • High fidelity patientderived xenografts for accelerating prostate cancer discovery and drug development
    • Lin D, Wyatt AW, Xue H, Wang Y, Dong X, Haegert A et al. High fidelity patientderived xenografts for accelerating prostate cancer discovery and drug development. Cancer Res 2014; 74: 1272-1283.
    • (2014) Cancer Res , vol.74 , pp. 1272-1283
    • Lin, D.1    Wyatt, A.W.2    Xue, H.3    Wang, Y.4    Dong, X.5    Haegert, A.6
  • 124
    • 84879690769 scopus 로고    scopus 로고
    • Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis
    • Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA et al. Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis. Nat Genet 2013; 45: 756-766.
    • (2013) Nat Genet , vol.45 , pp. 756-766
    • Rahrmann, E.P.1    Watson, A.L.2    Keng, V.W.3    Choi, K.4    Moriarity, B.S.5    Beckmann, D.A.6
  • 125
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • Gillies RJ, Verduzco D, Gatenby RA. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer. 2012; 12: 487-493.
    • (2012) Nat Rev Cancer. , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 126
    • 84891835786 scopus 로고    scopus 로고
    • Molecular-targeted agents combination therapy for cancer: Developments and potentials
    • Li F, Zhao C, Wang L. Molecular-targeted agents combination therapy for cancer: Developments and potentials. Int J Cancer 2014; 134: 1257-1269.
    • (2014) Int J Cancer , vol.134 , pp. 1257-1269
    • Li, F.1    Zhao, C.2    Wang, L.3
  • 127
    • 84880615410 scopus 로고    scopus 로고
    • Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: A rationale to combine targeted drugs based on protein expression inhibition profiles
    • Aftimos PG, Wiedig M, Langouo Fontsa M, Awada A, Ghanem G, Journe F. Sequential use of protein kinase inhibitors potentiates their toxicity to melanoma cells: A rationale to combine targeted drugs based on protein expression inhibition profiles. Int J Oncol 2013; 43: 919-926.
    • (2013) Int J Oncol , vol.43 , pp. 919-926
    • Aftimos, P.G.1    Wiedig, M.2    Langouo Fontsa, M.3    Awada, A.4    Ghanem, G.5    Journe, F.6
  • 128
    • 84886028975 scopus 로고    scopus 로고
    • High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells
    • Hongisto V, Jernstrom S, Fey V, Mpindi JP, Kleivi Sahlberg K, Kallioniemi O et al. High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells. PLoS One 2013; 8: E77232.
    • (2013) PLoS One , vol.8 , pp. e77232
    • Hongisto, V.1    Jernstrom, S.2    Fey, V.3    Mpindi, J.P.4    Kleivi Sahlberg, K.5    Kallioniemi, O.6
  • 129
    • 78449290991 scopus 로고    scopus 로고
    • Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs
    • Ho WJ, Pham EA, Kim JW, Ng CW, Kim JH, Kamei DT et al. Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs. Cancer Sci 2010; 101: 2637-2643.
    • (2010) Cancer Sci , vol.101 , pp. 2637-2643
    • Ho, W.J.1    Pham, E.A.2    Kim, J.W.3    Ng, C.W.4    Kim, J.H.5    Kamei, D.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.