Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas

British Journal of Cancer

Volumn 106, Issue 8, 2012, Pages 1367-1373

  Gallardo, A ^a   Lerma, E ^a   Escuin, D ^b   Tibau, A ^a   Munoz J ^a   Ojeda, B ^a   Barnadas, A ^a   Adrover, E ^c   Sanchez Tejada L ^c   Giner, D ^c   Ortiz Martinez F ^c   Peiro G ^c  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

Author keywords

breast cancer; EGFR; HER2; IGF1R; PTEN PI3K Akt pathway; trastuzumab resistance

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MUCIN 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P27; PROTEIN P53; SOMATOMEDIN C RECEPTOR; TRASTUZUMAB;

ADJUVANT CHEMOTHERAPY; ADJUVANT THERAPY; ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER PATIENT; CONTROLLED STUDY; DEREGULATION; DNA METHYLATION; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; METASTASIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; TUMOR RECURRENCE;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL, HUMANIZED; BREAST NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM STAGING; PHOSPHATIDYLINOSITOL 3-KINASES; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

EID: 84859627290     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.85     Document Type: Article

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