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Volumn 134, Issue 6, 2014, Pages 1257-1269

Molecular-targeted agents combination therapy for cancer: Developments and potentials

Author keywords

anticancer efficacy; chemotherapy; combination therapy; molecular targeted agents; relapse; signaling pathway

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYTOTOXIC AGENT; DABRAFENIB; DACARBAZINE; DOCETAXEL; ERLOTINIB; EVEROLIMUS; FLUDARABINE; GEFITINIB; GEMCITABINE; MATUZUMAB; MONOCLONAL ANTIBODY DC101; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PICTILISIB; PLACEBO; PLATINUM COMPLEX; SELUMETINIB; SORAFENIB; TOPOTECAN; TRAMETINIB; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR; VEMURAFENIB; VINBLASTINE; WORTMANNIN;

EID: 84891835786     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28261     Document Type: Review
Times cited : (112)

References (161)
  • 1
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316: 1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 2
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • Guix M, Faber AC, Wang SE, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J Clin Invest 2008; 118: 2609-19.
    • (2008) J Clin Invest , vol.118 , pp. 2609-2619
    • Guix, M.1    Faber, A.C.2    Wang, S.E.3
  • 3
    • 50849111710 scopus 로고    scopus 로고
    • Rational targeting of Notch signaling in cancer
    • Rizzo P, Osipo C, Foreman K, et al. Rational targeting of Notch signaling in cancer. Oncogene 2008; 27: 5124-31.
    • (2008) Oncogene , vol.27 , pp. 5124-5131
    • Rizzo, P.1    Osipo, C.2    Foreman, K.3
  • 4
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G, Baruchel S, Rak J, et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 2000; 105: R15-R24.
    • (2000) J Clin Invest , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 5
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL)
    • Reck M, Von Pawel J, Zatloukal P, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010; 21: 1804-9.
    • (2010) Ann Oncol , vol.21 , pp. 1804-1809
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 6
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL
    • Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAiL. J Clin Oncol 2009; 27: 1227-34.
    • (2009) J Clin Oncol , vol.27 , pp. 1227-1234
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3
  • 7
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 8
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • Aghajanian C, Blank SV, Goff BA, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012; 30: 2039-45.
    • (2012) J Clin Oncol , vol.30 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.V.2    Goff, B.A.3
  • 9
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang ML, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007; 357: 2666-76.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.L.2    Gralow, J.3
  • 10
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
    • Scagliotti G, Novello S, von Pawel J, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010; 28: 1835-42.
    • (2010) J Clin Oncol , vol.28 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    Von Pawel, J.3
  • 11
    • 36849041878 scopus 로고    scopus 로고
    • Randomized phase III study of paclitaxel plus carboplatin with or without sorafenib as second-line treatment in patients with advanced melanoma
    • Agarwala S, Keilholz U, Hogg D, et al. Randomized phase III study of paclitaxel plus carboplatin with or without sorafenib as second-line treatment in patients with advanced melanoma. J Clin Oncol 2007; 25: 8510.
    • (2007) J Clin Oncol , vol.25 , pp. 8510
    • Agarwala, S.1    Keilholz, U.2    Hogg, D.3
  • 12
    • 77956033802 scopus 로고    scopus 로고
    • Final results of E2603: A double-blind, randomized phase III trial comparing carboplatin/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma
    • Flaherty K, Lee S, Schuchter L, et al. Final results of E2603: a double-blind, randomized phase III trial comparing carboplatin/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma. J Clin Oncol 2010; 28: 8511.
    • (2010) J Clin Oncol , vol.28 , pp. 8511
    • Flaherty, K.1    Lee, S.2    Schuchter, L.3
  • 13
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2009; 27: 2823-30.
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3
  • 14
    • 33845358271 scopus 로고    scopus 로고
    • A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma
    • Mita MM, Rowinsky EK, Forero L, et al. A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma. Cancer Chemother Pharmacol 2007; 59: 165-74.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 165-174
    • Mita, M.M.1    Rowinsky, E.K.2    Forero, L.3
  • 15
    • 79953196070 scopus 로고    scopus 로고
    • Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2, randomised, double-blind, placebo-controlled study
    • Martin M, Roche H, Pinter T, et al. Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol 2011; 12: 369-76.
    • (2011) Lancet Oncol , vol.12 , pp. 369-376
    • Martin, M.1    Roche, H.2    Pinter, T.3
  • 16
    • 84875727313 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab-based combination regimens in patients with previously untreated metastatic colorectal cancer: Final results from a randomised phase II study of bevacizumab plus 5-fluorouracil, leucovorin plus irinotecan versus bevacizumab plus capecitabine plus irinotecan (FNCLCC ACCORD 13/0503 study)
    • Ducreux M, Adenis A, Pignon JP, et al. Efficacy and safety of bevacizumab-based combination regimens in patients with previously untreated metastatic colorectal cancer: final results from a randomised phase II study of bevacizumab plus 5-fluorouracil, leucovorin plus irinotecan versus bevacizumab plus capecitabine plus irinotecan (FNCLCC ACCORD 13/0503 study). Eur J Cancer 2013; 49: 1236-45.
    • (2013) Eur J Cancer , vol.49 , pp. 1236-1245
    • Ducreux, M.1    Adenis, A.2    Pignon, J.P.3
  • 17
    • 80051638135 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer
    • Lara PN, Douillard JY, Nakagawa K, et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol 2011; 29: 2965-71.
    • (2011) J Clin Oncol , vol.29 , pp. 2965-2971
    • Lara, P.N.1    Douillard, J.Y.2    Nakagawa, K.3
  • 18
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • Xiong HQ, Rosenberg A, LoBuglio A, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J Clin Oncol 2004; 22: 2610-16.
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3
  • 19
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Köhne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-17.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3
  • 20
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009; 373: 1525-31.
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 21
    • 77949891126 scopus 로고    scopus 로고
    • Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099
    • Lynch TJ, Patel T, Dreisbach L, et al. Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J Clin Oncol 2010; 28: 911-17.
    • (2010) J Clin Oncol , vol.28 , pp. 911-917
    • Lynch, T.J.1    Patel, T.2    Dreisbach, L.3
  • 22
    • 65249157122 scopus 로고    scopus 로고
    • A phase 2 study of cetuximab in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced nonsmall cell lung cancer
    • Kim ES, Mauer AM, William WN, Jr, et al. A phase 2 study of cetuximab in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced nonsmall cell lung cancer. Cancer 2009; 115: 1713-22.
    • (2009) Cancer , vol.115 , pp. 1713-1722
    • Kim, E.S.1    Mauer, A.M.2    William, Jr.W.N.3
  • 23
    • 62749156047 scopus 로고    scopus 로고
    • Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial
    • Kurtz JE, Hardy-Bessard AC, Deslandres M, et al. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: a phase II GINECO trial. Gynecol Oncol 2009; 113: 16-20.
    • (2009) Gynecol Oncol , vol.113 , pp. 16-20
    • Kurtz, J.E.1    Hardy-Bessard, A.C.2    Deslandres, M.3
  • 24
    • 84891830690 scopus 로고    scopus 로고
    • A phase i pharmacokinetic study of matuzumab in combination with paclitaxel in patients with EGFR-expressing advanced non-small cell lung cancer
    • Hartmann J, Kollmannsberger C, Cascorbi I, et al. A phase I pharmacokinetic study of matuzumab in combination with paclitaxel in patients with EGFR-expressing advanced non-small cell lung cancer. Invest New Drugs 2012: 1-8.
    • (2012) Invest New Drugs , pp. 1-8
    • Hartmann, J.1    Kollmannsberger, C.2    Cascorbi, I.3
  • 25
    • 84856718345 scopus 로고    scopus 로고
    • A phase i study of 5-azacytidine and erlotinib in advanced solid tumor malignancies
    • Bauman J, Verschraegen C, Belinsky S, et al. A phase I study of 5-azacytidine and erlotinib in advanced solid tumor malignancies. Cancer Chemother Pharmacol 2012; 69: 547-54.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 547-554
    • Bauman, J.1    Verschraegen, C.2    Belinsky, S.3
  • 26
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada clinical trials group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada clinical trials group. J Clin Oncol 2007; 25: 1960-6.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 27
    • 84880443548 scopus 로고    scopus 로고
    • Gefitinib in combination with weekly docetaxel in patients with metastatic breast cancer caused unexpected toxicity: Results from a randomized phase II clinical trial
    • Engebraaten O, Edvardsen H, Løkkevik E, et al. Gefitinib in combination with weekly docetaxel in patients with metastatic breast cancer caused unexpected toxicity: results from a randomized phase II clinical trial. ISRN Oncol 2012; 2012: 176789.
    • (2012) ISRN Oncol , vol.2012 , pp. 176789
    • Engebraaten, O.1    Edvardsen, H.2    Løkkevik, E.3
  • 28
    • 77951917301 scopus 로고    scopus 로고
    • Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer
    • Polcher M, Eckhardt M, Coch C, et al. Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer. Cancer Chemother Pharmacol 2010; 66: 203-7.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 203-207
    • Polcher, M.1    Eckhardt, M.2    Coch, C.3
  • 29
    • 43749110700 scopus 로고    scopus 로고
    • Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 Study Group
    • McDermott DF, Sosman JA, Gonzalez R, et al. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol 2008; 26: 2178-85.
    • (2008) J Clin Oncol , vol.26 , pp. 2178-2185
    • McDermott, D.F.1    Sosman, J.A.2    Gonzalez, R.3
  • 30
    • 36849079626 scopus 로고    scopus 로고
    • An open-label phase II study of sorafenib and dacarbazine as first-line therapy in patients with advanced melanoma
    • Bayer B, Bayer OO, Bayer OB,. An open-label phase II study of sorafenib and dacarbazine as first-line therapy in patients with advanced melanoma. J Clin Oncol (Meet Abstr) 2007; 25: 8529.
    • (2007) J Clin Oncol (Meet Abstr) , vol.25 , pp. 8529
    • Bayer, B.1    Bayer, O.O.2    Bayer, O.B.3
  • 31
    • 84862988257 scopus 로고    scopus 로고
    • Sorafenib in combination with capecitabine: An oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer
    • Baselga J, Segalla JGM, Roché H, et al. Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer. J Clin Oncol 2012; 30: 1484-91.
    • (2012) J Clin Oncol , vol.30 , pp. 1484-1491
    • Baselga, J.1    Segalla, J.G.M.2    Roché, H.3
  • 32
    • 79959604565 scopus 로고    scopus 로고
    • A phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
    • Fracasso PM, Williams KJ, Chen RC, et al. A phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies. Cancer Chemother Pharmacol 2011; 67: 1225-37.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 1225-1237
    • Fracasso, P.M.1    Williams, K.J.2    Chen, R.C.3
  • 33
    • 84877947967 scopus 로고    scopus 로고
    • A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer
    • Ma CX, Ellis MJ, Petroni GR, et al. A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Res Treat 2013; 137: 483-92.
    • (2013) Breast Cancer Res Treat , vol.137 , pp. 483-492
    • Ma, C.X.1    Ellis, M.J.2    Petroni, G.R.3
  • 34
    • 73849119080 scopus 로고    scopus 로고
    • Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
    • Sessa C, Tosi D, Vigano L, et al. Phase Ib study of weekly mammalian target of rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel. Ann Oncol 2010; 21: 1315-22.
    • (2010) Ann Oncol , vol.21 , pp. 1315-1322
    • Sessa, C.1    Tosi, D.2    Vigano, L.3
  • 35
    • 78049513393 scopus 로고    scopus 로고
    • Phase Ib study of the mTOR inhibitor ridaforolimus with capecitabine
    • Perotti A, Locatelli A, Sessa C, et al. Phase Ib study of the mTOR inhibitor ridaforolimus with capecitabine. J Clin Oncol 2010; 28: 4554-61.
    • (2010) J Clin Oncol , vol.28 , pp. 4554-4561
    • Perotti, A.1    Locatelli, A.2    Sessa, C.3
  • 36
    • 77956848562 scopus 로고    scopus 로고
    • Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer
    • Ramalingam SS, Harvey RD, Saba N, et al. Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer 2010; 116: 3903-9.
    • (2010) Cancer , vol.116 , pp. 3903-3909
    • Ramalingam, S.S.1    Harvey, R.D.2    Saba, N.3
  • 37
    • 79959583486 scopus 로고    scopus 로고
    • Phase i trial of capecitabine plus everolimus (RAD001) in patients with previously treated metastatic gastric cancer
    • Lim T, Lee J, Lee DJ, et al. Phase I trial of capecitabine plus everolimus (RAD001) in patients with previously treated metastatic gastric cancer. Cancer Chemother Pharmacol 2011; 68: 255-62.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 255-262
    • Lim, T.1    Lee, J.2    Lee, D.J.3
  • 38
    • 83255167036 scopus 로고    scopus 로고
    • Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): A randomised, placebo-controlled, phase 3 study
    • Pavel ME, Hainsworth JD, Baudin E, et al. Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study. Lancet 2011; 378: 2005-12.
    • (2011) Lancet , vol.378 , pp. 2005-2012
    • Pavel, M.E.1    Hainsworth, J.D.2    Baudin, E.3
  • 39
    • 34547687425 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral protein kinase C β-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer
    • Rademaker-Lakhai JM, Beerepoot LV, Mehra N, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C β-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin Cancer Res 2007; 13: 4474-81.
    • (2007) Clin Cancer Res , vol.13 , pp. 4474-4481
    • Rademaker-Lakhai, J.M.1    Beerepoot, L.V.2    Mehra, N.3
  • 40
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • Karp DD, Paz-Ares LG, Novello S, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009; 27: 2516-22.
    • (2009) J Clin Oncol , vol.27 , pp. 2516-2522
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3
  • 41
    • 84866943631 scopus 로고    scopus 로고
    • A phase i trial of dasatinib, a Src-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer
    • Secord AA, Teoh DK, Barry WT, et al. A phase I trial of dasatinib, a Src-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer. Clin Cancer Res 2012; 18: 5489-98.
    • (2012) Clin Cancer Res , vol.18 , pp. 5489-5498
    • Secord, A.A.1    Teoh, D.K.2    Barry, W.T.3
  • 42
    • 78649973762 scopus 로고    scopus 로고
    • Final efficacy and safety results of a randomized Phase II study of the PARP inhibitor iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple negative breast cancer (TNBC)
    • O'Shaughnessy J, Osborne C, Pippen J,. Final efficacy and safety results of a randomized Phase II study of the PARP inhibitor iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple negative breast cancer (TNBC). Ann Oncol 2010; 21.
    • (2010) Ann Oncol , pp. 21
    • O'Shaughnessy, J.1    Osborne, C.2    Pippen, J.3
  • 43
    • 75049085049 scopus 로고    scopus 로고
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
    • Dresemann G, Weller M, Rosenthal MA, et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J Neurooncol 2010; 96: 393-402.
    • (2010) J Neurooncol , vol.96 , pp. 393-402
    • Dresemann, G.1    Weller, M.2    Rosenthal, M.A.3
  • 44
    • 50349097617 scopus 로고    scopus 로고
    • Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: Implications for antiangiogenic drugs as chemosensitizing agents
    • Shaked Y, Henke E, Roodhart JM, et al. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell 2008; 14: 263-73.
    • (2008) Cancer Cell , vol.14 , pp. 263-273
    • Shaked, Y.1    Henke, E.2    Roodhart, J.M.3
  • 45
    • 78049318854 scopus 로고    scopus 로고
    • Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: A new paradigm for understanding the therapeutic effect of combined treatment
    • Ortholan C, Durivault J, Hannoun-Levi J-M, et al. Bevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatment. Eur J Cancer 2010; 46: 3022-36.
    • (2010) Eur J Cancer , vol.46 , pp. 3022-3036
    • Ortholan, C.1    Durivault, J.2    Hannoun-Levi, J.-M.3
  • 46
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie DA, Tamayo P, Boehm JS, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009; 462: 108-12.
    • (2009) Nature , vol.462 , pp. 108-112
    • Barbie, D.A.1    Tamayo, P.2    Boehm, J.S.3
  • 47
    • 84862731796 scopus 로고    scopus 로고
    • Co-targeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer
    • Williams TM, Flecha AR, Keller P, et al. Co-targeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer. Mol Cancer Ther 2012; 11: 1193-202.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1193-1202
    • Williams, T.M.1    Flecha, A.R.2    Keller, P.3
  • 48
    • 40749124035 scopus 로고    scopus 로고
    • The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel
    • Haass NK, Sproesser K, Nguyen TK, et al. The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel. Clin Cancer Res 2008; 14: 230-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 230-239
    • Haass, N.K.1    Sproesser, K.2    Nguyen, T.K.3
  • 49
    • 70349402909 scopus 로고    scopus 로고
    • Combination of class i PI3K inhibitor, GDC-0941, with standard of care therapeutics results in enhanced anti-tumor responses in human cancer models in vitro and in vivo
    • Sampath D, Belvin M, Guan J, et al. Combination of class I PI3K inhibitor, GDC-0941, with standard of care therapeutics results in enhanced anti-tumor responses in human cancer models in vitro and in vivo. EJC Supplements 2008; 6: 69-70.
    • (2008) EJC Supplements , vol.6 , pp. 69-70
    • Sampath, D.1    Belvin, M.2    Guan, J.3
  • 50
    • 18044365018 scopus 로고    scopus 로고
    • Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway
    • Yu C, Mao X, Li WX,. Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. Biochem Biophys Res Commun 2005; 331: 391-7.
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 391-397
    • Yu, C.1    Mao, X.2    Li, W.X.3
  • 51
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367: 1694-703.
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 52
    • 77956839364 scopus 로고    scopus 로고
    • Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: A phase 2 trial of the Sarah Cannon Oncology Research Consortium
    • Hainsworth JD, Infante JR, Spigel DR, et al. Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium. Cancer 2010; 116: 4122-9.
    • (2010) Cancer , vol.116 , pp. 4122-4129
    • Hainsworth, J.D.1    Infante, J.R.2    Spigel, D.R.3
  • 53
    • 80052197143 scopus 로고    scopus 로고
    • A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer
    • Altomare I, Bendell JC, Bullock KE, et al. A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancer. Oncologist 2011; 16: 1131-7.
    • (2011) Oncologist , vol.16 , pp. 1131-1137
    • Altomare, I.1    Bendell, J.C.2    Bullock, K.E.3
  • 54
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011; 29: 3126-32.
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 55
    • 78650984926 scopus 로고    scopus 로고
    • Phase i study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
    • Andre F, Campone M, O'Regan R, et al. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 2010; 28: 5110-15.
    • (2010) J Clin Oncol , vol.28 , pp. 5110-5115
    • Andre, F.1    Campone, M.2    O'Regan, R.3
  • 56
    • 77958161544 scopus 로고    scopus 로고
    • Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer
    • Price KA, Azzoli CG, Krug LM, et al. Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer. J Thorac Oncol 2010; 5: 1623-9.
    • (2010) J Thorac Oncol , vol.5 , pp. 1623-1629
    • Price, K.A.1    Azzoli, C.G.2    Krug, L.M.3
  • 58
    • 71049122718 scopus 로고    scopus 로고
    • Response to imatinib plus sirolimus in advanced chordoma
    • Stacchiotti S, Marrari A, Tamborini E, et al. Response to imatinib plus sirolimus in advanced chordoma. Ann Oncol 2009; 20: 1886-94.
    • (2009) Ann Oncol , vol.20 , pp. 1886-1894
    • Stacchiotti, S.1    Marrari, A.2    Tamborini, E.3
  • 59
    • 80052428136 scopus 로고    scopus 로고
    • A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinoma
    • Harzstark AL, Small EJ, Weinberg VK, et al. A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinoma. Cancer 2011; 117: 4194-200.
    • (2011) Cancer , vol.117 , pp. 4194-4200
    • Harzstark, A.L.1    Small, E.J.2    Weinberg, V.K.3
  • 60
    • 84856702095 scopus 로고    scopus 로고
    • Pharmacokinetic drug interaction between AEE788 and RAD001 causing thrombocytopenia in patients with glioblastoma
    • Reardon DA, Cloughesy T, Rich J, et al. Pharmacokinetic drug interaction between AEE788 and RAD001 causing thrombocytopenia in patients with glioblastoma. Cancer Chemother Pharmacol 2012; 69: 281-7.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 281-287
    • Reardon, D.A.1    Cloughesy, T.2    Rich, J.3
  • 61
    • 78650218632 scopus 로고    scopus 로고
    • A phase i dose-escalation study to evaluate safety and tolerability of sorafenib combined with sirolimus in patients with advanced solid cancer
    • Desar IM, Timmer-Bonte JN, Burger DM, et al. A phase I dose-escalation study to evaluate safety and tolerability of sorafenib combined with sirolimus in patients with advanced solid cancer. Br J Cancer 2010; 103: 1637-43.
    • (2010) Br J Cancer , vol.103 , pp. 1637-1643
    • Desar, I.M.1    Timmer-Bonte, J.N.2    Burger, D.M.3
  • 62
    • 62349097073 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A phase I/II study
    • Cohen EE, Davis DW, Karrison TG, et al. Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol 2009; 10: 247-57.
    • (2009) Lancet Oncol , vol.10 , pp. 247-257
    • Cohen, E.E.1    Davis, D.W.2    Karrison, T.G.3
  • 63
    • 79957823572 scopus 로고    scopus 로고
    • Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): A double-blind, placebo-controlled, phase 3 trial
    • Herbst RS, Ansari R, Bustin F, et al. Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial. Lancet 2011; 377: 1846-54.
    • (2011) Lancet , vol.377 , pp. 1846-1854
    • Herbst, R.S.1    Ansari, R.2    Bustin, F.3
  • 64
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27: 672-80.
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 65
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360: 563-72.
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 66
    • 84860148054 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer
    • Martín M, Makhson A, Gligorov J, et al. Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer. Oncologist 2012; 17: 469-75.
    • (2012) Oncologist , vol.17 , pp. 469-475
    • Martín, M.1    Makhson, A.2    Gligorov, J.3
  • 67
    • 77951894266 scopus 로고    scopus 로고
    • Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer
    • Soria J-C, Smit E, Khayat D, et al. Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer. J Clin Oncol 2010; 28: 1527-33.
    • (2010) J Clin Oncol , vol.28 , pp. 1527-1533
    • Soria, J.-C.1    Smit, E.2    Khayat, D.3
  • 68
    • 84867502679 scopus 로고    scopus 로고
    • A phase Ib, dose-finding study of erlotinib in combination with a fixed dose of pertuzumab in patients with advanced non-small-cell lung cancer
    • Felip E, Ranson M, Cedrés S, et al. A phase Ib, dose-finding study of erlotinib in combination with a fixed dose of pertuzumab in patients with advanced non-small-cell lung cancer. Clin Lung Cancer 2012; 13: 432-41.
    • (2012) Clin Lung Cancer , vol.13 , pp. 432-441
    • Felip, E.1    Ranson, M.2    Cedrés, S.3
  • 69
    • 34548077118 scopus 로고    scopus 로고
    • Phase i targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
    • Duran I, Hotte SJ, Hirte H, et al. Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors. Clin Cancer Res 2007; 13: 4849-57.
    • (2007) Clin Cancer Res , vol.13 , pp. 4849-4857
    • Duran, I.1    Hotte, S.J.2    Hirte, H.3
  • 70
    • 63049093371 scopus 로고    scopus 로고
    • Phase i trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma
    • Feldman DR, Baum MS, Ginsberg MS, et al. Phase I trial of bevacizumab plus escalated doses of sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 1432-9.
    • (2009) J Clin Oncol , vol.27 , pp. 1432-1439
    • Feldman, D.R.1    Baum, M.S.2    Ginsberg, M.S.3
  • 71
    • 84855340600 scopus 로고    scopus 로고
    • Phase i study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours
    • Pili R, Salumbides B, Zhao M, et al. Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours. Br J Cancer 2012; 106: 77-84.
    • (2012) Br J Cancer , vol.106 , pp. 77-84
    • Pili, R.1    Salumbides, B.2    Zhao, M.3
  • 72
    • 77958007059 scopus 로고    scopus 로고
    • A phase I/II trial of sorafenib and infliximab in advanced renal cell carcinoma
    • Larkin JM, Ferguson TR, Pickering LM, et al. A phase I/II trial of sorafenib and infliximab in advanced renal cell carcinoma. Br J Cancer 2010; 103: 1149-53.
    • (2010) Br J Cancer , vol.103 , pp. 1149-1153
    • Larkin, J.M.1    Ferguson, T.R.2    Pickering, L.M.3
  • 73
    • 34547209343 scopus 로고    scopus 로고
    • Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
    • McCubrey JA, Steelman LS, Chappell WH, et al. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 2007; 1773: 1263-84.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1263-1284
    • McCubrey, J.A.1    Steelman, L.S.2    Chappell, W.H.3
  • 74
    • 84860380245 scopus 로고    scopus 로고
    • Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro
    • Koh YW, Shah MH, Agarwal K, et al. Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro. Endocr Relat Cancer 2012; 19: 29-38.
    • (2012) Endocr Relat Cancer , vol.19 , pp. 29-38
    • Koh, Y.W.1    Shah, M.H.2    Agarwal, K.3
  • 75
    • 84863393851 scopus 로고    scopus 로고
    • Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis
    • Takahashi O, Komaki R, Smith PD, et al. Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis. Clin Cancer Res 2012; 18: 1641-54.
    • (2012) Clin Cancer Res , vol.18 , pp. 1641-1654
    • Takahashi, O.1    Komaki, R.2    Smith, P.D.3
  • 76
    • 66149138797 scopus 로고    scopus 로고
    • Combined MEK and EGFR inhibition demonstrates synergistic activity in EGFR-dependent NSCLC
    • Balko JM, Jones BR, Coakley VL, et al. Combined MEK and EGFR inhibition demonstrates synergistic activity in EGFR-dependent NSCLC. Cancer Biol Ther 2009; 8: 522-30.
    • (2009) Cancer Biol Ther , vol.8 , pp. 522-530
    • Balko, J.M.1    Jones, B.R.2    Coakley, V.L.3
  • 77
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483: 100-3.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3
  • 78
    • 77953276524 scopus 로고    scopus 로고
    • Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
    • Paraiso KHT, Fedorenko IV, Cantini LP, et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 2010; 102: 1724-30.
    • (2010) Br J Cancer , vol.102 , pp. 1724-1730
    • Paraiso, K.H.T.1    Fedorenko, I.V.2    Cantini, L.P.3
  • 79
    • 84869067183 scopus 로고    scopus 로고
    • Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas
    • Lito P, Pratilas Christine A, Joseph Eric W, et al. Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas. Cancer Cell 2012; 22: 668-82.
    • (2012) Cancer Cell , vol.22 , pp. 668-682
    • Lito, P.1    Pratilas Christine, A.2    Joseph Eric, W.3
  • 80
    • 84859765844 scopus 로고    scopus 로고
    • Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
    • Duncan James S, Whittle Martin C, Nakamura K, et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 2012; 149: 307-21.
    • (2012) Cell , vol.149 , pp. 307-321
    • Duncan James, S.1    Whittle Martin, C.2    Nakamura, K.3
  • 81
    • 84862732834 scopus 로고    scopus 로고
    • Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations
    • Greger J, Eastman S, Zhang V, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther 2012; 11: 909-20.
    • (2012) Mol Cancer Ther , vol.11 , pp. 909-920
    • Greger, J.1    Eastman, S.2    Zhang, V.3
  • 82
    • 78651458656 scopus 로고    scopus 로고
    • AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
    • Chandarlapaty S, Sawai A, Scaltriti M, et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 2011; 19: 58-71.
    • (2011) Cancer Cell , vol.19 , pp. 58-71
    • Chandarlapaty, S.1    Sawai, A.2    Scaltriti, M.3
  • 83
    • 84864012288 scopus 로고    scopus 로고
    • Negative feedback and adaptive resistance to the targeted therapy of cancer
    • Chandarlapaty S,. Negative feedback and adaptive resistance to the targeted therapy of cancer. Cancer Discov 2012; 2: 311-19.
    • (2012) Cancer Discov , vol.2 , pp. 311-319
    • Chandarlapaty, S.1
  • 84
    • 56449111358 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
    • Eichhorn PJA, Gili M, Scaltriti M, et al. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res 2008; 68: 9221-30.
    • (2008) Cancer Res , vol.68 , pp. 9221-9230
    • Eichhorn, P.J.A.1    Gili, M.2    Scaltriti, M.3
  • 85
    • 34548596728 scopus 로고    scopus 로고
    • A dual phosphoinositide-3-kinase α/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
    • Fan QW, Cheng CK, Nicolaides TP, et al. A dual phosphoinositide-3-kinase α/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 2007; 67: 7960-5.
    • (2007) Cancer Res , vol.67 , pp. 7960-7965
    • Fan, Q.W.1    Cheng, C.K.2    Nicolaides, T.P.3
  • 86
    • 84891835353 scopus 로고    scopus 로고
    • Targeting of compensatory signaling pathways identified in a synthetic lethal screen leads to synergistic growth inhibition in bladder cancer cells
    • Axelrod MJ, Gioeli D, Weber MJ,. Targeting of compensatory signaling pathways identified in a synthetic lethal screen leads to synergistic growth inhibition in bladder cancer cells. Proc Am Assoc Cancer Res Annu Meet 2010; 51: 397.
    • (2010) Proc Am Assoc Cancer Res Annu Meet , vol.51 , pp. 397
    • Axelrod, M.J.1    Gioeli, D.2    Weber, M.J.3
  • 87
    • 77955763968 scopus 로고    scopus 로고
    • The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-Met inhibition
    • Nakachi I, Naoki K, Soejima K, et al. The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-Met inhibition. Mol Cancer Res 2010; 8: 1142-51.
    • (2010) Mol Cancer Res , vol.8 , pp. 1142-1151
    • Nakachi, I.1    Naoki, K.2    Soejima, K.3
  • 88
    • 7444270714 scopus 로고    scopus 로고
    • Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3
    • Takaoka M, Harada H, Andl CD, et al. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res 2004; 64: 7711-23.
    • (2004) Cancer Res , vol.64 , pp. 7711-7723
    • Takaoka, M.1    Harada, H.2    Andl, C.D.3
  • 89
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • Morgillo F, Kim WY, Kim ES, et al. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 2007; 13: 2795-803.
    • (2007) Clin Cancer Res , vol.13 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.Y.2    Kim, E.S.3
  • 90
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S, Wang W, Li Q, et al. Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res 2008; 68: 9479-87.
    • (2008) Cancer Res , vol.68 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3
  • 91
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • Nahta R, Yu DH, Hung MC, et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006; 3: 269-80.
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 269-280
    • Nahta, R.1    Yu, D.H.2    Hung, M.C.3
  • 92
    • 33645652766 scopus 로고    scopus 로고
    • The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib
    • Normanno N, Luca AD, Maiello MR, et al. The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. J Cell Physiol 2006; 207: 420-7.
    • (2006) J Cell Physiol , vol.207 , pp. 420-427
    • Normanno, N.1    Luca, A.D.2    Maiello, M.R.3
  • 93
    • 33745220580 scopus 로고    scopus 로고
    • Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells
    • Bertrand FE, Steelman LS, Chappell WH, et al. Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells. Leukemia 2006; 20: 1254-60.
    • (2006) Leukemia , vol.20 , pp. 1254-1260
    • Bertrand, F.E.1    Steelman, L.S.2    Chappell, W.H.3
  • 94
    • 5644252461 scopus 로고    scopus 로고
    • Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells
    • Shelton JG, Steelman LS, White ER, et al. Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle 2004; 3: 372-9.
    • (2004) Cell Cycle , vol.3 , pp. 372-379
    • Shelton, J.G.1    Steelman, L.S.2    White, E.R.3
  • 95
    • 78649831949 scopus 로고    scopus 로고
    • Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells
    • Sunayama J, Matsuda KI, Sato A, et al. Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. Stem Cells 2010; 28: 1930-9.
    • (2010) Stem Cells , vol.28 , pp. 1930-1939
    • Sunayama, J.1    Matsuda, K.I.2    Sato, A.3
  • 96
    • 54849373400 scopus 로고    scopus 로고
    • Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development
    • Tran MA, Gowda R, Sharma A, et al. Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development. Cancer Res 2008; 68: 7638-49.
    • (2008) Cancer Res , vol.68 , pp. 7638-7649
    • Tran, M.A.1    Gowda, R.2    Sharma, A.3
  • 97
    • 50949104555 scopus 로고    scopus 로고
    • Response and determinants of cancer cell susceptibility to PI3K inhibitors: Combined targeting of PI3K and Mek1 as an effective anticancer strategy
    • Yu K, Toral-Barza L, Shi C, et al. Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy. Cancer Biol Ther 2008; 7: 307-15.
    • (2008) Cancer Biol Ther , vol.7 , pp. 307-315
    • Yu, K.1    Toral-Barza, L.2    Shi, C.3
  • 98
    • 78751513089 scopus 로고    scopus 로고
    • PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways
    • Gedaly R, Angulo P, Hundley J, et al. PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways. Anticancer Res 2010; 30: 4951-8.
    • (2010) Anticancer Res , vol.30 , pp. 4951-4958
    • Gedaly, R.1    Angulo, P.2    Hundley, J.3
  • 99
    • 84863985238 scopus 로고    scopus 로고
    • PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation
    • Gedaly R, Angulo P, Hundley J, et al. PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation. J Surg Res 2012; 176: 542-8.
    • (2012) J Surg Res , vol.176 , pp. 542-548
    • Gedaly, R.1    Angulo, P.2    Hundley, J.3
  • 100
    • 68049085887 scopus 로고    scopus 로고
    • In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
    • Hoeflich KP, O'Brien C, Boyd Z, et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009; 15: 4649-64.
    • (2009) Clin Cancer Res , vol.15 , pp. 4649-4664
    • Hoeflich, K.P.1    O'Brien, C.2    Boyd, Z.3
  • 101
    • 84862907761 scopus 로고    scopus 로고
    • The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells
    • Zou ZQ, Zhang LN, Wang F, et al. The novel dual PI3K/mTOR inhibitor GDC-0941 synergizes with the MEK inhibitor U0126 in non-small cell lung cancer cells. Mol Med Rep 2012; 5: 503-8.
    • (2012) Mol Med Rep , vol.5 , pp. 503-508
    • Zou, Z.Q.1    Zhang, L.N.2    Wang, F.3
  • 102
    • 47349099502 scopus 로고    scopus 로고
    • Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells
    • Lasithiotakis KG, Sinnberg TW, Schittek B, et al. Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. J Invest Dermatol 2008; 128: 2013-23.
    • (2008) J Invest Dermatol , vol.128 , pp. 2013-2023
    • Lasithiotakis, K.G.1    Sinnberg, T.W.2    Schittek, B.3
  • 103
    • 78649729548 scopus 로고    scopus 로고
    • Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo
    • Meng J, Dai B, Fang B, et al. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PLoS One 2010; 5: e14124.
    • (2010) PLoS One , vol.5
    • Meng, J.1    Dai, B.2    Fang, B.3
  • 104
    • 84859874162 scopus 로고    scopus 로고
    • The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer
    • Shimizu T, Tolcher AW, Papadopoulos KP, et al. The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer. Clin Cancer Res 2012; 18: 2316-25.
    • (2012) Clin Cancer Res , vol.18 , pp. 2316-2325
    • Shimizu, T.1    Tolcher, A.W.2    Papadopoulos, K.P.3
  • 105
    • 80052749408 scopus 로고    scopus 로고
    • Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer
    • Gioeli D, Wunderlich W, Sebolt-Leopold J, et al. Compensatory pathways induced by MEK inhibition are effective drug targets for combination therapy against castration-resistant prostate cancer. Mol Cancer Ther 2011; 10: 1581-90.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1581-1590
    • Gioeli, D.1    Wunderlich, W.2    Sebolt-Leopold, J.3
  • 106
    • 84872387485 scopus 로고    scopus 로고
    • Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models
    • Corcoran Ryan B, Cheng Katherine A, Hata Aaron N, et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell 2013; 23: 121-8.
    • (2013) Cancer Cell , vol.23 , pp. 121-128
    • Corcoran Ryan, B.1    Cheng Katherine, A.2    Hata Aaron, N.3
  • 107
    • 84870825008 scopus 로고    scopus 로고
    • JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: A rationale for cotargeting these pathways in metastatic breast cancer
    • Britschgi A, Andraos R, Brinkhaus H, et al. JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer. Cancer Cell 2012; 22: 796-811.
    • (2012) Cancer Cell , vol.22 , pp. 796-811
    • Britschgi, A.1    Andraos, R.2    Brinkhaus, H.3
  • 108
    • 77950841318 scopus 로고    scopus 로고
    • A phase i study of bortezomib in combination with standard 5-fluorouracil and external-beam radiation therapy for the treatment of locally advanced or metastatic rectal cancer
    • O'Neil BH, Raftery L, Calvo BF, et al. A phase I study of bortezomib in combination with standard 5-fluorouracil and external-beam radiation therapy for the treatment of locally advanced or metastatic rectal cancer. Clin Colorectal Cancer 2010; 9: 119-25.
    • (2010) Clin Colorectal Cancer , vol.9 , pp. 119-125
    • O'Neil, B.H.1    Raftery, L.2    Calvo, B.F.3
  • 109
    • 77952548567 scopus 로고    scopus 로고
    • A randomized phase II study of bortezomib and pemetrexed, in combination or alone, in patients with previously treated advanced non-small-cell lung cancer
    • Scagliotti GV, Germonpré P, Bosquée L, et al. A randomized phase II study of bortezomib and pemetrexed, in combination or alone, in patients with previously treated advanced non-small-cell lung cancer. Lung Cancer 2010; 68: 420-6.
    • (2010) Lung Cancer , vol.68 , pp. 420-426
    • Scagliotti, G.V.1    Germonpré, P.2    Bosquée, L.3
  • 110
    • 79952263744 scopus 로고    scopus 로고
    • A phase i clinical-pharmacodynamic study of the farnesyltransferase inhibitor tipifarnib in combination with the proteasome inhibitor bortezomib in advanced acute leukemias
    • Lancet JE, Duong VH, Winton EF, et al. A phase I clinical-pharmacodynamic study of the farnesyltransferase inhibitor tipifarnib in combination with the proteasome inhibitor bortezomib in advanced acute leukemias. Clin Cancer Res 2011; 17: 1140-6.
    • (2011) Clin Cancer Res , vol.17 , pp. 1140-1146
    • Lancet, J.E.1    Duong, V.H.2    Winton, E.F.3
  • 111
    • 79957539428 scopus 로고    scopus 로고
    • Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: Results of a phase 1/2 study
    • Richardson PG, Chanan-Khan AA, Lonial S, et al. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br J Haematol 2011; 153: 729-40.
    • (2011) Br J Haematol , vol.153 , pp. 729-740
    • Richardson, P.G.1    Chanan-Khan, A.A.2    Lonial, S.3
  • 112
    • 58149180924 scopus 로고    scopus 로고
    • A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors
    • Tse AN, Klimstra DS, Gonen M, et al. A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors. Clin Cancer Res 2008; 14: 6704-11.
    • (2008) Clin Cancer Res , vol.14 , pp. 6704-6711
    • Tse, A.N.1    Klimstra, D.S.2    Gonen, M.3
  • 113
    • 80355125870 scopus 로고    scopus 로고
    • Phase i and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia
    • Kaufmann SH, Karp JE, Litzow MR, et al. Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia. Haematologica 2011; 96: 1619-26.
    • (2011) Haematologica , vol.96 , pp. 1619-1626
    • Kaufmann, S.H.1    Karp, J.E.2    Litzow, M.R.3
  • 114
    • 79955603500 scopus 로고    scopus 로고
    • Phase i study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors
    • Hubbard J, Erlichman C, Toft DO, et al. Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors. Invest New Drugs 2011; 29: 473-80.
    • (2011) Invest New Drugs , vol.29 , pp. 473-480
    • Hubbard, J.1    Erlichman, C.2    Toft, D.O.3
  • 115
    • 84856023437 scopus 로고    scopus 로고
    • A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma
    • Hendrickson AE, Oberg AL, Glaser G, et al. A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma. Gynecol Oncol 2012; 124: 210-15.
    • (2012) Gynecol Oncol , vol.124 , pp. 210-215
    • Hendrickson, A.E.1    Oberg, A.L.2    Glaser, G.3
  • 116
    • 36849055007 scopus 로고    scopus 로고
    • Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase i dose-escalation study
    • Modi S, Stopeck AT, Gordon MS, et al. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study. J Clin Oncol 2007; 25: 5410-17.
    • (2007) J Clin Oncol , vol.25 , pp. 5410-5417
    • Modi, S.1    Stopeck, A.T.2    Gordon, M.S.3
  • 117
    • 79960985354 scopus 로고    scopus 로고
    • HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
    • Modi S, Stopeck A, Linden H, et al. HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011; 17: 5132-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 5132-5139
    • Modi, S.1    Stopeck, A.2    Linden, H.3
  • 118
    • 77954712921 scopus 로고    scopus 로고
    • Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin
    • Vaishampayan UN, Burger AM, Sausville EA, et al. Safety, efficacy, pharmacokinetics, and pharmacodynamics of the combination of sorafenib and tanespimycin. Clin Cancer Res 2010; 16: 3795-804.
    • (2010) Clin Cancer Res , vol.16 , pp. 3795-3804
    • Vaishampayan, U.N.1    Burger, A.M.2    Sausville, E.A.3
  • 119
    • 75749156293 scopus 로고    scopus 로고
    • Safety and efficacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC)
    • Paz-Ares L, Sanchez Torres JM, Diaz-Padilla I, et al. Safety and efficacy of AMG 655 in combination with paclitaxel and carboplatin (PC) in patients with advanced non-small cell lung cancer (NSCLC). ASCO Meet Abstr 2009; 27: e19048.
    • (2009) ASCO Meet Abstr , vol.27
    • Paz-Ares, L.1    Sanchez Torres, J.M.2    Diaz-Padilla, I.3
  • 121
    • 84857055427 scopus 로고    scopus 로고
    • First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: A phase I/II open-label and double-blind study
    • Demetri GD, Le Cesne A, Chawla SP, et al. First-line treatment of metastatic or locally advanced unresectable soft tissue sarcomas with conatumumab in combination with doxorubicin or doxorubicin alone: a phase I/II open-label and double-blind study. Eur J Cancer 2012; 48: 547-63.
    • (2012) Eur J Cancer , vol.48 , pp. 547-563
    • Demetri, G.D.1    Le Cesne, A.2    Chawla, S.P.3
  • 123
    • 79960202283 scopus 로고    scopus 로고
    • The safety of IPI-926, a novel Hedgehog pathway inhibitor, in combination with gemcitabine in patients (pts) with metastatic pancreatic cancer
    • Stephenson J, Richards D, Wolpin B, et al. The safety of IPI-926, a novel Hedgehog pathway inhibitor, in combination with gemcitabine in patients (pts) with metastatic pancreatic cancer. J Clin Oncol 2011; 29: 4114.
    • (2011) J Clin Oncol , vol.29 , pp. 4114
    • Stephenson, J.1    Richards, D.2    Wolpin, B.3
  • 124
    • 34548528069 scopus 로고    scopus 로고
    • Phase I/II trial of temsirolimus combined with interferon alfa for advanced renal cell carcinoma
    • Motzer RJ, Hudes GR, Curti BD, et al. Phase I/II trial of temsirolimus combined with interferon alfa for advanced renal cell carcinoma. J Clin Oncol 2007; 25: 3958-64.
    • (2007) J Clin Oncol , vol.25 , pp. 3958-3964
    • Motzer, R.J.1    Hudes, G.R.2    Curti, B.D.3
  • 125
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356: 2271-81.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 126
    • 79953182631 scopus 로고    scopus 로고
    • Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: A phase 2 study
    • Ansell SM, Tang H, Kurtin PJ, et al. Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study. Lancet Oncol 2011; 12: 361-8.
    • (2011) Lancet Oncol , vol.12 , pp. 361-368
    • Ansell, S.M.1    Tang, H.2    Kurtin, P.J.3
  • 127
    • 69049096137 scopus 로고    scopus 로고
    • A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumab
    • Mani A, Roda J, Young D, et al. A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumab. Breast Cancer Res Treat 2009; 117: 83-9.
    • (2009) Breast Cancer Res Treat , vol.117 , pp. 83-89
    • Mani, A.1    Roda, J.2    Young, D.3
  • 128
    • 84862840384 scopus 로고    scopus 로고
    • Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV
    • Meier W, du Bois A, Rau J, et al. Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV. Gynecol Oncol 2012; 126: 236-40.
    • (2012) Gynecol Oncol , vol.126 , pp. 236-240
    • Meier, W.1    Du Bois, A.2    Rau, J.3
  • 129
    • 63549098589 scopus 로고    scopus 로고
    • Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205
    • Li T, Christos PJ, Sparano JA, et al. Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205. Ann Oncol 2009; 20: 642-7.
    • (2009) Ann Oncol , vol.20 , pp. 642-647
    • Li, T.1    Christos, P.J.2    Sparano, J.A.3
  • 130
    • 79954625512 scopus 로고    scopus 로고
    • A phase i clinical trial of safingol in combination with cisplatin in advanced solid tumors
    • Dickson MA, Carvajal RD, Merrill AH, Jr, et al. A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clin Cancer Res 2011; 17: 2484-92.
    • (2011) Clin Cancer Res , vol.17 , pp. 2484-2492
    • Dickson, M.A.1    Carvajal, R.D.2    Merrill, Jr.A.H.3
  • 131
    • 77951591066 scopus 로고    scopus 로고
    • Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer
    • Danila DC, Morris MJ, de Bono JS, et al. Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer. J Clin Oncol 2010; 28: 1496-501.
    • (2010) J Clin Oncol , vol.28 , pp. 1496-1501
    • Danila, D.C.1    Morris, M.J.2    De Bono, J.S.3
  • 132
    • 51649089123 scopus 로고    scopus 로고
    • Gemtuzumab-ozogamicin in combination with fludarabine, cytarabine, idarubicin (FLAI-GO) as induction therapy in CD33-positive AML patients younger than 65 years
    • Candoni A, Martinelli G, Toffoletti E, et al. Gemtuzumab-ozogamicin in combination with fludarabine, cytarabine, idarubicin (FLAI-GO) as induction therapy in CD33-positive AML patients younger than 65 years. Leuk Res 2008; 32: 1800-8.
    • (2008) Leuk Res , vol.32 , pp. 1800-1808
    • Candoni, A.1    Martinelli, G.2    Toffoletti, E.3
  • 133
    • 77649140377 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: Results of the ERISAC randomized placebo-controlled trial
    • Bundred NJ, Cramer A, Morris J, et al. Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial. Clin Cancer Res 2010; 16: 1605-12.
    • (2010) Clin Cancer Res , vol.16 , pp. 1605-1612
    • Bundred, N.J.1    Cramer, A.2    Morris, J.3
  • 134
    • 84864512253 scopus 로고    scopus 로고
    • Combination anastrozole and fulvestrant in metastatic breast cancer
    • Mehta RS, Barlow WE, Albain KS, et al. Combination anastrozole and fulvestrant in metastatic breast cancer. N Engl J Med 2012; 367: 435-44.
    • (2012) N Engl J Med , vol.367 , pp. 435-444
    • Mehta, R.S.1    Barlow, W.E.2    Albain, K.S.3
  • 135
    • 70350450612 scopus 로고    scopus 로고
    • Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia
    • Schimmer AD, Estey EH, Borthakur G, et al. Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia. J Clin Oncol 2009; 27: 4741-6.
    • (2009) J Clin Oncol , vol.27 , pp. 4741-4746
    • Schimmer, A.D.1    Estey, E.H.2    Borthakur, G.3
  • 136
    • 78650174731 scopus 로고    scopus 로고
    • Single-arm phase II study of conformal radiation therapy and temozolomide plus fractionated stereotactic conformal boost in high-grade gliomas: Final report
    • Balducci M, Apicella G, Manfrida S, et al. Single-arm phase II study of conformal radiation therapy and temozolomide plus fractionated stereotactic conformal boost in high-grade gliomas: final report. Strahlenther Onkol 2010; 186: 558-64.
    • (2010) Strahlenther Onkol , vol.186 , pp. 558-564
    • Balducci, M.1    Apicella, G.2    Manfrida, S.3
  • 137
    • 42749083267 scopus 로고    scopus 로고
    • Randomized phase 3 trial of interferon γ-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: Results from a prospectively designed analysis of progression-free survival
    • Alberts DS, Marth C, Alvarez RD, et al. Randomized phase 3 trial of interferon γ-1b plus standard carboplatin/paclitaxel versus carboplatin/paclitaxel alone for first-line treatment of advanced ovarian and primary peritoneal carcinomas: results from a prospectively designed analysis of progression-free survival. Gynecol Oncol 2008; 109: 174-81.
    • (2008) Gynecol Oncol , vol.109 , pp. 174-181
    • Alberts, D.S.1    Marth, C.2    Alvarez, R.D.3
  • 138
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol 2012; 30: 2046-54.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 139
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • Neckers L, Workman P,. Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 2012; 18: 64-76.
    • (2012) Clin Cancer Res , vol.18 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 140
    • 22244485706 scopus 로고    scopus 로고
    • Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
    • Shimamura T, Lowell AM, Engelman JA, et al. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res 2005; 65: 6401-8.
    • (2005) Cancer Res , vol.65 , pp. 6401-6408
    • Shimamura, T.1    Lowell, A.M.2    Engelman, J.A.3
  • 141
    • 33745071182 scopus 로고    scopus 로고
    • Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT
    • Sain N, Krishnan B, Ormerod MG, et al. Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT. Mol Cancer Ther 2006; 5: 1197-208.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1197-1208
    • Sain, N.1    Krishnan, B.2    Ormerod, M.G.3
  • 142
    • 84875539014 scopus 로고    scopus 로고
    • Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models
    • Proia DA, Sang J, He S, et al. Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models. Invest New Drugs 2012: 30: 2201-9.
    • (2012) Invest New Drugs , vol.30 , pp. 2201-2209
    • Proia, D.A.1    Sang, J.2    He, S.3
  • 143
    • 28944449421 scopus 로고    scopus 로고
    • Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy
    • Sayers TJ, Murphy WJ,. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer Immunol Immunother 2006; 55: 76-84.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 76-84
    • Sayers, T.J.1    Murphy, W.J.2
  • 144
    • 77953071740 scopus 로고    scopus 로고
    • Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors
    • Lee S, Yagita H, Sayers TJ, et al. Optimized combination therapy using bortezomib, TRAIL and TLR agonists in established breast tumors. Cancer Immunol Immunother 2010; 59: 1073-81.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1073-1081
    • Lee, S.1    Yagita, H.2    Sayers, T.J.3
  • 145
    • 77956565472 scopus 로고    scopus 로고
    • A combination of DR5 agonistic monoclonal antibody with gemcitabine targets pancreatic cancer stem cells and results in long-term disease control in human pancreatic cancer model
    • Rajeshkumar N, Rasheed ZA, García-García E, et al. A combination of DR5 agonistic monoclonal antibody with gemcitabine targets pancreatic cancer stem cells and results in long-term disease control in human pancreatic cancer model. Mol Cancer Ther 2010; 9: 2582-92.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2582-2592
    • Rajeshkumar, N.1    Rasheed, Z.A.2    García-García, E.3
  • 146
    • 72449176627 scopus 로고    scopus 로고
    • Safety and efficacy of AMG 655 plus modified FOLFOX6 (mFOLFOX6) and bevacizumab (B) for the first-line treatment of patients (pts) with metastatic colorectal cancer (mCRC)
    • Saltz L, Infante J, Schwartzberg L, et al. Safety and efficacy of AMG 655 plus modified FOLFOX6 (mFOLFOX6) and bevacizumab (B) for the first-line treatment of patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol 2009; 27: 4079.
    • (2009) J Clin Oncol , vol.27 , pp. 4079
    • Saltz, L.1    Infante, J.2    Schwartzberg, L.3
  • 147
    • 72449138830 scopus 로고    scopus 로고
    • A phase Ib/II trial of AMG 655 and panitumumab (pmab) for the treatment (tx) of metastatic colorectal cancer (mCRC): Safety results
    • Rougier P, Infante J, Van Laethem J, et al. A phase Ib/II trial of AMG 655 and panitumumab (pmab) for the treatment (tx) of metastatic colorectal cancer (mCRC): safety results. J Clin Oncol 2009; 27: 4130.
    • (2009) J Clin Oncol , vol.27 , pp. 4130
    • Rougier, P.1    Infante, J.2    Van Laethem, J.3
  • 148
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • Rubin LL, De Sauvage FJ,. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006; 5: 1026-33.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    De Sauvage, F.J.2
  • 149
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/[beta]-catenin signaling in cancer stemness and malignant behavior
    • Fodde R, Brabletz T,. Wnt/[beta]-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007; 19: 150-8.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 151
    • 77953700950 scopus 로고    scopus 로고
    • Targeting Notch to target cancer stem cells
    • Pannuti A, Foreman K, Rizzo P, et al. Targeting Notch to target cancer stem cells. Clin Cancer Res 2010; 16: 3141-52.
    • (2010) Clin Cancer Res , vol.16 , pp. 3141-3152
    • Pannuti, A.1    Foreman, K.2    Rizzo, P.3
  • 152
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen L, Felipe De Sousa EM, van der Heijden M, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010; 12: 468-76.
    • (2010) Nat Cell Biol , vol.12 , pp. 468-476
    • Vermeulen, L.1    Felipe De Sousa, E.M.2    Van Der Heijden, M.3
  • 153
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Zhao C, Chen A, Jamieson CH, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 2009; 458: 776-9.
    • (2009) Nature , vol.458 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 154
    • 84863338229 scopus 로고    scopus 로고
    • The crosstalk of mTOR/S6K1 and Hedgehog pathways
    • Wang Y, Ding Q, Yen C-J, et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 2012; 21: 374-87.
    • (2012) Cancer Cell , vol.21 , pp. 374-387
    • Wang, Y.1    Ding, Q.2    Yen, C.-J.3
  • 156
    • 79951553370 scopus 로고    scopus 로고
    • XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML
    • Carter BZ, Mak DH, Morris SJ, et al. XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML. Apoptosis 2011; 16: 67-74.
    • (2011) Apoptosis , vol.16 , pp. 67-74
    • Carter, B.Z.1    Mak, D.H.2    Morris, S.J.3
  • 157
    • 52449105507 scopus 로고    scopus 로고
    • Phase i study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia
    • Klisovic RB, Blum W, Wei X, et al. Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia. Clin Cancer Res 2008; 14: 3889-95.
    • (2008) Clin Cancer Res , vol.14 , pp. 3889-3895
    • Klisovic, R.B.1    Blum, W.2    Wei, X.3
  • 158
    • 81255127285 scopus 로고    scopus 로고
    • Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: A controlled phase 2B trial
    • Quoix E, Ramlau R, Westeel V, et al. Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial. Lancet Oncol 2011; 12: 1125-33.
    • (2011) Lancet Oncol , vol.12 , pp. 1125-1133
    • Quoix, E.1    Ramlau, R.2    Westeel, V.3
  • 159
    • 84886944075 scopus 로고    scopus 로고
    • Combining targeted therapy with immunotherapy (interferon-α): Rational, efficacy in gastrointestinal stromal tumor model, and implications in other malignancies
    • Chen L, Gouw L, Sabripour M, et al. Combining targeted therapy with immunotherapy (interferon-α): rational, efficacy in gastrointestinal stromal tumor model, and implications in other malignancies. Oncoimmunology 2012; 1: 773-6.
    • (2012) Oncoimmunology , vol.1 , pp. 773-776
    • Chen, L.1    Gouw, L.2    Sabripour, M.3
  • 160
    • 79952259564 scopus 로고    scopus 로고
    • Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
    • Arcila ME, Oxnard GR, Nafa K, et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011; 17: 1169-80.
    • (2011) Clin Cancer Res , vol.17 , pp. 1169-1180
    • Arcila, M.E.1    Oxnard, G.R.2    Nafa, K.3
  • 161
    • 79952716897 scopus 로고    scopus 로고
    • Rebiopsy of patients (pts) with acquired resistance to epidermal growth factor tyrosine-kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC)
    • Arcila M, Riely G, Zakowski M, et al. Rebiopsy of patients (pts) with acquired resistance to epidermal growth factor tyrosine-kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC). J Clin Oncol 2009; 27: 8025.
    • (2009) J Clin Oncol , vol.27 , pp. 8025
    • Arcila, M.1    Riely, G.2    Zakowski, M.3


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