Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2

Journal of Cardiovascular Translational Research

Volumn 8, Issue 5, 2015, Pages 293-318

  Pasipoularides, Ares ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Duke NSF Research Center for Emerging Cardiovascular Technologies   (United States)

Author keywords

Cardiac cytomechanics; Cardiac gene regulation; Endocardial vortical shear and squeeze; Epigenetic factors; Filling vortex forces; Flow imaging modalities; Intracardiac flow; Next Generation Sequencing (NGS) technologies

Indexed keywords

CELL SURFACE RECEPTOR; INTEGRIN;

ARTICLE; CELL COMPONENT; CELL JUNCTION; CELL NUCLEUS; CELL STRUCTURE; COMPUTATIONAL FLUID DYNAMICS; CYTOLOGY; DIASTOLE; ELASTICITY; ENDOCARDIUM; EPIGENETICS; EVOLUTIONARY ADAPTATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENOTYPE ENVIRONMENT INTERACTION; HEART FIBROBLAST; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE CELL; HEART RIGHT VENTRICLE; HEART VENTRICLE REMODELING; HUMAN; INTERMEDIATE FILAMENT; ISCHEMIC HEART DISEASE; MECHANOTRANSDUCTION; MICROFILAMENT; MICROTUBULE; NONHUMAN; NUCLEOSKELETON; PRIORITY JOURNAL; SHEAR FLOW; SIGNAL TRANSDUCTION; TORQUE; VORTEX MOTION; CARDIAC MUSCLE; CORONARY ARTERY DISEASE; GENETIC EPIGENESIS; GENETICS; GENOME; HEART; HEART VENTRICLE FUNCTION; HYDRODYNAMICS; PHYSIOLOGY; TRANSLATIONAL RESEARCH;

CORONARY DISEASE; EPIGENESIS, GENETIC; GENE EXPRESSION; GENOME; HEART; HUMANS; HYDRODYNAMICS; MECHANOTRANSDUCTION, CELLULAR; MYOCARDIUM; RECEPTORS, CELL SURFACE; TRANSLATIONAL MEDICAL RESEARCH; VENTRICULAR FUNCTION;

EID: 84938287070     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-015-9630-8     Document Type: Article

References (231)

1. Pasipoularides, A. (2010). Heart's Vortex: Intracardiac Blood Flow Phenomena (p. 960). Shelton: CT: People's Medical Publishing House.
2. Pasipoularides, A. (2012). Diastolic filling vortex forces and cardiac adaptations: probing the epigenetic nexus. Hellenic Journal of Cardiology, 53, 458–69.
3. Pasipoularides, A. (2015). Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: Part 1. Journal of Cardiovascular Translational Research, 8, 76–87. doi:10.1007/s12265-015-9611-y.
4. Hines, L. M., Stampfer, M. J., Ma, J., et al. (2001). Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. New England Journal of Medicine, 344, 549–555.
5. Talmud, P. J., Stephens, J. W., Hawe, E., et al. (2005). The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4. Annals of Human Genetics, 69, 613–622.
6. Brull, D. J., Dhamrait, S., Moulding, R., et al. (2002). The effect of fibrinogen genotype on fibrinogen levels after strenuous physical exercise. Thrombosis and Haemostasis, 87, 37–41.
7. Abu-Amero, K. K., Al-Boudari, O. M., Mohamed, G. H., & Dzimiri, N. (2006). T null and M null genotypes of the glutathione S-transferase gene are risk factors for CAD independent of smoking. BMC Medical Genetics, 7, 38.
8. Pimstone, S. N., Sun, X. M., du Souich, C., Frohlich, J. J., Hayden, M. R., & Soutar, A. K. (1998). Phenotypic variation in heterozygous familial hypercholesterolemia: a comparison of Chinese patients with the same or similar mutations in the LDL receptor gene in China or Canada. Arteriosclerosis Thrombosis and Vascular Biology, 18, 309–315.
9. Garrod, A. (1902). The incidence of alkaptonuria: a study in chemical individuality. Lancet, 2, 1616–20.
10. Qin, Z., Buehler, M. J., & Kreplak, L. (2010). A multi-scale approach to understand the mechanobiology of intermediate filaments. Journal of Biomechanics, 43, 15–22.
11. Fuchs, E., & Cleveland, D. W. (1998). A structural scaffolding of intermediate filaments in health and disease. Science, 279(5350), 514–9.
12. Calaghan, S. C., Le Guennec, J. Y., & White, E. (2004). Cytoskeletal modulation of electrical and mechanical activity in cardiac myocytes. Progress in Biophysics and Molecular Biology, 84, 29–59.
13. Capetanaki, Y., Bloch, R. J., Kouloumenta, A., Mavroidis, M., & Psarras, S. (2007). Muscle intermediate filaments and their links to membranes and membranous organelles. Experimental Cell Research, 313, 2063–76.
14. Deroanne, C. F., Lapiere, C. M., & Nusgens, B. V. (2001). In vitro tubulogenesis of endothelial cells by relaxation of the coupling extracellular matrix-cytoskeleton. Cardiovascular Research, 49, 647–58.
15. Buss, F., & Kendrick-Jones, J. (2011). Multifunctional myosin VI has a multitude of cargoes. Proceedings of the National Academy of Sciences of the United States of America, 108, 5927–8.
16. Hoffman, L. M., Jensen, C. C., Chaturvedi, A., Yoshigi, M., & Beckerle, M. C. (2012). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Molecular Biology of the Cell, 23, 1846–59.
17. Mengistu, M., Brotzman, H., Ghadiali, S., & Lowe-Krentz, L. (2011). Fluid shear stress-induced JNK activity leads to actin remodeling for cell alignment. Journal of Cellular Physiology, 226, 110–21.
18. Granzier, H. L., & Irving, T. C. (1995). Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. Biophysical Journal, 68, 1027–44.
19. Gregorio, C. C., & Antin, P. B. (2000). To the heart of myofibril assembly. Trends in Cell Biology, 10, 355–62.
20. Zile, M., Koide, M., Sato, H., et al. (1999). Role of microtubules in the contractile dysfunction of hypertrophied myocardium. Journal of the American College of Cardiology, 33, 250–60.
21. Tagawa, H., Wang, N., Narishige, T., Ingber, D. E., Zile, M. R., & Cooper, G. (1997). Cytoskeletal mechanics in pressure overload cardiac hypertrophy. Circulation Research, 80, 281–89.
22. Haggart, C. R., Ames, E. G., Lee, J. K., & Holmes, J. W. (2014). Effects of stretch and shortening on gene expression in intact myocardium. Physiological Genomics, 46, 57–65.
23. Ingber, D. E., & Tensegrity, I. (2003). Cell structure and hierarchical systems biology. Journal of Cell Science, 116, 1157–73.
24. Kumar, S., Maxwell, I. Z., Heisterkamp, A., et al. (2006). Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophysical Journal, 90, 3762–73.
25. Trepat, X., Deng, L., An, S. S., et al. (2007). Universal physical responses to stretch in the living cell. Nature, 447, 592–595.
26. Soares, E., Silva, M., Depken, M., Stuhrmann, B., Korsten, M., MacKintosh, F. C., & Koenderink, G. H. (2011). Active multistage coarsening of actin networks driven by myosin motors. Proceedings of the National Academy of Sciences, 108, 9408–13.
27. Vale, R. D. (2003). The molecular motor toolbox for intracellular transport. Cell, 112, 467–80.
28. Geiger, B., & Bershadsky, A. (2002). Exploring the neighborhood: adhesion-coupled cell mechanosensors. Cell, 110, 139–42.
29. Sarantitis, I., Papanastasopoulos, P., Manousi, M., Baikoussis, N. G., & Apostolakis, E. (2012). The cytoskeleton of the cardiac muscle cell. Hellenic Journal of Cardiology, 53, 367–79.
30. Kostin, S., Hein, S., Arnon, E., Scholz, D., & Schaper, J. (2000). The cytoskeleton and related proteins in the human failing heart. Heart Failure Reviews, 5, 271–80.
31. Ervasti, J. M. (2003). Costameres: the Achilles’ heel of Herculean muscle. Journal of Biological Chemistry, 278, 13591–4.
32. Samarel, A. M. (2014). Focal adhesion signaling in heart failure. Pflügers Archiv - European Journal of Physiology, 466, 1101–11.
33. Wheelock, M. J., & Johnson, K. R. (2003). Cadherins as modulators of cellular phenotype. Annual Review of Cell and Developmental Biology, 19, 207–35.
34. Kim, S. A., Tai, C.-Y., Mok, L.-P., Mosser, E. A., & Schuman, E. M. (2011). Calcium dependent dynamics of cadherin interactions at cell-cell junctions. Proceedings of the National Academy of Sciences of the United States of America, 108, 9857–62.
35. Yap, A. S., Crampton, M. S., & Hardin, J. (2007). Making and breaking contacts: the cellular biology of cadherin regulation. Current Opinion in Cell Biology, 19, 508–14.
36. Resink, T. J., Philippova, M., Joshi, M. B., Kyriakakis, E., & Erne, P. (2009). Cadherins and cardiovascular disease. Swiss Medical Weekly, 139, 122–34.
37. Koenderink, G. H., Dogic, Z., Nakamura, F., et al. (2009). An active biopolymer network controlled by molecular motors. Proceedings of the National Academy of Sciences, 106, 15192–7.
38. Wen, Q., & Janmey, P. A. (2011). Polymer physics of the cytoskeleton. Current Opinion in Solid State and Materials Science, 15, 177–82.
39. Pasipoularides, A., Vlachos, P. P., & Little, W. C. (2015). Vortex formation time is not an index of ventricular function. Journal of Cardiovascular Translational Research, 8, 54–8. doi:10.1007/s12265-015-9607-7.
40. Pasipoularides, A. (2015). Fluid dynamics of ventricular filling in heart failure: overlooked problems of RV/LV chamber dilatation. Hellenic Journal of Cardiology, 56, 85–95.
41. Yurchenco, P. (2011). Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harbor Perspectives in Biology, 3, a004911.
42. Sivakumar, P., Gupta, S., Sarkar, S., & Sen, S. (2008). Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy. Molecular and Cellular Biochemistry, 307, 159–67.
43. Page-McCaw, A., Ewald, A. J., & Werb, Z. (2007). Matrix metalloproteinases and the regulation of tissue remodelling. Nature Reviews Molecular Cell Biology, 8, 221–33.
44. Tyagi, S. C., & Joshua, I. G. (2014). Exercise and nutrition in myocardial matrix metabolism, remodeling, regeneration, epigenetics, microcirculation, and muscle. Canadian Journal of Physiology and Pharmacology, 92, 521–3.
45. Mujumdar, V. S., Smiley, L. M., & Tyagi, S. C. (2001). Activation of matrix metalloproteinase dilates and decreases cardiac tensile strength. International Journal of Cardiology, 79, 277–86.
46. Pasipoularides, A. D., Shu, M., Womack, M. S., Shah, A., Von Ramm, O., & Glower, D. D. (2003). RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations. American Journal of Physiology. Heart and Circulatory Physiology, 284, H56–H65.
47. Pasipoularides, A. (2013). Right and left ventricular diastolic pressure–volume relations: a comprehensive review. Journal of Cardiovascular Translational Research, 6, 239–52.
48. Pasipoularides, A. (2011). LV twisting-and-untwisting in HCM: ejection begets filling. Diastolic functional aspects of HCM. American Heart Journal, 162, 798–810.
49. Muiznieks, L. D., Weiss, A. S., & Keeley, F. W. (2010). Structural disorder and dynamics of elastin. Biochemistry and Cell Biology, 88, 239–50.
50. Castaldo, C., Di Meglio, F., Miraglia, R., et al. (2013). Cardiac fibroblast-derived extracellular matrix (biomatrix) as a model for the studies of cardiac primitive cell biological properties in normal and pathological adult human heart. BioMed Research International, 2013, 352370.
51. Souders, C. A., Bowers, S. L., & Baudino, T. A. (2009). Cardiac fibroblast: the renaissance cell. Circulation Research, 105, 1164–76.
52. Thompson, S. A., Blazeski, A., Copeland, C. R., et al. (2014). Acute slowing of cardiac conduction in response to myofibroblast coupling to cardiomyocytes through N-cadherin. Journal of Molecular and Cellular Cardiology, 68, 29–37.
53. Schéele, S., Nyström, A., Durbeej, M., Talts, J. F., Ekblom, M., & Ekblom, P. (2007). Laminin isoforms in development and disease. Journal of Molecular Medicine (Berl), 85, 825–36.
54. Pankov, R., & Yamada, K. M. (2002). Fibronectin at a glance. Journal of Cell Science, 115, 3861–3.
55. Smith, M. L., Gourdon, D., Little, W. C., et al. (2007). Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biology, 5(10), e268.
56. Hynes, R. O. (2009). The extracellular matrix: not just pretty fibrils. Science, 326, 1216–9.
57. Fan, D., Takawale, A., Lee, J., & Kassiri, Z. (2012). Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis and Tissue Repair, 5, 15–28.
58. Wang, P., Valentijn, A. J., Gilmore, A. P., & Streuli, C. H. (2003). Early events in the anoikis program occur in the absence of caspase activation. Journal of Biological Chemistry, 278, 19917–25.
59. Heidkamp, M. C., Bayer, A. L., Kalina, J. A., Eble, D. M., & Samarel, A. M. (2002). GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes. Circulation Research, 90, 1282–9.
60. Provenzano, P. P., & Keely, P. J. (2011). Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling. Journal of Cell Science, 124, 1195–205.
61. Harburger, D. S., & Calderwood, D. A. (2009). Integrin signalling at a glance. Journal of Cell Science, 122(Pt 2), 159–63.
62. Bhat, R., & Bissell, M. J. (2013). Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype. WIREs Developmental Biology. doi:10.1002/wdev.130.
63. Tamkun, J. W., DeSimone, D. W., Fonda, D., et al. (1986). Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell, 46, 271–82.
64. Hynes, R. O. (2002). Integrins: bidirectional, allosteric signaling machines. Cell, 110, 673–687.
65. Schwartz, M. A. (2010). Integrins and extracellular matrix in mechanotransduction. Cold Spring Harbor Perspectives in Biology, 2, a005066.
66. Berrier, A. L., & Yamada, K. M. (2007). Cell-matrix adhesion. Journal of Cellular Physiology, 213, 565–73.
67. Choquet, D., Felsenfeld, D. P., & Sheetz, M. P. (1997). Extracellular matrix rigidity causes strengthening of integrin-cytoskeletal linkages. Cell, 88, 39–48.
68. Takada, Y., Ye, X., & Simon, S. (2007). The integrins. Genome Biology, 8, 215.1–215.9.
69. Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011). Dynamic molecular processes mediate cellular mechanotransduction. Nature, 475, 316–23.
70. Peng, X., Kraus, M. S., Wei, H., et al. (2006). Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. Journal of Clinical Investigation, 116, 217–27.
71. Peng, X., Wu, X., Druso, J. E., et al. (2008). Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 105, 6638–43.
72. Legate, K. R., Wickström, S. A., & Fässler, R. (2009). Genetic and cell biological analysis of integrin outside-in signaling. Genes and Development, 23, 397–418.
73. + current in vascular endothelial cells. Nature, 331, 168–70.
74. Brakemeier, S., Eichler, I., Hopp, H., Kohler, R., & Hoyer, J. (2002). Up-regulation of endothelial stretch-activated cation channels by fluid shear stress. Cardiovascular Research, 53, 209–18.
75. Bray, M. A., Sheehy, S. P., & Parker, K. K. (2008). Sarcomere alignment is regulated by myocyte shape. Cell Motility and the Cytoskeleton, 65, 641–51.
76. Salameh, A., & Dhein, S. (2013). Effects of mechanical forces and stretch on intercellular gap junction coupling. Biochimica et Biophysica Acta, 1828, 147–56.
77. Yefimov, S., van der Giessen, E., Onck, P. R., & Marrink, S. J. (2008). Mechanosensitive membrane channels in action. Biophysical Journal, 94, 2994–3002.
78. Gervasio, O. L., Phillips, W. D., Cole, L., & Allen, D. G. (2011). Caveolae respond to cell stretch and contribute to stretch-induced signaling. Journal of Cell Science, 124, 3581–90.
79. Rizzo, V., Morton, C., DePaola, N., Schnitzer, J. E., & Davies, P. F. (2003). Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro. American Journal of Physiology Heart and Circulatory Physiology, 285, H1720–9.
80. Parton, R. G., & del Pozo, M. (2013). Caveolae as plasma membrane sensors, protectors and organizers. Nature Reviews Molecular Cell Biology, 14, 98–112.
81. Davies, P. F. (1995). Flow-mediated endothelial mechanotransduction. Physiological Reviews, 75, 519–60.
82. Tamada, M., Sheetz, M. P., & Sawada, Y. (2004). Activation of a signaling cascade by cytoskeleton stretch. Developmental Cell, 7, 709–18.
83. Roca-Cusachs, P., del Rio, A., Puklin-Faucher, E., Gauthier, N. C., Biais, N., & Sheetz, M. P. (2013). Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation. Proceedings of the National Academy of Sciences of the United States of America, 110, E1361–E1370.
84. Vogel, V. (2006). Mechanotransduction involving multimodular proteins: converting force into biochemical signals. Annual Review of Biophysics and Biomolecular Structure, 35, 459–88.
85. Vogel, V., & Sheetz, M. (2006). Local force and geometry sensing regulate cell functions. Nature Reviews Molecular Cell Biology, 7, 265–75.
86. Wang, N., Butler, J. P., & Ingber, D. E. (1993). Mechanotransduction across the cell surface and through the cytoskeleton. Science, 260, 1124–7.
87. Shapiro, L., Fannon, A. M., Kwong, P. D., et al. (1995). Structural basis of cell-cell adhesion by cadherins. Nature, 374, 327–37.
88. Kim, S. A., Tai, C. Y., Mok, L. P., Mosser, E. A., & Schuman, E. M. (2011). Calcium-dependent dynamics of cadherin interactions at cell-cell junctions. Proceedings of the National Academy of Sciences, 108, 9857–62.
89. Calderwood, D. A. (2004). Integrin activation. Journal of Cell Science, 117, 657–66.
90. Tarbell, J. M., & Pahakis, M. Y. (2006). Mechanotransduction and the glycocalyx. Journal of Internal Medicine, 259, 339–50.
91. Critchley, D. R. (2004). Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion. Biochemical Society Transactions, 32, 831–6.
92. Giannone, G., Mège, R. M., & Thoumine, O. (2009). Multi-level molecular clutches in motile cell processes. Trends in Cell Biology, 19, 475–86.
93. Liu, Z., Tan, J. L., Cohen, D. M., et al. (2010). Mechanical tugging force regulates the size of cell–cell junctions. Proceedings of the National Academy of Sciences of the United States of America, 107, 9944–9.
94. Morgan, M. R., Humphries, M. J., & Bass, M. D. (2007). Synergistic control of cell adhesion by integrins and syndecans. Nature Reviews Molecular Cell Biology, 8, 957–69.
95. Sastry, S. K., & Burridge, K. (2000). Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Experimental Cell Research, 261, 25–36.
96. Martinez-Rico, C., Pincet, F., Thiery, J. P., & Dufour, S. (2010). Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility. Journal of Cell Science, 123, 712–22.
97. Samarel, A. M. (2005). Costameres, focal adhesions, and cardiomyocyte mechanotransduction. American Journal of Physiology. Heart and Circulatory Physiology, 289, H2291–301.
98. McCain, M. L., & Parker, K. K. (2011). Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflügers Archiv-European Journal of Physiology, 462, 89–104.
99. Chopra, A., Tabdanov, E., Patel, H., Janmey, P. A., & Kresh, J. Y. (2011). Cardiac myocyte remodeling mediated by N-cadherin- dependent mechanosensing. American Journal of Physiology. Heart and Circulatory Physiology, 300, H1252–66.
100. Wilson, A. J., Schoenauer, R., Ehler, E., Agarkova, I., & Bennett, P. M. (2014). Cardiomyocyte growth and sarcomerogenesis at the intercalated disc. Cellular and Molecular Life Sciences, 71, 165–81.
101. Perriard, J. C., Hirschy, A., & Ehler, E. (2003). Dilated cardiomyopathy: a disease of the intercalated disc? Trends in Cardiovascular Medicine, 13, 30–8.
102. Pilichou, K., Nava, A., Basso, C., et al. (2006). Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy. Circulation, 113, 1171–79.
103. Wang, N., Tytell, J. D., & Ingber, D. E. (2009). Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nature Reviews Molecular Cell Biology, 10, 75–82.
104. Kull, F. J., & Endow, S. A. (2013). Force generation by kinesin and myosin cytoskeletal motor proteins. Journal of Cell Science, 126, 9–19.
105. Kastritis, P. L., & Bonvin, A. M. (2012). On the binding affinity of macromolecular interactions: daring to ask why proteins interact. Journal of the Royal Society Interface, 10, 20120835.
106. Gustavsson, M., Traaseth, N. J., CB Karim, C. B., et al. (2011). Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase. Journal of Molecular Biology, 408, 755–65.
107. MacLennan, D. H., & Kranias, E. G. (2003). Phospholamban: a crucial regulator of cardiac contractility. Nature Reviews Molecular Cell Biology, 4, 566–77.
108. Hu, S., Chen, J., Butler, J. P., & Wang, N. (2005). Prestress mediates force propagation into the nucleus. Biochemical and Biophysical Research Communications, 329, 423–8.
109. Na, S., Collin, O., Chowdhury, F., et al. (2008). Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proceedings of the National Academy of Sciences of the United States of America, 105, 6626–31.
110. Kouzarides, T. (2007). Chromatin modifications and their function. Cell, 128, 693–705.
111. Pasipoularides, A. (2007). Complementarity and competitiveness of the intrinsic and extrinsic components of the total ventricular load: Demonstration after valve replacement in aortic stenosis Editorial. American Heart Journal, 153, 4–6.
112. Ingber, D. E. (2008). Tensegrity-based mechanosensing from macro to micro. Progress in Biophysics and Molecular Biology, 97, 163–79.
113. Ingber, D. E. (2006). Cellular mechanotransduction: putting all the pieces together again. FASEB Journal, 20, 811–827.
114. Granzier, H. L., & Labeit, S. (2004). The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circulation Research, 94, 284–95.
115. Dorn, G. W., II, Robbins, J., & Sugden, P. H. (2003). Phenotyping hypertrophy: eschew obfuscation. Circulation Research, 92, 1171–5.
116. Blaauw, E., Lorenzen-Schmidt, I., Babiker, F. A., et al. (2013). Stretch-induced upregulation of connective tissue growth factor in rabbit cardiomyocytes. Journal of Cardiovascular Translational Research, 6, 861–9.
117. Xu, L., Glass, C. K., & Rosenfeld, M. G. (1999). Coactivator and corepressor complexes in nuclear receptor function. Current Opinion in Genetics and Development, 9, 140–7.
118. Dahl, K. N., & Kalinowski, A. (2011). Nucleoskeleton mechanics at a glance. Journal of Cell Science, 124, 675–8.
119. Webster, M., Witkin, K. L., & Cohen-Fix, O. (2009). Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly. Journal of Cell Science, 122, 1477–86.
120. Starr, D. A., & Fridolfsson, H. N. (2010). Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annual Review of Cell and Developmental Biology, 26, 421–44.
121. Janmey, P. A., Wells, R. G., Assoian, R. K., & McCulloch, C. A. (2013). From tissue mechanics to transcription factors. Differentiation, 86, 112–20.
122. Stroud, M. J., Banerjee, I., Veevers, J., & Chen, J. (2014). Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease. Circulation Research, 114, 538–48.
123. Simon, D. N., & Wilson, K. L. (2011). The nucleoskeleton as a genome-associated dynamic 'network of networks'. Nature Reviews Molecular Cell Biology, 12, 695–708.
124. Tzur, Y. B., Wilson, K. L., & Gruenbaum, Y. (2006). SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton. Nature Reviews Molecular Cell Biology, 7, 782–8.
125. Dahl, K. N., Ribeiro, A. J., & Lammerding, J. (2008). Nuclear shape, mechanics, and mechanotransduction. Circulation Research, 102, 1307–18.
126. Nickerson, J. (2001). Experimental observations of a nuclear matrix. Journal of Cell Science, 114, 463–74.
127. Orr, A. W., Helmke, B. P., Blackman, B. R., & Schwartz, M. A. (2006). Mechanisms of mechanotransduction. Developmental Cell, 10, 11–20.
128. De, R., Zemel, A., & Safran, S. A. (2008). Do cells sense stress or strain? Measurement of cellular orientation can provide a clue. Biophysical Journal, 94, L29–31.
129. Ohno, M., Gibbons, G. H., Dzau, V. J., & Cooke, J. P. (1993). Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. Circulation, 88, 193–7.
130. Dzau, V. J. (2002). Transcription factor decoy. Circulation Research, 90, 1234–6.
131. Georgatos, S. D. (1994). Towards an understanding of nuclear morphogenesis. Journal of Cellular Biochemistry, 55, 69–76.
132. Zlatanova, J., & Leuba, S. H. (2002). Stretching and imaging single DNA molecules and chromatin. Journal of Muscle Research and Cell Motility, 23, 377–95.
133. Marko, J. F., & Poirier, M. G. (2003). Micromechanics of chromatin and chromosomes. Biochemistry and Cell Biology, 81, 209–20.
134. Trinkle-Mulcahy, L., & Lamond, A. I. (2007). Toward a high-resolution view of nuclear dynamics. Science, 318, 1402–7.
135. Knudsen, H. L., & Frangos, J. A. (1997). Role of cytoskeleton in shear stress-induced endothelial nitric oxide production. American Journal of Physiology Heart and Circulatory Physiology, 273, H347–55.
136. Visa, N. (2005). Actin in transcription. EMBO Reports, 6, 218–9.
137. Bettinger, B. T., Gilbert, D. M., & Amberg, D. C. (2004). Actin up in the nucleus. Nature Reviews Molecular Cell Biology, 5, 410–5.
138. Olave, I. A., Reck-Peterson, S. L., & Crabtree, G. R. (2002). Nuclear actin and actin-related proteins in chromatin remodeling. Annual Review of Biochemistry, 71, 755–81.
139. Jaalouk, D. E., & Lammerding, J. (2009). Mechanotransduction gone awry. Nature Reviews Molecular Cell Biology, 10, 63–73.
140. Helmke, B. P. (2005). Molecular control of cytoskeletal mechanics by hemodynamic forces. Physiology, 20, 43–53.
141. Nauli, S. M., Kawanabe, Y., Kaminski, J. J., Pearce, W. J., Ingber, D. E., & Zhou, J. (2008). Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation, 117, 1161–71.
142. Boo, Y. C., & Jo, H. (2003). Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. American Journal of Physiology Cell Physiology, 285, C499–508.
143. Bellin, R. M., Kubicek, J. D., Frigault, M. J., et al. (2009). Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches. Proceedings of the National Academy of Sciences, 106, 22102–7.
144. Li, C., Hu, Y., Mayr, M., & Xu, Q. (1999). Cyclic strain stress-induced mitogen-activated protein kinase (MAPK) phosphatase 1 expression in vascular smooth muscle cells is regulated by Ras/Rac-MAPK pathways. Journal of Biological Chemistry, 274, 25273–80.
145. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., et al. (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature, 369, 156–60.
146. Davis, R. J. (1993). The mitogen-activated protein kinase signal transduction pathway. Journal of Biological Chemistry, 268, 14553–6.
147. Griffith, L. G., & Swartz, M. A. (2006). Capturing complex 3D tissue physiology in vitro. Nature Reviews Molecular Cell Biology, 7, 211–24.
148. Tzima, E., Irani-Tehrani, M., Kiosses, W. B., et al. (2005). A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature, 437(7057), 426–31.
149. Faust, U., Hampe, N., Rubner, W., et al. (2011). Cyclic stress at mHz frequencies aligns fibroblasts in direction of zero strain. PLoS ONE, 6(12), e28963.
150. De, R., Zemel, A., & Safran, S. A. (2007). Dynamics of cell orientation. Nature Physics, 3, 655–9.
151. Waddington, C. H. (1939). An introduction to modern genetics. New York: Macmillan.
152. Mirotsou, M., Dzau, V. J., Pratt, R. E., & Weinberg, E. O. (2006). Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy. Physiological Genomics, 27, 86–94.
153. Hirschy, A., Schatzmann, F., Ehler, E., & Perriard, J. C. (2006). Establishment of cardiac cytoarchitecture in the developing mouse heart. Developmental Biology, 289, 430–41.
154. Creemers, E. E., & Pinto, Y. M. (2011). Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovascular Research, 89, 265–72.
155. Pasipoularides, A. D., Shu, M., Shah, A., & Glower, D. D. (2002). Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload and ischemia. Journal of Thoracic and Cardiovascular Surgery, 124, 964–72.
156. Pasipoularides, A. D., Shu, M., Shah, A., Silvestry, S., & Glower, D. D. (2002). Right ventricular diastolic function in canine models of pressure overload, volume overload and ischemia. American Journal of Physiology. Heart and Circulatory Physiology, 283, H2140–50.
157. Mirsky, I., & Pasipoularides, A. (1990). Clinical assessment of diastolic function. Progress in Cardiovascular Diseases, 32, 291–318.
158. Pasipoularides, A., Mirsky, I., Hess, O. M., Grimm, J., & Krayenbuehl, J. P. (1986). Muscle relaxation and passive diastolic properties in man. Circulation, 74, 991–1001.
159. Gelpi, R. J., Pasipoularides, A., Lader, A. S., et al. (1991). Changes in diastolic cardiac function in developing and stable perinephritic hypertension in conscious dogs. Circulation Research, 68, 555–67.
160. Mirsky, I., & Pasipoularides, A. (1980). Elastic properties of normal and hypertrophied cardiac muscle. Federation Proceedings, 39, 156–61.
161. Colombelli, J., Besser, A., Kress, H., et al. (2009). Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. Journal of Cell Science, 122, 1665–79.
162. Wille, J. J., Elson, E. L., & Okamoto, R. J. (2006). Cellular and matrix mechanics of bioartificial tissues during continuous cyclic stretch. Annals of Biomedical Engineering, 34, 1678–90.
163. Balestrini, J. L., & Billiar, K. L. (2006). Equibiaxial cyclic stretch stimulates fibroblasts to rapidly remodel fibrin. Journal of Biomechanics, 39, 2983–90.
164. Hirata, H., Sokabe, M., & Lim, C. T. (2014). Molecular mechanisms underlying the force-dependent regulation of actin-to-ECM linkage at the focal adhesions. Progress in Molecular Biology and Translational Science, 126, 135–54.
165. Grashoff, C., Hoffman, B. D., Brenner, M. D., et al. (2010). Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature, 466, 263–6.
166. Riveline, D., Zamir, E., Balaban, N. Q., et al. (2001). Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. Journal of Cell Biology, 153, 1175–86.
167. Galbraith, C. G., Yamada, K. M., & Sheetz, M. P. (2002). The relationship between force and focal complex development. Journal of Cell Biology, 159, 695–705.
168. Kuo, J. C. (2014). Focal adhesions function as a mechanosensor. Progress in Molecular Biology and Translational Science, 126, 55–73.
169. Haase, K., Al-Rekabi, Z., & Pelling, A. E. (2014). Mechanical cues direct focal adhesion dynamics. Progress in Molecular Biology and Translational Science, 126, 103–34.
170. Brancaccio, M., Hirsch, E., Notte, A., Selvetella, G., Lembo, G., & Tarone, G. (2006). Integrin signalling: The tug-of-war in heart hypertrophy. Cardiovascular Research, 70, 422–33.
171. Pasipoularides, A., Shu, M., Shah, A., Womack, M. S., & Glower, D. D. (2003). Diastolic right ventricular filling vortex in normal and volume overload states. American Journal of Physiology Heart and Circulatory Physiology, 284, H1064–72.
172. Pasipoularides, A., Shu, M., Shah, A., Tucconi, A., & Glower, D. D. (2003). RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models. American Journal of Physiology Heart and Circulatory Physiology, 285, H1956–65.
173. Pasipoularides, A. (2011). Analysis of vortex flow imaging in normal and dysfunctional RV’s. American Society of Echocardiography 22nd Annual Scientific Sessions, Montreal, 2011. EE02d – Flow Vortex Imaging; PROLibraries.com.
174. Pasipoularides, A. (2013). Evaluation of right and left ventricular diastolic filling. Journal of Cardiovascular Translational Research, 6, 623–39.
175. Pasipoularides, A. (2008). Invited commentary: Functional Imaging (FI) combines imaging datasets and computational fluid dynamics to simulate cardiac flows. Journal of Applied Physiology, 105, 1015.
176. Dodge, H. T., Hay, R. E., & Sandler, H. (1962). Pressure-volume characteristics of the diastolic left ventricle of man with heart disease. American Heart Journal, 64, 503–11.
177. Ross, J., Jr., Sonnenblick, E. H., Taylor, R. R., & Covell, J. W. (1971). Diastolic geometry and sarcomere length in the chronically dilated canine left ventricle. Circulation Research, 28, 49–61.
178. Paulus, W. J., Grossman, W., Serizawa, T., Bourdillon, P. D., Pasipoularides, A., & Mirsky, I. (1985). Different effects of two types of ischemia on myocardial systolic and diastolic function. American Journal of Physiology Heart and Circulatory Physiology, 248, H719–28.
179. Glower, D. D., Schaper, J., Kabas, J. S., et al. (1987). Relation between reversal of diastolic creep and recovery of systolic function after ischemic myocardial injury in conscious dogs. Circulation Research, 60, 850–60.
180. Komamura, K., Shannon, R. P., Pasipoularides, A., et al. (1992). Alterations in left ventricular diastolic function in conscious dogs with pacing-induced heart failure. Journal of Clinical Investigation, 89, 1825–38.
181. Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., et al. (2011). Role of YAP/TAZ in mechanotransduction. Nature, 474, 179–83.
182. Low, B. C., Pan, C. Q., Shivashankar, C. V., Bershadsky, A., Sudol, M., & Sheetz, M. (2014). YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. FEBS Letters, 588, 2663–70.
183. Reddy, P., Deguchi, M., Cheng, Y., & Hsueh, A. J. W. (2013). Actin Cytoskeleton Regulates Hippo Signaling. PLoS ONE, 8(9), e73763. doi:10.1371/journal.pone.0073763.
184. Hong, W., & Guan, K. L. (2012). The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Seminars in Cell and Developmental Biology, 23, 785–93.
185. Pan, D. (2010). The hippo signaling pathway in development and cancer. Developmental Cell, 19, 491–505.
186. Li, Z., Zhao, B., Wang, P., et al. (2010). Structural insights into the YAP and TEAD complex. Genes and Development, 24, 235–40.
187. Heallen, T., Zhang, M., Wang, J., et al. (2011). Hippo Pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science, 332, 458–61.
188. Soonpaa, M. H., & Field, L. J. (1998). Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circulation Research, 83, 15–26.
189. Hall, J. L., & Terzic, A. (2011). Heart failure transcriptome: when discoveries change practice? Circulation Cardiovascular Genetics, 4, 469–71.
190. Stastna, M., Abraham, M. R., & Van Eyk, J. E. (2009). Cardiac stem/progenitor cells, secreted proteins, and proteomics. FEBS Letters, 583, 1800–7.
191. Bergmann, O., Bhardwaj, R. D., Bernard, S., et al. (2009). Evidence for cardiomyocyte renewal in humans. Science, 324, 98–102.
192. Pagliari, S., Vilela-Silva, A. C., Forte, G., et al. (2011). Cooperation of biological and mechanical signals in cardiac progenitor cell differentiation. Advanced Materials, 23, 514–8.
193. van der Bogt, K. E., Sheikh, A. Y., Schrepfer, S., et al. (2008). Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation, 118, S121–9.
194. Orlic, D., Kajstura, J., Chimenti, S., et al. (2001). Bone marrow cells regenerate infarcted myocardium. Nature, 410, 701–5.
195. Varelas, X., Miller, B. W., Sopko, R., et al. (2010). The Hippo pathway regulates Wnt/beta-catenin signaling. Developmental Cell, 18, 579–91.
196. Zhang, J., & Friedman, M. H. (2012). Adaptive response of vascular endothelial cells to an acute increase in shear stress magnitude. American Journal of Physiology. Heart and Circulatory Physiology, 302, H983–91.
197. Li, Y. S., Haga, J. H., & Chien, S. (2005). Molecular basis of the effects of shear stress on vascular endothelial cells. Journal of Biomechanics, 38, 1949–71.
198. Garcia-Cardena, G., Comander, J., Anderson, K. R., Blackman, B. R., & Gimbrone, M. A., Jr. (2001). Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proceedings of the National Academy of Sciences, 98, 4478–85.
199. Silberman, M., Barac, Y. D., Yahav, H., et al. (2009). Shear stress-induced transcriptional regulation via hybrid promoters as a potential tool for promoting angiogenesis. Angiogenesis, 12, 231–42.
200. Lockhart, D. J., & Winzeler, E. A. (2000). Genomics, gene expression and DNA arrays. Nature, 405, 827–36.
201. Pandey, A., & Mann, M. (2000). Proteomics to study genes and genomes. Nature, 405, 837–46.
202. Barnes, J., Pat, B., Chen, Y. W., et al. (2014). Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy. Therapeutic Advances in Cardiovascular Disease, 8, 97–118.
203. Nygård, S., Reitan, T., Clancy, T., et al. (2014). Identifying pathogenic processes by integrating microarray data with prior knowledge. BMC Bioinformatics, 15, 115. doi:10.1186/1471-2105-15-115.
204. Rowell, J., Koitabashi, N., Kass, D. A., & Barth, A. S. (2014). Dynamic gene expression patterns in animal models of early and late heart failure reveal biphasic-bidirectional transcriptional activation of signaling pathways. Physiological Genomics, 46, 779–87.
205. Nattel, S., Frelin, Y., Gaborit, N., Louault, C., & Demolombe, S. (2010). Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates. Journal of Molecular and Cellular Cardiology, 48, 96–105.
206. Horn, S., Lueking, A., Murphy, D., et al. (2006). Profiling humoral autoimmune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip. Proteomics, 6, 605–13.
207. Anisimov, S. V. (2008). Serial Analysis of Gene Expression (SAGE): 13 years of application in research. Current Pharmaceutical Biotechnology, 9, 338–50.
208. Tarasov, K. V., Brugh, S. A., Tarasova, Y. S., & Boheler, K. R. (2007). Serial analysis of gene expression (SAGE): a useful tool to analyze the cardiac transcriptome. Methods in Molecular Biology, 366, 41–59.
209. Patino, W. D., Mian, O. Y., & Hwang, P. M. (2002). Serial analysis of gene expression: technical considerations and applications to cardiovascular biology. Circulation Research, 91, 565–9.
210. Velculescu, V. E., Zhang, L., Vogelstein, B., & Kinzler, K. W. (1995). Serial analysis of gene expression. Science, 270, 484–7.
211. Liew, C. C., & Dzau, V. J. (2004). Molecular genetics and genomics of heart failure. Nature Reviews Genetics, 5, 811–25.
212. Haqqani, A. S., Kelly, J. F., & Stanimirovic, D. B. (2008). Quantitative protein profiling by mass spectrometry using label-free proteomics. Methods in Molecular Biology, 439, 241–56.
213. Hall, J. L., Grindle, S., Han, X., et al. (2004). Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiological Genomics, 17, 283–91.
214. Hall, J. L., Birks, E. J., Grindle, S., et al. (2007). Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy. European Heart Journal, 28, 613–27.
215. Metzker, M. L. (2010). Sequencing technologies–the next generation. Nature Reviews Genetics, 11, 31–46.
216. Anandhakumar, C., Kizaki, S., Bando, T., Pandian, G. N., & Sugiyama, H. (2015). Advancing small-molecule-based chemical biology with next-generation sequencing technologies. Chembiochem, 16, 20–38.
217. Li, R., Zhu, H., Ruan, J., et al. (2010). De novo assembly of human genomes with massively parallel short read sequencing. Genome Research, 20, 265–72.
218. Li, B., Fillmore, N., Bai, Y., et al. (2014). Evaluation of de novo transcriptome assemblies from RNA-Seq data. Genome Biology, 15, 553. doi:10.1186/s13059-014-0553-5.
219. Gut, I. G. (2013). New sequencing technologies. Clinical and Translational Oncology, 15, 879–81.
220. Rizzo, J. M., & Buck, M. J. (2012). Key principles and clinical applications of "next-generation" DNA sequencing. Cancer Prevention Research (Philadelphia, Pa), 5, 887–900.
221. Marian, A. J. (2012). Challenges in medical applications of whole exome/genome sequencing discoveries. Trends in Cardiovascular Medicine, 22, 219–23.
222. Barbato, E., Lara-Pezzi, E., Stolen, C., et al. (2014). Advances in induced pluripotent stem cells, genomics, biomarkers, and antiplatelet therapy highlights of the year in JCTR 2013. Journal of Cardiovascular Translational Research, 7, 518–25.
223. Mitchell, A., Guan, W., Staggs, R., et al. (2013). Identification of differentially expressed transcripts and pathways in blood one week and six months following implant of left ventricular assist devices. PloS One, 8(10), e77951. doi:10.1371/journal.pone.0077951.
224. Maier, T., Guell, M., & Serrano, L. (2009). Correlation of mRNA and protein in complex biological samples. FEBS Letters, 583, 3966–73.
225. Vogel, C., & Marcotte, E. M. (2012). Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nature Reviews Genetics, 13, 227–32.
226. Schwanhausser, B., Busse, D., Li, N., Dittmar, G., et al. (2011). Global quantification of mammalian gene expression control. Nature, 473(7347), 337–42.
227. Bartel, D. P. (2009). MicroRNAs: target recognition and regulatory functions. Cell, 136, 215–33.
228. Ferrai, C., de Castro, I. J., Lavitas, L., Chotalia, M., & Pombo, A. (2010). Gene positioning. Cold Spring Harbor Perspectives in Biology, 2, a000588. doi:10.1101/cshperspect.a000588.
229. Wong, I. Y., Bhatia, S. N., & Toner, M. (2013). Nanotechnology: emerging tools for biology and medicine. Genes and Development, 27, 2397–408.
230. Maher, B. (2012). ENCODE: The human encyclopaedia. Nature, 489, 46–8.
231. The ENCODE Project Consortium. (2012). An integrated encyclopedia of DNA elements in the human genome. Nature, 489, 57–74.