Mechanotransduction: The role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 1, 2011, Pages 89-104

  McCain, Megan L ^a,b   Parker, Kevin Kit ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Cardiac myocytes; Cardiac sarcomere; Cytoskeleton; Heart; Mechanosensitivity; Mechanotransduction

Indexed keywords

CADHERIN; CONNECTIN; INTEGRIN;

CARDIOMYOPATHY; CELL ADHESION; CELL COMMUNICATION; CELL COMPOSITION; CELL CONTACT; CELL FUNCTION; CELL JUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; CHROMATIN ASSEMBLY AND DISASSEMBLY; COSTAMERE; CYTOARCHITECTURE; EPITHELIUM; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; GENE EXPRESSION; HEART DEVELOPMENT; HEART DISEASE; HEART FAILURE; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEMODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MECHANICAL STRESS; MECHANOTRANSDUCTION; MICROTUBULE; MUSCLE CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RIGIDITY; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

EID: 85027956045     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0951-4     Document Type: Review

References (190)

1. CL Adams YT Chen SJ Smith WJ Nelson 1998 Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein J Cell Biol 142 1105 1119 9722621 1:CAS:528:DyaK1cXls1ehsrk%3D (Pubitemid 28402064)
2. F Ahmad SK Banerjee ML Lage XN Huang SH Smith S Saba J Rager DA Conner AM Janczewski K Tobita JP Tinney IP Moskowitz AR Perez-Atayde BB Keller MA Mathier SG Shroff CE Seidman JG Seidman 2008 The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy PLoS ONE 3 e2642 18612386
3. Y Aihara M Kurabayashi Y Saito Y Ohyama T Tanaka S Takeda K Tomaru K Sekiguchi M Arai T Nakamura R Nagai 2000 Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter Hypertension 36 48 53 10904011 1:CAS:528:DC%2BD3cXlslehur4%3D (Pubitemid 30602151)
4. G Anastasi G Cutroneo R Gaeta D Di Mauro A Arco A Consolo G Santoro F Trimarchi A Favaloro 2009 Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle Int J Mol Med 23 149 159 19148538
5. BD Angst LU Khan NJ Severs K Whitely S Rothery RP Thompson AI Magee RG Gourdie 1997 Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium Circ Res 80 88 94 8978327 1:CAS:528:DyaK2sXhtVKntA%3D%3D (Pubitemid 27030373)
6. P Anversa R Ricci G Olivetti 1986 Quantitative structural analysis of the myocardium during physiologic growth and induced cardiac hypertrophy: a review J Am Coll Cardiol 7 1140 1149 2937828 1:STN:280:DyaL287mvFenug%3D%3D (Pubitemid 16103115)
7. HJ Auman H Coleman HE Riley F Olale HJ Tsai D Yelon 2007 Functional modulation of cardiac form through regionally confined cell shape changes PLoS Biol 5 e53 17311471
8. CJ Babbitt SY Shai AE Harpf CG Pham RS Ross 2002 Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle Histochem Cell Biol 118 431 439 12483308 1:CAS:528:DC%2BD38XpsV2hsLc%3D (Pubitemid 35478193)
9. P Bajaj X Tang TA Saif R Bashir 2010 Stiffness of the substrate influences the phenotype of embryonic chicken cardiac myocytes J Biomed Mater Res A 95 1261 1269 20939058
10. EL Baker MH Zaman 2010 The biomechanical integrin J Biomech 43 38 44 19811786
11. P Beauchamp C Choby T Desplantez K de Peyer K Green KA Yamada R Weingart JE Saffitz AG Kleber 2004 Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice Circ Res 95 170 178 15192022 1:CAS:528:DC%2BD2cXls1GqtbY%3D (Pubitemid 38988683)
12. AM Belkin NI Zhidkova F Balzac F Altruda D Tomatis A Maier G Tarone VE Koteliansky K Burridge 1996 Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells J Cell Biol 132 211 226 8567725 1:CAS:528: DyaK28Xlt1eruw%3D%3D
13. CA Beltrami N Finato M Rocco GA Feruglio C Puricelli E Cigola EH Sonnenblick G Olivetti P Anversa 1995 The cellular basis of dilated cardiomyopathy in humans J Mol Cell Cardiol 27 291 305 7760353 1:CAS:528:DyaK2MXjvVyisrw%3D
14. G Bendig M Grimmler IG Huttner G Wessels T Dahme S Just N Trano HA Katus MC Fishman W Rottbauer 2006 Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart Genes Dev 20 2361 2372 16921028 1:CAS:528:DC%2BD28XptlSnt74%3D (Pubitemid 44320385)
15. E Berdougo H Coleman DH Lee DY Stainier D Yelon 2003 Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish Development 130 6121 6129 14573521 1:CAS:528:DC%2BD2cXktFOr (Pubitemid 38008813)
16. MF Berry AJ Engler YJ Woo TJ Pirolli LT Bish V Jayasankar KJ Morine TJ Gardner DE Discher HL Sweeney 2006 Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance Am J Physiol Heart Circ Physiol 290 H2196 H2203 16473959 1:CAS:528:DC%2BD28XlvVeksLg%3D
17. B Bhana RK Iyer WL Chen R Zhao KL Sider M Likhitpanichkul CA Simmons M Radisic 2010 Influence of substrate stiffness on the phenotype of heart cells Biotechnol Bioeng 105 1148 1160 20014437 1:CAS:528:DC%2BC3cXisFKltLg%3D
18. H Bien L Yin E Entcheva 2003 Cardiac cell networks on elastic microgrooved scaffolds IEEE Eng Med Biol Mag 22 108 112 14699943 (Pubitemid 38005038)
19. E Blaauw FA van Nieuwenhoven P Willemsen T Delhaas FW Prinzen LH Snoeckx M van Bilsen GJ van der Vusse 2010 Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes Am J Physiol Heart Circ Physiol 299 H780 H787 20639217 1:CAS:528:DC%2BC3cXht1Wgur3O
20. SY Boateng RJ Belin DL Geenen KB Margulies JL Martin M Hoshijima PP de Tombe B Russell 2007 Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein Am J Physiol Heart Circ Physiol 292 H259 H269 16963613 1:CAS:528:DC%2BD2sXisFGisr8%3D
21. J Boland J Troquet 1980 Intracellular action potential changes induced in both ventricles of the rat by an acute right ventricular pressure overload Cardiovasc Res 14 735 740 7260968 1:STN:280:DyaL3M3lvVGhsw%3D%3D (Pubitemid 11167202)
22. TK Borg RE Gay LD Johnson 1982 Changes in the distribution of fibronectin and collagen during development of the neonatal rat heart Coll Relat Res 2 211 218 6759014 1:CAS:528:DyaL38Xlt1CrsLY%3D (Pubitemid 12022105)
23. TK Borg K Rubin E Lundgren K Borg B Obrink 1984 Recognition of extracellular matrix components by neonatal and adult cardiac myocytes Dev Biol 104 86 96 6734942 1:CAS:528:DyaL2cXksFansro%3D
24. M Brancaccio L Fratta A Notte E Hirsch R Poulet S Guazzone M De Acetis C Vecchione G Marino F Altruda L Silengo G Tarone G Lembo 2003 Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload Nat Med 9 68 75 12496958 1:CAS:528:DC%2BD3sXivF2r (Pubitemid 36098262)
25. M Brancaccio S Guazzone N Menini E Sibona E Hirsch M De Andrea M Rocchi F Altruda G Tarone L Silengo 1999 Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain J Biol Chem 274 29282 29288 10506186 1:CAS:528:DyaK1MXmslWqtbo%3D
26. M Brancaccio E Hirsch A Notte G Selvetella G Lembo G Tarone 2006 Integrin signalling: the tug-of-war in heart hypertrophy Cardiovasc Res 70 422 433 16466704 1:CAS:528:DC%2BD28Xks1Wlur8%3D
27. CP Brangwynne FC MacKintosh S Kumar NA Geisse J Talbot L Mahadevan KK Parker DE Ingber DA Weitz 2006 Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement J Cell Biol 173 733 741 16754957 1:CAS:528:DC%2BD28Xls1Shsrc%3D (Pubitemid 46165581)
28. MA Bray SP Sheehy KK Parker 2008 Sarcomere alignment is regulated by myocyte shape Cell Motil Cytoskeleton 65 641 651 18561184
29. TA Bullard TK Borg RL Price 2005 The expression and role of protein kinase C in neonatal cardiac myocyte attachment, cell volume, and myofibril formation is dependent on the composition of the extracellular matrix Microsc Microanal 11 224 234 16060975 1:CAS:528:DC%2BD2MXktVOqur0%3D
30. TA Bullard JL Hastings JM Davis TK Borg RL Price 2007 Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch Can J Physiol Pharmacol 85 243 250 17487266 1:CAS:528:DC%2BD2sXmsVWntLs%3D (Pubitemid 46846436)
31. N Bursac KK Parker S Iravanian L Tung 2002 Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle Circ Res 91 e45 e54 12480825 1:STN:280: DC%2BD38jhvValsQ%3D%3D
32. BM Cadre M Qi DM Eble TR Shannon DM Bers AM Samarel 1998 Cyclic stretch down-regulates calcium transporter gene expression in neonatal rat ventricular myocytes J Mol Cell Cardiol 30 2247 2259 9925362 1:CAS:528:DyaK1cXotFCgsrk%3D (Pubitemid 28549977)
33. JM Capasso D Fitzpatrick P Anversa 1992 Cellular mechanisms of ventricular failure: myocyte kinetics and geometry with age Am J Physiol 262 H1770 H1781 1621835 1:STN:280:DyaK38zitFejtA%3D%3D
34. W Carver RL Price DS Raso L Terracio TK Borg 1994 Distribution of beta-1 integrin in the developing rat heart J Histochem Cytochem 42 167 175 8288862 1:CAS:528:DyaK2cXhtlSmtLc%3D
35. W Carver L Terracio TK Borg 1993 Expression and accumulation of interstitial collagen in the neonatal rat heart Anat Rec 236 511 520 8363055 1:CAS:528:DyaK3sXkvFajtbk%3D (Pubitemid 23193319)
36. CS Chen JL Alonso E Ostuni GM Whitesides DE Ingber 2003 Cell shape provides global control of focal adhesion assembly Biochem Biophys Res Commun 307 355 361 12859964 1:CAS:528:DC%2BD3sXlt1arur8%3D (Pubitemid 36818878)
37. CS Chen M Mrksich S Huang GM Whitesides DE Ingber 1997 Geometric control of cell life and death Science 276 1425 1428 9162012 1:CAS:528: DyaK2sXjsFOhu7s%3D (Pubitemid 27235413)
38. CS Chen M Mrksich S Huang GM Whitesides DE Ingber 1998 Micropatterned surfaces for control of cell shape, position, and function Biotechnol Prog 14 356 363 9622515 1:CAS:528:DyaK1cXjtVWitLg%3D (Pubitemid 28278815)
39. D Choquet DP Felsenfeld MP Sheetz 1997 Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages Cell 88 39 48 9019403 1:CAS:528:DyaK2sXltFOguw%3D%3D (Pubitemid 27180329)
40. CY Chung H Bien E Entcheva 2007 The role of cardiac tissue alignment in modulating electrical function J Cardiovasc Electrophysiol 18 1323 1329 17916158 (Pubitemid 350115781)
41. Chung CY, Bien H, Sobie EA, Dasari V, McKinnon D, Rosati B, Entcheva E (2010) Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization. FASEB J (in press)
42. WA Clark ML Decker M Behnke-Barclay DM Janes RS Decker 1998 Cell contact as an independent factor modulating cardiac myocyte hypertrophy and survival in long-term primary culture J Mol Cell Cardiol 30 139 155 9500872 1:CAS:528:DyaK1cXhtlGiu7g%3D (Pubitemid 28069752)
43. KL Clark KE Yutzey DW Benson 2006 Transcription factors and congenital heart defects Annu Rev Physiol 68 97 121 16460268 1:CAS:528:DC%2BD28XksFWksr0%3D
44. EH Danen P Sonneveld C Brakebusch R Fassler A Sonnenberg 2002 The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis J Cell Biol 159 1071 1086 12486108 1:CAS:528:DC%2BD3sXjt1en (Pubitemid 36055761)
45. BA Danowski K Imanaka-Yoshida JM Sanger JW Sanger 1992 Costameres are sites of force transmission to the substratum in adult rat cardiomyocytes J Cell Biol 118 1411 1420 1522115 1:CAS:528:DyaK38Xls1ymsLw%3D
46. HW de Jonge DH Dekkers AB Houtsmuller HS Sharma JM Lamers 2007 Differential signaling and hypertrophic responses in cyclically stretched vs endothelin-1 stimulated neonatal rat cardiomyocytes Cell Biochem Biophys 47 21 32 17406057 (Pubitemid 46570695)
47. AA de Melker A Sonnenberg 1999 Integrins: alternative splicing as a mechanism to regulate ligand binding and integrin signaling events Bioessays 21 499 509 10402956 (Pubitemid 29267049)
48. E de Pater L Clijsters SR Marques YF Lin ZV Garavito-Aguilar D Yelon J Bakkers 2009 Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart Development 136 1633 1641 19395641
49. PP de Tombe RD Mateja K Tachampa YA Mou GP Farman TC Irving 2010 Myofilament length dependent activation J Mol Cell Cardiol 48 851 858 20053351
50. RA Desai L Gao S Raghavan WF Liu CS Chen 2009 Cell polarity triggered by cell-cell adhesion via E-cadherin J Cell Sci 122 905 911 19258396 1:CAS:528:DC%2BD1MXlt1Oqsbo%3D
51. IJ Domian M Chiravuri P van der Meer AW Feinberg X Shi Y Shao SM Wu KK Parker KR Chien 2009 Generation of functional ventricular heart muscle from mouse ventricular progenitor cells Science 326 426 429 19833966 1:CAS:528:DC%2BD1MXht1GgtLfP
52. AJ Engler C Carag-Krieger CP Johnson M Raab HY Tang DW Speicher JW Sanger JM Sanger DE Discher 2008 Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating J Cell Sci 121 3794 3802 18957515 1:CAS:528:DC%2BD1cXhsFaktLjO
53. AJ Engler S Sen HL Sweeney DE Discher 2006 Matrix elasticity directs stem cell lineage specification Cell 126 677 689 16923388 1:CAS:528: DC%2BD28Xpt1aktbg%3D (Pubitemid 44233625)
54. E Entcheva H Bien 2005 Acoustic micromachining of three-dimensional surfaces for biological applications Lab Chip 5 179 183 15672132 1:CAS:528:DC%2BD2MXmsV2itw%3D%3D (Pubitemid 40260860)
55. D Falconnet G Csucs HM Grandin M Textor 2006 Surface engineering approaches to micropattern surfaces for cell-based assays Biomaterials 27 3044 3063 16458351 1:CAS:528:DC%2BD28XhsFGhsbY%3D (Pubitemid 43247579)
56. F Farhadian F Contard A Corbier A Barrieux L Rappaport JL Samuel 1995 Fibronectin expression during physiological and pathological cardiac growth J Mol Cell Cardiol 27 981 990 7563110 1:CAS:528:DyaK2MXlsl2msbk%3D
57. R Fassler J Rohwedel V Maltsev W Bloch S Lentini K Guan D Gullberg J Hescheler K Addicks AM Wobus 1996 Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin J Cell Sci 109 Pt 13 2989 2999 9004034 (Pubitemid 27029269)
58. VG Fast AG Kleber 1993 Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes Circ Res 73 914 925 8403261 1:STN:280:DyaK2c%2Fgs12qsg%3D%3D (Pubitemid 23306136)
59. AW Feinberg A Feigel SS Shevkoplyas S Sheehy GM Whitesides KK Parker 2007 Muscular thin films for building actuators and powering devices Science 317 1366 1370 17823347 1:CAS:528:DC%2BD2sXpvFWmurk%3D (Pubitemid 47417472)
60. MC Fishman KR Chien 1997 Fashioning the vertebrate heart: earliest embryonic decisions Development 124 2099 2117 9187138 1:CAS:528: DyaK2sXktFSitLY%3D (Pubitemid 27283233)
61. MJ Flick SF Konieczny 2000 The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin J Cell Sci 113 Pt 9 1553 1564 10751147 1:CAS:528:DC%2BD3cXjvFaqtbk%3D (Pubitemid 30312504)
62. J Folkman A Moscona 1978 Role of cell shape in growth control Nature 273 345 349 661946 1:CAS:528:DyaE1cXlslOju70%3D (Pubitemid 8344174)
63. D Frank C Kuhn B Brors C Hanselmann M Ludde HA Katus N Frey 2008 Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program Hypertension 51 309 318 18158353 1:CAS:528:DC%2BD1cXmt1Oitg%3D%3D (Pubitemid 351159944)
64. MR Franz D Burkhoff DT Yue K Sagawa 1989 Mechanically induced action potential changes and arrhythmia in isolated and in situ canine hearts Cardiovasc Res 23 213 223 2590905 1:STN:280:DyaK3c%2FnsFWltA%3D%3D (Pubitemid 19084608)
65. MR Franz R Cima D Wang D Profitt R Kurz 1992 Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias Circulation 86 968 978 1381296 1:STN:280:DyaK38zos1Kqug%3D%3D
66. DO Furst M Osborn R Nave K Weber 1988 The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line J Cell Biol 106 1563 1572 2453516 1:STN:280: DyaL1c3ivVWksg%3D%3D
67. T Furukawa T Yamane T Terai Y Katayama M Hiraoka 1996 Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton Pflugers Arch 431 504 512 8596692 1:CAS:528:DyaK28XjtV2qsL4%3D (Pubitemid 26091693)
68. A Galli LJ DeFelice 1994 Inactivation of L-type Ca channels in embryonic chick ventricle cells: dependence on the cytoskeletal agents colchicine and taxol Biophys J 67 2296 2304 7696470 1:CAS:528:DyaK2MXisVajtbk%3D (Pubitemid 24369653)
69. A Ganz M Lambert A Saez P Silberzan A Buguin RM Mege B Ladoux 2006 Traction forces exerted through N-cadherin contacts Biol Cell 98 721 730 16895521 1:CAS:528:DC%2BD28Xht1Wqur7O (Pubitemid 44896108)
70. G Gaudesius M Miragoli SP Thomas S Rohr 2003 Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin Circ Res 93 421 428 12893743 1:CAS:528:DC%2BD3sXmslCmt7s%3D (Pubitemid 37100007)
71. B Geiger A Bershadsky 2001 Assembly and mechanosensory function of focal contacts Curr Opin Cell Biol 13 584 592 11544027 1:CAS:528:DC%2BD3MXmsFersLc%3D (Pubitemid 32817017)
72. NA Geisse SP Sheehy KK Parker 2009 Control of myocyte remodeling in vitro with engineered substrates In Vitro Cell Dev Biol Anim 45 343 350 19252956
73. AM Gerdes 1992 Remodeling of ventricular myocytes during cardiac hypertrophy and heart failure J Fla Med Assoc 79 253 255 1534117 1:STN:280:DyaK383mvVygug%3D%3D
74. AM Gerdes 2002 Cardiac myocyte remodeling in hypertrophy and progression to failure J Card Fail 8 S264 S268 12555130
75. AM Gerdes JM Capasso 1995 Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure J Mol Cell Cardiol 27 849 856 7602601 1:CAS:528:DyaK2MXltVertbk%3D
76. AM Gerdes SE Kellerman JA Moore KE Muffly LC Clark PY Reaves KB Malec PP McKeown DD Schocken 1992 Structural remodeling of cardiac myocytes in patients with ischemic cardiomyopathy Circulation 86 426 430 1638711 1:STN:280: DyaK38zks1yiuw%3D%3D
77. EJ Goncharova Z Kam B Geiger 1992 The involvement of adherens junction components in myofibrillogenesis in cultured cardiac myocytes Development 114 173 183 1576958 1:STN:280:DyaK383kvFajsg%3D%3D
78. SM Gopalan C Flaim SN Bhatia M Hoshijima R Knoell KR Chien JH Omens AD McCulloch 2003 Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers Biotechnol Bioeng 81 578 587 12514807 1:CAS:528:DC%2BD3sXhtFKisLk%3D (Pubitemid 36222316)
79. RG Gourdie CR Green NJ Severs 1991 Gap junction distribution in adult mammalian myocardium revealed by an anti-peptide antibody and laser scanning confocal microscopy J Cell Sci 99 Pt 1 41 55 1661743
80. RG Gourdie CR Green NJ Severs RP Thompson 1992 Immunolabelling patterns of gap junction connexins in the developing and mature rat heart Anat Embryol (Berl) 185 363 378 1:STN:280:DyaK38zgtlOkug%3D%3D
81. DA Grant 1999 Ventricular constraint in the fetus and newborn Can J Cardiol 15 95 104 10024865 1:STN:280:DyaK1M7kvFSjtg%3D%3D (Pubitemid 29080523)
82. Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NM, Yu Q, Tschope C, McNabb M, Larson DF, Labeit S, Gotthardt M (2009) Truncation of titin's elastic PEVK region leads to cardiomyopathy with diastolic dysfunction. Circ Res 105:557-564
83. W Grossman D Jones LP McLaurin 1975 Wall stress and patterns of hypertrophy in the human left ventricle J Clin Invest 56 56 64 124746 1:STN:280:DyaE2M7ovFyrsQ%3D%3D
84. SJ Gwak SH Bhang IK Kim SS Kim SW Cho O Jeon KJ Yoo AJ Putnam BS Kim 2008 The effect of cyclic strain on embryonic stem cell-derived cardiomyocytes Biomaterials 29 844 856 18022225 1:CAS:528:DC%2BD2sXhsVGltbvE (Pubitemid 350266049)
85. TJ Harris U Tepass 2010 Adherens junctions: from molecules to morphogenesis Nat Rev Mol Cell Biol 11 502 514 20571587 1:CAS:528: DC%2BC3cXnvVShtb4%3D
86. M Helmes K Trombitas T Centner M Kellermayer S Labeit WA Linke H Granzier 1999 Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring Circ Res 84 1339 1352 10364572 1:CAS:528:DyaK1MXjsleltL4%3D (Pubitemid 29270049)
87. M Helmes K Trombitas H Granzier 1996 Titin develops restoring force in rat cardiac myocytes Circ Res 79 619 626 8781495 1:CAS:528:DyaK28XlsVOns7s%3D (Pubitemid 26276922)
88. CM Hertig M Eppenberger-Eberhardt S Koch HM Eppenberger 1996 N-cadherin in adult rat cardiomyocytes in culture. I. Functional role of N-cadherin and impairment of cell-cell contact by a truncated N-cadherin mutant J Cell Sci 109 Pt 1 1 10 8834785 1:CAS:528:DyaK28XosVaiuw%3D%3D (Pubitemid 26037922)
89. LL Hilenski XH Ma N Vinson L Terracio TK Borg 1992 The role of beta 1 integrin in spreading and myofibrillogenesis in neonatal rat cardiomyocytes in vitro Cell Motil Cytoskeleton 21 87 100 1373110 1:STN:280:DyaK383hslSksQ%3D%3D
90. LL Hilenski L Terracio TK Borg 1991 Myofibrillar and cytoskeletal assembly in neonatal rat cardiac myocytes cultured on laminin and collagen Cell Tissue Res 264 577 587 1907887 1:STN:280:DyaK3MzjtValtA%3D%3D
91. LL Hilenski L Terracio R Sawyer TK Borg 1989 Effects of extracellular matrix on cytoskeletal and myofibrillar organization in vitro Scanning Microsc 3 535 548 2683045 1:STN:280:DyaK3c%2FkvFSgtg%3D%3D (Pubitemid 20022036)
92. A Hirschy F Schatzmann E Ehler JC Perriard 2006 Establishment of cardiac cytoarchitecture in the developing mouse heart Dev Biol 289 430 441 16337936 1:CAS:528:DC%2BD28XksVKjsg%3D%3D (Pubitemid 43049945)
93. LK Hornberger S Singhroy T Cavalle-Garrido W Tsang F Keeley M Rabinovitch 2000 Synthesis of extracellular matrix and adhesion through beta(1) integrins are critical for fetal ventricular myocyte proliferation Circ Res 87 508 515 10988244 1:CAS:528:DC%2BD3cXmvFKisrg%3D
94. M Hoshijima 2006 Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures Am J Physiol Heart Circ Physiol 290 H1313 H1325 16537787 1:CAS:528:DC%2BD28Xks1Sgu7Y%3D
95. JR Hove RW Koster AS Forouhar G Acevedo-Bolton SE Fraser M Gharib 2003 Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis Nature 421 172 177 12520305 1:CAS:528:DC%2BD3sXhs1KhsQ%3D%3D (Pubitemid 36090985)
96. MJ Humphries 2000 Integrin structure Biochem Soc Trans 28 311 339 10961914 1:CAS:528:DC%2BD3cXmsVeitb4%3D
97. JD Humphries A Byron MJ Humphries 2006 Integrin ligands at a glance J Cell Sci 119 3901 3903 16988024 1:CAS:528:DC%2BD2sXit1Cgsw%3D%3D (Pubitemid 44650863)
98. JM Icardo JL Ojeda 1984 Effects of colchicine on the formation and looping of the tubular heart of the embryonic chick Acta Anat (Basel) 119 1 9 1:STN:280:DyaL2c3islSnsw%3D%3D (Pubitemid 14102258)
99. K Imanaka-Yoshida KA Knudsen KK Linask 1998 N-cadherin is required for the differentiation and initial myofibrillogenesis of chick cardiomyocytes Cell Motil Cytoskeleton 39 52 62 9453713 1:CAS:528:DyaK1cXkslShsg%3D%3D (Pubitemid 28042458)
100. DE Ingber 2003 Tensegrity I. Cell structure and hierarchical systems biology J Cell Sci 116 1157 1173 12615960 1:CAS:528:DC%2BD3sXivFWhtbY%3D (Pubitemid 36410656)
101. DE Ingber 2006 Cellular mechanotransduction: putting all the pieces together again FASEB J 20 811 827 16675838 1:CAS:528:DC%2BD28XksVegtrY%3D (Pubitemid 44943939)
102. N Itasaki H Nakamura H Sumida M Yasuda 1991 Actin bundles on the right side in the caudal part of the heart tube play a role in dextro-looping in the embryonic chick heart Anat Embryol (Berl) 183 29 39 1:STN:280: DyaK3M3ntlamug%3D%3D
103. JG Jacot AD McCulloch JH Omens 2008 Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes Biophys J 95 3479 3487 18586852 1:CAS:528:DC%2BD1cXht1SrsL7O
104. M Kamisago SD Sharma SR DePalma S Solomon P Sharma B McDonough L Smoot MP Mullen PK Woolf ED Wigle JG Seidman CE Seidman 2000 Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy N Engl J Med 343 1688 1696 11106718 1:CAS:528:DC%2BD3cXovVGhu74%3D
105. AM Katz 2002 Maladaptive growth in the failing heart: the cardiomyopathy of overload Cardiovasc Drugs Ther 16 245 249 12374903 1:CAS:528: DC%2BD38XnvFKhu7c%3D (Pubitemid 35398626)
106. DH Kim EA Lipke P Kim R Cheong S Thompson M Delannoy KY Suh L Tung A Levchenko 2010 Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs Proc Natl Acad Sci USA 107 565 570 20018748 1:CAS:528:DC%2BC3cXhtFCnu70%3D
107. AG Kleber Y Rudy 2004 Basic mechanisms of cardiac impulse propagation and associated arrhythmias Physiol Rev 84 431 488 15044680 1:CAS:528: DC%2BD2cXjtlCktLg%3D (Pubitemid 38365490)
108. R Knoll M Hoshijima HM Hoffman V Person I Lorenzen-Schmidt ML Bang T Hayashi N Shiga H Yasukawa W Schaper W McKenna M Yokoyama NJ Schork JH Omens AD McCulloch A Kimura CC Gregorio W Poller J Schaper HP Schultheiss KR Chien 2002 The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy Cell 111 943 955 12507422 1:CAS:528:DC%2BD3sXis1Kisg%3D%3D (Pubitemid 36044687)
109. M Kruger WA Linke 2009 Titin-based mechanical signalling in normal and failing myocardium J Mol Cell Cardiol 46 490 498 19639676
110. Lange S, Auerbach D, McLoughlin P, Perriard E, Schafer BW, Perriard JC, Ehler E (2002) Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci 115:4925-4936 (Pubitemid 36054644)
111. KA Lapidos R Kakkar EM McNally 2004 The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma Circ Res 94 1023 1031 15117830 1:CAS:528:DC%2BD2cXjt1yksr4%3D (Pubitemid 38579696)
112. KS Latacha MC Remond A Ramasubramanian AY Chen EL Elson LA Taber 2005 Role of actin polymerization in bending of the early heart tube Dev Dyn 233 1272 1286 15986456 1:CAS:528:DC%2BD2MXnvVWrt7Y%3D (Pubitemid 40995125)
113. Q le Duc Q Shi I Blonk A Sonnenberg N Wang D Leckband J de Rooij 2010 Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner J Cell Biol 189 1107 1115 20584916
114. TP Lele S Kumar 2007 Brushes, cables, and anchors: recent insights into multiscale assembly and mechanics of cellular structural networks Cell Biochem Biophys 47 348 360 17652780 1:CAS:528:DC%2BD2sXnt1Clurw%3D (Pubitemid 47339851)
115. MM LeWinter H Granzier 2010 Cardiac titin: a multifunctional giant Circulation 121 2137 2145 20479164
116. WA Linke 2008 Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction Cardiovasc Res 77 637 648 17475230 1:CAS:528:DC%2BD1cXjvVaju7Y%3D (Pubitemid 351301882)
117. Z Liu JL Tan DM Cohen MT Yang NJ Sniadecki SA Ruiz CM Nelson CS Chen 2010 Mechanical tugging force regulates the size of cell-cell junctions Proc Natl Acad Sci USA 107 9944 9949 20463286 1:CAS:528:DC%2BC3cXnslCrsbo%3D
118. A Luk E Ahn GS Soor J Butany 2009 Dilated cardiomyopathy: a review J Clin Pathol 62 219 225 19017683 1:STN:280:DC%2BD1M7nt1aksA%3D%3D
119. E Lundgren L Terracio TK Borg 1985 Adhesion of cardiac myocytes to extracellular matrix components Basic Res Cardiol 80 Suppl 1 69 74 3994641
120. E Lundgren L Terracio S Mardh TK Borg 1985 Extracellular matrix components influence the survival of adult cardiac myocytes in vitro Exp Cell Res 158 371 381 4007060 1:CAS:528:DyaL2MXks12isr0%3D (Pubitemid 15070262)
121. Y Luo GL Radice 2003 Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus J Cell Sci 116 1471 1479 12640032 1:CAS:528: DC%2BD3sXjtlyrtLY%3D (Pubitemid 36527494)
122. FJ Manasek MB Burnside RE Waterman 1972 Myocardial cell shape change as a mechanism of embryonic heart looping Dev Biol 29 349 371 4120601 1:STN:280:DyaE3s7jslartQ%3D%3D
123. FJ Manasek RG Monroe 1972 Early cardiac morphogenesis is independent of function Dev Biol 27 584 588 5029499 1:STN:280:DyaE387pt1Gmtg%3D%3D
124. A Manning JC McLachlan 1990 Looping of chick embryo hearts in vitro J Anat 168 257 263 2323996 1:STN:280:DyaK3c3hs1Cjuw%3D%3D (Pubitemid 20053166)
125. BD Matthews DR Overby R Mannix DE Ingber 2006 Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels J Cell Sci 119 508 518 16443749 1:CAS:528:DC%2BD28Xit1Kltro%3D
126. CJ Meyer FJ Alenghat P Rim JH Fong B Fabry DE Ingber 2000 Mechanical control of cyclic AMP signalling and gene transcription through integrins Nat Cell Biol 2 666 668 10980709 1:CAS:528:DC%2BD3cXmslGks7k%3D
127. MK Miller ML Bang CC Witt D Labeit C Trombitas K Watanabe H Granzier AS McElhinny CC Gregorio S Labeit 2003 The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules J Mol Biol 333 951 964 14583192 1:CAS:528:DC%2BD3sXosVygu7o%3D (Pubitemid 37324498)
128. AF Moorman VM Christoffels 2003 Cardiac chamber formation: development, genes, and evolution Physiol Rev 83 1223 1267 14506305 1:CAS:528: DC%2BD3sXoslyjsbY%3D (Pubitemid 37222272)
129. M Mrksich CS Chen Y Xia LE Dike DE Ingber GM Whitesides 1996 Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold Proc Natl Acad Sci USA 93 10775 10778 8855256 1:CAS:528:DyaK28XmtVOltb8%3D (Pubitemid 26333065)
130. SF Nagueh G Shah Y Wu G Torre-Amione NM King S Lahmers CC Witt K Becker S Labeit HL Granzier 2004 Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy Circulation 110 155 162 15238456 1:CAS:528:DC%2BD2cXltlOrt7Y%3D (Pubitemid 38924583)
131. J Nawata I Ohno S Isoyama J Suzuki S Miura J Ikeda K Shirato 1999 Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats Cardiovasc Res 43 371 381 10536667 1:CAS:528:DyaK1MXlsVKqsbc%3D (Pubitemid 29356375)
132. H Niimura KK Patton WJ McKenna J Soults BJ Maron JG Seidman CE Seidman 2002 Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly Circulation 105 446 451 11815426 1:CAS:528:DC%2BD38XhsVGmtb0%3D (Pubitemid 34141700)
133. G Olivetti R Ricci C Lagrasta E Maniga EH Sonnenblick P Anversa 1988 Cellular basis of wall remodeling in long-term pressure overload-induced right ventricular hypertrophy in rats Circ Res 63 648 657 2970334 1:STN:280: DyaL1czhtFChsw%3D%3D
134. P Oliviero C Chassagne N Salichon A Corbier G Hamon F Marotte D Charlemagne L Rappaport JL Samuel 2000 Expression of laminin alpha2 chain during normal and pathological growth of myocardium in rat and human Cardiovasc Res 46 346 355 10773239 1:CAS:528:DC%2BD3cXisFGqsrk%3D (Pubitemid 30204607)
135. KK Parker AL Brock C Brangwynne RJ Mannix N Wang E Ostuni NA Geisse JC Adams GM Whitesides DE Ingber 2002 Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces FASEB J 16 1195 1204 12153987 1:CAS:528:DC%2BD38XlslWrt7o%3D (Pubitemid 34815407)
136. KK Parker DE Ingber 2007 Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering Philos Trans R Soc Lond B Biol Sci 362 1267 1279 17588874 1:CAS:528:DC%2BD2sXps1Sjt74%3D (Pubitemid 47195021)
137. KK Parker J Tan CS Chen L Tung 2008 Myofibrillar architecture in engineered cardiac myocytes Circ Res 103 340 342 18635822 1:CAS:528: DC%2BD1cXptlKnu74%3D
138. KK Parker LK Taylor JB Atkinson DE Hansen JP Wikswo 2001 The effects of tubulin-binding agents on stretch-induced ventricular arrhythmias Eur J Pharmacol 417 131 140 11301068 1:CAS:528:DC%2BD3MXis1SjsLo%3D (Pubitemid 32299876)
139. DM Pedrotty RY Klinger N Badie S Hinds A Kardashian N Bursac 2008 Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay Am J Physiol Heart Circ Physiol 295 H390 H400 18502901 1:CAS:528:DC%2BD1cXoslyns74%3D
140. RJ Pelham Jr Y Wang 1997 Cell locomotion and focal adhesions are regulated by substrate flexibility Proc Natl Acad Sci USA 94 13661 13665 9391082 1:CAS:528:DyaK2sXotValtro%3D (Pubitemid 28009639)
141. NS Peters NJ Severs SM Rothery C Lincoln MH Yacoub CR Green 1994 Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium Circulation 90 713 725 8044940 1:STN:280:DyaK2czitVantw%3D%3D (Pubitemid 24242737)
142. CG Pham AE Harpf RS Keller HT Vu SY Shai JC Loftus RS Ross 2000 Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway Am J Physiol Heart Circ Physiol 279 H2916 H2926 11087248 1:CAS:528:DC%2BD3cXptFSlsrc%3D
143. DA Pijnappels MJ Schalij AA Ramkisoensing J van Tuyn AA de Vries A van der Laarse DL Ypey DE Atsma 2008 Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integration with cardiomyocyte cultures Circ Res 103 167 176 18556577 1:CAS:528: DC%2BD1cXot1Oju74%3D
144. RL Price C Chintanowonges I Shiraishi TK Borg L Terracio 1996 Local and regional variations in myofibrillar patterns in looping rat hearts Anat Rec 245 83 93 8731044 1:STN:280:DyaK283ptFyhug%3D%3D (Pubitemid 26121569)
145. GL Radice H Rayburn H Matsunami KA Knudsen M Takeichi RO Hynes 1997 Developmental defects in mouse embryos lacking N-cadherin Dev Biol 181 64 78 9015265 1:CAS:528:DyaK2sXmtlGmug%3D%3D (Pubitemid 27079635)
146. MC Remond JA Fee EL Elson LA Taber 2006 Myosin-based contraction is not necessary for cardiac c-looping in the chick embryo Anat Embryol (Berl) 211 443 454 1:CAS:528:DC%2BD28XhtVagsrvM (Pubitemid 44484320)
147. AJ Ridley MA Schwartz K Burridge RA Firtel MH Ginsberg G Borisy JT Parsons AR Horwitz 2003 Cell migration: integrating signals from front to back Science 302 1704 1709 14657486 1:CAS:528:DC%2BD3sXpsVWns7o%3D (Pubitemid 37505725)
148. RS Ross TK Borg 2001 Integrins and the myocardium Circ Res 88 1112 1119 11397776 1:CAS:528:DC%2BD3MXksVejtLg%3D (Pubitemid 34132510)
149. RS Ross C Pham SY Shai JI Goldhaber C Fenczik CC Glembotski MH Ginsberg JC Loftus 1998 Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes Circ Res 82 1160 1172 9633916 1:CAS:528:DyaK1cXjvVCms70%3D (Pubitemid 28311124)
150. A Salameh A Wustmann S Karl K Blanke D Apel D Rojas-Gomez H Franke FW Mohr J Janousek S Dhein 2010 Cyclic mechanical stretch induces cardiomyocyte orientation and polarization of the gap junction protein connexin43 Circ Res 106 1592 1602 20378856 1:CAS:528:DC%2BC3cXmsFyis78%3D
151. JL Samuel A Barrieux S Dufour I Dubus F Contard V Koteliansky F Farhadian F Marotte JP Thiery L Rappaport 1991 Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload J Clin Invest 88 1737 1746 1834701 1:CAS:528:DyaK3MXmslKru7s%3D
152. JL Samuel F Farhadian A Sabri F Marotte V Robert L Rappaport 1994 Expression of fibronectin during rat fetal and postnatal development: an in situ hybridisation and immunohistochemical study Cardiovasc Res 28 1653 1661 7842459 1:CAS:528:DyaK2MXivFWhsLg%3D (Pubitemid 24344139)
153. J Schaper B Speiser 1992 The extracellular matrix in the failing human heart Basic Res Cardiol 87 Suppl 1 303 309 1497574
154. MA Schwartz MH Ginsberg 2002 Networks and crosstalk: integrin signalling spreads Nat Cell Biol 4 E65 E68 11944032 1:CAS:528:DC%2BD38XivV2jtr4%3D
155. Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, 2nd, Heller-Brown J, Peterson KL, Omens JH, McCulloch AD, Chen J (2008) An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest 118:3870-3880
156. VF Shimko WC Claycomb 2008 Effect of mechanical loading on three-dimensional cultures of embryonic stem cell-derived cardiomyocytes Tissue Eng A 14 49 58 1:CAS:528:DC%2BD1cXovFKhsA%3D%3D (Pubitemid 351520439)
157. DG Simpson ML Decker WA Clark RS Decker 1993 Contractile activity and cell-cell contact regulate myofibrillar organization in cultured cardiac myocytes J Cell Biol 123 323 336 8408216 1:CAS:528:DyaK3sXmtFyisL0%3D (Pubitemid 23313958)
158. DG Simpson M Majeski TK Borg L Terracio 1999 Regulation of cardiac myocyte protein turnover and myofibrillar structure in vitro by specific directions of stretch Circ Res 85 e59 e69 10559148 1:STN:280: DC%2BD3c%2FjtVWruw%3D%3D
159. DG Simpson L Terracio M Terracio RL Price DC Turner TK Borg 1994 Modulation of cardiac myocyte phenotype in vitro by the composition and orientation of the extracellular matrix J Cell Physiol 161 89 105 7929612 1:CAS:528:DyaK2cXmsFans7o%3D (Pubitemid 24315654)
160. SH Smith SP Bishop 1985 Regional myocyte size in compensated right ventricular hypertrophy in the ferret J Mol Cell Cardiol 17 1005 1011 2933527 1:STN:280:DyaL28%2Fmt1Khtg%3D%3D (Pubitemid 16228242)
161. AP Soler KA Knudsen 1994 N-cadherin involvement in cardiac myocyte interaction and myofibrillogenesis Dev Biol 162 9 17 8125202 1:STN:280:DyaK2c7ntV2hug%3D%3D (Pubitemid 24098527)
162. AT Soufan G van den Berg JM Ruijter PA de Boer MJ van den Hoff AF Moorman 2006 Regionalized sequence of myocardial cell growth and proliferation characterizes early chamber formation Circ Res 99 545 552 16888243 1:CAS:528:DC%2BD28XosFGnsbY%3D (Pubitemid 44337827)
163. MS Spach JF Heidlage RC Barr PC Dolber 2004 Cell size and communication: role in structural and electrical development and remodeling of the heart Heart Rhythm 1 500 515 15851207 (Pubitemid 39462627)
164. MS Spach JF Heidlage PC Dolber RC Barr 2000 Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth Circ Res 86 302 311 10679482 1:CAS:528:DC%2BD3cXhsVKlsro%3D (Pubitemid 30108824)
165. D Srivastava EN Olson 2000 A genetic blueprint for cardiac development Nature 407 221 226 11001064 1:CAS:528:DC%2BD3cXmvVSlsro%3D
166. LA Taber 2001 Biomechanics of cardiovascular development Annu Rev Biomed Eng 3 1 25 11447055 1:CAS:528:DC%2BD3MXmsFKqtLY%3D (Pubitemid 32928031)
167. LA Taber IE Lin EB Clark 1995 Mechanics of cardiac looping Dev Dyn 203 42 50 7647373 1:STN:280:DyaK2MznsFeisg%3D%3D
168. H Tagawa N Wang T Narishige DE Ingber MR Zile Gt Cooper 1997 Cytoskeletal mechanics in pressure-overload cardiac hypertrophy Circ Res 80 281 289 9012750 1:CAS:528:DyaK2sXovVSruw%3D%3D (Pubitemid 27058701)
169. CY Tay H Yu M Pal WS Leong NS Tan KW Ng DT Leong LP Tan 2010 Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage Exp Cell Res 316 1159 1168 20156435 1:CAS:528:DC%2BC3cXksVejur0%3D
170. L Terracio K Rubin D Gullberg E Balog W Carver R Jyring TK Borg 1991 Expression of collagen binding integrins during cardiac development and hypertrophy Circ Res 68 734 744 1835909 1:CAS:528:DyaK3MXisVCqs7Y%3D
171. A Terzic Y Kurachi 1996 Actin microfilament disrupters enhance K(ATP) channel opening in patches from guinea-pig cardiomyocytes J Physiol 492 Pt 2 395 404 9019537 1:CAS:528:DyaK28XivVKhtb4%3D
172. SP Thomas JP Kucera L Bircher-Lehmann Y Rudy JE Saffitz AG Kleber 2003 Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43 Circ Res 92 1209 1216 12730095 1:CAS:528:DC%2BD3sXkt12qtL4%3D (Pubitemid 36723648)
173. K Tobita EA Schroder JP Tinney JB Garrison BB Keller 2002 Regional passive ventricular stress-strain relations during development of altered loads in chick embryo Am J Physiol Heart Circ Physiol 282 H2386 H2396 12003850 1:CAS:528:DC%2BD38Xks12ntLw%3D
174. AS Torsoni SS Constancio W Nadruz Jr SK Hanks KG Franchini 2003 Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes Circ Res 93 140 147 12805241 1:CAS:528: DC%2BD3sXlsVOnsbg%3D (Pubitemid 36919701)
175. H Tsutsui K Ishihara C Gt 1993 Cytoskeletal role in the contractile dysfunction of hypertrophied myocardium Science 260 682 687 8097594 1:STN:280:DyaK3s3kt1eqtw%3D%3D (Pubitemid 23167592)
176. H Tsutsui H Tagawa RL Kent PL McCollam K Ishihara M Nagatsu C Gt 1994 Role of microtubules in contractile dysfunction of hypertrophied cardiocytes Circulation 90 533 555 8026043 1:STN:280:DyaK2c3pvVajsw%3D%3D (Pubitemid 24203722)
177. MM Ulrich AM Janssen MJ Daemen L Rappaport JL Samuel F Contard JF Smits JP Cleutjens 1997 Increased expression of fibronectin isoforms after myocardial infarction in rats J Mol Cell Cardiol 29 2533 2543 9299376 1:CAS:528: DyaK2sXmtlCjtLo%3D (Pubitemid 27404445)
178. G van den Berg R Abu-Issa BA de Boer MR Hutson PA de Boer AT Soufan JM Ruijter ML Kirby MJ van den Hoff AF Moorman 2009 A caudal proliferating growth center contributes to both poles of the forming heart tube Circ Res 104 179 188 19059840
179. A van der Flier AC Gaspar S Thorsteinsdottir C Baudoin E Groeneveld CL Mummery A Sonnenberg 1997 Spatial and temporal expression of the beta1D integrin during mouse development Dev Dyn 210 472 486 9415431 (Pubitemid 27516672)
180. M Wagner MA Siddiqui 2007 Signal transduction in early heart development (I): cardiogenic induction and heart tube formation Exp Biol Med (Maywood) 232 852 865 1:CAS:528:DC%2BD2sXnsFWjtLs%3D (Pubitemid 47026791)
181. KB Walsh GE Parks 2002 Changes in cardiac myocyte morphology alter the properties of voltage-gated ion channels Cardiovasc Res 55 64 75 12062709 1:CAS:528:DC%2BD38XksVSit7w%3D (Pubitemid 34615940)
182. PM Werchan WR Summer AM Gerdes KH McDonough 1989 Right ventricular performance after monocrotaline-induced pulmonary hypertension Am J Physiol 256 H1328 H1336 2524170 1:STN:280:DyaL1M3ksFSitw%3D%3D
183. DP White PT Caswell JC Norman 2007 alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration J Cell Biol 177 515 525 17485491 1:CAS:528: DC%2BD2sXltF2gt7s%3D (Pubitemid 46718279)
184. JC Wu TH Chung YZ Tseng SM Wang 1999 N-cadherin/catenin-based costameres in cultured chicken cardiomyocytes J Cell Biochem 75 93 104 10462708 1:CAS:528:DyaK1MXlslWnsLg%3D
185. JC Wu HC Sung TH Chung RM DePhilip 2002 Role of N-cadherin- and integrin-based costameres in the development of rat cardiomyocytes J Cell Biochem 84 717 724 11835397
186. S Yamada WJ Nelson 2007 Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion J Cell Biol 178 517 527 17646397 1:CAS:528:DC%2BD2sXos1CrsLY%3D (Pubitemid 47196158)
187. L Yin H Bien E Entcheva 2004 Scaffold topography alters intracellular calcium dynamics in cultured cardiomyocyte networks Am J Physiol Heart Circ Physiol 287 H1276 H1285 15105172 1:CAS:528:DC%2BD2cXnvVaqsbk%3D
188. J Zhuang KA Yamada JE Saffitz AG Kleber 2000 Pulsatile stretch remodels cell-to-cell communication in cultured myocytes Circ Res 87 316 322 10948066 1:CAS:528:DC%2BD3cXmtFCku70%3D (Pubitemid 30655973)
189. W Zierhut HG Zimmer AM Gerdes 1991 Effect of angiotensin converting enzyme inhibition on pressure-induced left ventricular hypertrophy in rats Circ Res 69 609 617 1714799 1:CAS:528:DyaK3MXlvVSls70%3D
190. C Zuppinger MC Schaub HM Eppenberger 2000 Dynamics of early contact formation in cultured adult rat cardiomyocytes studied by N-cadherin fused to green fluorescent protein J Mol Cell Cardiol 32 539 555 10756112 1:CAS:528:DC%2BD3cXit12hsrc%3D (Pubitemid 30658924)