Nanotechnology: Emerging tools for biology and medicine

Genes and Development

Volumn 27, Issue 22, 2013, Pages 2397-2408

  Wong, Ian Y ^a,b   Bhatia, Sangeeta N ^c,d   Toner, Mehmet ^e  

^a Brown University   (United States)

^b BROWN UNIVERSITY   (United States)

^c HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Biomarker; Microfluidics; Microneedle; Nanoparticle; Single cell; Targeted delivery

Indexed keywords

GOLD NANOPARTICLE; NANOMATERIAL; NANONEEDLE; NANOWIRE; UNCLASSIFIED DRUG;

CIRCULATING TUMOR CELL; MEASUREMENT ACCURACY; MINIMALLY INVASIVE PROCEDURE; NANOBIOTECHNOLOGY; NANOCHIP; NANOMEDICINE; PRIORITY JOURNAL; REVIEW; SYSTEMS BIOLOGY;

BIOMARKER; MICROFLUIDICS; MICRONEEDLE; NANOPARTICLE; SINGLE CELL; TARGETED DELIVERY;

HUMANS; MEDICINE; NANOTECHNOLOGY;

EID: 84887601919     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.226837.113     Document Type: Review

References (95)

1. Agresti J. J, Antipov E, Abate AR, Ahn K, Rowat AC, Baret J-C, Marquez M., Klibanov AM, Griffiths AD, Weitz DA. 2010. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc Natl Acad Sci 107: 4004-4009.
2. Aldaye F. A, Palmer AL, Sleiman HF. 2008. Assembling materials with DNA as the guide. Science 321: 1795-1799.
3. Alivisatos P. 2004. The use of nanocrystals in biological detection. Nat Biotechnol 22: 47-52.
4. Alivisatos A. P, Andrews AM, Boyden ES, Chun M, Church GM, Deisseroth K., Donoghue JP, Fraser SE, Lippincott-Schwartz J, Looger L. L, et al. 2013. Nanotools for neuroscience and brain activity mapping. ACS Nano 7: 1850-1866.
5. Anderson N. L, Anderson NG. 2002. The human plasma proteome: History, character, and diagnostic prospects. Mol Cell Proteomics 1: 845-867.
6. Baker M. 2012. Digital PCR hits its stride. Nat Methods 9: 541.
7. Baker B. M, Chen CS. 2012. Deconstructing the third dimension: How 3D culture microenvironments alter cellular cues. J Cell Sci 125: 3015-3024.
8. Bao G., Mitragotri S, Tong S. 2013. Multifunctional nanoparticles for drug delivery and molecular imaging. Annu Rev Biomed Eng 15: 253-282.
9. Bayley H., Cremer PS. 2001. Stochastic sensors inspired by biology. Nature 413: 226-230.
10. Branton D., Deamer DW, Marziali A, Bayley H, Benner SA, Butler T., Di Ventra M, Garaj S, Hibbs A, Huang X, et al. 2008. The potential and challenges of nanopore sequencing. Nat Biotechnol 26: 1146-1153.
11. Brolo A.G. 2012. Plasmonics for future biosensors. Nat Photonics 6: 709-713.
12. Chauhan V. P, Stylianopoulos T, Boucher Y, Jain RK. 2011. Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies. Annu Rev Chem Biomol Eng 2: 281-298.
13. Cheng A. A, Lu TK. 2012. Synthetic biology: An emerging engineering discipline. Annu Rev Biomed Eng 14: 155-178.
14. Cheng Z., Al Zaki A, Hui JZ, Muzykantov VR, Tsourkas A. 2012. Multifunctional nanoparticles: Cost versus benefit of adding targeting and imaging capabilities. Science 338: 903-910.
15. Chin C. D, Linder V, Sia SK. 2012. Commercialization of microfluidic point-of-care diagnostic devices. Lab Chip 12: 2118-2134.
16. Choi Y., Kang T, Lee LP. 2009. Plasmon resonance energy transfer (PRET)-based molecular imaging of cytochrome c in living cells. Nano Lett 9: 85-90.
17. Csete M. E, Doyle JC. 2002. Reverse engineering of biological complexity. Science 295: 1664-1669.
18. Davis M. E, Chen ZG, Shin DM. 2008. Nanoparticle therapeutics: An emerging treatment modality for cancer. Nat Rev Drug Discov 7: 771-782.
19. Davis M. E, Zuckerman JE, Choi CHJ, Seligson D, Tolcher A, Alabi C. A, Yen Y, Heidel JD, Ribas A. 2010. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464: 1067-1070.
20. DeMuth P. C, Min Y, Huang B, Kramer JA, Miller AD, Barouch DH, Hammond PT, Irvine DJ. 2013. Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater 12: 367-376.
21. De Weer P. 2000. A century of thinking about cell membranes. Annu Rev Physiol 62: 919-926.
22. Di Carlo D., Irimia D, Tompkins RG, Toner M. 2007. Continuous inertial focusing, ordering, and separation of particles in microchannels. Proc Natl Acad Sci 104: 18892-18897.
23. Dietz H., Douglas SM, Shih WM. 2009. Folding DNA into twisted and curved nanoscale shapes. Science 325: 725-730.
24. Douglas S. M, Bachelet I, Church GM. 2012. A logic-gated nanorobot for targeted transport of molecular payloads. Science 335: 831-834.
25. Dunlop J., Bowlby M, Peri R, Vasilyev D, Arias R. 2008. Highthroughput electrophysiology: An emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov 7: 358-368.
26. Even-Ram S, Yamada KM. 2005. Cell migration in 3D matrix. Curr Opin Cell Biol 17: 524-532.
27. Fan R., Vermesh O, Srivastava A, Yen BKH, Qin L, Ahmad H, Kwong G. A, Liu C-C, Gould J, Hood L, et al. 2008. Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood. Nat Biotechnol 26: 1373-1378.
28. Geng Y., Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE. 2007. Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2: 249-255.
29. Guo M. T, Rotem A, Heyman JA, Weitz DA. 2012. Droplet microfluidics for high-throughput biological assays. Lab Chip 12: 2146-2155.
30. Hall A. R, Scott A, Rotem D, Mehta KK, Bayley H, Dekker C. 2010. Hybrid pore formation by directed insertion of α-haemolysin into solid-state nanopores. Nat Nanotechnol 5: 874-877.
31. Helgeson M. E, Chapin SC, Doyle PS. 2011. Hydrogel microparticles from lithographic processes: Novel materials for fundamental and applied colloid science. Curr Opin Coll Int Sci 16: 106-117.
32. Hori S. S, Gambhir SS. 2011. Mathematical model identifies blood biomarker-based early cancer detection strategies and limitations. Sci Transl Med 3: 109ra116.
33. Hrkach J., Von Hoff D, Mukkaram Ali M, Andrianova E, Auer J, Campbell T., De Witt D, Figa M, Figueiredo M, Horhota A et al. 2012. Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med 4: 128ra139.
34. Jebrail M. J, Yang H, Mudrik JM, Lafreniere NM, McRoberts C, Al-Dirbashi OY, Fisher L, Chakraborty P, Wheeler AR. 2011. A digital microfluidic method for dried blood spot analysis. Lab Chip 11: 3218-3224.
35. 2signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes. Nat Nanotechnol 5: 302-309.
36. Kafri R., Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. 2013. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature 494: 480-483.
37. Ke Y., Ong LL, Shih WM, Yin P. 2012. Three-dimensional structures self-assembled from DNA bricks. Science 338: 1177-1183.
38. Kim D.-H, Ghaffari R, Lu N, Rogers JA. 2012a. Flexible and stretchable electronics for biointegrated devices. Annu Rev Biomed Eng 14: 113-128.
39. Kim D.-H, Provenzano PP, Smith CL, Levchenko A. 2012b. Matrix nanotopography as a regulator of cell function. J Cell Biol 197: 351-360.
40. Kwong G. A, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y., et al. 2013. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol 31: 63-70.
41. Leamon J. H, Link DR, Egholm M, Rothberg JM. 2006. Overview: Methods and applications for droplet compartmentalization of biology. Nat Methods 3: 541-543.
42. Lee H., Sun E, Ham D, Weissleder R. 2008. Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med 14: 869-874.
43. Legant W. R, Miller JS, Blakely BL, Cohen DM, Genin GM, Chen CS. 2010. Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nat Methods 7: 969-971.
44. Love J.C. 2010. Integrated process design for single-cell analytical technologies. AIChE J 56: 2496-2502.
45. Love K. T, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin J. R, Qin J, Cantley W, Qin LL, Racie T, et al. 2010. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci 107: 1864-1869.
46. Ma C., Fan R, Ahmad H, Shi Q, Comin-Anduix B, Chodon T, Koya R. C, Liu C-C, Kwong GA, Radu CG, et al. 2011. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nat Med 17: 738-743.
47. Mach A. J, Adeyiga OB, Di Carlo D. 2013. Microfluidic sample preparation for diagnostic cytopathology. Lab Chip 13: 1011-1026.
48. Madou M.J. 2012. Fundamentals of microfabrication and nanotechnology. CRC Press, Boca Raton, FL.
49. Maheswaran S., Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura C. V, Inserra E, Diederichs S, Iafrate AJ, Bell DW, et al. 2008. Detection of mutations in EGFR in circulating lungcancer cells. N Engl J Med 359: 366-377.
50. Melin J., Quake SR. 2007. Microfluidic large-scale integration: The evolution of design rules for biological automation. Annu Rev Biophys Biomol Struct 36: 213-231.
51. Merkel T. J, Jones SW, Herlihy KP, Kersey FR, Shields AR, Napier M, Luft JC, Wu H, Zamboni WC, Wang AZ, et al. 2011. Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles. Proc Natl Acad Sci 108: 586-591.
52. Mitragotri S., Lahann J. 2009. Physical approaches to biomaterial design. Nat Mater 8: 15-23.
53. Mousa N. A, Jebrail MJ, Yang H, Abdelgawad M, Metalnikov P, Chen J., Wheeler AR, Casper RF. 2009. Droplet-scale estrogen assays in breast tissue, blood, and serum. Sci Transl Med 1: 1ra2.
54. Nagrath S., Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, et al. 2007. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450: 1235-1239.
55. Nel A. E, Mädler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M. 2009. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8: 543-557.
56. Nelson C. M, Bissell MJ. 2006. Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol 22: 287-309.
57. Ozkumur E., Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, Yu M, Chen P-I, Morgan B, Trautwein J et al. 2013. Inertial focusing for tumor antigen-dependent and-independent sorting of rare circulating tumor cells. Sci Transl Med 5: 179ra147.
58. Park K., Millet LJ, Kim N, Li H, Jin X, Popescu G, Aluru NR, Hsia K. J, Bashir R. 2010. Measurement of adherent cell mass and growth. Proc Natl Acad Sci 107: 20691-20696.
59. Prakash M., Gershenfeld N. 2007. Microfluidic bubble logic. Science 315: 832-835.
60. Prausnitz M. R, Mitragotri S, Langer R. 2004. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3: 115-124.
61. Pregibon D. C, Toner M, Doyle PS. 2007. Multifunctional encoded particles for high-throughput biomolecule analysis. Science 315: 1393-1396.
62. Ren Y., Cheung HW, von Maltzhan G, Agrawal A, Cowley GS, Weir B. A, Boehm JS, Tamayo P, Karst AM, Liu JF et al. 2012. Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci Transl Med 4: 147ra112.
63. Rothemund P. WK. 2006. Folding DNA to create nanoscale shapes and patterns. Nature 440: 297-302.
64. Ruoslahti E. 2012. Peptides as targeting elements and tissue penetration devices for nanoparticles. Adv Mater 24: 3747-3756.
65. Schneider T., Kreutz J, Chiu DT. 2013. The potential impact of droplet microfluidics in biology. Anal Chem 85: 3476-3482.
66. Seeman N.C. 2003. DNA in a material world. Nature 421: 427-431.
67. Shalek A. K, Robinson JT, Karp ES, Lee JS, Ahn D-R, Yoon M-H, Sutton A., Jorgolli M, Gertner RS, Gujral TS, et al. 2010. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci 107: 1870-1875.
68. Shalek A. K, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen M. S, Robinson JT, Pochet N, Neuberg D, Gertner RS, et al. 2012. Nanowire-mediated delivery enables functional interrogation of primary immune cells: Application to the analysis of chronic lymphocytic leukemia. Nano Lett 12: 6498-6504.
69. Shao H., Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg F. H, Breakefield XO, Weissleder R, Lee H. 2012. Protein typing of circulating microvesicles allows realtime monitoring of glioblastoma therapy. Nat Med 18: 1835-1840.
70. Shi J., Votruba AR, Farokhzad OC, Langer R. 2010. Nanotechnology in drug delivery and tissue engineering: From discovery to applications. Nano Lett 10: 3223-3230.
71. Shih W. M, Lin C. 2010. Knitting complex weaves with DNA origami. Curr Opin Struct Biol 20: 276-282.
72. Skalak R., Branemark PI. 1969. Deformation of red blood cells in capillaries. Science 164: 717-719.
73. Snijder B., Pelkmans L. 2011. Origins of regulated cell-to-cell variability. Nat Rev Mol Cell Biol 12: 119-125.
74. Son S., Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis S.R. 2012. Direct observation of mammalian cell growth and size regulation. Nat Methods 9: 910-912.
75. Stone H. A, Stroock AD, Ajdari A. 2004. Engineering flows in small devices. Annu Rev Fluid Mech 36: 381-411.
76. Stott S. L, Hsu C-H, Tsukrov DI, Yu M, Miyamoto DT, Floyd FP, Springer S., Irimia D, Nagrath S, Sequist LV, et al. 2010. Isolation of circulating tumor cells using a microvortexgenerating herringbone-chip. Proc Natl Acad Sci 107: 18392-18397.
77. Sugahara K. N, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Girard O. M, Hanahan D, Mattrey RF, Ruoslahti E. 2009. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 16: 510-520.
78. Sullivan S. P, Koutsonanos DG, del Pilar Martin M, Lee JW, Zarnitsyn V., Choi S-O, Murthy N, Compans RW, Skountzou I, Prausnitz MR. 2010. Dissolving polymer microneedle patches for influenza vaccination. Nat Med 16: 915-920.
79. Teesalu T., Sugahara KN, Kotamraju VR, Ruoslahti E. 2009. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad Sci 106: 16157-16162.
80. Tian B., Liu J, Dvir T, Jin L, Tsui JH, Qing Q, Suo Z, Langer R, Kohane D. S, Lieber CM. 2012. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater 11: 986-994.
81. Toner M., Irimia D. 2005. Blood-on-a-chip. Annu Rev Biomed Eng 7: 77-103.
82. VanDersarl JJ, Xu AM, Melosh NA. 2012. Nanostraws for direct fluidic intracellular access. Nano Lett 12: 3881-3886.
83. Venkatesan B. M, Bashir R. 2011. Nanopore sensors for nucleic acid analysis. Nat Nanotechnol 6: 615-624.
84. Vincent M. E, Liu W, Haney EB, Ismagilov RF. 2010. Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals. Chem Soc Rev 39: 974-984.
85. von Maltzahn G, Park J-H, Lin KY, Singh N, Schwöppe C, Mesters R., Berdel WE, Ruoslahti E, Sailor MJ, Bhatia SN. 2011. Nanoparticles that communicate in vivo to amplify tumour targeting. Nat Mater 10: 545-552.
86. Wang J., Byrne JD, Napier ME, DeSimone JM. 2011a. More effective nanomedicines through particle design. Small 7: 1919-1931.
87. Wang S., Liu K, Liu J, Yu ZTF, Xu X, Zhao L, Lee T, Lee EK, Reiss J, Lee Y-K, et al. 2011b. Highly efficient capture of circulating tumor cells by using nanostructured silicon substrates with integrated chaotic micromixers. Angew Chem Int Ed 50: 3084-3088.
88. Wang S., Ota S, Guo B, Ryu J, Rhodes C, Xiong Y, Kalim S, Zeng L, Chen Y, Teitell MA, et al. 2011c. Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonicresonator sensor array. Nano Lett 11: 3431-3434.
89. Wheeler A.R. 2008. Chemistry. Putting electrowetting to work. Science 322: 539-540.
90. Whitehead K. A, Langer R, Anderson DG. 2009. Knocking down barriers: Advances in siRNA delivery. Nat Rev Drug Discov 8: 129-138.
91. Whitesides G.M. 2003. The 'right' size in nanobiotechnology. Nat Biotechnol 21: 1161-1165.
92. Whitesides G. M, Ostuni E, Takayama S, Jiang X, Ingber DE. 2001. Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 3: 335-373.
93. Xie X., Xu AM, Leal-Ortiz S, Cao Y, Garner CC, Melosh NA. 2013. Nanostraw-electroporation system for highly efficient intracellular delivery and transfection. ACS Nano 7: 4351-4358.
94. Yoo J.-W, Irvine DJ, Discher DE, Mitragotri S. 2011. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov 10: 521-535.
95. Yu M., Stott S, Toner M, Maheswaran S, Haber DA. 2011. Circulating tumor cells: Approaches to isolation and characterization. J Cell Biol 192: 373-382.