Fluid dynamics of ventricular filling in heart failure: Overlooked problems of RV/LV chamber dilatation

Hellenic Journal of Cardiology

Volumn 56, Issue 1, 2015, Pages 85-95

  Pasipoularides, Ares ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diastolic ventriculoannular disproportion (DVAD); Dilated ventricle; Filling RV LV vortex; Surgical ventricular remodelling

Indexed keywords

BLOOD PRESSURE TRANSDUCER; CARDIOVASCULAR CATHETER; COMPUTATIONAL FLUID DYNAMICS; CORONARY ARTERY BLOOD FLOW; DIASTOLIC DYSFUNCTION; HEART DILATATION; HEART FAILURE; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE ISCHEMIA; HEART RIGHT VENTRICLE OVERLOAD; HEART VENTRICLE OVERLOAD; HUMAN; PRESSURE OVERLOAD; REVIEW; THREE DIMENSIONAL ECHOCARDIOGRAPHY; DIASTOLE; DISEASE COURSE; DISEASE MANAGEMENT; HEART VENTRICLE; HEART VENTRICLE REMODELING; HEMODYNAMICS; HYDRODYNAMICS; PATHOLOGY; PATHOPHYSIOLOGY;

DIASTOLE; DISEASE MANAGEMENT; DISEASE PROGRESSION; HEART FAILURE; HEART VENTRICLES; HEMODYNAMICS; HUMANS; HYDRODYNAMICS; VENTRICULAR REMODELING;

EID: 84923169839     PISSN: 11099666     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (70)

1. Pasipoularides A. Heart’s Vortex: intracardiac blood flow phenomena. Shelton, CT: People’s Medical Publishing House; 2010. 960 pp.
2. Mirsky I, Pasipoularides A. Clinical assessment of diastolic function. Prog Cardiovasc Dis. 1990; 32: 291-318.
3. Pasipoularides A. Right and left ventricular diastolic pressure- volume relations: a comprehensive review. J Cardiovasc Transl Res. 2013; 6: 239-252.
4. Zile MR, Baicu CF, Gaasch WH. Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med. 2004; 350: 1953-1959.
5. Ouzounian M, Lee DS, Liu PP. Diastolic heart failure: mechanisms and controversies. Nat Clin Pract Card. 2008; 5: 375-386.
6. Gaasch WH, Zile MR. Left ventricular diastolic dysfunction and diastolic heart failure. Annu Rev Med. 2004; 55: 373-394.
7. Rathi VK, Biederman RW. Expanding role of cardiovascular magnetic resonance in left and right ventricular diastolic function. Heart Fail Clin. 2009; 5: 421-35.
8. Thomas MD, Fox KF, Coats AJ, Sutton GC. The epidemiological enigma of heart failure with preserved systolic function. Eur J Heart Fail. 2004; 6: 125-136.
9. Pasipoularides A. Clinical assessment of ventricular ejection dynamics with and without outflow obstruction. J Am Coll Cardiol. 1990; 15: 859-882.
10. Little WC, Downes TR, Applegate RJ. Invasive evaluation of left ventricular diastolic performance. Herz. 1990; 15: 362-376.
11. Pasipoularides A. RV/LV diastolic flow field: why are measured intraventricular pressure gradients small? Rev Esp Cardiol. 2013; 66: 337-341.
12. Fredriksson AG, Zajac J, Eriksson J, et al. 4-D blood flow in the human right ventricle. Am J Physiol Heart Circ Physiol. 2011; 301: H2344-2350.
13. Ghosh E, Kovács SJ. The vortex formation time to diastolic function relation: assessment of pseudonormalized versus normal filling. Physiol Rep. 2013; 1: e00170.
14. Raman SV, Simonetti OP. The CMR examination in heart failure. Heart Fail Clin. 2009; 5: 283-300.
15. Rathi VK, Doyle M, Yamrozik J, et al. Routine evaluation of left ventricular diastolic function by cardiovascular magnetic resonance: a practical approach. J Cardiovasc Magn Reson. 2008; 10: 36.
16. Marwick TH, Raman SV, Carrió I, Bax JJ. Recent developments in heart failure imaging. JACC Cardiovasc Imaging. 2010; 3: 429-439.
17. Pasipoularides AD, Shu M, Womack MS, Shah A, Von Ramm O, Glower DD. RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations. Am J Physiol Heart Circ Physiol. 2003; 284: H56-65.
18. Goenka AH, Flamm SD. Cardiac magnetic resonance imaging for the investigation of cardiovascular disorders. Part 1: current applications. Tex Heart Inst J. 2014; 41: 7-20.
19. Grothues F, Braun-Dullaeus R. Serial assessment of ventricular morphology and function. Heart Fail Clin. 2009; 5: 301-314.
20. Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009; 22: 107-133.
21. Fyrenius A, Wigström L, Bolger AF, et al. Pitfalls in Doppler evaluation of diastolic function: insights from 3-dimensional magnetic resonance imaging. J Am Soc Echocardiogr. 1999; 12: 817-826.
22. Pasipoularides A. Evaluation of right and left ventricular diastolic filling. J Cardiovasc Transl Res. 2013; 6: 623-639.
23. Redfield MM. Understanding “diastolic” heart failure. N Engl J Med. 2004; 350: 1930-1931.
24. Phan TT, Shivu GN, Abozguia K, Sanderson JE, Frenneaux M. The pathophysiology of heart failure with preserved ejection fraction: from molecular mechanisms to exercise haemodynamics. Int J Cardiol. 2012; 158: 337-343.
25. Pasipoularides A. LV twisting and untwisting in HCM: ejec tion begets filling. Diastolic functional aspects of HCM. Am Heart J. 2011; 162: 798-810.
26. Tønnessen T, Knudsen CW. Surgical left ventricular remodeling in heart failure. Eur J Heart Fail. 2005; 7: 704-709.
27. Isaaz K, Pasipoularides A. Noninvasive assessment of intrinsic ventricular load dynamics in dilated cardiomyopathy. J Am Coll Cardiol. 1991; 17: 112-121.
28. Pasipoularides A, Shu M, Shah A, Womack MS, Glower DD. Diastolic right ventricular filling vortex in normal and volume overload states. Am J Physiol Heart Circ Physiol. 2003; 284: H1064-1072.
29. Pasipoularides A, Shu M, Shah A, Tucconi A, Glower DD. RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models. Am J Physiol Heart Circ Physiol. 2003; 285: H1956-1965.
30. Pasipoularides A. Complementarity and competitiveness of the intrinsic and extrinsic components of the total ventricular load: demonstration after valve replacement in aortic stenosis. Am Heart J. 2007; 153: 4-6.
31. Pasipoularides A. Functional Imaging (FI) combines imaging datasets and computational fluid dynamics to simulate cardiac flows. J Appl Physiol 2008; 105: 1015.
32. Pasipoularides A. Analysis of vortex flow imaging in normal and dysfunctional RV’s. American Society of Echocardiography 22nd Annual Scientific Sessions, Montreal, 2011. EE02d - Flow Vortex Imaging; PROLibraries.com. Available from: http://www.prolibraries.com/ase/?select=session&sessionID=3049.
33. Pasipoularides AD, Shu M, Shah A, Glower DD. Right ventricular diastolic relaxation in conscious dog models of pressure overload, volume overload, and ischemia. J Thorac Cardiovasc Surg. 2002; 124: 964-972.
34. Pasipoularides A, Shu M, Shah A, Silvestry S, Glower DD. Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia. Am J Physiol Heart Circ Physiol. 2002; 283: H2140-2150.
35. Ihara T, Shannon RP, Komamura K, et al. Effects of anaesthesia and recent surgery on diastolic function. Cardiovasc Res. 1994; 28: 325-336.
36. Condos WR Jr, Latham RD, Hoadley SD, Pasipoularides A. Hemodynamics of the Mueller maneuver in man: right and left heart micromanometry and Doppler echocardiography. Circulation. 1987; 76: 1020-1028.
37. Craig WE, Murgo JP, Pasipoularides A. Evaluation of time course of left ventricular isovolumic relaxation in humans. In: Grossman W, Lorell BH, eds. Diastolic relaxation of the heart. Boston: Martinus, Nijhoff; 1988. pp. 125-132.
38. Zile MR, Tomita M, Ishihara K, et al. Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation. Circulation. 1993; 87: 1378-1388.
39. Pacileo G, Limongelli G, Verrengia M, Gimeno J, Di Salvo G, Calabrò R. Backscatter evaluation of myocardial functional and textural findings in children with right ventricular pressure and/or volume overload. Am J Cardiol. 2004; 93: 594-597.
40. Pasipoularides A, Mirsky I, Hess OM, Grimm J, Krayenbuehl HP. Myocardial relaxation and passive diastolic properties in man. Circulation. 1986; 74: 991-1001.
41. Wang XF, Deng YB, Nanda NC, Deng J, Miller AP, Xie MX. Live three-dimensional echocardiography: imaging principles and clinical application. Echocardiography. 2003; 20: 593-604.
42. Bazilevs Y, del Alamo JC, Humphrey JD. From imaging to prediction: emerging non-invasive methods in pediatric cardiology. Prog Ped Cardiol. 2010; 30: 81-89.
43. Ebbers T, Wigström L, Bolger AF, Engvall J, Karlsson M. Estimation of relative cardiovascular pressures using time-resolved three-dimensional phase contrast MRI. Magn Reson Med. 2001; 45: 872-879.
44. Bolger AF, Heiberg E, Karlsson M, et al. Transit of blood flow through the human left ventricle mapped by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2007; 9: 741-747.
45. Lu J, Li W, Zhong Y, Luo A, Xie S, Yin L. Intuitive visualization and quantification of intraventricular convection in acute ischemic left ventricular failure during early diastole using color Doppler-based echocardiographic vector flow mapping. Int J Cardiovasc Imaging. 2012; 28: 1035-1047.
46. Mangual JO, Domenichini F, Pedrizzetti G. Describing the highly three dimensional right ventricle flow. Ann Biomed Eng. 2012; 40: 1790-1801.
47. Pasipoularides A, Murgo JP, Miller JW, Craig WE. Nonobstructive left ventricular ejection pressure gradients in man. Circ Res. 1987; 61: 220-227.
48. Georgiadis JG, Wang M, Pasipoularides A. Computational fluid dynamics of left ventricular ejection. Ann Biomed Eng. 1992; 20: 81-97.
49. Pasipoularides A. Fluid dynamic aspects of ejection in hypertrophic cardiomyopathy. Hellenic J Cardiol. 2011; 52: 416-426.
50. Isaaz K. A theoretical model for the noninvasive assessment of the transmitral pressure-flow relation. J Biomech. 1992; 25: 581-590.
51. Rodevand O, Bjornerheim R, Edvardsen T, Smiseth OA, Ihlen H. Diastolic flow pattern in the normal left ventricle. J Am Soc Echocardiogr. 1999; 12: 500-507.
52. Zajac J, Eriksson J, Dyverfeldt P, Bolger AF, Ebbers T, Carlhäll C-J. Turbulent kinetic energy in normal and myopathic left ventricles. J Magn Reson Imaging. 2014 Apr 8. doi: 10.1002/jmri.24633. [Epub ahead of print].
53. Houlind K, Schroeder AP, Egeblad H, Pedersen EM. Agedependent changes in spatial and temporal blood velocity distribution of early left ventricular filling. Magn Reson Imaging. 1999; 17: 859-868.
54. Cortina C, Bermejo J, Yotti R, et al. Noninvasive assessment of the right ventricular filling pressure gradient. Circulation. 2007; 116: 1015-1023.
55. Yotti R, Bermejo J, Antoranz JC, et al. A noninvasive method for assessing impaired diastolic suction in patients with dilated cardiomyopathy. Circulation. 2005; 112: 2921-2929.
56. Loerakker S, Cox LG, van Heijst GJ, de Mol BA, van de Vosse FN. Influence of dilated cardiomyopathy and a left ventricular assist device on vortex dynamics in the left ventricle. Comput Methods Biomech Biomed Engin. 2008; 11: 649-660.
57. Chan BT, Abu Osman NA, Lim E, et al. Sensitivity analysis of left ventricle with dilated cardiomyopathy in fluid structure simulation. PLoS One. 2013; 8: e67097.
58. Charonko JJ, Kumar R, Stewart K, Little WC, Vlachos PP. Vortices formed on the mitral valve tips aid normal left ventricular filling. Ann Biomed Eng. 2013; 41: 1049-1061.
59. Kim DH, Seo JS, Choi YS, et al. Determinants of left ventricular vortex flow parameters assessed by contrast echocardiography in an in vivo animal model. Echocardiography. 2013; 30: 588-598.
60. Taylor DE, Wade JD. Pattern of blood flow within the heart: a stable system. Cardiovasc Res. 1973; 7: 14-21.
61. Pasipoularides A, Vlachos PP, Little WC. Vortex formation time is not an index of ventricular function. J Cardiovasc Transl Res. 2015. In press.
62. Pasipoularides A. Historical continuity in the methodology of modern medical science: Leonardo leads the way. Int J Cardiol. 2014; 171: 103-115.
63. Bellhouse BJ. Fluid mechanics of a model mitral valve and left ventricle. Cardiovasc Res. 1972; 6: 199-210.
64. Pasipoularides A. Diastolic filling vortex forces and cardiac adaptations: probing the epigenetic nexus. Hellenic J Cardiol. 2012; 53: 458-469.
65. Pasipoularides A. Mechanotransduction mechanisms for intraventricular diastolic vortex forces and myocardial deformations: Part 1. J Cardiovasc Transl Res. 2015. In press.
66. Yamamoto K, Masuyama T, Tanouchi J, et al. Intraventricular dispersion of early diastolic filling: a new marker of left ventricular diastolic dysfunction. Am Heart J. 1995; 129: 291-299.
67. Little WC. Diastolic dysfunction beyond distensibility: adverse effects of ventricular dilatation. Circulation. 2005; 112: 2888-2890.
68. Glower DD, Tuttle RH, Shaw LK, Orozco RE, Rankin JS. Patient survival characteristics after routine mitral valve repair for ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 2005; 129: 860-868.
69. Konstantinides S. The right ventricle revisited. Hellenic J Cardiol. 2013; 54: 419-421.
70. Vizzardi E, D’Aloia A, Caretta G, et al. Long-term prognostic value of longitudinal strain of right ventricle in patients with moderate heart failure. Hellenic J Cardiol. 2014; 55: 150-155.