Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy

European Heart Journal

Volumn 28, Issue 5, 2007, Pages 613-627

  Hall, Jennifer L ^a   Birks, Emma J ^b,c   Grindle, Suzanne ^a   Cullen, Martin E ^b   Barton, Paul J ^b   Rider, James E ^a   Lee, Sangjin ^a   Harwalker, Subash ^a   Mariash, Ami ^a   Adhikari, Neeta ^a   Charles, Nathan J ^a   Felkin, Leanne E ^b   Polster, Sean ^a   George, Robert S ^b   Miller, Leslie W ^a   Yacoub, Magdi H ^b,d  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF FLORENCE   (Italy)

Author keywords

EPAC2; Gene expression; Genomics; Heart failure; Left ventricular assist device

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN II ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLENBUTEROL; CYCLIC AMP; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CONVALESCENCE; EXPLANT; FEMALE; FOLLOW UP; GENE CONTROL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HEART ASSIST DEVICE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HUMAN; HUMAN TISSUE; IMPLANTATION; MALE; MICROARRAY ANALYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ADULT; COMBINED MODALITY THERAPY; FEMALE; GENE EXPRESSION PROFILING; HEART FAILURE, CONGESTIVE; HEART-ASSIST DEVICES; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34247620544     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehl365     Document Type: Article

References (33)

1. Jessup M, Brozena S. Heart failure. N Engl J Med 2003;348:2007-2018.
2. Barton PJ, Birks EJ, Felkin LE, Cullen ME, Koban MU, Yacoub MH. Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure. J Heart Lung Transplant 2003;22:738-744.
3. Barton PJ, Felkin LE, Birks EJ, Cullen ME, Banner NR, Grindle S, Hall JL, Miller LW, Yacoub MH. Myocardial insulin-like growth factor-I gene expression during recovery from heart failure after combined left ventricular assist device and clenbuterol therapy. Circulation 2005;112:I46-I50.
4. Blaxall BC, Tschannen-Moran BM, Milano CA, Koch WJ. Differential gene expression and genomic patient stratification following left ventricular assist device support. J Am Coll Cardiol 2003;41:1096-1106.
5. Hall JL, Grindle S, Han X, Fermin D, Park S, Chen Y, Bache RJ, Mariash A, Guan Z, Ormaza S, Thompson J, Graziano J, de Sam Lazaro SE, Pan S, Simari RD, Miller LW. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiol Genomics 2004;17:283-291.
6. Huang X, Pan W, Park S, Han X, Miller LW, Hall J. Modeling the relationship between LVAD support time and gene expression changes in the human heart by penalized partial least squares. Bioinformatics 2004;20:888-894.
7. Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D. Mixed messages: transcription patterns in failing and recovering human myocardium. Circ Res 2005;96:592-599.
8. Razeghi P, Bruckner BA, Sharma S, Youker KA, Frazier OH, Taegtmeyer H. Mechanical unloading of the failing human heart fails to activate the protein kinase B/Akt/glycogen synthase kinase-3beta survival pathway. Cardiology 2003;100:17-22.
9. Razeghi P, Young ME, Ying J, Depre C, Uray IP, Kolesar J, Shipley GL, Moravec CS, Davies PJ, Frazier OH, Taegtmeyer H. Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading. Cardiology 2002;97:203-209.
10. Chen Y, Park S, Li Y, Missov E, Hou M, Han X, Hall JL, Miller LW, Bache RJ. Alterations of gene expression in failing myocardium following left ventricular assist device support. Physiol Genomics 2003;14:251- 260.
11. Rodrigue-Way A, Burkhoff D, Geesaman BJ, Golden S, Xu J, Pollman MJ, Donoghue M, Jeyaseelan R, Houser S, Breitbart RE, Marks A, Acton S. Sarcomeric genes involved in reverse remodeling of the heart during left ventricular assist device support. J Heart Lung Transplant 2005;24:73-80.
12. Chaudhary KW, Rossman EI, Piacentino V III, Kenessey A, Weber C, Gaughan JP, Ojamaa K, Klein I, Bers DM, Houser SR, Margulies KB. Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart. J Am Coll Cardiol 2004;44:837-845.
13. Chen X, Piacentino V III, Furukawa S, Goldman B, Margulies KB, Houser SR. L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circ Res 2002;91:517-524.
14. Harding JD, Piacentino V III, Gaughan JP, Houser SR, Margulies KB. Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure. Circulation 2001;104:1241- 1247.
15. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim DD, Tierney AR, Levitan RG, Watson JT, Meier P, Ronan NS, Shapiro PA, Lazar RM, Miller LW, Gupta L, Frazier OH, Desvigne-Nickens P, Oz MC, Poirier VL. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001;345:1435-1443.
16. Birks EJ, Tansley PD, Yacoub MH, Bowles CT, Hipkin M, Hardy J, Banner NR, Khaghani A. Incidence and clinical management of life-threatening left ventricular assist device failure. J Heart Lung Transplant 2004;23:964-969.
17. Yacoub MH, Tansley P, Birks EJ, Banner NR, Khaghani A, Bowles C. A novel combination therapy to reverse end-stage heart failure. Transplant Proc 2001;33:2762-2764.
18. Birks EJ, Tansley P, Hardy J, RS G, Bowles C, M B, Banner NR, A K, Yacoub MH. Reversal of severe heart failure with left ventricular assist and pharmacologic therapy. N Engl J Med 2006;355:1873-1884.
19. Birks EJ, Hall JL, Barton PJ, Grindle S, Latif N, Hardy JP, Rider JE, Banner NR, Khaghani A, Miller LW, Yacoub MH. Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support. Circulation 2005;112:I57-I64.
20. Cullen ME, Yuen AH, Felkin LE, Smolenski R, Hall JL, Grindle S, Miller LW, Birks EJ, Yacoub MH, Barton PJ. Myocardial expression of the arginine: glycine aminotransferase gene is elevated in heart failure and normalized following post-LVAD recovery: potential implications for local creatine synthesis. Circulation (accepted, Scientific Sessions, American Heart Association Meetings, 2005)
21. Aquila LA, McCarthy PM, Smedira NG, Young JB, Moravec CS. Cytoskeletal structure and recovery in single human cardiac myocytes. J Heart Lung Transplant 2004;23:954-963.
22. Dipla K, Mattiello JA, Jeevanandam V, Houser SR, Margulies KB. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation 1998;97:2316-2322.
23. Ogletree-Hughes ML, Stull LB, Sweet WE, Smedira NG, McCarthy PM, Moravec CS. Mechanical unloading restores beta-adrenergic responsiveness and reverses receptor downregulation in the failing human heart. Circulation 2001;104:881-886.
24. Terracciano CM, Harding SE, Adamson D, Koban M, Tansley P, Birks EJ, Barton PJ, Yacoub MH. Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy. Eur Heart J 2003;24:1329-1339.
25. Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 2002;415:206-212.
26. Holz GG. Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 2004;53:5-13.
27. Seino S, Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev 2005;85:1303-1342.
28. Soppa GK, Smolenski RT, Latif N, Yuen AH, Malik A, Karbowska J, Kochan Z, Terracciano CM, Yacoub MH. Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle. Am J Physiol Heart Circ Physiol 2005;288:H1468-H1476.
29. Barberis L, Wary KK, Fiucci G, Liu F, Hirsch E, Brancaccio M, Altruda F, Tarone G, Giancotti FG. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 2000;275:36532-36540.
30. Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 2003;9:68-75.
31. Brancaccio M, Hirsch E, Notte A, Selvetella G, Lembo G, Tarone G. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res 2006;70:422-433.
32. De Acetis M, Notte A, Accornero F, Selvetella G, Brancaccio M, Vecchione C, Sbroggio M, Collino F, Pacchioni B, Lanfranchi G, Aretini A, Ferretti R, Maffei A, Altruda F, Silengo L, Tarone G, Lembo G. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 2005;96:1087-1094.
33. Keller RS, Shai SY, Babbitt CJ, Pham CG, Solaro RJ, Valencik ML, Loftus JC, Ross RS. Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. Am J Pathol 2001;158:1079-1090.