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Volumn 308, Issue 3, 2015, Pages H183-H192

Mending a broken heart: The role of mitophagy in cardioprotection

Author keywords

Autophagy; BNIP3; FUNDC1; Mitochondria; Mitophagy; Parkin

Indexed keywords

ACTIVATING MOLECULE IN BECLIN1 REGULATED AUTOPHAGY 1; AUTOPHAGY PROTEIN 12; AUTOPHAGY PROTEIN 5; BAX INTERACTING FACTOR 1; BECLIN 1; CARDIOLIPIN; DYNAMIN RELATED PROTEIN 1; FUNDC1 PROTEIN; HEXOKINASE 1; MITOCHONDRIAL DNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOFUSIN 1; MITOFUSIN 2; PARKIN; PHOSPHATASE AND TENSIN HOMOLOG INDUCED PUTATIVE KINASE 1; PROTEIN; PROTEIN BNIP3; PROTEIN NIX; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1; UBIQUITIN PROTEIN LIGASE;

EID: 84936928502     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00708.2014     Document Type: Article
Times cited : (93)

References (101)
  • 2
    • 77951920370 scopus 로고    scopus 로고
    • The cardiac mitochondrion: Nexus of stress
    • Baines CP. The cardiac mitochondrion: nexus of stress. Annu Rev Physiol 72: 61–80, 2010.
    • (2010) Annu Rev Physiol , vol.72 , pp. 61-80
    • Baines, C.P.1
  • 3
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysse-gur J, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29: 2570–2581, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouysse-Gur, J.6    Mazure, N.M.7
  • 4
    • 79959344616 scopus 로고    scopus 로고
    • PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function
    • Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci USA 108: 9572–9577, 2011.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9572-9577
    • Billia, F.1    Hauck, L.2    Konecny, F.3    Rao, V.4    Shen, J.5    Mak, T.W.6
  • 6
    • 84895544715 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and complications associated with diabetes
    • Blake R, Trounce IA. Mitochondrial dysfunction and complications associated with diabetes. Biochim Biophys Acta 1840: 1404–1412, 2014.
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 1404-1412
    • Blake, R.1    Trounce, I.A.2
  • 7
    • 77953704724 scopus 로고    scopus 로고
    • Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells
    • Carreira RS, Lee Y, Ghochani M, Gustafsson AB, Gottlieb RA. Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy 6: 462–472, 2010.
    • (2010) Autophagy , vol.6 , pp. 462-472
    • Carreira, R.S.1    Lee, Y.2    Ghochani, M.3    Gustafsson, A.B.4    Gottlieb, R.A.5
  • 9
    • 84876531457 scopus 로고    scopus 로고
    • PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
    • Chen Y, Dorn GW, 2nd. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340: 471–475, 2013.
    • (2013) Science , vol.340 , pp. 471-475
    • Chen, Y.1    Dorn, G.W.2
  • 11
    • 84894490723 scopus 로고    scopus 로고
    • LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: Implications for Parkinson disease
    • Chu CT, Bayir H, Kagan VE. LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: implications for Parkinson disease. Autophagy 10: 376–378, 2014.
    • (2014) Autophagy , vol.10 , pp. 376-378
    • Chu, C.T.1    Bayir, H.2    Kagan, V.E.3
  • 14
    • 79952693640 scopus 로고    scopus 로고
    • Mitophagy and Parkinson’s disease: The PINK1-parkin link
    • Deas E, Wood NW, Plun-Favreau H. Mitophagy and Parkinson’s disease: the PINK1-parkin link. Biochim Biophys Acta 1813: 623–633, 2011.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 623-633
    • Deas, E.1    Wood, N.W.2    Plun-Favreau, H.3
  • 15
    • 77956252454 scopus 로고    scopus 로고
    • Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming
    • Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW, Yin XM. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem 285: 27879–27890, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 27879-27890
    • Ding, W.X.1    Ni, H.M.2    Li, M.3    Liao, Y.4    Chen, X.5    Stolz, D.B.6    Dorn, G.W.7    Yin, X.M.8
  • 18
    • 77955514158 scopus 로고    scopus 로고
    • Mitochondrial pruning by Nix and BNip3: An essential function for cardiac-expressed death factors
    • Dorn GW 2nd. Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. J Cardiovasc Transl Res 3: 374–383, 2010.
    • (2010) J Cardiovasc Transl Res , vol.3 , pp. 374-383
    • Dorn, G.W.1
  • 19
    • 0035487007 scopus 로고    scopus 로고
    • The mitochondrial permeability transition initiates autophagy in rat hepatocytes
    • Elmore SP, Qian T, Grissom SF, Lemasters JJ. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 15: 2286–2287, 2001.
    • (2001) FASEB J , vol.15 , pp. 2286-2287
    • Elmore, S.P.1    Qian, T.2    Grissom, S.F.3    Lemasters, J.J.4
  • 21
    • 0030881952 scopus 로고    scopus 로고
    • Haguenauer-Tsapis R. Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J
    • Galan JM, Haguenauer-Tsapis R. Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J 16: 5847– 5854, 1997.
    • (1997) 16: 5847– , pp. 5854
    • Galan, J.M.1
  • 22
    • 78649463381 scopus 로고    scopus 로고
    • Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
    • Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 19: 4861–4870, 2010.
    • (2010) Hum Mol Genet , vol.19 , pp. 4861-4870
    • Gegg, M.E.1    Cooper, J.M.2    Chau, K.Y.3    Rojo, M.4    Schapira, A.H.5    Taanman, J.W.6
  • 24
    • 79955623510 scopus 로고    scopus 로고
    • During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
    • Gomes LC, Di Benedetto G, Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 13: 589–598, 2011.
    • (2011) Nat Cell Biol , vol.13 , pp. 589-598
    • Gomes, L.C.1    Di Benedetto, G.2    Scorrano, L.3
  • 25
    • 33749570745 scopus 로고    scopus 로고
    • Enhancing macroau-tophagy protects against ischemia/reperfusion injury in cardiac myo-cytes
    • Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroau-tophagy protects against ischemia/reperfusion injury in cardiac myo-cytes. J Biol Chem 281: 29776–29787, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 29776-29787
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 27
    • 84861733247 scopus 로고    scopus 로고
    • Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy
    • Hanna RA, Quinsay MN, Orogo AM, Giang K, Rikka S, Gustafsson AB. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem 287: 19094–19104, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 19094-19104
    • Hanna, R.A.1    Quinsay, M.N.2    Orogo, A.M.3    Giang, K.4    Rikka, S.5    Gustafsson, A.B.6
  • 28
    • 84905573756 scopus 로고    scopus 로고
    • Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy
    • Hollville E, Carroll RG, Cullen SP, Martin SJ. Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy. Mol Cell 55: 451–466, 2014.
    • (2014) Mol Cell , vol.55 , pp. 451-466
    • Hollville, E.1    Carroll, R.G.2    Cullen, S.P.3    Martin, S.J.4
  • 29
    • 84902007678 scopus 로고    scopus 로고
    • Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes
    • Honda S, Arakawa S, Nishida Y, Yamaguchi H, Ishii E, Shimizu S. Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nat Commun 5: 4004, 2014.
    • (2014) Nat Commun , vol.5 , pp. 4004
    • Honda, S.1    Arakawa, S.2    Nishida, Y.3    Yamaguchi, H.4    Ishii, E.5    Shimizu, S.6
  • 33
    • 50249148905 scopus 로고    scopus 로고
    • Cardiolipin, the heart of mitochondrial metabolism
    • Houtkooper RH, Vaz FM. Cardiolipin, the heart of mitochondrial metabolism. Cell Mol Life Sci 65: 2493–2506, 2008.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2493-2506
    • Houtkooper, R.H.1    Vaz, F.M.2
  • 37
    • 78649685455 scopus 로고    scopus 로고
    • Mitochondrial membrane potential regulates PINK1 import and proteo-lytic destabilization by PARL
    • Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteo-lytic destabilization by PARL. J Cell Biol 191: 933–942, 2010.
    • (2010) J Cell Biol , vol.191 , pp. 933-942
    • Jin, S.M.1    Lazarou, M.2    Wang, C.3    Kane, L.A.4    Narendra, D.P.5    Youle, R.J.6
  • 38
    • 79952355107 scopus 로고    scopus 로고
    • Selective autophagy mediated by autophagic adapter proteins
    • Johansen T, Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 7: 279–296, 2011.
    • (2011) Autophagy , vol.7 , pp. 279-296
    • Johansen, T.1    Lamark, T.2
  • 41
    • 84936928789 scopus 로고    scopus 로고
    • Mitochondria: From cell death executioners to regulators of cell differentiation
    • In press
    • Kasahara A, Scorrano L. Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol. In press.
    • Trends Cell Biol
    • Kasahara, A.1    Scorrano, L.2
  • 42
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132–141, 2011.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 44
    • 84898757170 scopus 로고    scopus 로고
    • Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins
    • Klionsky DJ, Schulman BA. Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. Nat Struct Mol Biol 21: 336–345, 2014.
    • (2014) Nat Struct Mol Biol , vol.21 , pp. 336-345
    • Klionsky, D.J.1    Schulman, B.A.2
  • 47
    • 84881329174 scopus 로고    scopus 로고
    • Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes
    • Kubli DA, Quinsay MN, Gustafsson AB. Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes. Commun Integr Biol 6: e24511, 2013.
    • (2013) Commun Integr Biol , vol.6
    • Kubli, D.A.1    Quinsay, M.N.2    Gustafsson, A.B.3
  • 48
    • 57049172037 scopus 로고    scopus 로고
    • Gustafsson AB. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion
    • H2031
    • Kubli DA, Quinsay MN, Huang C, Lee Y, Gustafsson AB. Bnip3 functions as a mitochondrial sensor of oxidative stress during myocardial ischemia and reperfusion. Am J Physiol Heart Circ Physiol 295: H2025–H2031, 2008.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Kubli, D.A.1    Quinsay, M.N.2    Huang, C.3    Lee, Y.4
  • 49
    • 34547471625 scopus 로고    scopus 로고
    • Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak
    • Kubli DA, Ycaza JE, Gustafsson AB. Bnip3 mediates mitochondrial dysfunction and cell death through Bax and Bak. Biochem J 405: 407–415, 2007.
    • (2007) Biochem J , vol.405 , pp. 407-415
    • Kubli, D.A.1    Ycaza, J.E.2    Gustafsson, A.B.3
  • 51
    • 51649124519 scopus 로고    scopus 로고
    • Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
    • Kundu M, Lindsten T, Yang CY, Wu J, Zhao F, Zhang J, Selak MA, Ney PA, Thompson CB. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 112: 1493–1502, 2008.
    • (2008) Blood , vol.112 , pp. 1493-1502
    • Kundu, M.1    Lindsten, T.2    Yang, C.Y.3    Wu, J.4    Zhao, F.5    Zhang, J.6    Selak, M.A.7    Ney, P.A.8    Thompson, C.B.9
  • 52
    • 67650517556 scopus 로고    scopus 로고
    • NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    • Lamark T, Kirkin V, Dikic I, Johansen T. NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8: 1986–1990, 2009.
    • (2009) Cell Cycle , vol.8 , pp. 1986-1990
    • Lamark, T.1    Kirkin, V.2    Dikic, I.3    Johansen, T.4
  • 53
    • 80355127945 scopus 로고    scopus 로고
    • Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes
    • Lee Y, Lee HY, Hanna RA, Gustafsson AB. Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol 301: H1924–H1931, 2011.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301 , pp. H1924-H1931
    • Lee, Y.1    Lee, H.Y.2    Hanna, R.A.3    Gustafsson, A.B.4
  • 54
    • 84859161154 scopus 로고    scopus 로고
    • Microautophagy: Lesser-known self-eating
    • Li WW, Li J, Bao JK. Microautophagy: lesser-known self-eating. Cell Mol Life Sci 69: 1125–1136, 2012.
    • (2012) Cell Mol Life Sci , vol.69 , pp. 1125-1136
    • Li, W.W.1    Li, J.2    Bao, J.K.3
  • 56
    • 64149124827 scopus 로고    scopus 로고
    • Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure
    • Lu L, Wu W, Yan J, Li X, Yu H, Yu X. Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. Int J Cardiol 134: 82–90, 2009.
    • (2009) Int J Cardiol , vol.134 , pp. 82-90
    • Lu, L.1    Wu, W.2    Yan, J.3    Li, X.4    Yu, H.5    Yu, X.6
  • 59
    • 84859151396 scopus 로고    scopus 로고
    • Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death
    • Ma X, Godar RJ, Liu H, Diwan A. Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death. Autophagy 8: 297–309, 2012.
    • (2012) Autophagy , vol.8 , pp. 297-309
    • Ma, X.1    Godar, R.J.2    Liu, H.3    Diwan, A.4
  • 61
    • 84881656587 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: From mechanisms to therapeutics
    • Marzetti E, Csiszar A, Dutta D, Balagopal G, Calvani R, Leeuwen-burgh C. Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol 305: H459–H476, 2013.
    • (2013) Am J Physiol Heart Circ Physiol , vol.305 , pp. H459-H476
    • Marzetti, E.1    Csiszar, A.2    Dutta, D.3    Balagopal, G.4    Calvani, R.5    Leeuwen-Burgh, C.6
  • 62
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
    • Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100: 914–922, 2007.
    • (2007) Circ Res , vol.100 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3    Abdellatif, M.4    Sakoda, H.5    Asano, T.6    Levine, B.7    Sadoshima, J.8
  • 63
    • 0015239454 scopus 로고
    • The turnover of mitochondria in a variety of tissues of young adult and aged rats
    • Menzies RA, Gold PH. The turnover of mitochondria in a variety of tissues of young adult and aged rats. J Biol Chem 246: 2425–2429, 1971.
    • (1971) J Biol Chem , vol.246 , pp. 2425-2429
    • Menzies, R.A.1    Gold, P.H.2
  • 64
    • 79959999581 scopus 로고    scopus 로고
    • Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum
    • Mijaljica D, Prescott M, Devenish RJ. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 7: 673–682, 2011.
    • (2011) Autophagy , vol.7 , pp. 673-682
    • Mijaljica, D.1    Prescott, M.2    Devenish, R.J.3
  • 65
    • 0024232662 scopus 로고
    • Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation
    • Mortimore GE, Wert JJ Jr, Adams CE. Modulation of the amino acid control of hepatic protein degradation by caloric deprivation. Two modes of alanine co-regulation. J Biol Chem 263: 19545–19551, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 19545-19551
    • Mortimore, G.E.1    Wert, J.J.2    Adams, C.E.3
  • 66
    • 78649300971 scopus 로고    scopus 로고
    • P62/ SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
    • Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/ SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy 6: 1090–1106, 2010.
    • (2010) Autophagy , vol.6 , pp. 1090-1106
    • Narendra, D.1    Kane, L.A.2    Hauser, D.N.3    Fearnley, I.M.4    Youle, R.J.5
  • 67
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795–803, 2008.
    • (2008) J Cell Biol , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 72
    • 77955844260 scopus 로고    scopus 로고
    • The mitochon-drial fusion-promoting factor mitofusin is a substrate of the PINK1/ parkin pathway
    • Poole AC, Thomas RE, Yu S, Vincow ES, Pallanck L. The mitochon-drial fusion-promoting factor mitofusin is a substrate of the PINK1/ parkin pathway. PLoS ONE 5: e10054, 2010.
    • (2010) Plos ONE , vol.5
    • Poole, A.C.1    Thomas, R.E.2    Yu, S.3    Vincow, E.S.4    Pallanck, L.5
  • 74
    • 77957683915 scopus 로고    scopus 로고
    • Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore
    • Quinsay MN, Thomas RL, Lee Y, Gustafsson AB. Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore. Autophagy 6: 17–24, 2010.
    • (2010) Autophagy , vol.6 , pp. 17-24
    • Quinsay, M.N.1    Thomas, R.L.2    Lee, Y.3    Gustafsson, A.B.4
  • 75
    • 79959987510 scopus 로고    scopus 로고
    • Lippincott-Schwartz J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci USA
    • Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci USA 108: 10190– 10195, 2011.
    • (2011) 108: 10190– , pp. 10195
    • Rambold, A.S.1    Kostelecky, B.2    Elia, N.3
  • 76
    • 0037047647 scopus 로고    scopus 로고
    • Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes
    • Regula KM, Ens K, Kirshenbaum LA. Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Circ Res 91: 226–231, 2002.
    • (2002) Circ Res , vol.91 , pp. 226-231
    • Regula, K.M.1    Ens, K.2    Kirshenbaum, L.A.3
  • 79
    • 0035057837 scopus 로고    scopus 로고
    • Control of mitochondrial morphology by a human mitofusin
    • Santel A, Fuller MT. Control of mitochondrial morphology by a human mitofusin. J Cell Sci 114: 867–874, 2001.
    • (2001) J Cell Sci , vol.114 , pp. 867-874
    • Santel, A.1    Fuller, M.T.2
  • 80
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26: 1749–1760, 2007.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 83
    • 84904734344 scopus 로고    scopus 로고
    • Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomy-opathy
    • Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW, 2nd. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomy-opathy. Circ Res 115: 348–353, 2014.
    • (2014) Circ Res , vol.115 , pp. 348-353
    • Song, M.1    Chen, Y.2    Gong, G.3    Murphy, E.4    Rabinovitch, P.S.5    Dorn, G.W.6
  • 85
    • 84870013071 scopus 로고    scopus 로고
    • Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy
    • Sun Y, Vashisht AA, Tchieu J, Wohlschlegel JA, Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem 287: 40652–40660, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 40652-40660
    • Sun, Y.1    Vashisht, A.A.2    Tchieu, J.3    Wohlschlegel, J.A.4
  • 86
    • 84876499607 scopus 로고    scopus 로고
    • Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphom-agenesis via suppression of mitophagy
    • Takahashi Y, Hori T, Cooper TK, Liao J, Desai N, Serfass JM, Young MM, Park S, Izu Y, Wang HG. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphom-agenesis via suppression of mitophagy. Blood 121: 1622–1632, 2013.
    • (2013) Blood , vol.121 , pp. 1622-1632
    • Takahashi, Y.1    Hori, T.2    Cooper, T.K.3    Liao, J.4    Desai, N.5    Serfass, J.M.6    Young, M.M.7    Park, S.8    Izu, Y.9    Wang, H.G.10
  • 87
    • 61849085267 scopus 로고    scopus 로고
    • Murine muscle cell models for Pompe disease and their use in studying therapeutic approaches
    • Takikita S, Myerowitz R, Zaal K, Raben N, Plotz PH. Murine muscle cell models for Pompe disease and their use in studying therapeutic approaches. Mol Genet Metab 96: 208–217, 2009.
    • (2009) Mol Genet Metab , vol.96 , pp. 208-217
    • Takikita, S.1    Myerowitz, R.2    Zaal, K.3    Raben, N.4    Plotz, P.H.5
  • 98
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124–131, 2010.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 100
    • 84865846785 scopus 로고    scopus 로고
    • AMP-activated protein kinase regulation and biological actions in the heart
    • Zaha VG, Young LH. AMP-activated protein kinase regulation and biological actions in the heart. Circ Res 111: 800–814, 2012.
    • (2012) Circ Res , vol.111 , pp. 800-814
    • Zaha, V.G.1    Young, L.H.2


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