Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy

Circulation Research

Volumn 115, Issue 3, 2014, Pages 348-353

  Song, Moshi ^a   Chen, Yun ^a   Gong, Guohua ^a   Murphy, Elizabeth ^b   Rabinovitch, Peter S ^c   Dorn, Gerald W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

cardiomyopathies; catalase; mitochondria; mitochondrial degradation; mitofusin 1

Indexed keywords

CATALASE; HYDROGEN PEROXIDE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOFUSIN 2; PARKIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CARDIAC DEGENERATION; CARDIOMYOPATHY; CELL DEGENERATION; CONTROLLED STUDY; HEART DEPOLARIZATION; HEART FAILURE; HEART MUSCLE CELL; IN VIVO STUDY; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIMARY MITOPHAGIC CARDIOMYOPATHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CARDIOMYOPATHIES; CATALASE; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOFUSIN 1;

ANIMALS; AUTOPHAGY; CARDIOMYOPATHIES; CYCLOPHILINS; FEMALE; GTP PHOSPHOHYDROLASES; HUMANS; HYDROGEN PEROXIDE; MALE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL MEMBRANES; MYOCARDIUM; MYOSIN HEAVY CHAINS; OXIDANTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84904734344     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.304384     Document Type: Article

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